No retraction, correction or concern found when last checked on Oct 22, 2026.

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

Nur Shafika Mohd Sairazi, K. N. S. Sirajudeen

Evidence-Based Complementary and Alternative Medicine · 2020 · Review · CC BY

doi:10.1155/2020/6565396

Abstract

In recent years, natural products, which originate from plants, animals, and fungi, together with their bioactive compounds have been intensively explored and studied for their therapeutic potentials for various diseases such as cardiovascular, diabetes, hypertension, reproductive, cancer, and neurodegenerative diseases. Neurodegenerative diseases, including Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are characterized by the progressive dysfunction and loss of neuronal structure and function that resulted in the neuronal cell death. Since the multifactorial pathological mechanisms are associated with neurodegeneration, targeting multiple mechanisms of actions and neuroprotection approach, which involves preventing cell death and restoring the function to damaged neurons, could be promising strategies for the prevention and therapeutic of neurodegenerative diseases. Natural products have emerged as potential neuroprotective agents for the treatment of neurodegenerative diseases. This review focused on the therapeutic potential of natural products and their bioactive compounds to exert a neuroprotective effect on the pathologies of neurodegenerative diseases.

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Ferreira R. S., Dos Santos N. A. G., Bernardes C. P., et al. Caffeic acid phenethyl ester (CAPE) protects PC12 cells against cisplatin-induced neurotoxicity by activating the AMPK/SIRT1, MAPK/erk, and PI3k/akt signaling pathways. Neurotoxicity Research. 2019;36(1):175-192.
Not in our library10.1007/s12640-019-00042-w
107.
Zaitone S. A., Ahmed E., Elsherbiny N. M., et al. Caffeic acid improves locomotor activity and lessens inflammatory burden in a mouse model of rotenone-induced nigral neurodegeneration: relevance to Parkinson’s disease therapy. Pharmacological Reports. 2019;71(1):32-41.
Not in our library10.1016/j.pharep.2018.08.004
108.
Barros Silva R., Santos N. A. G., Martins N. M., et al. Caffeic acid phenethyl ester protects against the dopaminergic neuronal loss induced by 6-hydroxydopamine in rats. Neuroscience. 2013;233:86-94.
Not in our library10.1016/j.neuroscience.2012.12.041
109.
Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine · 2009
No notice
110.
Ahmad M., Saleem S., Ahmad A. S., et al. Neuroprotective effects of Withania somnifera on 6-hydroxydopamine induced Parkinsonism in rats. Human & Experimental Toxicology. 2005;24(3):137-147.
Not in our library10.1191/0960327105ht509oa
111.
Sankar S. R., Manivasagam T., Krishnamurti A., Ramanathan M. The neuroprotective effect of Withania somnifera root extract in MPTP-intoxicated mice: an analysis of behavioral and biochemical variables. Cellular and Molecular Biology Letters. 2007;12(4):473-481.
Not in our library10.2478/s11658-007-0015-0
112.
RajaSankar S., Manivasagam T., Sankar V., et al. Withania somnifera root extract improves catecholamines and physiological abnormalities seen in a Parkinson’s disease model mouse. Journal of Ethnopharmacology. 2009;125(3):369-373.
Not in our library10.1016/j.jep.2009.08.003
113.
Manjunath M. J., Muralidhara. Effect of Withania somnifera supplementation on rotenone-induced oxidative damage in cerebellum and striatum of the male mice brain. Central Nervous System Agents in Medicinal Chemistry. 2013;13(1):43-56.
Not in our library10.2174/1871524911313010007
114.
Kumar P., Kumar A. Possible neuroprotective effect of Withania somnifera root extract against 3-nitropropionic acid-induced behavioral, biochemical, and mitochondrial dysfunction in an animal model of huntington’s disease. Journal of Medicinal Food. 2009;12(3):591-600.
Not in our library10.1089/jmf.2008.0028
115.
Dutta K., Patel P., Julien J.-P. Protective effects of Withania somnifera extract in SOD1G93A mouse model of amyotrophic lateral sclerosis. Experimental Neurology. 2018;309:193-204.
Not in our library10.1016/j.expneurol.2018.08.008
116.
Choudhary D., Bhattacharyya S., Bose S. Efficacy and safety of ashwagandha (Withania somnifera (L.) dunal) root extract in improving memory and cognitive functions. Journal of Dietary Supplements. 2017;14(6):599-612.
Not in our library10.1080/19390211.2017.1284970
117.
Chengappa K. N. R., Bowie C. R., Schlicht P. J., Fleet D., Brar J. S., Jindal R. Randomized placebo-controlled adjunctive study of an extract of Withania somniferafor cognitive dysfunction in bipolar disorder. The Journal of Clinical Psychiatry. 2013;74(11):1076-1083.
Not in our library10.4088/jcp.13m08413
118.
Pingali U., Pilli R., Fatima N. Effect of standardized aqueous extract of Withania somniferaon tests of cognitive and psychomotor performance in healthy human participants. Pharmacognosy Research. 2014;6(1):12-18.
Not in our library10.4103/0974-8490.122912
119.
Kuboyama T., Tohda C., Komatsu K. Withanoside IV and its active metabolite, sominone, attenuate Aβ (25–35)-induced neurodegeneration. European Journal of Neuroscience. 2006;23(6):1417-1426.
Not in our library10.1111/j.1460-9568.2006.04664.x
120.
Protective Role of Ashwagandha Leaf Extract and Its Component Withanone on Scopolamine-Induced Changes in the Brain and Brain-Derived Cells · 2011
No notice
121.
Pandey A., Bani S., Dutt P., Kumar Satti N., Avtar Suri K., Nabi Qazi G. Multifunctional neuroprotective effect of Withanone, a compound from Withania somnifera roots in alleviating cognitive dysfunction. Cytokine. 2018;102:211-221.
Not in our library10.1016/j.cyto.2017.10.019
122.
Dar N. J., Bhat J. A., Satti N. K., Sharma P. R., Hamid A., Ahmad M. Withanone, an active constituent from Withania somnifera, affords protection against NMDA-induced excitotoxicity in neuron-like cells. Molecular Neurobiology. 2017;54(7):5061-5073.
Not in our library10.1007/s12035-016-0044-7
123.
Patel P., Julien J.-P., Kriz J. Early-stage treatment with Withaferin A reduces levels of misfolded superoxide dismutase 1 and extends lifespan in a mouse model of amyotrophic lateral sclerosis. Neurotherapeutics. 2015;12(1):217-233.
Not in our library10.1007/s13311-014-0311-0
124.
Martorana F., Guidotti G., Brambilla L., Rossi D. Withaferin A inhibits nuclear factor-κB-dependent pro-inflammatory and stress response pathways in the astrocytes. Neural Plasticity. 2015;2015:9.
Not in our library10.1155/2015/381964
125.
Min K.-j., Choi K., Kwon T. K. Withaferin A down-regulates lipopolysaccharide-induced cyclooxygenase-2 expression and PGE2 production through the inhibition of STAT1/3 activation in microglial cells. International Immunopharmacology. 2011;11(8):1137-1142.
Not in our library10.1016/j.intimp.2011.02.029
126.
