MicroRNAs: regulators of oncogenesis and stemness

<p>Abstract</p> <p>MicroRNAs (miRNAs) are essential post-transcriptional regulators that determine cell identity and fate. Aberrant expression of miRNAs can lead to diseases, including cancer. Expression of many miRNAs in the de-differentiated brain tumor cancer stem cells resembles that of neural stem cells. In this issue of <it>BMC Medicine</it>, Silber et al provide evidence of the expression of such miRNAs and their potential to mediate differentiation in both stem cell populations. In this commentary, we discuss the known functions of miRNAs in cancer and stem cells, their therapeutic potential and how the findings of Silber et al provide insight into the role of miR-124/miR-137 dysregulation in glioblastomas.</p>

Abstract licence: CC BY-NC-ND

17 more references, whose wording the paper’s licence keeps private.

• MicroRNA signatures differentiate Crohn’s disease from ulcerative colitis · 2015

• miR-146a Inhibits Cell Growth, Cell Migration and Induces Apoptosis in Non-Small Cell Lung Cancer Cells · 2013

• MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells · 2009

• miRNA in the Regulation of Skeletal Muscle Adaptation to Acute Endurance Exercise in C57Bl/6J Male Mice · 2009

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