Hypoxia-regulated target genes implicated in tumor metastasis

Abstract

Hypoxia is an important microenvironmental factor that induces cancer metastasis. Hypoxia/hypoxia-inducible factor-1α (HIF-1α) regulates many important steps of the metastatic processes, especially epithelial-mesenchymal transition (EMT) that is one of the crucial mechanisms to cause early stage of tumor metastasis. To have a better understanding of the mechanism of hypoxia-regulated metastasis, various hypoxia/HIF-1α-regulated target genes are categorized into different classes including transcription factors, histone modifiers, enzymes, receptors, kinases, small GTPases, transporters, adhesion molecules, surface molecules, membrane proteins, and microRNAs. Different roles of these target genes are described with regards to their relationship to hypoxia-induced metastasis. We hope that this review will provide a framework for further exploration of hypoxia/HIF-1α-regulated target genes and a comprehensive view of the metastatic picture induced by hypoxia.

Cited by papers we hold 14

• Oral squamous cell carcinomas: state of the field and emerging directions · 2023
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• Engineering hyaluronic acid-based cryogels for CD44-mediated breast tumor reconstruction · 2022
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• Hypoxia-induced therapy resistance: Available hypoxia-targeting strategies and current advances in head and neck cancer · 2021
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• The Role of Tumor Microenvironment in Cancer Metastasis: Molecular Mechanisms and Therapeutic Opportunities · 2021
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• Matrix Metalloproteinases Shape the Tumor Microenvironment in Cancer Progression · 2021
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• Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond · 2020
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• Pathophysiological implications of hypoxia in human diseases · 2020
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• Clinical update on head and neck cancer: molecular biology and ongoing challenges · 2019
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• Retinoblastoma protein (Rb) links hypoxia to altered mechanical properties in cancer cells as measured by an optical tweezer · 2017
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• Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression · 2017
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• Oncogenic miR-210-3p promotes prostate cancer cell EMT and bone metastasis via NF-κB signaling pathway · 2017
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• Targeting the Redox Balance in Inflammatory Skin Conditions · 2013
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• Regulation of pyruvate metabolism and human disease · 2013
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• Impact of microRNAs on regulatory networks and pathways in human colorectal carcinogenesis and development of metastasis · 2013
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