Baitharu I., Jain V., Deep S. N., et al. Withanolide A prevents neurodegeneration by modulating hippocampal glutathione biosynthesis during hypoxia. PLoS One. 2014;9(10).
Not in our library10.1371/journal.pone.0105311
127.
Kurapati K. R., Samikkannu T., Atluri V. S., Kaftanovskaya E., Yndart A., Nair M. P. β-Amyloid1-42, HIV-1Ba-L (clade B) infection and drugs of abuse induced degeneration in human neuronal cells and protective effects of ashwagandha (Withania somnifera) and its constituent Withanolide A. PLoS One. 2014;9(11).
Not in our library10.1371/journal.pone.0112818
128.
Kumar G., Patnaik R. Exploring neuroprotective potential of Withania somnifera phytochemicals by inhibition of GluN2B-containing NMDA receptors: an in silico study. Medical Hypotheses. 2016;92:35-43.
Not in our library10.1016/j.mehy.2016.04.034
129.
Sun G. Y., Li R., Cui J., et al. Withania somnifera and its withanolides attenuate oxidative and inflammatory responses and up-regulate antioxidant responses in BV-2 microglial cells. NeuroMolecular Medicine. 2016;18(3):241-252.
Not in our library10.1007/s12017-016-8411-0
130.
Crane E. A., Heydenreuter W., Beck K. R., et al. Profiling withanolide A for therapeutic targets in neurodegenerative diseases. Bioorganic & Medicinal Chemistry. 2019;27(12):2508-2520.
Not in our library10.1016/j.bmc.2019.03.022
131.
Xiang Y.-Z., Shang H.-C., Gao X.-M., Zhang B.-L. A comparison of the ancient use of ginseng in traditional Chinese medicine with modern pharmacological experiments and clinical trials. Phytotherapy Research. 2008;22(7):851-858.
Not in our library10.1002/ptr.2384
132.
Jiao L., Li B., Wang M., Liu Z., Zhang X., Liu S. Antioxidant activities of the oligosaccharides from the roots, flowers and leaves of Panax ginseng C.A. Meyer. Carbohydrate Polymers. 2014;106:293-298.
Not in our library10.1016/j.carbpol.2014.02.035
133.
Yuan H.-D., Kim J.-T., Kim S.-H., Chung S.-H. Ginseng and diabetes: the evidences from in vitro, animal and human studies. Journal of Ginseng Research. 2012;36(1):27-39.
Not in our library10.5142/jgr.2012.36.1.27
134.
Chen S., Wang Z., Huang Y., et al. Ginseng and anticancer drug combination to improve cancer chemotherapy: a critical review. Evidence-Based Complementary and Alternative Medicine. 2014;2014:13.
Not in our library10.1155/2014/168940
135.
Yang Y., Ren C., Zhang Y., Wu X. Ginseng: an nonnegligible natural remedy for healthy aging. Aging and Disease. 2017;8(6):708-720.
Not in our library10.14336/ad.2017.0707
136.
Ahuja A., Kim J. H., Kim J.-H., Yi Y.-S., Cho J. Y. Functional role of ginseng-derived compounds in cancer. Journal of Ginseng Research. 2018;42(3):248-254.
Not in our library10.1016/j.jgr.2017.04.009
137.
Arring N. M., Millstine D., Marks L. A., Nail L. M. Ginseng as a treatment for fatigue: a systematic review. Journal of Alternative and Complementary Medicine. 2018;24(7):624-633.
Not in our library10.1089/acm.2017.0361
138.
Sathishkumar N., Sathiyamoorthy S., Ramya M., Yang D.-U., Lee H. N., Yang D.-C. Molecular docking studies of anti-apoptotic BCL-2, BCL-XL, and MCL-1 proteins with ginsenosides fromPanax ginseng. Journal of Enzyme Inhibition and Medicinal Chemistry. 2012;27(5):685-692.
Not in our library10.3109/14756366.2011.608663
139.
Therapeutic Potential of Ginsenosides as an Adjuvant Treatment for Diabetes · 2018
No notice
140.
Protective effects of ginseng on neurological disorders · 2015
No notice
141.
Cho I.-H. Effects of Panax ginseng in neurodegenerative diseases. Journal of Ginseng Research. 2012;36(4):342-353.
Not in our library10.5142/jgr.2012.36.4.342
142.
Rastogi V., Santiago-Moreno J., Doré S. Effects of Panax ginseng in neurodegenerative diseases. Frontiers in Cellular Neuroscience. 2015;8:p. 457.
Not in our library10.3389/fncel.2014.00457
143.
Cheng Z., Zhang M., Ling C., et al. Neuroprotective effects of ginsenosides against cerebral ischemia. Molecules. 2019;24:p. 6.
Not in our library10.3390/molecules24061102
144.
Lee C. H., Kim J.-H. A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases. Journal of Ginseng Research. 2014;38(3):161-166.
Not in our library10.1016/j.jgr.2014.03.001
145.
Lu J.-M., Yao Q., Chen C. Ginseng compounds: an update on their molecular mechanisms and medical applications. Current Vascular Pharmacology. 2009;7(3):293-302.
Not in our library10.2174/157016109788340767
146.
Jun Y. L., Bae C.-H., Kim D., Koo S., Kim S. Korean red ginseng protects dopaminergic neurons by suppressing the cleavage of p35 to p25 in a Parkinson’s disease mouse model. Journal of Ginseng Research. 2015;39(2):148-154.
Not in our library10.1016/j.jgr.2014.10.003
147.
Kim D., Jeon H., Ryu S., Koo S., Ha K.-T., Kim S. Proteomic analysis of the effect of Korean red ginseng in the striatum of a Parkinson’s disease mouse model. PLoS One. 2016;11(10).
Not in our library10.1371/journal.pone.0164906
148.
Kim D., Kwon S., Jeon H., Ryu S., Ha K.-T., Kim S. Proteomic change by Korean red ginseng in the substantia nigra of a Parkinson’s disease mouse model. Journal of Ginseng Research. 2018;42(4):429-435.
Not in our library10.1016/j.jgr.2017.04.008
149.
Ryu S., Koo S., Ha K.-T., Kim S. Neuroprotective effect of Korea red ginseng extract on 1-methyl-4-phenylpyridinium-induced apoptosis in PC12 cells. Animal Cells and Systems. 2016;20(6):363-368.
Not in our library10.1080/19768354.2016.1257510
150.
Ryu S., Jeon H., Koo S., Kim S. Korean red ginseng enhances neurogenesis in the subventricular zone of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice. Frontiers in Aging Neuroscience. 2018;10:p. 355.
Not in our library10.3389/fnagi.2018.00355
151.
Choi J. H., Jang M., Nah S.-Y., Oh S., Cho I.-H. Multitarget effects of Korean Red Ginseng in animal model of Parkinson’s disease: antiapoptosis, antioxidant, antiinflammation, and maintenance of blood-brain barrier integrity. Journal of Ginseng Research. 2018;42(3):379-388.
Not in our library10.1016/j.jgr.2018.01.002
152.
Hu S., Han R., Mak S., Han Y. Protection against 1-methyl-4-phenylpyridinium ion (MPP+)-induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells. Journal of Ethnopharmacology. 2011;135(1):34-42.
Not in our library10.1016/j.jep.2011.02.017
153.
