No retraction, correction or concern found when last checked on Nov 2, 2026.

Intensive care of the cancer patient: recent achievements and remaining challenges

Elie Azoulay, Marcio Soares, Michael Darmon and 3 more

Annals of Intensive Care · 2011 · Review · CC BY-NC-ND

Abstract

A few decades have passed since intensive care unit (ICU) beds have been available for critically ill patients with cancer. Although the initial reports showed dismal prognosis, recent data suggest that an increased number of patients with solid and hematological malignancies benefit from intensive care support, with dramatically decreased mortality rates. Advances in the management of the underlying malignancies and support of organ dysfunctions have led to survival gains in patients with life-threatening complications from the malignancy itself, as well as infectious and toxic adverse effects related to the oncological treatments. In this review, we will appraise the prognostic factors and discuss the overall perspective related to the management of critically ill patients with cancer. The prognostic significance of certain factors has changed over time. For example, neutropenia or autologous bone marrow transplantation (BMT) have less adverse prognostic implications than two decades ago. Similarly, because hematologists and oncologists select patients for ICU admission based on the characteristics of the malignancy, the underlying malignancy rarely influences short-term survival after ICU admission. Since the recent data do not clearly support the benefit of ICU support to unselected critically ill allogeneic BMT recipients, more outcome research is needed in this subgroup. Because of the overall increased survival that has been reported in critically ill patients with cancer, we outline an easy-to-use and evidence-based ICU admission triage criteria that may help avoid depriving life support to patients with cancer who can benefit. Lastly, we propose a research agenda to address unanswered questions.

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References 107

1.
Coleman MP Quaresma M Berrino F Lutz JM De Angelis R Capocaccia R Baili P Rachet B Gatta G Hakulinen T Micheli A Sant M Weir HK Elwood JM Tsukuma H Koifman S Ga ES Francisci S Santaquilani M Verdecchia A Storm HH Young JL Cancer survival in five continents: a worldwide population-based study (CONCORD)Lancet Oncol2008 9730756Epub 2008 Jul 17
Not in our library10.1016/s1470-2045(08)70179-7
2.
Kinsey T Jemal A Liff J Ward E Thun M Secular trends in mortality from common cancers in the United States by educational attainment, 1993-2001J Natl Cancer Inst2008 10010031012Epub 2008 Jul 8
Not in our library10.1093/jnci/djn207
3.
Jemal A Siegel R Ward E Hao Y Xu J Murray T Thun MJ Cancer statistics, 2008CA Cancer J Clin2008 587196Epub 2008 Feb 20
Not in our library10.3322/ca.2007.0010
4.
Atlanta U.S. Department of Health and Human Services CfdcapanciU.S. Cancer Statistics Working Group. United States Cancer Statistics: 1999-2005 Incidence and Mortality Web-based Reporthttp://www.cdc.gov/uscs 2009
Not in our library
5.
Ferlay J Autier P Boniol M Heanue M Colombet M Boyle P Estimates of the cancer incidence and mortality in Europe in 2006Ann Oncol2007 18581592
Not in our library10.1093/annonc/mdl498
6.
Rodriguez-Abreu D Bordoni A Zucca E Epidemiology of hematological malignanciesAnn Oncol2007 18Suppl 1i3i8
Not in our library10.1093/annonc/mdl443
7.
Linker C Damon L Ries C Navarro W Intensified and shortened cyclical chemotherapy for adult acute lymphoblastic leukemiaJ Clin Oncol2002 2024642471
Not in our library10.1200/jco.2002.07.116
8.
Richardson PG Sonneveld P Schuster MW Irwin D Stadtmauer EA Facon T Harousseau JL Ben-Yehuda D Lonial S Goldschmidt H Reece D San-Miguel JF Blade J Boccadoro M Cavenagh J Dalton WS Boral AL Esseltine DL Porter JB Schenkein D Anderson KC Bortezomib or high-dose dexamethasone for relapsed multiple myelomaN Engl J Med2005 35224872498
Not in our library10.1056/nejmoa043445
9.
