Fibrin Gel as an Injectable Biodegradable Scaffold and Cell Carrier for Tissue Engineering

Abstract

Due to the increasing needs for organ transplantation and a universal shortage of donated tissues, tissue engineering emerges as a useful approach to engineer functional tissues. Although different synthetic materials have been used to fabricate tissue engineering scaffolds, they have many limitations such as the biocompatibility concerns, the inability to support cell attachment, and undesirable degradation rate. Fibrin gel, a biopolymeric material, provides numerous advantages over synthetic materials in functioning as a tissue engineering scaffold and a cell carrier. Fibrin gel exhibits excellent biocompatibility, promotes cell attachment, and can degrade in a controllable manner. Additionally, fibrin gel mimics the natural blood‐clotting process and self‐assembles into a polymer network. The ability for fibrin to cure in situ has been exploited to develop injectable scaffolds for the repair of damaged cardiac and cartilage tissues. Additionally, fibrin gel has been utilized as a cell carrier to protect cells from the forces during the application and cell delivery processes while enhancing the cell viability and tissue regeneration. Here, we review the recent advancement in developing fibrin‐based biomaterials for the development of injectable tissue engineering scaffold and cell carriers.

References 62

1. 1.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library10.3109/15360288.2015.1037530

2. 2.

   Jockenhoevel S., Zund G., Hoerstrup S. P., et al. Fibrin gel–advantages of a new scaffold in cardiovascular tissue engineering. European Journal of Cardio-Thoracic Surgery. 2001;19(4):424-430.

   Not in our library10.1016/s1010-7940(01)00624-8

3. 3.

   Grad S., Kupcsik L., Gorna K., Gogolewski S., Alini M. The use of biodegradable polyurethane scaffolds for cartilage tissue engineering: potential and limitations. Biomaterials. 2003;24(28):5163-5171.

   Not in our library10.1016/s0142-9612(03)00462-9

4. 4.

   Gunatillake P. A., Adhikari R. Biodegradable synthetic polymers for tissue engineering. European Cells and Materials. 2003;5:1-16.

   Not in our library10.22203/ecm.v005a01

5. 5.

   Maia F. R., Lourenço A. H., Granja P. L., Gonçalves R. M., Barrias C. C. Effect of cell density on mesenchymal stem cells aggregation in RGD-alginate 3D matrices under osteoinductive conditions. Macromolecular Bioscience. 2014;14(6):759-771.

   Not in our library10.1002/mabi.201300567

6. 6.

   Liu X., Peng W., Wang Y., et al. Synthesis of an RGD-grafted oxidized sodium alginate-N-succinyl chitosan hydrogel and an in vitro study of endothelial and osteogenic differentiation. Journal of Materials Chemistry B. 2013;1(35):4484-4492.

   Not in our library10.1039/c3tb20552e

7. 7.

   Wolberg A. S. Thrombin generation and fibrin clot structure. Blood Reviews. 2007;21(3):131-142.

   Not in our library10.1016/j.blre.2006.11.001

8. 8.

   Ahmed T. A. E., Dare E. V., Hincke M. Fibrin: a versatile scaffold for tissue engineering applications. Tissue Engineering Part B: Reviews. 2008;14(2):199-215.

   Not in our library10.1089/ten.teb.2007.0435

9. 9.

   Ehrbar M., Metters A., Zammaretti P., Hubbell J. A., Zisch A. H. Endothelial cell proliferation and progenitor maturation by fibrin-bound VEGF variants with differential susceptibilities to local cellular activity. Journal of Controlled Release. 2005;101(1–3):93-109.

   Not in our library10.1016/j.jconrel.2004.07.018

10. 10.

    Jackson M. R. Fibrin sealants in surgical practice: an overview. The American Journal of Surgery. 2001;182(2):S1-S7.

    Not in our library10.1016/s0002-9610(01)00770-x

11. 11.

