Interplay of periglomerular and granule cell inhibitory synapses on mitral cell spiking

Mitral cells in the olfactory bulb (OB) receive dendrodendritic inhibitory synaptic inputs at two different levels of OB: at the glomerular level, inhibitory input is provided by periglomerular (PG) cells and, at a deeper level (the external plexiform layer), inhibitory input is provided by granule (Gr) cells [1]. It is thought that both kinds of inhibition control mitral cell spiking in specific ways: PG early inhibition would regulate spike initiation while Gr inhibition would coordinate spike synchronization among mitral cells [1,2]. However, recent computational modeling studies have suggested that, although acting at separate locations, PG and Gr inhibitory synapses may have integrated effects on mitral cell spiking which may be beneficial for odor Figure 1 Firing rate of mitral cell as a function of maximal conductances of inhibitory synapses made by PG (horizontal axis) and Gr (vertical axis) cells. The color-code bar on the right indicates frequency in Hz.

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   Non-topographical contrast enhancement in the olfactory bulb · 2006

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