Pfreundschuh M Trumper L Osterborg A Pettengell R Trneny M Imrie K Ma D Gill D Walewski J Zinzani PL Stahel R Kvaloy S Shpilberg O Jaeger U Hansen M Lehtinen T Lopez-Guillermo A Corrado C Scheliga A Milpied N Mendila M Rashford M Kuhnt E Loeffler M CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) GroupLancet Oncol2006 7379391
Not in our library10.1016/s1470-2045(06)70664-7
10.
Khassawneh BY White P Jr Anaissie EJ Barlogie B Hiller FC Outcome from mechanical ventilation after autologous peripheral blood stem cell transplantationChest2002 121185188
Not in our library10.1378/chest.121.1.185
11.
Peigne V Rusinova K Karlin L Darmon M Fermand JP Schlemmer B Azoulay E Continued survival gains in recent years among critically ill myeloma patientsIntensive Care Med2009 35512518
Not in our library10.1007/s00134-008-1320-4
12.
Darmon M Guichard I Vincent F Schlemmer B Azoulay E Prognostic significance of acute renal injury in acute tumor lysis syndromeLeuk Lymphoma2010 51221227
Not in our library10.3109/10428190903456959
13.
Azoulay E Fieux F Moreau D Thiery G Rousselot P Parrot A Le Gall Jr Dombret H Schlemmer B Acute monocytic leukemia presenting as acute respiratory failureAm J Respir Crit Care Med2003 16713291333
Not in our library10.1164/rccm.200206-554oc
14.
Creput C Galicier L Buyse S Azoulay E Understanding organ dysfunction in hemophagocytic lymphohistiocytosisIntensive Care Med2008 3411771187
Not in our library10.1007/s00134-008-1111-y
15.
Tanvetyanon T Leighton JC Life-sustaining treatments in patients who died of chronic congestive heart failure compared with metastatic cancerCrit Care Med2003 316064
Not in our library10.1097/00003246-200301000-00009
16.
Benoit DD Vandewoude KH Decruyenaere JM Hoste EA Colardyn FA Outcome and early prognostic indicators in patients with a hematologic malignancy admitted to the intensive care unit for a life-threatening complicationCrit Care Med2003 31104112
Not in our library10.1097/00003246-200301000-00017
17.
Lecuyer L Chevret S Thiery G Darmon M Schlemmer B Azoulay E The ICU trial: a new admission policy for cancer patients requiring mechanical ventilationCrit Care Med2007 35808814
Not in our library10.1097/01.ccm.0000256846.27192.7a
18.
Soares M Azoulay E Critical care management of lung cancer patients to prolong life without prolonging dyingIntensive Care Med2009 3520122014
Not in our library10.1007/s00134-009-1633-y
19.
Azoulay E Afessa B The intensive care support of patients with malignancy: do everything that can be doneIntensive Care Med2006 3235Epub 2005 Nov 25
Not in our library10.1007/s00134-005-2835-6
20.
Darmon M Thiery G Ciroldi M De Miranda S Galicier L Raffoux E Le Gall Jr Schlemmer B Azoulay E Intensive care in patients with newly diagnosed malignancies and a need for cancer chemotherapyCrit Care Med2005 3324882493
Not in our library10.1097/01.ccm.0000181728.13354.0a
21.
Benoit DD Depuydt PO Vandewoude KH Offner FC Boterberg T De Cock CA Noens LA Janssens AM Decruyenaere JM Outcome in severely ill patients with hematological malignancies who received intravenous chemotherapy in the intensive care unitIntensive Care Med2006 329399
Not in our library10.1007/s00134-005-2836-5
22.
Vandijck DM Benoit DD Depuydt PO Offner FC Blot SI Van Tilborgh AK Nollet J Steel E Noens LS Decruyenaere JM Impact of recent intravenous chemotherapy on outcome in severe sepsis and septic shock patients with hematological malignanciesIntensive Care Med2008 34847855
Not in our library10.1007/s00134-008-1002-2
23.
Azoulay E Alberti C Bornstain C Leleu G Moreau D Recher C Chevret S Le Gall Jr Brochard L Schlemmer B Improved survival in cancer patients requiring mechanical ventilatory support: impact of noninvasive mechanical ventilatory supportCrit Care Med2001 29519525
Not in our library10.1097/00003246-200103000-00009
24.
