Through the Looking Glass: Differential Noradenergic Modulation of Prefrontal Cortical Function

Abstract

Ghosts rising off the lakeIn to moonlight In between Never so alive Norepinephrine (NE) facilitates the functioning of many brain areas, otten by increasing "signals" relative to "noise".In most brain regions, NE enhances neural processing through actions at beta and alpha-1 adrenergic receptors.This review will provide a brief overview of the receptor mechanisms influencing subcortical and posterior cortical functions and contrast these actions with the very different mechanisms by which NE modulates the working memory functions of the prefrontal cortex (PFC; Fig. 1). BETA-AND ALPHA-I-ADRENOCEPTOR STIMULATION ENHANCE POSTERIOR CORTICAL AND SUBCORTICAL FUNCTIONSNE has widespread effects on arousal state, stimulus processing, and plasticity including long-term memory consolidation.Most of these NE actions involve beta adrenergic mechanisms, although alpha-1 receptor stimulation also has important effects on excitability and cortical

Cited by papers we hold 2

• Neuromodulation of prefrontal cortex cognitive function in primates: the powerful roles of monoamines and acetylcholine · 2021
  No notice
• Noradrenergic Modulation of Cognition in Health and Disease · 2017
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.