Jang M., Lee M. J., Kim C. S., Cho I. H. Korean red ginseng extract attenuates 3-nitropropionic acid-induced huntington’s-like symptoms. Evidence-Based Complementary And Alternative Medicine. 2013;2013:17.
Not in our library10.1155/2013/237207
154.
Lee M. J., Chang B. J., Oh S., Nah S.-Y., Cho I.-H. Korean red ginseng mitigates spinal demyelination in a model of acute multiple sclerosis by downregulating p38 mitogen-activated protein kinase and nuclear factor-κB signaling pathways. Journal of Ginseng Research. 2018;42(4):436-446.
Not in our library10.1016/j.jgr.2017.04.013
155.
Tan X., Gu J., Zhao B., et al. Ginseng improves cognitive deficit via the RAGE/NF-κB pathway in advanced glycation end product-induced rats. Journal of Ginseng Research. 2015;39(2):116-124.
Not in our library10.1016/j.jgr.2014.09.002
156.
Kim J., Kim S. H., Lee D.-S., et al. Effects of fermented ginseng on memory impairment and β-amyloid reduction in Alzheimer’s disease experimental models. Journal of Ginseng Research. 2013;37(1):100-107.
Not in our library10.5142/jgr.2013.37.100
157.
Zhou T.-t., Zu G., Wang X., et al. Immunomodulatory and neuroprotective effects of ginsenoside Rg1 in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) -induced mouse model of Parkinson’s disease. International Immunopharmacology. 2015;29(2):334-343.
Not in our library10.1016/j.intimp.2015.10.032
158.
Chen X.-c., Zhou Y.-c., Chen Y., Zhu Y.-g., Fang F., Chen L.-m. Ginsenoside Rg1 reduces MPTP-induced substantia nigra neuron loss by suppressing oxidative stress1. Acta Pharmacologica Sinica. 2005;26(1):56-62.
Not in our library10.1111/j.1745-7254.2005.00019.x
159.
Zhang Y.-L., Liu Y., Kang X.-P., et al. Ginsenoside Rb1 confers neuroprotection via promotion of glutamate transporters in a mouse model of Parkinson’s disease. Neuropharmacology. 2018;131:223-237.
Not in our library10.1016/j.neuropharm.2017.12.012
160.
Chen X. C., Chen Y., Zhu Y. G., Fang F., Chen L. M. Protective effect of ginsenoside Rg1 against MPTP-induced apoptosis in mouse substantia nigra neurons. Acta Pharmacologica Sinica. 2002;23(9):829-834.
Not in our library
161.
Heng Y., Zhang Q.-S., Mu Z., Hu J.-F., Yuan Y.-H., Chen N.-H. Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting α-synuclein abnormalities in the substantia nigra. Toxicology Letters. 2016;243:7-21.
Not in our library10.1016/j.toxlet.2015.12.005
162.
Xu B.-B., Liu C.-Q., Gao X., Zhang W.-Q., Wang S.-W., Cao Y.-L. Possible mechanisms of the protection of ginsenoside Re against MPTP-induced apoptosis in substantia nigra neurons of Parkinson’s disease mouse model. Journal of Asian Natural Products Research. 2005;7(3):215-224.
Not in our library10.1080/10286020410001690172
163.
Rajabian A., Rameshrad M., Hosseinzadeh H. Therapeutic potential of Panax ginseng and its constituents, ginsenosides and gintonin, in neurological and neurodegenerative disorders: a patent review. Expert Opinion on Therapeutic Patents. 2019;29(1):55-72.
Not in our library10.1080/13543776.2019.1556258
164.
Zhou T., Zu G., Zhang X., et al. Neuroprotective effects of ginsenoside Rg1 through the Wnt/β-catenin signaling pathway in both in vivo and in vitro models of Parkinson’s disease. Neuropharmacology. 2016;101:480-489.
Not in our library10.1016/j.neuropharm.2015.10.024
165.
Liu Y., Zhang R.-Y., Zhao J., et al. Ginsenoside Rd protects SH-SY5Y cells against 1-Methyl-4-phenylpyridinium induced injury. International Journal of Molecular Sciences. 2015;16(7):14395-14408.
Not in our library10.3390/ijms160714395
166.
Zhao B.-S., Liu Y., Gao X.-Y., Zhai H.-Q., Guo J.-Y., Wang X.-Y. Effects of ginsenoside Rg1 on the expression of toll-like receptor 3, 4 and their signalling transduction factors in the NG108-15 murine neuroglial cell line. Molecules. 2014;19(10):16925-16936.
Not in our library10.3390/molecules191016925
167.
Hwang J. Y., Shim J. S., Song M.-Y., Yim S.-V., Lee S. E., Park K.-S. Proteomic analysis reveals that the protective effects of ginsenoside Rb1 are associated with the actin cytoskeleton in β-amyloid-treated neuronal cells. Journal of Ginseng Research. 2016;40(3):278-284.
Not in our library10.1016/j.jgr.2015.09.004
168.
Zhang Y., Pi Z., Song F., Liu Z. Ginsenosides attenuate d-galactose- and AlCl3-inducedspatial memory impairment by restoring the dysfunction of the neurotransmitter systems in the rat model of Alzheimer’s disease. Journal of Ethnopharmacology. 2016;194:188-195.
Not in our library10.1016/j.jep.2016.09.007
169.
Song L., Xu M.-B., Zhou X.-L., Zhang D.-p., Zhang S.-l., Zheng G.-q. A preclinical systematic review of ginsenoside-rg1 in experimental Parkinson’s disease. Oxidative Medicine and Cellular Longevity. 2017;2017:14.
Not in our library10.1155/2017/2163053
170.
Lee S.-T., Chu K., Sim J.-Y., Heo J.-H., Kim M. Panax ginseng enhances cognitive performance in Alzheimer disease. Alzheimer Disease & Associated Disorders. 2008;22(3):222-226.
Not in our library10.1097/wad.0b013e31816c92e6
171.
Zeng X., Deng Y., Feng Y., et al. Pharmacokinetics and safety of ginsenoside Rd following a single or multiple intravenous dose in healthy Chinese volunteers. The Journal of Clinical Pharmacology. 2010;50(3):285-292.
Not in our library10.1177/0091270009344334
172.
Liu X., Xia J., Wang L., et al. Efficacy and safety of ginsenoside-Rd for acute ischaemic stroke: a randomized, double-blind, placebo-controlled, phase II multicenter trial. European Journal of Neurology. 2009;16(5):569-575.
Not in our library10.1111/j.1468-1331.2009.02534.x
173.
Liu X., Wang L., Wen A., et al. Ginsenoside-Rd improves outcome of acute ischaemic stroke-a randomized, double-blind, placebo-controlled, multicenter trial. European Journal of Neurology. 2012;19(6):855-863.
Not in our library10.1111/j.1468-1331.2011.03634.x
174.
Shi J. S., Yu J. X., Chen X. P., Xu R. X. Pharmacological actions of Uncaria alkaloids, rhynchophylline and isorhynchophylline. Acta Pharmacologica Sinica. 2003;24(2):97-101.
Not in our library
175.