Azoulay E Recher C Alberti C Soufir L Leleu G Le Gall Jr Fermand JP Schlemmer B Changing use of intensive care for hematological patients: the example of multiple myelomaIntensive Care Med1999 2513951401
Not in our library10.1007/s001340051087
25.
Kress JP Christenson J Pohlman AS Linkin DR Hall JB Outcomes of critically ill cancer patients in a university hospital settingAm J Respir Crit Care Med1999 16019571961
Not in our library10.1164/ajrccm.160.6.9812055
26.
Larche J Azoulay E Fieux F Mesnard L Moreau D Thiery G Darmon M Le Gall Jr Schlemmer B Improved survival of critically ill cancer patients with septic shockIntensive Care Med2003 2916881695Epub 2003 Sep 12
Not in our library10.1007/s00134-003-1957-y
27.
Pene F Aubron C Azoulay E Blot F Thiery G Raynard B Schlemmer B Nitenberg G Buzyn A Arnaud P Socie G Mira JP Outcome of critically ill allogeneic hematopoietic stem-cell transplantation recipients: a reappraisal of indications for organ failure supportsJ Clin Oncol2006 24643649Epub 2005 Dec 27
Not in our library10.1200/jco.2005.03.9073
28.
Legriel S Marijon H Darmon M Lemiale V Bedos JP Schlemmer B Azoulay E Central neurological complications in critically ill patients with malignanciesIntensive Care Med36232240
Not in our library10.1007/s00134-009-1709-8
29.
Soares M Salluh JI Ferreira CG Luiz RR Spector N Rocco Jr Impact of two different comorbidity measures on the 6-month mortality of critically ill cancer patientsIntensive Care Med2005 31408415Epub 2005 Jan 28
Not in our library10.1007/s00134-005-2554-z
30.
Soares M Salluh JI Spector N Rocco Jr Characteristics and outcomes of cancer patients requiring mechanical ventilatory support for >24 hrsCrit Care Med2005 33520526
Not in our library10.1097/01.ccm.0000155783.46747.04
31.
Staudinger T Stoiser B Mullner M Locker GJ Laczika K Knapp S Burgmann H Wilfing A Kofler J Thalhammer F Frass M Outcome and prognostic factors in critically ill cancer patients admitted to the intensive care unitCrit Care Med2000 2813221328
Not in our library10.1097/00003246-200005000-00011
32.
Schellongowski P Benesch M Lang T Traunmuller F Zauner C Laczika K Locker GJ Frass M Staudinger T Comparison of three severity scores for critically ill cancer patientsIntensive Care Med2004 30430436Epub 2003 Nov 4
Not in our library10.1007/s00134-003-2043-1
33.
Darmon M Azoulay E Alberti C Fieux F Moreau D Gall Jr Schlemmer B Impact of neutropenia duration on short-term mortality in neutropenic critically ill cancer patientsIntensive Care Med2002 2817751780
Not in our library10.1007/s00134-002-1528-7
34.
Groeger JS White P Jr Nierman Dm Glassman J Shi W Horak D Price K Outcome for cancer patients requiring mechanical ventilationJ Clin Oncol1999 17991997
Not in our library10.1200/jco.1999.17.3.991
35.
Depuydt PO Benoit DD Vandewoude KH Decruyenaere JM Colardyn FA Outcome in noninvasively and invasively ventilated hematologic patients with acute respiratory failureChest2004 12612991306
Not in our library10.1378/chest.126.4.1299
36.
Soares M Depuydt PO Salluh JI Mechanical ventilation in cancer patients: clinical characteristics and outcomesCrit Care Clin264158
Not in our library10.1016/j.ccc.2009.09.005
37.
Benoit DD Hoste EA Depuydt PO Offner FC Lameire NH Vandewoude KH Dhondt AW Noens LA Decruyenaere JM Outcome in critically ill medical patients treated with renal replacement therapy for acute renal failure: comparison between patients with and those without haematological malignanciesNephrol Dial Transplant2005 20552558Epub 2005 Jan 25
Not in our library10.1093/ndt/gfh637
38.
Darmon M Thiery G Ciroldi M Porcher R Schlemmer B Azoulay E Should dialysis be offered to cancer patients with acute kidney injury?Intensive Care Med2007 33765772
Not in our library10.1007/s00134-007-0579-1
39.
