The effect of fast created inbreeding on litter size and body weights in mice

<p>Abstract</p> <p>This study was designed to reveal any differences in effects of fast created <it>versus </it>total inbreeding on reproduction and body weights in mice. A line selected for large litter size for 124 generations (H) and a control line (K) maintained without selection for the same number of generations were crossed (HK) and used as a basis for the experiment. Within the HK cross, full sib, cousin or random mating were practised for two generations in order to create new inbreeding (IB_F) at a fast rate. In the first generation of systematic mating, old inbreeding was regenerated in addition to creation of new inbreeding from the mating design giving total inbreeding (IB_T). The number of pups born alive (NBA) and body weights of the animals were then analysed by a model including both IB_Tand IB_F. The IB_Tof the dam was in the present study found to reduce the mean NBA with -0.48 (± 0.22) (p < 0.05) pups per 10% increase in the inbreeding coefficient, while the additional effect of IB_Fwas -0.42 (± 0.27). For the trait NBA per female mated, the effect of IB_Twas estimated to be -0.45 (± 0.29) per 10% increase in the inbreeding coefficient and the effect of IB_Fwas -0.90 (± 0.37) (p < 0.05) pups. In the present study, only small or non-significant effects of IB_Fof the dam could be found on sex-ratio and body weights at three and six weeks of age in a population already adjusted for IB_T.</p>

Abstract licence: CC BY

• Identification of genomic regions associated with inbreeding depression in Holstein and Jersey dairy cattle · 2014

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