Interleukin-4 receptor alpha gene variants and allergic disease
Hall Ian P
Respiratory Research · 2000
doi:10.1186/rr3 (opens in a new tab)
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Abstract
<p>Abstract</p> <p>The interleukin-4 (IL-4) signalling cascade has been identified as a pathway potentially important in the development of asthma. Genetic variants within this signalling pathway might contribute to the risk of developing asthma in a given individual. A number of polymorphisms have been described within the IL-4 receptor α (IL-4Rα) gene. In addition polymorphism occurs in the promoter for the IL-4 gene itself. This commentary accompanies a paper by C Ober <it>et al</it> describing the contribution of IL-4Rα polymorphism to susceptibility to asthma and atopy in the Hutterite population and other outbred populations collected during the collaborative studies on the genetics of asthma (CSGA) programme.</p>
Abstract licence: CC BY-NC-ND
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