Soares M Salluh JI Carvalho MS Darmon M Rocco Jr Spector N Prognosis of critically ill patients with cancer and acute renal dysfunctionJ Clin Oncol2006 2440034010
Not in our library10.1200/jco.2006.05.7869
40.
Azoulay E Mokart D Rabbat A Pene F Kouatchet A Bruneel F Vincent F Hamidfar R Moreau D Mohammedi I Epinette G Beduneau G Castelain V De Lassence A Gruson D Lemiale V Renard B Chevret S Schlemmer B Diagnostic bronchoscopy in hematology and oncology patients with acute respiratory failure: prospective multicenter dataCrit Care Med2008 36100107
Not in our library10.1097/01.ccm.0000295590.33145.c4
41.
Massion PB Dive AM Doyen C Bulpa P Jamart J Bosly A Installe E Prognosis of hematologic malignancies does not predict intensive care unit mortalityCrit Care Med2002 3022602270
Not in our library10.1097/00003246-200210000-00014
42.
Brenner H Long-term survival rates of cancer patients achieved by the end of the 20th century: a period analysisLancet2002 36011311135
Not in our library10.1016/s0140-6736(02)11199-8
43.
Brenner H Gondos A Arndt V Recent major progress in long-term cancer patient survival disclosed by modeled period analysisJ Clin Oncol2007 2532743280
Not in our library10.1200/jco.2007.11.3431
44.
O'brien SG Guilhot F Larson RA Gathmann I Baccarani M Cervantes F Cornelissen JJ Fischer T Hochhaus A Hughes T Lechner K Nielsen JL Rousselot P Reiffers J Saglio G Shepherd J Simonsson B Gratwohl A Goldman JM Kantarjian H Taylor K Verhoef G Bolton AE Capdeville R Druker BJ Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemiaN Engl J Med2003 3489941004
Not in our library10.1056/nejmoa022457
45.
Talpaz M Shah NP Kantarjian H Donato N Nicoll J Paquette R Cortes J O'Brien S Nicaise C Bleickardt E Blackwood-Chirchir MA Iyer V Chen TT Huang F Decillis AP Sawyers CL Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemiasN Engl J Med2006 35425312541
Not in our library10.1056/nejmoa055229
46.
Wossmann W Schrappe M Meyer U Zimmermann M Reiter A Incidence of tumor lysis syndrome in children with advanced stage Burkitt's lymphoma/leukemia before and after introduction of prophylactic use of urate oxidaseAnn Hematol2003 82160165
Not in our library10.1007/s00277-003-0608-2
47.
Rano A Agusti C Jimenez P Angrill J Benito N Danes C Gonzalez J Rovira M Pumarola T Moreno A Torres A Pulmonary infiltrates in non-HIV immunocompromised patients: a diagnostic approach using non-invasive and bronchoscopic proceduresThorax2001 56379387
Not in our library10.1136/thorax.56.5.379
48.
Hilbert G Gruson D Vargas F Valentino R Chene G Boiron JM Pigneux A Reiffers J Gbikpi-Benissan G Cardinaud JP Noninvasive continuous positive airway pressure in neutropenic patients with acute respiratory failure requiring intensive care unit admissionCrit Care Med2000 2831853190
Not in our library10.1097/00003246-200009000-00012
49.
Hilbert G Gruson D Vargas F Valentino R Gbikpi-Benissan G Dupon M Reiffers J Cardinaud JP Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failureN Engl J Med2001 344481487
Not in our library10.1056/nejm200102153440703
50.
Azoulay E Thiery G Chevret S Moreau D Darmon M Bergeron A Yang K Meignin V Ciroldi M Le Gall Jr Tazi A Schlemmer B The prognosis of acute respiratory failure in critically ill cancer patientsMedicine (Baltimore)2004 83360370
Not in our library10.1097/01.md.0000145370.63676.fb
51.
Hilbert G Gruson D Vargas F Valentino R Favier JC Portel L Gbikpi-Benissan G Cardinaud JP Bronchoscopy with bronchoalveolar lavage via the laryngeal mask airway in high-risk hypoxemic immunosuppressed patientsCrit Care Med2001 29249255
Not in our library10.1097/00003246-200102000-00004
52.
