Optimization of Cas9 RNA sequence to reduce its unexpected effects as a microRNA sponge
Junfeng Jiang, Tao Zeng, Li Zhang and 22 more
Molecular Cancer · 2022
doi:10.1186/s12943-022-01604-x (opens in a new tab)
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Abstract
Highlights Cas9 RNA functions as a miRNA sponge. Let-7 is the dominant regulated miRNA by Cas9 RNA. RNA sequence optimization of Cas9 by synonymous mutation improves its safety.
Abstract licence: CC BY-NC-ND
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