Xian Y.-F., Lin Z.-X., Mao Q.-Q., et al. Bioassay-guided isolation of neuroprotective compounds from Uncaria rhynchophylla against beta-amyloid-induced neurotoxicity. Evidence-Based Complementary and Alternative Medicine. 2012;2012:8.
Not in our library10.1155/2012/802625
176.
Kang T.-H., Murakami Y., Matsumoto K., et al. Rhynchophylline and isorhynchophylline inhibit NMDA receptors expressed in Xenopus oocytes. European Journal of Pharmacology. 2002;455(1):27-34.
Not in our library10.1016/s0014-2999(02)02581-5
177.
Hsieh C.-L., Chen M.-F., Li T.-C., et al. Anticonvulsant effect of Uncaria rhynchophylla (Miq) jack. The American Journal of Chinese Medicine. 1999;27(2):257-264.
Not in our library10.1142/s0192415x9900029x
178.
Hsieh C.-L., Tang N.-Y., Chiang S.-Y., Hsieh C.-T., Lin J.-G. Anticonvulsive and free radical scavenging actions of two herbs, Uncaria rhynchophylla (Miq) jack and Gastrodia elata Bl., in kainic acid-treated rats. Life Sciences. 1999;65(20):2071-2082.
Not in our library10.1016/s0024-3205(99)00473-7
179.
Tang N.-Y., Liu C.-H., Su S.-Y., et al. Uncaria rhynchophylla (Miq) Jack plays a role in neuronal protection in kainic acid-treated rats. The American Journal of Chinese Medicine. 2010;38(2):251-263.
Not in our library10.1142/s0192415x10007828
180.
Lin Y.-W., Hsieh C.-L. Oral Uncaria rhynchophylla (UR) reduces kainic acid-induced epileptic seizures and neuronal death accompanied by attenuating glial cell proliferation and S100B proteins in rats. Journal of Ethnopharmacology. 2011;135(2):313-320.
Not in our library10.1016/j.jep.2011.03.018
181.
Liu C. H., Lin Y. W., Tang N. Y., Liu H. J., Hsieh C. L. Neuroprotective effect of Uncaria rhynchophylla in kainic acid-induced epileptic seizures by modulating hippocampal mossy fiber sprouting, neuron survival, astrocyte proliferation, and S100B expression. Evidence-Based Complementary and Alternative Medicine. 2012;2012:11.
Not in our library10.1155/2012/194790
182.
Suk K., Kim S. Y., Leem K., et al. Neuroprotection by methanol extract of Uncaria rhynchophylla against global cerebral ischemia in rats. Life Sciences. 2002;70(21):2467-2480.
Not in our library10.1016/s0024-3205(02)01534-5
183.
Fujiwara H., Iwasaki K., Furukawa K., et al. Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer’s β-amyloid proteins. Journal of Neuroscience Research. 2006;84(2):427-433.
Not in our library10.1002/jnr.20891
184.
Shim J. S., Kim H. G., Ju M. S., Choi J. G., Jeong S. Y., Oh M. S. Effects of the hook of Uncaria rhynchophylla on neurotoxicity in the 6-hydroxydopamine model of Parkinson’s disease. Journal of Ethnopharmacology. 2009;126(2):361-365.
Not in our library10.1016/j.jep.2009.08.023
185.
Pal B., Kumar S. S. Evaluation of anti-Parkinson’s activity of Uncaria rhynchophylla in 6-hydroxy dopamine lesioned rat model. International Journal of Applied Research. 2015;1(6):203-206.
Not in our library
186.
Lan Y. L., Zhou J. J., Liu J., et al. Uncaria rhynchophylla ameliorates Parkinson’s disease by inhibiting HSP90 expression: insights from quantitative proteomics. Cellular Physiology and Biochemistry. 2018;47(4):1453-1464.
Not in our library10.1159/000490837
187.
Jung H. Y., Nam K. N., Woo B. C., Kim K. P., Kim S. O., Lee E. H. Hirsutine, an indole alkaloid of Uncaria rhynchophylla, inhibits inflammation-mediated neurotoxicity and microglial activation. Molecular Medicine Reports. 2013;7(1):154-158.
Not in our library10.3892/mmr.2012.1135
188.
Hu S., Mak S., Zuo X., Li H., Wang Y., Han Y. Neuroprotection against MPP (+)-Induced cytotoxicity through the activation of PI3-K/Akt/GSK3beta/MEF2D signaling pathway by rhynchophylline, the major tetracyclic oxindole alkaloid isolated from Uncaria rhynchophylla. Frontiers in Pharmacology. 2018;9:p. 768.
Not in our library10.3389/fphar.2018.00768
189.
Yang Y., Ji W. G., Zhu Z. R., Wu Y. L., Zhang Z. Y., Qu S. C. Rhynchophylline suppresses soluble Aβ1-42-induced impairment of spatial cognition function via inhibiting excessive activation of extrasynaptic NR2B-containing NMDA receptors. Neuropharmacology. 2018;135:100-112.
Not in our library10.1016/j.neuropharm.2018.03.007
190.
Neuroprotective Effects of Rhynchophylline Against Ischemic Brain Injury via Regulation of the Akt/mTOR and TLRs Signaling Pathways · 2014
Not checked
191.
Shao H., Mi Z., Ji W. G., et al. Rhynchophylline protects against the amyloid beta-induced increase of spontaneous discharges in the hippocampal CA1 region of rats. Neurochemical Research. 2015;40(11):2365-2373.
Not in our library10.1007/s11064-015-1730-y
192.
Li X. M., Zhang X. J., Dong M. X. Isorhynchophylline attenuates MPP (+)-Induced apoptosis through endoplasmic reticulum stress- and mitochondria-dependent pathways in PC12 cells: involvement of antioxidant activity. Neuromolecular Medicine. 2017;19(4):480-492.
Not in our library10.1007/s12017-017-8462-x
193.
Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla · 2017
Not checked
194.
Isorhynchophylline alleviates learning and memory impairments induced by aluminum chloride in mice · 2018
Not checked
195.
Li Q., Niu C., Zhang X., Dong M. Gastrodin and isorhynchophylline synergistically inhibit MPP(+) -Induced oxidative stress in SH-SY5Y cells by targeting ERK1/2 and GSK-3beta pathways: involvement of Nrf2 nuclear translocation. ACS Chemical Neuroscience. 2018;9(3):482-493.
Not in our library10.1021/acschemneuro.7b00247
196.
Thomas N. V., Kim S.-K. Beneficial effects of marine algal compounds in cosmeceuticals. Marine Drugs. 2013;11(1):146-164.
Not in our library10.3390/md11010146
197.
Dawczynski C., Schafer U., Leiterer M., Jahreis G. Nutritional and toxicological importance of macro, trace, and ultra-trace elements in algae food products. Journal of Agricultural and Food Chemistry. 2007;55(25):10470-10475.
Not in our library10.1021/jf0721500
198.
Holdt S. L., Kraan S. Bioactive compounds in seaweed: functional food applications and legislation. Journal of Applied Phycology. 2011;23(3):543-597.
Not in our library10.1007/s10811-010-9632-5
199.
Uncovering Potential Applications of Cyanobacteria and Algal Metabolites in Biology, Agriculture and Medicine: Current Status and Future Prospects · 2017
No notice
200.
