С60 Fullerenes Diminish Dysfunctions in Rat Muscle Soleus With Chronic Alcohol Intoxication

It is known that reactive oxygen species are important in the development of alcoholic myopathy, and their suppression by C60 fullerene nanoparticles, as potent antioxidants, is opening up a new direction for their use in biomedical nanotechnology. Here, for the first time, the biomechanical and biochemical parameters of the functioning of rat muscle soleus under alcohol intoxication at 3, 6, and 9 months were analyzed. C60 fullerene, as a therapeutic nanoagent, at an oral dose of 1 mg kg−1 was used along with alcohol throughout the experiment. The findings indicate that significant dysfunctions develop in the rat muscle soleus after chronic alcohol intoxication. However, these dysfunctions are significantly reduced due to exposure to C60 fullerenes, particularly with prolonged alcoholization of animals (9 months) and the development of high-intensity fatigue processes.

Abstract licence: CC BY

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