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Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of <it>Listeria monocytogenes</it>

Van de Velde Sébastien, Carryn Stéphane, Van Bambeke Françoise and 3 more

Gut Pathogens · 2009

doi:10.1186/1757-4749-1-23 (opens in a new tab)

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Abstract

<p>Abstract</p> <p>While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against <it>Listeria monocytogenes</it>. Herein we reveal that both PBP4 and Lmo0441 (a PBP-like protein) play a direct role in cephalosporin activity in <it>L. monocytogenes </it>while PBP4 additionally has a protective affect against both penicillin and carbapenem.</p>

Abstract licence: CC BY-NC-ND

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