    Ratnalingam V., Keat Eu A. L., Ng G. L., Taharin R., John E. Fibrin adhesive is better than sutures in pterygium surgery. Cornea. 2010;29(5):485-489.

    Not in our library10.1097/ico.0b013e3181c29696

12. 12.

    Fuller C. Reduction of intraoperative air leaks with Progel in pulmonary resection: a comprehensive review. Journal of Cardiothoracic Surgery. 2013;8(1, article 90).

    Not in our library10.1186/1749-8090-8-90

13. 13.

    de Boer M. T., Boonstra E. A., Lisman T., Porte R. J. Role of fibrin sealants in liver surgery. Digestive Surgery. 2012;29(1):54-61.

    Not in our library10.1159/000335735

14. 14.

    Sidelmann J. J., Gram J., Jespersen J., Kluft C. Fibrin clot formation and lysis: basic mechanisms. Seminars in Thrombosis and Hemostasis. 2000;26(6):605-618.

    Not in our library10.1055/s-2000-13216

15. 15.

    Kjaergad H. K., Weis-Fogh U. S. Important factors influencing the strength of autologous fibrin glue: the fibrin concentration and reaction time—comparison of strength with commercial fibrin glue. European Surgical Research. 1994;26(5):273-276.

    Not in our library10.1159/000129346

16. 16.

    Nimni M. E., Cheung D., Strates B., Kodama M., Sheikh K. Chemically modified collagen: a natural biomaterial for tissue replacement. Journal of Biomedical Materials Research. 1987;21(6):741-771.

    Not in our library10.1002/jbm.820210606

17. 17.

    Swartz D. D., Russell J. A., Andreadis S. T. Engineering of fibrin-based functional and implantable small-diameter blood vessels. The American Journal of Physiology—Heart and Circulatory Physiology. 2005;288(3):H1451-H1460.

    Not in our library10.1152/ajpheart.00479.2004

18. 18.

    Sierra D. H. Fibrin sealant adhesive systems: a review of their chemistry, material properties and clinical applications. Journal of Biomaterials Applications. 1993;7(4):309-352.

    Not in our library10.1177/088532829300700402

19. 19.

    Malafaya P. B., Silva G. A., Reis R. L. Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications. Advanced Drug Delivery Reviews. 2007;59(4-5):207-233.

    Not in our library10.1016/j.addr.2007.03.012

20. 20.

    Fortelny R. H., Petter-Puchner A. H., Glaser K. S., Redl H. Use of fibrin sealant (Tisseel/Tissucol) in hernia repair: a systematic review. Surgical Endoscopy. 2012;26(7):1803-1812.

    Not in our library10.1007/s00464-012-2156-0

21. 21.

    Spotnitz W. D. Fibrin sealant: past, present, and future: a brief review. World Journal of Surgery. 2010;34(4):632-634.

    Not in our library10.1007/s00268-009-0252-7

22. 22.

    Sameem M., Wood T. J., Bain J. R. A systematic review on the use of fibrin glue for peripheral nerve repair. Plastic and Reconstructive Surgery. 2011;127(6):2381-2390.

    Not in our library10.1097/prs.0b013e3182131cf5

23. 23.

    Hogan M., Mohamed M., Tao Z.-W., Gutierrez L., Birla R. Establishing the framework to support bioartificial heart fabrication using fibrin-based three-dimensional artificial heart muscle. Artificial Organs. 2014;39(2):165-171.

    Not in our library10.1111/aor.12318

24. 24.

    Undas A., Ariëns R. A. S. Fibrin clot structure and function: a role in the pathophysiology of arterial and venous thromboembolic diseases. Arteriosclerosis, Thrombosis, and Vascular Biology. 2011;31(12):e88-e99.

    Not in our library10.1161/atvbaha.111.230631

25. 25.

    Rowe S. L., Lee S., Stegemann J. P. Influence of thrombin concentration on the mechanical and morphological properties of cell-seeded fibrin hydrogels. Acta Biomaterialia. 2007;3(1):59-67.