Benoit DD Depuydt PO Peleman RA Offner FC Vandewoude KH Vogelaers DP Blot SI Noens LA Colardyn FA Decruyenaere JM Documented and clinically suspected bacterial infection precipitating intensive care unit admission in patients with hematological malignancies: impact on outcomeIntensive Care Med2005 31934942
Not in our library10.1007/s00134-005-2599-z
53.
Lecuyer L Chevret S Guidet B Aegerter P Martel P Schlemmer B Azoulay E Case volume and mortality in haematological patients with acute respiratory failureEur Respir J2008 32748754Epub 2008 Apr 30
Not in our library10.1183/09031936.00142907
54.
Ardeshna KM Smith P Norton A Hancock BW Hoskin PJ Maclennan KA Marcus RE Jelliffe A Vaughan G Hudson Linch DC Long-term effect of a watch and wait policy versus immediate systemic treatment for asymptomatic advanced-stage non-Hodgkin lymphoma: a randomised controlled trialLancet2003 362516522
Not in our library10.1016/s0140-6736(03)14110-4
55.
Hampshire PA Welch CA Mccrossan LA Francis K Harrison DA Admission factors associated with hospital mortality in patients with haematological malignancy admitted to UK adult, general critical care units: a secondary analysis of the ICNARC Case Mix Programme DatabaseCrit Care2009 13R137
Not in our library10.1186/cc8016
56.
Meyer S Gortner L Gottschling S Comment on "impact of recent intravenous chemotherapy on outcome in severe sepsis and septic shock patients with haematological malignancies" by Vandijck et alIntensive Care Med2008 341929author reply 1930-1931
Not in our library10.1007/s00134-008-1222-5
57.
Soares M Caruso P Silva E Teles JM Lobo SM Friedman G Dal Pizzol F Mello PV Bozza FA Silva UV Torelly AP Knibel MF Rezende E Netto JJ Piras C Castro A Ferreira BS Rea-Neto A Olmedo PB Salluh JI Characteristics and outcomes of patients with cancer requiring admission to intensive care units: a prospective multicenter studyCrit Care Med2010 38915
Not in our library10.1097/ccm.0b013e3181c0349e
58.
Coiffier B Altman A Pui CH Younes A Cairo MS Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based reviewJ Clin Oncol2008 2627672778
Not in our library10.1200/jco.2007.15.0177
59.
Tosi P Barosi G Lazzaro C Liso V Marchetti M Morra E Pession A Rosti G Santoro A Zinzani PL Tura S Consensus conference on the management of tumor lysis syndromeHaematologica2008 9318771885
Not in our library10.3324/haematol.13290
60.
Azoulay E Schlemmer B Diagnostic strategy in cancer patients with acute respiratory failureIntensive Care Med2006 32808822Epub 2006 Apr 29
Not in our library10.1007/s00134-006-0129-2
61.
Afessa B Azoulay E Critical care of the hematopoietic stem cell transplant recipientCrit Care Clin2010 26133150
Not in our library10.1016/j.ccc.2009.09.001
62.
Meert AP Berghmans T Hardy M Markiewicz E Sculier JP Non-invasive ventilation for cancer patients with life-support techniques limitationSupport Care Cancer2006 14167171Epub 2005 Jun 10
Not in our library10.1007/s00520-005-0845-0
63.
Oh SY Lee SJ Lee J Lee S Kim SH Kwon HC Lee GW Kang JH Hwang IG Jang JS Lim HY Park YS Kang WK Kim HJ Gastric leptomeningeal carcinomatosis: multi-center retrospective analysis of 54 casesWorld J Gastroenterol2009 1550865090
Not in our library10.3748/wjg.15.5086
64.
Ruffato A Mattioli S Pileri S Daddi N D'ovidio F Pilotti V Tazzari P Do bone marrow isolated tumor cells influence long-term survival of non-small cell lung cancer?Eur J Cardiothorac Surg2009 35463468
Not in our library10.1016/j.ejcts.2008.11.017
65.
Price KJ Thall PF Kish SK Shannon VR Andersson BS Prognostic indicators for blood and marrow transplant patients admitted to an intensive care unitAm J Respir Crit Care Med1998 158876884
Not in our library10.1164/ajrccm.158.3.9711076
66.
