The fate of orally available antimicrobials

By comparing data from different animal species, the purpose is to explore the different routes of administration with regard to the stimulation of antimicrobial resistance. A historical review on the emergence of resistance to beta-lactamas and tetracycline in Staphylococcus aureus and Escherichia coli in different animal species and humans will be provided. Data on commonly used treatment regimens for humans and animal will be compared and the potential impact on selection, co-selection and spread of resistance will be discussed escriptively. Special attention will be given to the difference in resistance development between topical, oral, and parenteral administration of antimicrobial agents. Attention to the route of administration might be an underestimated approach to mitigate the risk of selection for pathogens resistant to antimicrobials in both human and veterinary medicine.

Abstract licence: CC BY-NC-ND

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