    Not in our library10.1016/j.actbio.2006.08.006

26. 26.

    Collet J. P., Park D., Lesty C., et al. Influence of fibrin network conformation and fibrin fiber diameter on fibrinolysis speed dynamic and structural approaches by confocal microscopy. Arteriosclerosis, Thrombosis, and Vascular Biology. 2000;20(5):1354-1361.

    Not in our library10.1161/01.atv.20.5.1354

27. 27.

    Thorsen S. The mechanism of plasminogen activation and the variability of the fibrin effector during tissue-type plasminogen activator—mediated fibrinolysis. Annals of the New York Academy of Sciences. 1992;667(1):52-63.

    Not in our library10.1111/j.1749-6632.1992.tb51597.x

28. 28.

    Whitmore E. Preparation of autologous plasma and fibrin gel. Google Patents. 1999.

    Not in our library

29. 29.

    Tous E., Purcell B., Ifkovits J. L., Burdick J. A. Injectable acellular hydrogels for cardiac repair. Journal of Cardiovascular Translational Research. 2011;4(5):528-542.

    Not in our library10.1007/s12265-011-9291-1

30. 30.

    Blombäck B., Bark N. Fibrinopeptides and fibrin gel structure. Biophysical Chemistry. 2004;112(2-3):147-151.

    Not in our library10.1016/j.bpc.2004.07.013

31. 31.

    Kubota K., Kogure H., Masuda Y., et al. Gelation dynamics and gel structure of fibrinogen. Colloids and Surfaces B: Biointerfaces. 2004;38(3-4):103-109.

    Not in our library10.1016/j.colsurfb.2004.02.017

32. 32.

    Konings J., Govers-Riemslag J. W. P., Philippou H., et al. Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin. Blood. 2011;118(14):3942-3951.

    Not in our library10.1182/blood-2011-03-339572

33. 33.

    Eyrich D., Brandl F., Appel B., et al. Long-term stable fibrin gels for cartilage engineering. Biomaterials. 2007;28(1):55-65.

    Not in our library10.1016/j.biomaterials.2006.08.027

34. 34.

    Jockenhoevel S., Flanagan T. C., Eberli D. Cardiovascular tissue engineering based on fibrin-gel-scaffolds. Tissue Engineering for Tissue and Organ Regeneration. 2011;(chapter 3).

    Not in our library10.5772/19761

35. 35.

    Vedakumari W. S., Prabu P., Babu S. C., Sastry T. P. Fibrin nanoparticles as Possible vehicles for drug delivery. Biochimica et Biophysica Acta—General Subjects. 2013;1830(8):4244-4253.

    Not in our library10.1016/j.bbagen.2013.04.032

36. 36.

    Kulkarni M. M., Greiser U., O'Brien T., Pandit A. A temporal gene delivery system based on fibrin microspheres. Molecular Pharmaceutics. 2011;8(2):439-446.

    Not in our library10.1021/mp100295z

37. 37.

    Rajangam T., An S. S. A. Improved fibronectin-immobilized fibrinogen microthreads for the attachment and proliferation of fibroblasts. International Journal of Nanomedicine. 2013;8:1037-1049.

    Not in our library10.2147/ijn.s37784

38. 38.

    Gugutkov D., Gustavsson J., Ginebra M. P., Altankov G. Fibrinogen nanofibers for guiding endothelial cell behavior. Biomaterials Science. 2013;1(10):1065-1073.

    Not in our library10.1039/c3bm60124b

39. 39.

    Gui L., Boyle M. J., Kamin Y. M., et al. Construction of tissue-engineered small-diameter vascular grafts in fibrin scaffolds in 30 days. Tissue Engineering—Part A. 2014;20(9-10):1499-1507.

    Not in our library10.1089/ten.tea.2013.0263

40. 40.

