Skip to content
naulon

No retraction, correction or concern found when last checked on Oct 23, 2026.

Nanoemulsion: An Emerging Novel Technology for Improving the Bioavailability of Drugs

Preeti, Sharda Sambhakar, Rohit Malik and 7 more (opens in a new tab)

Scientifica · 2023 · Review

doi:10.1155/2023/6640103 (opens in a new tab)

Abstract

The pharmaceutical sector has made considerable strides recently, emphasizing improving drug delivery methods to increase the bioavailability of various drugs. When used as a medication delivery method, nanoemulsions have multiple benefits. Their small droplet size, which is generally between 20 and 200 nanometers, creates a significant interfacial area for drug dissolution, improving the solubility and bioavailability of drugs that are weakly water-soluble. Additionally, nanoemulsions are a flexible platform for drug administration across various therapeutic areas since they can encapsulate hydrophilic and hydrophobic medicines. Nanoemulsion can be formulated in multiple dosage forms, for example, gels, creams, foams, aerosols, and sprays by using low-cost standard operative processes and also be taken orally, topically, topically, intravenously, intrapulmonary, intranasally, and intraocularly. The article explores nanoemulsion formulation and production methods, emphasizing the role of surfactants and cosurfactants in creating stable formulations. In order to customize nanoemulsions to particular medication delivery requirements, the choice of components and production techniques is crucial in assuring the stability and efficacy of the finished product. Nanoemulsions are a cutting-edge technology with a lot of potential for improving medication bioavailability in a variety of therapeutic contexts. They are a useful tool in the creation of innovative pharmaceutical formulations due to their capacity to enhance drug solubility, stability, and delivery. Nanoemulsions are positioned to play a crucial role in boosting medication delivery and enhancing patient outcomes as this field of study continues to advance.

References 151

  1. 1.

    Mason T. G., Wilking J. N., Meleson K., Chang C. B., Graves S. M. Nanoemulsions: formation, structure, and physical properties. Journal of Physics: Condensed Matter. 2006;18:R635-R666.

    Not in our library10.1088/0953-8984/18/41/r01 (opens in a new tab)

  2. 2.

    Ee S. L., Duan X., Liew J., Nguyen Q. D. Droplet size and stability of nano-emulsions produced by the temperature phase inversion method. Chemical Engineering Journal. 2008;140(1-3):626-631.

    Not in our library10.1016/j.cej.2007.12.016 (opens in a new tab)

  3. 3.

    McClements D. J. Nanoemulsion-based oral delivery systems for lipophilic bioactive components: nutraceuticals and pharmaceuticals. Therapeutic Delivery. 2013;4(7):841-857.

    Not in our library10.4155/tde.13.46 (opens in a new tab)

  4. 4.

    Lee S. J., Choi S. J., Li Y., Decker E. A., McClements D. J. Protein-stabilized nanoemulsions and emulsions: comparison of physicochemical stability, lipid oxidation, and lipase digestibility. Journal of Agricultural and Food Chemistry. 2011;59(1):415-427.

    Not in our library10.1021/jf103511v (opens in a new tab)

  5. 5.

    Bouchemal K., Briançon S., Perrier E., Fessi H. Nano-emulsion formulation using spontaneous emulsification: solvent, oil and surfactant optimisation. International Journal of Pharmaceutics. 2004;280(1-2):241-251.

    Not in our library10.1016/j.ijpharm.2004.05.016 (opens in a new tab)

  6. 6.

    Yu H., Huang Q. Improving the oral bioavailability of curcumin using novel organogel-based nanoemulsions. Journal of Agricultural and Food Chemistry. 2012;60(21):5373-5379.

    Not in our library10.1021/jf300609p (opens in a new tab)

  7. 7.

    Zhang Y., Shang Z., Gao C., et al. Nanoemulsion for solubilization, stabilization, and in vitro release of pterostilbene for oral delivery. AAPS PharmSciTech. 2014;15(4):1000-1008.

    Not in our library10.1208/s12249-014-0129-4 (opens in a new tab)

  8. 8.

    Yukuyama M. N., Ghisleni D. D. M., Pinto T. J. A., Bou‐Chacra N. A. Nanoemulsion: process selection and application in cosmetics– a review. International Journal of Cosmetic Science. 2016;38(1):13-24.

    Not in our library10.1111/ics.12260 (opens in a new tab)

  9. 9.

    Wang L., Li X., Zhang G., Dong J., Eastoe J. Oil-in-water nanoemulsions for pesticide formulations. Journal of Colloid and Interface Science. 2007;314(1):230-235.

    Not in our library10.1016/j.jcis.2007.04.079 (opens in a new tab)

  10. 10.