Ahn B. R., Moon H. E., Kim H. R., Jung H. A., Choi J. S. Neuroprotective effect of edible brown alga Eisenia bicyclis on amyloid beta peptide-induced toxicity in PC12 cells. Archives of Pharmacal Research. 2012;35(11):1989-1998.
Not in our library10.1007/s12272-012-1116-5
201.
Silva J., Alves C., Pinteus S., Mendes S., Pedrosa R. Neuroprotective effects of seaweeds against 6-hydroxidopamine-induced cell death on an in vitro human neuroblastoma model. BMC Complementary and Alternative Medicine. 2018;18(1):p. 58.
Not in our library10.1186/s12906-018-2103-2
202.
Silva J., Alves C., Freitas R., et al. Antioxidant and neuroprotective potential of the Brown seaweed Bifurcaria bifurcata in an in vitro Parkinson’s disease model. Marine Drugs. 2019;17:p. 2.
Not in our library10.3390/md17020085
203.
Heo S. J., Cha S. H., Kim K. N., et al. Neuroprotective effect of phlorotannin isolated from Ishige okamurae against H2O2 -induced oxidative stress in murine hippocampal neuronal cells, HT22. Applied Biochemistry and Biotechnology. 2012;166(6):1520-1532.
Not in our library10.1007/s12010-012-9545-7
204.
Um M. Y., Lim D. W., Son H. J., Cho S., Lee C. Phlorotannin-rich fraction from Ishige foliacea brown seaweed prevents the scopolamine-induced memory impairment via regulation of ERK-CREB-BDNF pathway. Journal of Functional Foods. 2018;40:110-116.
Not in our library10.1016/j.jff.2017.10.014
205.
Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications · 2016
No notice
206.
Silva T. H., Alves A., Popa E. G., et al. Marine algae sulfated polysaccharides for tissue engineering and drug delivery approaches. Biomatter. 2012;2(4):278-289.
Not in our library10.4161/biom.22947
207.
Venkatesan J., Anil S., Kim S.-K., Shim M. S. Seaweed polysaccharide-based nanoparticles: preparation and applications for drug delivery. Polymers. 2016;8(2):p. 30.
Not in our library10.3390/polym8020030
208.
Sana K., Munawar A., Farhan S., Huma B.-U.-A., Hafiz Ansar Rasul S., Maiti S. Therapeutic potential of seaweed bioactive compounds. Seaweed Biomaterials. 2018.
Not in our library
209.
Luo D., Zhang Q., Wang H., et al. Fucoidan protects against dopaminergic neuron death in vivo and in vitro. European Journal of Pharmacology. 2009;617(1–3):33-40.
Not in our library10.1016/j.ejphar.2009.06.015
210.
Zhang F. L., He Y., Zheng Y., et al. Therapeutic effects of fucoidan in 6-hydroxydopamine-lesioned rat model of Parkinson’s disease: role of NADPH oxidase-1. CNS Neuroscience and Therapeutics. 2014;20(12):1036-1044.
Not in our library10.1111/cns.12340
211.
Zhang L., Hao J., Zheng Y., et al. Fucoidan protects dopaminergic neurons by enhancing the mitochondrial function in a rotenone-induced rat model of Parkinson’s disease. Aging and Disease. 2018;9(4):590-604.
Not in our library10.14336/ad.2017.0831
212.
Wei H., Gao Z., Zheng L., et al. Protective effects of fucoidan on Aβ 25–35 and d-gal-induced neurotoxicity in PC12 cells and d-gal-induced cognitive dysfunction in mice. Marine Drugs. 2017;15(3):p. 77.
Not in our library10.3390/md15030077
213.
Alghazwi M., Smid S., Karpiniec S., Zhang W. Comparative study on neuroprotective activities of fucoidans from Fucus vesiculosus and Undaria pinnatifida. International Journal of Biological Macromolecules. 2019;122:255-264.
Not in our library10.1016/j.ijbiomac.2018.10.168
214.
Kim M. H., Namgoong H., Jung B. D., et al. Fucoidan Attenuates 6-hydroxydopamine-induced neurotoxicity by exerting anti-oxidative and anti-apoptotic actions in SH-Sy5y cells. Korean Journal of Veterinary Research. 2017;57(1):1-7.
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215.
Vijayakumar S., Menakha M. Pharmaceutical applications of cyanobacteria-a review. Journal of Acute Medicine. 2015;5(1):15-23.
Not in our library10.1016/j.jacme.2015.02.004
216.
Ku C. S., Yang Y., Park Y., Lee J. Health benefits of blue-green algae: prevention of cardiovascular disease and nonalcoholic fatty liver disease. Journal of Medicinal Food. 2013;16(2):103-111.
Not in our library10.1089/jmf.2012.2468
217.
Nagarajan M., Maruthanayagam V., Sundararaman M. A review of pharmacological and toxicological potentials of marine cyanobacterial metabolites. Journal of Applied Toxicology. 2012;32(3):153-185.
Not in our library10.1002/jat.1717
218.
Raja R., Hemaiswarya S., Ganesan V., Carvalho I. S. Recent developments in therapeutic applications of Cyanobacteria. Critical Reviews in Microbiology. 2016;42(3):394-405.
Not in our library10.3109/1040841x.2014.957640
219.
Borowitzka M. A., Levine I. A., Fleurence J. Chapter 3-biology of microalgae. Microalgae in Health and Disease Prevention. 2018;23-72.
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220.
Zhang F., Lu J., Zhang J. G., Xie J. X. Protective effects of a polysaccharide from Spirulina platensis on dopaminergic neurons in an MPTP-induced Parkinson’s disease model in C57BL/6J mice. Neural Regeneration Research. 2015;10(2):308-313.
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221.
Lima F. A. V., Joventino I. P., Joventino F. P., et al. Neuroprotective activities of spirulina platensis in the 6-OHDA model of parkinson’s disease are related to its anti-inflammatory effects. Neurochemical Research. 2017;42(12):3390-3400.
Not in our library10.1007/s11064-017-2379-5
222.
Bermejo-Bescós P., Piñero-Estrada E., Villar del Fresno Á.M. Neuroprotection by Spirulina platensis protean extract and phycocyanin against iron-induced toxicity in SH-SY5Y neuroblastoma cells. Toxicology in Vitro. 2008;22(6):1496-1502.
Not in our library10.1016/j.tiv.2008.05.004
223.
Bermejo P., Piñero E., Villar Á. M. Iron-chelating ability and antioxidant properties of phycocyanin isolated from a protean extract of Spirulinaplatensis. Food Chemistry. 2008;110(2):436-445.
Not in our library10.1016/j.foodchem.2008.02.021
224.
Chen J.-C., Liu K. S., Yang T.-J., Hwang J.-H., Chan Y.-C., Lee I. T. Spirulina and C-phycocyanin reduce cytotoxicity and inflammation-related genes expression of microglial cells. Nutritional Neuroscience. 2012;15(6):252-256.
Not in our library10.1179/1476830512y.0000000020
225.
Kay R. A., Barton L. L. Microalgae as food and supplement. Critical Reviews in Food Science and Nutrition. 1991;30(6):555-573.
Not in our library10.1080/10408399109527556
226.