Rubenfeld GD Crawford SW Withdrawing life support from mechanically ventilated recipients of bone marrow transplants: a case for evidence-based guidelinesAnn Intern Med1996 125625633
Not in our library10.7326/0003-4819-125-8-199610150-00001
67.
Afessa B Tefferi A Dunn WF Litzow MR Peters SG Intensive care unit support and Acute Physiology and Chronic Health Evaluation III performance in hematopoietic stem cell transplant recipientsCrit Care Med2003 3117151721
Not in our library10.1097/01.ccm.0000065761.51367.2d
68.
Afessa B Tefferi A Litzow MR Krowka MJ Wylam ME Peters SG Diffuse alveolar hemorrhage in hematopoietic stem cell transplant recipientsAm J Respir Crit Care Med2002 166641645
Not in our library10.1164/rccm.200112-141cc
69.
Afessa B Tefferi A Litzow MR Peters SG Outcome of diffuse alveolar hemorrhage in hematopoietic stem cell transplant recipientsAm J Respir Crit Care Med2002 16613641368
Not in our library10.1164/rccm.200208-792oc
70.
Afessa B Litzow MR Tefferi A Bronchiolitis obliterans and other late onset non-infectious pulmonary complications in hematopoietic stem cell transplantationBone Marrow Transplant2001 28425434
Not in our library10.1038/sj.bmt.1703142
71.
Guiguet M Blot F Escudier B Antoun S Leclercq B Nitenberg G Severity-of-illness scores for neutropenic cancer patients in an intensive care unit: Which is the best predictor? Do multiple assessment times improve the predictive value?Crit Care Med1998 26488493
Not in our library10.1097/00003246-199803000-00020
72.
Thiery G Azoulay E Darmon M Ciroldi M De Miranda S Levy V Fieux F Moreau D Le Gall Jr Schlemmer B Outcome of cancer patients considered for intensive care unit admission: a hospital-wide prospective studyJ Clin Oncol2005 2344064413
Not in our library10.1200/jco.2005.01.487
73.
Gruson D Vargas F Hilbert G Bui N Maillot T Mayet T Pillet O Chene G Gbikpi-Benissan G Predictive factors of intensive care unit admission in patients with haematological malignancies and pneumoniaIntensive Care Med2004 30965971
Not in our library10.1007/s00134-004-2237-1
74.
Antonelli M Conti G Riccioni L Meduri GU Noninvasive positive-pressure ventilation via face mask during bronchoscopy with BAL in high-risk hypoxemic patientsChest1996 110724728
Not in our library10.1378/chest.110.3.724
75.
Maitre B Jaber S Maggiore SM Bergot E Richard JC Bakthiari H Housset B Boussignac G Brochard L Continuous positive airway pressure during fiberoptic bronchoscopy in hypoxemic patients. A randomized double-blind study using a new deviceAm J Respir Crit Care Med2000 16210631067
Not in our library10.1164/ajrccm.162.3.9910117
76.
Darmon M Azoulay E Critical care management of cancer patients: cause for optimism and need for objectivityCurr Opin Oncol2009 21318326
Not in our library10.1097/cco.0b013e32832b68b6
77.
Cheung AM Tansey CM Tomlinson G Diaz-Granados N Matte A Barr A Mehta S Mazer CD Guest CB Stewart TE Al-Saidi F Cooper AB Cook D Slutsky AS Herridge MS Two-year outcomes, health care use, and costs of survivors of acute respiratory distress syndromeAm J Respir Crit Care Med2006 174538544
Not in our library10.1164/rccm.200505-693oc
78.
Herridge MS Cheung AM Tansey CM Matte-Martyn A Diaz-Granados N Al-Saidi F Cooper AB Guest CB Mazer CD Mehta S Stewart TE Barr A Cook D Slutsky AS One-year outcomes in survivors of the acute respiratory distress syndromeN Engl J Med2003 348683693
Not in our library10.1056/nejmoa022450
79.