    Tan S., Stanslas J., Basri M., et al. Nanoemulsion-based parenteral drug delivery system of carbamazepine: preparation, characterization, stability evaluation and blood-brain pharmacokinetics. Current Drug Delivery. 2015;12(6):795-804.

    Not in our library10.2174/1567201812666150901112544 (opens in a new tab)

  11. 11.

    Sharma N., Mishra S., Sharma S., Deshpande R. D., Sharma R. K. Preparation and optimization of nanoemulsions for targeting drug delivery. International Journal of Drug Development and Research. 2013;5(4):37-48.

    Not in our library

  12. 12.

    Al-Edresi S., Baie S. Formulation and stability of whitening VCO-in-waternano-cream. International Journal of Pharmaceutics. 2009;373(1-2):174-178.

    Not in our library10.1016/j.ijpharm.2009.02.011 (opens in a new tab)

  13. 13.

    Makidon P. E., Nigavekar S. S., Bielinska A. U., et al. Characterization of stability and nasal delivery systems for immunization with nanoemulsion-based vaccines. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2010;23(2):77-89.

    Not in our library10.1089/jamp.2009.0766 (opens in a new tab)

  14. 14.

    Lala R. R., Awari N. G. Nanoemulsion-based gel formulations of COX-2 inhibitors for enhanced efficacy in inflammatory conditions. Applied Nanoscience. 2014;4(2):143-151.

    Not in our library10.1007/s13204-012-0177-6 (opens in a new tab)

  15. 15.

    Hussain A., Samad A., Singh S. K., et al. Nanoemulsion gel-based topical delivery of an antifungal drug: in vitro activity and in vivo evaluation. Drug Delivery. 2016;23(2):642-657.

    Not in our library10.3109/10717544.2014.933284 (opens in a new tab)

  16. 16.

    Nasr M., Nawaz S., Elhissi A. Amphotericin B lipid nanoemulsion aerosols for targeting peripheral respiratory airways via nebulization. International Journal of Pharmaceutics. 2012;436(1-2):611-616.

    Not in our library10.1016/j.ijpharm.2012.07.028 (opens in a new tab)

  17. 17.

    Amani A., York P., Chrystyn H., Clark B. J. Evaluation of a nanoemulsion-based formulation for respiratory delivery of budesonide by nebulizers. AAPS PharmSciTech. 2010;11(3):1147-1151.

    Not in our library10.1208/s12249-010-9486-9 (opens in a new tab)

  18. 18.

    Tamarkin D., Besonov A., Eini M., Danziger J. Foam prepared from nanoemulsions and uses. 2007.

    Not in our library

  19. 19.

    Mou D., Chen H., Du D., et al. Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs. International Journal of Pharmaceutics. 2008;353(1-2):270-276.

    Not in our library10.1016/j.ijpharm.2007.11.051 (opens in a new tab)

  20. 20.

    Khani S., Keyhanfar F., Amani A. Design and evaluation of oral nanoemulsion drug delivery system of mebudipine. Drug Delivery. 2016;23(6):2035-2043.

    Not in our library10.3109/10717544.2015.1088597 (opens in a new tab)

  21. 21.

    Pawar V. K., Panchal S. B., Singh Y., et al. Immunotherapeutic vitamin E nanoemulsion synergies the antiproliferative activity of paclitaxel in breast cancer cells via modulating Th1 and Th2 immune response. Journal of Controlled Release. 2014;196:295-306.

    Not in our library10.1016/j.jconrel.2014.10.010 (opens in a new tab)

  22. 22.

    Bhanushali R. S., Gatne M. M., Gaikwad R. V., Bajaj A. N., Morde M. A. Nanoemulsion based intranasal delivery of antimigraine drugs for nose to brain targeting. Indian Journal of Pharmaceutical Sciences. 2009;71(6):p. 707.

    Not in our library

  23. 23.

    Ammar H. O., Salama H. A., Ghorab M., Mahmoud A. A. Nanoemulsion as a potential ophthalmic delivery system for dorzolamide hydrochloride. AAPS PharmSciTech. 2009;10(3):808-819.

    Not in our library10.1208/s12249-009-9268-4 (opens in a new tab)

  24. 24.

    Khan A. A., Mudassir J., Mohtar N., Darwis Y. Advanced drug delivery to the lymphatic system: lipid-based nanoformulations. International Journal of Nanomedicine. 2013;8:2733-2744.

    Not in our library10.2147/ijn.s41521 (opens in a new tab)

  25. 25.