Marine algal natural products with anti-oxidative, anti-inflammatory, and anti-cancer properties · 2013
No notice
227.
Koh E.-J., Kim K.-J., Song J.-H., et al. Spirulina maxima extract ameliorates learning and memory impairments via inhibiting GSK-3β phosphorylation induced by intracerebroventricular injection of amyloid-β 1–42 in mice. International Journal of Molecular Sciences. 2017;18(11):p. 2401.
Not in our library10.3390/ijms18112401
228.
Koh E.-J., Kim K.-J., Choi J., Kang D.-H., Lee B.-Y. Spirulina maxima extract prevents cell death through BDNF activation against amyloid beta 1–42 (Aβ1-42) induced neurotoxicity in PC12 cells. Neuroscience Letters. 2018;673:33-38.
Not in our library10.1016/j.neulet.2018.02.057
229.
Chamorro G., Pérez-Albiter M., Serrano-García N., Mares-Sámano J. J., Rojas P. Spirulina maxima pretreatment partially protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. Nutritional Neuroscience. 2006;9(5-6):207-212.
Not in our library10.1080/10284150600929748
230.
Tobon-Velasco J. C., Palafox-Sanchez V., Mendieta L., et al. Antioxidant effect of Spirulina (Arthrospira) maxima in a neurotoxic model caused by 6-OHDA in the rat striatum. Journal of Neural Transmission. 2013;120(8):1179-1189.
Not in our library10.1007/s00702-013-0976-2
231.
Pérez-Juárez A., Pacheco-Rosado J., Paniagua N., Alva Sánchez C., Chamorro G. Neuroprotective effect of spirulina (arthrospira) maxima against kainic acid-induced neurotoxicity. Journal of Medicinal Plants Research. 2012;6(2).
Not in our library10.5897/jmpr11.718
232.
Choi W. Y., Do H. K., Lee H. Y. Effect of fermented Spirulina maxima extract on cognitive-enhancing activities in mice with scopolamine-induced dementia. Evidence-Based Complementary and Alternative Medicine. 2018;2018:9.
Not in our library10.1155/2018/7218504
233.
Koh E. J., Seo Y. J., Choi J., et al. Spirulina maxima extract prevents neurotoxicity via promoting activation of BDNF/CREB signaling pathways in neuronal cells and mice. Molecules. 2017;22:p. 8.
Not in our library10.3390/molecules22081363
234.
Zhang N., Dou D., Ran X., Kang T. Neuroprotective effect of arctigenin against neuroinflammation and oxidative stress induced by rotenone. RSC Advances. 2018;8(5):2280-2292.
Not in our library10.1039/c7ra10906g
235.
Chonpathompikunlert P., Boonruamkaew P., Sukketsiri W., Hutamekalin P., Sroyraya M. The antioxidant and neurochemical activity of Apium graveolens L. and its ameliorative effect on MPTP-induced Parkinson-like symptoms in mice. BMC Complementary and Alternative Medicine. 2018;18(1):p. 103.
Not in our library10.1186/s12906-018-2166-0
236.
Venkateshgobi V., Rajasankar S., Johnson W., Prabu K., Ramkumar M. Neuroprotective effect of agaricus blazei extract against rotenone-induced motor and nonmotor symptoms in experimental model of parkinson’s disease. International Journal of Nutrition, Pharmacology, Neurological Diseases. 2018;8(2):59-65.
Not in our library
237.
VenkateshGobi V., Rajasankar S., Ramkumar M., et al. Agaricus blazei extract abrogates rotenone-induced dopamine depletion and motor deficits by its anti-oxidative and anti-inflammatory properties in Parkinsonic mice. Nutritional Neuroscience. 2018;21(9):657-666.
Not in our library10.1080/1028415x.2017.1337290
238.
Ren Z.-X., Zhao Y.-F., Cao T., Zhen X.-C. Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson’s disease by suppressing glycogen synthase kinase-3 beta activity. Acta Pharmacologica Sinica. 2016;37(10):1315-1324.
Not in our library10.1038/aps.2016.42
239.
Ye Q., Wang W., Hao C., Mao X. Agaropentaose protects SH-SY5Y cells against 6-hydroxydopamine-induced neurotoxicity through modulating NF-κB and p38MAPK signaling pathways. Journal of Functional Foods. 2019;57:222-232.
Not in our library10.1016/j.jff.2019.04.017
240.
Ameen A. M., Elkazaz A. Y., Mohammad H. M. F., Barakat B. M. Anti-inflammatory and neuroprotective activity of boswellic acids in rotenone parkinsonian rats. Canadian Journal of Physiology and Pharmacology. 2017;95(7):819-829.
Not in our library10.1139/cjpp-2016-0158
241.
A.-S. Omar M.E., A. S. Amany, R. Y. Eman, N. Y. Noha, S. Nermeen, and A. E.-T. Sayed, “Capsicum protects against rotenone-induced toxicity in mice brain via reduced oxidative stress and 5-lipoxygenase activation,” Journal of Pharmacy and Pharmacology Research, vol. 2, no. 3, pp. 60–77, 2018
Not in our library
242.
Neuroprotective effects of a Coeloglossum viride var. Bracteatum extract in vitro and in vivo · 2017
Not checked
243.
Ojha R. P., Rastogi M., Devi B. P., Agrawal A., Dubey G. P. Neuroprotective effect of curcuminoids against inflammation-mediated dopaminergic neurodegeneration in the MPTP model of Parkinson’s disease. Journal of Neuroimmune Pharmacology. 2012;7(3):609-618.
Not in our library10.1007/s11481-012-9363-2
244.
Ojha S., Javed H., Azimullah S., Haque M. E. β-Caryophyllene, a phytocannabinoid attenuates oxidative stress, neuroinflammation, glial activation, and salvages dopaminergic neurons in a rat model of Parkinson disease. Molecular and Cellular Biochemistry. 2016;418(1-2):59-70.
Not in our library10.1007/s11010-016-2733-y
245.
Mori M. A., Delattre A. M., Carabelli B., et al. Neuroprotective effect of omega-3 polyunsaturated fatty acids in the 6-OHDA model of Parkinson’s disease is mediated by a reduction of inducible nitric oxide synthase. Nutritional Neuroscience. 2018;21(5):341-351.
Not in our library10.1080/1028415x.2017.1290928
246.
Chompoopong S., Jarungjitaree S., Punbanlaem T., et al. Neuroprotective effects of germinated Brown rice in rotenone-induced Parkinson’s-like disease rats. NeuroMolecular Medicine. 2016;18(3):334-346.
Not in our library10.1007/s12017-016-8427-5
247.
Aruna K., Rajeswari P. D. R., Sankar S. R. The effect of Oxalis corniculata extract against the behavioral changes induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice. Journal of Applied Pharmaceutical Science. 2017;7(03):148-153.
Not in our library
248.
Sarbishegi M., Charkhat Gorgich E. A., Khajavi O., Komeili G., Salimi S. The neuroprotective effects of hydro-alcoholic extract of olive (Olea europaea L.) leaf on rotenone-induced Parkinson’s disease in rat. Metabolic Brain Disease. 2018;33(1):79-88.
Not in our library10.1007/s11011-017-0131-0
249.