Tansey CM Louie M Loeb M Gold WL Muller MP De Jager J Cameron JI Tomlinson G Mazzulli T Walmsley SL Rachlis AR Mederski BD Silverman M Shainhouse Z Ephtimios IE Avendano M Downey J Styra R Yamamura D Gerson M Stanbrook MB Marras TK Phillips EJ Zamel N Richardson SE Slutsky AS Herridge MS One-year outcomes and health care utilization in survivors of severe acute respiratory syndromeArch Intern Med2007 16713121320
Not in our library10.1001/archinte.167.12.1312
80.
Nelson JE Meier DE Oei EJ Nierman DM Senzel RS Manfredi PL Davis SM Morrison RS Self-reported symptom experience of critically ill cancer patients receiving intensive careCrit Care Med2001 29277282
Not in our library10.1097/00003246-200102000-00010
81.
Azoulay E Timsit JF Sprung CL Soares M Rusinova K Lafabrie A Abizanda R Svantesson M Rubulotta F Ricou B Benoit D Heyland D Joynt G Francais A Azeivedo-Maia P Owczuk R Benbenishty J De Vita M Valentin A Ksomos A Cohen S Kompan L Ho K Abroug F Kaarlola A Gerlach H Kyprianou T Michalsen A Chevret S Schlemmer B Prevalence and factors of intensive care unit conflicts: the conflicus studyAm J Respir Crit Care Med2009 180853860
Not in our library10.1164/rccm.200810-1614oc
82.
Poncet MC Toullic P Papazian L Kentish-Barnes N Timsit JF Pochard F Chevret S Schlemmer B Azoulay E Burnout syndrome in critical care nursing staffAm J Respir Crit Care Med2007 175698704
Not in our library10.1164/rccm.200606-806oc
83.
Hamric AB Blackhall LJ Nurse-physician perspectives on the care of dying patients in intensive care units: collaboration, moral distress, and ethical climateCrit Care Med2007 35422429
Not in our library10.1097/01.ccm.0000254722.50608.2d
84.
Gaeta S Price KJ End-of-life issues in critically ill cancer patientsCrit Care Clin26219227
Not in our library10.1016/j.ccc.2009.10.002
85.
Stover DE Zaman MB Hajdu SI Lange M Gold J Armstrong D Bronchoalveolar lavage in the diagnosis of diffuse pulmonary infiltrates in the immunosuppressed hostAnn Intern Med1984 10117
Not in our library10.7326/0003-4819-101-1-1
86.
Prebet T Boissel N Reutenauer S Thomas X Delaunay J Cahn JY Pigneux A Quesnel B Witz F Thepot S Ugo V Terre C Recher C Tavernier E Hunault M Esterni B Castaigne S Guilhot F Dombret H Vey N Acute myeloid leukemia with translocation (8;21) or inversion (16) in elderly patients treated with conventional chemotherapy: a collaborative study of the French CBF-AML intergroupJ Clin Oncol2009 2747474753
Not in our library10.1200/jco.2008.21.0674
87.
Walsh TJ Advances and challenges in infectious diseases supportive care of patients with hematologic malignancies, hematopoietic stem cell transplantation, and severe aplastic anemiaSemin Hematol2009 46191197
Not in our library10.1053/j.seminhematol.2009.05.001
88.
L'her E Noninvasive ventilation outside the intensive care unit: a new standard of care?Crit Care Med2005 3316421643
Not in our library10.1097/01.ccm.0000170409.58831.0a
89.
Elliott MW Confalonieri M Nava S Where to perform noninvasive ventilation?Eur Respir J2002 1911591166
Not in our library10.1183/09031936.02.00297202
90.
Hill NS Where should noninvasive ventilation be delivered?Respir Care2009 546270
Not in our library10.4187/002013209793800439
91.
Sinuff T Kahnamoui K Cook DJ Luce JM Levy MM Rationing critical care beds: a systematic reviewCrit Care Med2004 3215881597
Not in our library10.1097/01.ccm.0000130175.38521.9f
92.
Azoulay E Pochard F Chevret S Vinsonneau C Garrouste M Cohen Y Thuong M Paugam C Apperre C De Cagny B Brun F Bornstain C Parrot A Thamion F Lacherade JC Bouffard Y Le Gall Jr Herve C Grassin M Zittoun R Schlemmer B Dhainaut JF Compliance with triage to intensive care recommendationsCrit Care Med2001 2921322136
Not in our library10.1097/00003246-200111000-00014
93.
