Molecular characterisation of the caprine (<it>Capra hircus</it>) lymphocyte function-associated antigen-1 alpha subunit-encoding cDNA

<p>Abstract</p> <p>Background</p> <p>Lymphocyte function-associated antigen-1 (LFA-1, CD11a/CD18, alpha L beta 2) is required for many cellular adhesive interactions during the immune response.</p> <p>Results</p> <p>The <it>Capra hircus </it>CD11a-encoding cDNA was sequenced and compared with its human, murine, rat, bovine and ovine counterparts. Despite some focal differences, it shares all the main characteristics of its known mammalian homologues.</p> <p>Conclusion</p> <p>Therefore, along with the caprine CD18-encoding cDNA, which has been available for a few months, the sequence data revealed here will allow the <it>Capra hircus </it>LFA-1 expression <it>in vitro </it>as a tool to explore the specificities of inflammation in the caprine species.</p>

Abstract licence: CC BY-NC-ND

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