Zhu G., Wang X., Wu S., Li X., Li Q. Neuroprotective effects of puerarin on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson’s disease model in mice. Phytotherapy Research. 2014;28(2):179-186.
Not in our library10.1002/ptr.4975
250.
Wang J., Xu H., Jiang H., Du X., Sun P., Xie J. Neurorescue effect of rosmarinic acid on 6-hydroxydopamine-lesioned nigral dopamine neurons in rat model of Parkinson’s disease. Journal of Molecular Neuroscience. 2012;47(1):113-119.
Not in our library10.1007/s12031-011-9693-1
251.
Chang H.-C., Liu K.-F., Teng C.-J., et al. Sophora tomentosa extract prevents MPTP-induced parkinsonism in C57BL/6 mice via the inhibition of GSK-3β phosphorylation and oxidative stress. Nutrients. 2019;11(2):p. 252.
Not in our library10.3390/nu11020252
252.
Kosaraju J., Chinni S., Roy P. D., Kannan E., Antony A. S., Kumar M. N. Neuroprotective effect of Tinospora cordifolia ethanol extract on 6-hydroxy dopamine induced Parkinsonism. Indian Journal of Pharmacology. 2014;46(2):176-180.
Not in our library10.4103/0253-7613.129312
253.
Alzahrani S., Ezzat W., Elshaer R. E., et al. Standarized Tribulus terrestris extract protects against rotenone-induced oxidative damage and nigral dopamine neuronal loss in mice. Journal of Physiology and Pharmacology. 2018;69:p. 6.
Not in our library10.26402/jpp.2018.6.14
254.
Bisht R., Joshi B. C., Kalia A. N., Prakash A. Antioxidant-rich fraction of urtica dioica mediated rescue of striatal mito-oxidative damage in MPTP-induced behavioral, cellular, and neurochemical alterations in rats. Molecular Neurobiology. 2017;54(7):5632-5645.
Not in our library10.1007/s12035-016-0084-z
255.
Ibrahim F. W., Noraashikin Zainudin U., Abdul Latif M., Hamid A. Neuroprotective effects of ethyl acetate extract of Zingiber zerumbet (L.) smith against oxidative stress on paraquat-induced parkinsonism in rats. Sains Malaysiana. 2018;47(10):2337-2347.
Not in our library10.17576/jsm-2018-4710-10
256.
Hishikawa N., Takahashi Y., Amakusa Y., et al. Effects of turmeric on Alzheimer’s disease with behavioral and psychological symptoms of dementia. Ayu. 2012;33(4):499-504.
Not in our library10.4103/0974-8520.110524
257.
de la Rubia Orti J. E., Garcia-Pardo M. P., Drehmer E., et al. Improvement of main cognitive functions in patients with alzheimer’s disease after treatment with coconut oil enriched mediterranean diet: a pilot study. Journal of Alzheimer’s Disease. 2018;65(2):577-587.
Not in our library10.3233/jad-180184
258.
Azmi N. H., Ismail M., Ismail N., Imam M. U., Alitheen N. B. M., Abdullah M. A. Germinated brown rice alters Aβ (1–42) aggregation and modulates Alzheimer’s disease-related genes in differentiated human SH-SY5Y cells. Evidence-Based Complementary and Alternative Medicine. 2015;2015:12.
Not in our library10.1155/2015/153684
259.
Wang R., Tang X. C. Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer’s disease. Neurosignals. 2005;14(1-2):71-82.
Not in our library10.1159/000085387
260.
Xu S. S., Gao Z. X., Weng Z., et al. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer’s disease. Zhongguo Yao Li Xue Bao. 1995;16(5):391-395.
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261.
Postu P. A., Noumedem J. A. K., Cioanca O., et al. Lactuca capensis reverses memory deficits in Aβ1-42-induced an animal model of Alzheimer’s disease. Journal of Cellular and Molecular Medicine. 2018;22(1):111-122.
Not in our library10.1111/jcmm.13299
262.
Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus · 2015
No notice
263.
Zhang L., Zhou Z., Zhai W., et al. Safflower yellow attenuates learning and memory deficits in amyloid β-induced Alzheimer’s disease rats by inhibiting neuroglia cell activation and inflammatory signaling pathways. Metabolic Brain Disease. 2019;34(3):927-939.
Not in our library10.1007/s11011-019-00398-0
264.
Khongsombat O., nakdook W., ingkaninan K. Inhibitory effects of Tabernaemontana divaricata root extract on oxidative stress and neuronal loss induced by amyloid β25–35 peptide in mice. Journal of Traditional and Complementary Medicine. 2018;8(1):184-189.
Not in our library10.1016/j.jtcme.2017.05.009
265.
Martinez-Oliveira P., de Oliveira M. F., Alves N., et al. Yacon leaf extract supplementation demonstrates neuroprotective effect against memory deficit related to β-amyloid-induced neurotoxicity. Journal of Functional Foods. 2018;48:665-675.
Not in our library10.1016/j.jff.2018.08.004
266.
Winter A. N., Ross E. K., Wilkins H. M., et al. An anthocyanin-enriched extract from strawberries delays disease onset and extends survival in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. Nutritional Neuroscience. 2018;21(6):414-426.
Not in our library10.1080/1028415x.2017.1297023
267.
Huang K.-K., Lin M.-N., Hsu Y.-L., Lu I.-H., Pan I.-H., Yang J.-L. Alpinia oxyphylla fruit extract ameliorates experimental autoimmune encephalomyelitis through the regulation of Th1/Th17 cells. Evidence-Based Complementary and Alternative Medicine. 2019;2019:15.
Not in our library10.1155/2019/6797030
268.
Wang M., Xie Y., Zhong Y., et al. Amelioration of experimental autoimmune encephalomyelitis by isogarcinol extracted from Garcinia mangostana L. Mangosteen. Journal of Agricultural and Food Chemistry. 2016;64(47):9012-9021.
Not in our library10.1021/acs.jafc.6b04145
269.
Ahn M., Kim J., Yang W., et al. Amelioration of experimental autoimmune encephalomyelitis by Ishige okamurae. Anatomy and Cell Biology. 2018;51(4):292-298.
Not in our library10.5115/acb.2018.51.4.292
270.
Noor N. A., Fahmy H. M., Mohammed F. F., Elsayed A. A., Radwan N. M. Nigella sativa amliorates inflammation and demyelination in the experimental autoimmune encephalomyelitis-induced Wistar rats. International Journal of Clinical and Experimental Pathology. 2015;8(6):6269-6286.
Not in our library
271.
Li W., Wu H., Gao C., Yang D., Yang D., Shen J. Radix rehmanniae extract ameliorates experimental autoimmune encephalomyelitis by suppressing macrophage-derived nitrative damage. Frontiers in Physiology. 2018;9:p. 864.
Not in our library10.3389/fphys.2018.00864
272.
Giacoppo S., Galuppo M., Lombardo G. E., et al. Neuroprotective effects of a polyphenolic white grape juice extract in a mouse model of experimental autoimmune encephalomyelitis. Fitoterapia. 2015;103:171-186.
Not in our library10.1016/j.fitote.2015.04.003
273.
Thangthaeng N., Poulose S. M., Fisher D. R., Shukitt-Hale B. Walnut extract modulates activation of microglia through alteration in intracellular calcium concentration. Nutrition Research. 2018;49:88-95.