Pastores SM Voigt LP Acute respiratory failure in the patient with cancer: diagnostic and management strategiesCrit Care Clin262140
Not in our library10.1016/j.ccc.2009.10.001
94.
Truwit JD Bernard GR Noninvasive ventilation--don't push too hardN Engl J Med2004 35025122515
Not in our library10.1056/nejme048049
95.
Tanvetyanon T Which patient with a do-not-intubate order is a candidate for noninvasive ventilation?Crit Care Med2004 3221482150
Not in our library10.1097/01.ccm.0000142903.66336.e6
96.
Adda M Coquet I Darmon M Thiery G Schlemmer B Azoulay E Predictors of noninvasive ventilation failure in patients with hematologic malignancy and acute respiratory failureCrit Care Med2008 3627662772
Not in our library10.1097/ccm.0b013e31818699f6
97.
Chu CM Chan VL Wong IW Leung WS Lin AW Cheung KF Noninvasive ventilation in patients with acute hypercapnic exacerbation of chronic obstructive pulmonary disease who refused endotracheal intubationCrit Care Med2004 32372377
Not in our library10.1097/01.ccm.0000108879.86838.4f
98.
Cuomo A Delmastro M Ceriana P Nava S Conti G Antonelli M Iacobone E Noninvasive mechanical ventilation as a palliative treatment of acute respiratory failure in patients with end-stage solid cancerPalliat Med2004 18602610
Not in our library10.1191/0269216304pm933oa
99.
Curtis Jr Cook DJ Sinuff T White DB Hill N Keenan SP Benditt JO Kacmarek R Kirchhoff KT Levy MM Noninvasive positive pressure ventilation in critical and palliative care settings: understanding the goals of therapyCrit Care Med2007 35932939
Not in our library10.1097/01.ccm.0000256725.73993.74
100.
Levy M Tanios MA Nelson D Short K Senechia A Vespia J Hill NS Outcomes of patients with do-not-intubate orders treated with noninvasive ventilationCrit Care Med2004 3220022007
Not in our library10.1097/01.ccm.0000142729.07050.c9
101.
Nava S Sturani C Hartl S Magni G Ciontu M Corrado A Simonds A End-of-life decision-making in respiratory intermediate care units: a European surveyEur Respir J2007 30156164
Not in our library10.1183/09031936.00128306
102.
Herbrecht R Denning DW Patterson TF Bennett JE Greene RE Oestmann JW Kern WV Marr KA Ribaud P Lortholary O Sylvester R Rubin RH Wingard Jr Stark P Durand C Caillot D Thiel E Chandrasekar PH Hodges MR Schlamm HT Troke PF De Pauw B Voriconazole versus amphotericin B for primary therapy of invasive aspergillosisN Engl J Med2002 347408415
Not in our library10.1056/nejmoa020191
103.
Hebert PC Wells G Blajchman MA Marshall J Martin C Pagliarello G Tweeddale M Schweitzer I Yetisir E A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials GroupN Engl J Med1999 340409417
Not in our library10.1056/nejm199902113400601
104.
Chagnon K Boissel N Raffoux E Dombret H Tazi A Bergeron A A new pattern of cytosine-arabinoside-induced lung toxicityBr J Haematol2009 147771774
Not in our library10.1111/j.1365-2141.2009.07895.x
105.
Bergeron A Rea D Levy V Picard C Meignin V Tamburini J Bruzzoni-Giovanelli H Calvo F Tazi A Rousselot P Lung abnormalities after dasatinib treatment for chronic myeloid leukemia: a case seriesAm J Respir Crit Care Med2007 176814818
Not in our library10.1164/rccm.200705-715cr
106.
Chagnon K Boissel N Raffoux E Dombret H Tazi A Bergeron A A new pattern of cytosine-arabinoside-induced lung toxicityBr J Haematol2009 147771774
Not in our library10.1111/j.1365-2141.2009.07895.x
107.
Legriel S Marijon H Darmon M Lemiale V Bedos JP Schlemmer B Azoulay E Central neurological complications in critically ill patients with malignanciesIntensive Care Med36232240
Not in our library10.1007/s00134-009-1709-8

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