    Garti N., Frenkel M., Shwartz R. Multiple emulsions. Part II: proposed technique to overcome unpleasant taste of drugs. Journal of Dispersion Science Andtechnology. 1983;4(3):237-252.

    Not in our library10.1080/01932698308943369 (opens in a new tab)

  26. 26.

    Singh Y., Meher J. G., Raval K., et al. Nanoemulsion: concepts, development and applications in drug delivery. Journal of Controlled Release. 2017;252:28-49.

    Not in our library10.1016/j.jconrel.2017.03.008 (opens in a new tab)

  27. 27.

    Karasulu H. Y. Microemulsions as novel drug carriers: the formation, stability, applications and toxicity. Expert Opinion on Drug Delivery. 2008;5(1):119-135.

    Not in our library10.1517/17425247.5.1.119 (opens in a new tab)

  28. 28.

    Schulman J. H., Stoeckenius W., Prince L. M. Mechanism of formation and structure of micro emulsions by electron microscopy. Journal of Physical Chemistry. 1959;63(10):1677-1680.

    Not in our library10.1021/j150580a027 (opens in a new tab)

  29. 29.

    Pouton C. W., Porter C. J. H. Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies. Advanced Drug Delivery Reviews. 2008;60(6):625-637.

    Not in our library10.1016/j.addr.2007.10.010 (opens in a new tab)

  30. 30.

    Singh B., Bandopadhyay S., Kapil R., Singh R., Katare O. P. Self-emulsifying drug delivery systems (SEDDS): formulation development, characterization, and applications. Critical Reviews in Therapeutic Drug Carrier Systems. 2009;26:427-451.

    Not in our library10.1615/critrevtherdrugcarriersyst.v26.i5.10 (opens in a new tab)

  31. 31.

    Ghosh V., Mukherjee A., Chandrasekaran N. Eugenol-loaded antimicrobial nanoemulsion preserves fruit juice against, microbial spoilage. Colloids and Surfaces B: Biointerfaces. 2014;114:392-397.

    Not in our library10.1016/j.colsurfb.2013.10.034 (opens in a new tab)

  32. 32.
  33. 33.

    Vyas T. K., Shahiwala A., Amiji M. M. Improved oral bioavailability and brain transport of Saquinavir upon administration in novel nanoemulsion formulations. International Journal of Pharmaceutics. 2008;347(1-2):93-101.

    Not in our library10.1016/j.ijpharm.2007.06.016 (opens in a new tab)

  34. 34.

    Jiang S. P., He S.-N., Li Y.-L., et al. Preparation and characteristics of lipid nanoemulsion formulations loaded with doxorubicin. International Journal of Nanomedicine. 2013;8:3141-3150.

    Not in our library10.2147/ijn.s47708 (opens in a new tab)

  35. 35.

    Anuchapreeda S., Fukumori Y., Okonogi S., Ichikawa H. Preparation of lipid nanoemulsions incorporating curcumin for cancer therapy. Journal of nanotechnology. 2012;2012:11.

    Not in our library10.1155/2012/270383 (opens in a new tab)

  36. 36.

    Hwang Y. Y., Ramalingam K., Bienek D. R., Lee V., You T., Alvarez R. Antimicrobial activity of nanoemulsion in combination with cetylpyridinium chloride in multidrug-resistant Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy. 2013;57(8):3568-3575.

    Not in our library10.1128/aac.02109-12 (opens in a new tab)

  37. 37.

    Abd-Elsalam K. A., Khokhlov A. R. Eugenol oil nanoemulsion: antifungal activity against Fusarium oxysporum f. sp. vasinfectum and phytotoxicity on cottonseeds. Applied Nanoscience. 2015;5(2):255-265.

    Not in our library10.1007/s13204-014-0398-y (opens in a new tab)

  38. 38.

    Ozturk B., Argin S., Ozilgen M., McClements D. J. Formation and stabilization of nanoemulsion-based vitamin E delivery systems using natural biopolymers: whey protein isolate and gum Arabic. Food Chemistry. 2015;188:256-263.

    Not in our library10.1016/j.foodchem.2015.05.005 (opens in a new tab)

  39. 39.

    Morais Diane J. M., Burgess J. Vitamin E nanoemulsions characterization and analysis. International Journal of Pharmaceutics. 2014;465(1-2):455-463.

    Not in our library10.1016/j.ijpharm.2014.02.034 (opens in a new tab)

  40. 40.
All 151 references

Cited by papers we hold 1

Questions about this paper

We email you if it is retracted, withdrawn, corrected or flagged.

Reads

Read by people on this page

None yet.

Checked or read by AI through naulon

None yet.

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.

Are you an author?

Is this your paper?

Claim it to add your note and be paid when agents cite it. Free.