Not in our library10.1016/j.nutres.2017.10.016
274.
Maqbool S., Younus I., Sadaf R., Fatima A. Neuro-pharmacological evaluation of anticonvulsant and neuroprotective activity of Cocculus laurifolius leaves in wistar rats. Metabolic Brain Disease. 2019;34(4):991-999.
Not in our library10.1007/s11011-019-00414-3
275.
Zhong S.-J., Wang L., Wu H.-T., Lan R., Qin X.-Y. Coeloglossum viride var. bracteatum extract improves learning and memory of chemically-induced aging mice through upregulating neurotrophins BDNF and FGF2 and sequestering neuroinflammation. Journal of Functional Foods. 2019;57:40-47.
Not in our library10.1016/j.jff.2019.03.045
276.
Jawaid T., Kamal M., Singh R., Shukla D., Devanathadesikan V., Sinha M. Anticonvulsant and neuroprotective effects of methanolic extract of Cinnamomum camphora leaves in rat brain. Oriental Pharmacy and Experimental Medicine. 2018;18(3):237-246.
Not in our library10.1007/s13596-018-0306-1
277.
Aldawsari H. M., Eid B. G., Neamatallah T., Zaitone S. A., Badr J. M. Anticonvulsant and neuroprotective activities of phragmanthera austroarabica extract in pentylenetetrazole-kindled mice. Evidence-Based Complementary and Alternative Medicine. 2017;2017:12.
Not in our library10.1155/2017/5148219
278.
Fachim H. A., Mortari M. R., Gobbo-Netto L., Dos Santos W. F. Neuroprotective activity of parawixin 10, a compound isolated from Parawixia bistriata spider venom (Araneidae: araneae) in rats undergoing intrahippocampal NMDA microinjection. Pharmacognosy Magazine. 2015;11(43):579-585.
Not in our library10.4103/0973-1296.160450
279.
Fachim H. A., Cunha A. O., Pereira A. C., et al. Neurobiological activity of Parawixin 10, a novel anticonvulsant compound isolated from Parawixia bistriata spider venom (Araneidae: araneae). Epilepsy and Behavior. 2011;22(2):158-164.
Not in our library10.1016/j.yebeh.2011.05.008
280.
Yon J.-M., Kim Y.-B., Park D. The ethanol fraction of white rose petal extract abrogates excitotoxicity-induced neuronal damage in vivo and in vitro through inhibition of oxidative stress and proinflammation. Nutrients. 2018;10(10):p. 1375.
Not in our library10.3390/nu10101375
281.
Naderali E., Nikbakht F., Ofogh S. N., Rasoolijazi H. The role of rosemary extract in degeneration of hippocampal neurons induced by kainic acid in the rat: a behavioral and histochemical approach. Journal of Integrative Neuroscience. 2018;17(1):19-25.
Not in our library10.3233/jin-170035
282.
Hu S., Maiti P., Ma Q., et al. Clinical development of curcumin in neurodegenerative disease. Expert Review of Neurotherapeutics. 2015;15(6):629-637.
Not in our library10.1586/14737175.2015.1044981
283.
Rigacci S., Stefani M. Nutraceuticals and amyloid neurodegenerative diseases: a focus on natural phenols. Expert Review of Neurotherapeutics. 2015;15(1):41-52.
Not in our library10.1586/14737175.2015.986101
284.
Singh M., Arseneault M., Sanderson T., Murthy V., Ramassamy C. Challenges for research on polyphenols from foods in Alzheimer’s disease: bioavailability, metabolism, and cellular and molecular mechanisms. Journal of Agricultural and Food Chemistry. 2008;56(13):4855-4873.
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285.
Zhao D., Simon J. E., Wu Q. A critical review on grape polyphenols for neuroprotection: strategies to enhance bioefficacy. Critical Reviews in Food Science and Nutrition. 2020;60(4):597-625.
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286.
Bilia A. R., Piazzini V., Risaliti L., et al. Nanocarriers: a successful tool to increase solubility, stability and optimise bioefficacy of natural constituents. Current Medicinal Chemistry. 2019;26(24):4631-4656.
Not in our library10.2174/0929867325666181101110050
287.
Renaud J., Martinoli M. G. Considerations for the use of polyphenols as therapies in neurodegenerative diseases. International Journal of Molecular Sciences. 2019;20(8).
Not in our library10.3390/ijms20081883
288.
Cascella M., Bimonte S., Muzio M. R., Schiavone V., Cuomo A. The efficacy of Epigallocatechin-3-gallate (green tea) in the treatment of Alzheimer’s disease: an overview of pre-clinical studies and translational perspectives in clinical practice. Infectious Agents and Cancer. 2017;12(1):p. 36.
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289.
Rein M. J., Renouf M., Cruz-Hernandez C., Actis-Goretta L., Thakkar S. K., da Silva Pinto M. Bioavailability of bioactive food compounds: a challenging journey to bioefficacy. British Journal of Clinical Pharmacology. 2013;75(3):588-602.
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290.
Hodgson A. B., Randell R. K., Jeukendrup A. E. The effect of green tea extract on fat oxidation at rest and during exercise: evidence of efficacy and proposed mechanisms. Advances in Nutrition. 2013;4(2):129-140.
Not in our library10.3945/an.112.003269
291.
Sharma R. A., Steward W. P., Gescher A. J. Pharmacokinetics and pharmacodynamics of curcumin. Advances In Experimental Medicine And Biology. 2007;595:453-470.
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Begum A. N., Jones M. R., Lim G. P., et al. Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer’s disease. Journal of Pharmacology and Experimental Therapeutics. 2008;326(1):196-208.
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293.
Rakotoarisoa M., Angelova A. Amphiphilic nanocarrier systems for curcumin delivery in neurodegenerative disorders. Medicines. 2018;5(4):p. 126.
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294.
Shoji Y., Nakashima H. Nutraceutics and delivery systems. Journal of Drug Targeting. 2004;12(6):385-391.
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295.
Coimbra M., Isacchi B., van Bloois L., et al. Improving solubility and chemical stability of natural compounds for medicinal use by incorporation into liposomes. International Journal of Pharmaceutics. 2011;416(2):433-442.
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296.
Ovais M., Zia N., Ahmad I., et al. Phyto-therapeutic and nanomedicinal approaches to cure alzheimer’s disease: present status and future opportunities. Frontiers in Aging Neuroscience. 2018;10:p. 284.
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297.
Niu X., Chen J., Gao J. Nanocarriers as a powerful vehicle to overcome blood-brain barrier in treating neurodegenerative diseases: focus on recent advances. Asian Journal of Pharmaceutical Sciences. 2019;14(5):480-496.
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298.
Teleanu D. M., Negut I., Grumezescu V., Grumezescu A. M., Teleanu R. I. Nanomaterials for drug delivery to the central nervous system. Nanomaterials. 2019;9(3):p. 371.
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Formulations of Curcumin Nanoparticles for Brain Diseases · 2019
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Cited by papers we hold 2

The Potential Benefits of Quercetin for Brain Health: A Review of Anti-Inflammatory and Neuroprotective Mechanisms · 2023
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Neuroprotective Natural Products for Alzheimer’s Disease · 2021
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