In vitro inhibition of human influenza A virus replication by chloroquine.

Abstract

Chloroquine is a 9-aminoquinolone with well-known anti-malarial effects. It has biochemical properties that could be applied to inhibit viral replication. We report here that chloroquine is able to inhibit influenza A virus replication, in vitro, and the IC50s of chloroquine against influenza A viruses H1N1 and H3N2 are lower than the plasma concentrations reached during treatment of acute malaria. The potential of chloroquine to be added to the limited range of anti-influenza drugs should be explored further, particularly since antiviral drugs play a vital role in influenza pandemic preparedness.

Cited by papers we hold 11

• An Update on Antiviral Therapy Against SARS-CoV-2: How Far Have We Come? · 2021
  Not checked
• The controversial therapeutic journey of chloroquine and hydroxychloroquine in the battle against SARS-CoV-2: A comprehensive review · 2021
  Not checked
• The H + -ATPase (V-ATPase): from proton pump to signaling complex in health and disease · 2021
  No notice
• COVID-19 Therapeutic Options Under Investigation · 2020
  Not checked
• Update on treatment and preventive interventions against COVID-19: an overview of potential pharmacological agents and vaccines · 2020
  Not checked
• The Use of Antimalarial Drugs against Viral Infection · 2020
  Not checked
• In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) · 2020
  No notice
• Hydroxychloroquine in rheumatic autoimmune disorders and beyond · 2020
  No notice
• Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika Virus Infection in Different Cell Models · 2016
  No notice
• Inhibition of influenza virus replication by targeting broad host cell pathways. · 2014
  Not checked
• Protein glycosylation in infectious disease pathobiology and treatment · 2011
  Not checked

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.