Research Progress of Epithelial-mesenchymal Transition Treatment and Drug Resistance in Colorectal Cancer
Qianyang Ni MD, Meng Li PhD, Suyang Yu PhD
Technology in Cancer Research & Treatment · 2022
doi:10.1177/15330338221081219 (opens in a new tab)
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Abstract
Colorectal cancer (CRC) is one of the most common malignancies in the world that seriously affects human health. Activation of epithelial-mesenchymal transition (EMT) is a physiological phenomenon during embryonic development that is essential for cell metastasis. EMT participates in various biological processes associated with trauma repair, organ fibrosis, migration, metastasis, and infiltration of tumor cells. EMT is a new therapeutic target for CRC; however, some patients with CRC develop resistance to some drugs due to EMT. This review focuses specifically on the status of treatments that target the EMT process and its role in the therapeutic resistance observed in patients with CRC.
Abstract licence: CC BY-NC
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