    Ye Q., Zünd G., Benedikt P., et al. Fibrin gel as a three dimensional matrix in cardiovascular tissue engineering. European Journal of Cardio-Thoracic Surgery. 2000;17(5):587-591.

    Not in our library10.1016/s1010-7940(00)00373-0

41. 41.

    Snyder T. N., Madhavan K., Intrator M., Dregalla R. C., Park D. A fibrin/hyaluronic acid hydrogel for the delivery of mesenchymal stem cells and potential for articular cartilage repair. Journal of Biological Engineering. 2014;8, article 10.

    Not in our library10.1186/1754-1611-8-10

42. 42.

    Lee K. Y., Mooney D. J. Hydrogels for tissue engineering. Chemical Reviews. 2001;101(7):1869-1880.

    Not in our library10.1021/cr000108x

43. 43.

    Chien C.-S., Ho H.-O., Liang Y.-C., Ko P.-H., Sheu M.-T., Chen C.-H. Incorporation of exudates of human platelet-rich fibrin gel in biodegradable fibrin scaffolds for tissue engineering of cartilage. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2012;100(4):948-955.

    Not in our library10.1002/jbm.b.32657

44. 44.

    Hong H., Stegemann J. P. 2D and 3D collagen and fibrin biopolymers promote specific ECM and integrin gene expression by vascular smooth muscle cells. Journal of Biomaterials Science, Polymer Edition. 2008;19(10):1279-1293.

    Not in our library10.1163/156856208786052380

45. 45.

    Christman K. L., Fok H. H., Sievers R. E., Fang Q., Lee R. J. Fibrin glue alone and skeletal myoblasts in a fibrin scaffold preserve cardiac function after myocardial infarction. Tissue Engineering. 2004;10(3-4):403-409.

    Not in our library10.1089/107632704323061762

46. 46.

    Christman K. L., Vardanian A. J., Fang Q., Sievers R. E., Fok H. H., Lee R. J. Injectable fibrin scaffold improves cell transplant survival, reduces infarct expansion, and induces neovasculature formation in ischemic myocardium. Journal of the American College of Cardiology. 2004;44(3):654-660.

    Not in our library10.1016/j.jacc.2004.04.040

47. 47.

    Ryu J. H., Kim I.-K., Cho S.-W., et al. Implantation of bone marrow mononuclear cells using injectable fibrin matrix enhances neovascularization in infarcted myocardium. Biomaterials. 2005;26(3):319-326.

    Not in our library10.1016/j.biomaterials.2004.02.058

48. 48.

    Zhang X., Wang H., Ma X., et al. Preservation of the cardiac function in infarcted rat hearts by the transplantation of adipose-derived stem cells with injectable fibrin scaffolds. Experimental Biology and Medicine. 2010;235(12):1505-1515.

    Not in our library10.1258/ebm.2010.010175

49. 49.

    Peretti G. M., Xu J.-W., Bonassar L. J., Kirchhoff C. H., Yaremchuk M. J., Randolph M. A. Review of injectable cartilage engineering using fibrin gel in mice and swine models. Tissue Engineering. 2006;12(5):1151-1168.

    Not in our library10.1089/ten.2006.12.1151

50. 50.

    Cakmak O., Babakurban S. T., Akkuzu H. G., et al. Injectable tissue-engineered cartilage using commercially available fibrin glue. The Laryngoscope. 2013;123(12):2986-2992.

    Not in our library10.1002/lary.24156

51. 51.

    Lee J.-C., Lee S. Y., Min H. J., et al. Synovium-derived mesenchymal stem cells encapsulated in a novel injectable gel can repair osteochondral defects in a rabbit model. Tissue Engineering Part A. 2012;18(19-20):2173-2186.

    Not in our library10.1089/ten.tea.2011.0643

52. 52.

    Chen W., Zhou H., Weir M. D., Bao C., Xu H. H. K. Umbilical cord stem cells released from alginate-fibrin microbeads inside macroporous and biofunctionalized calcium phosphate cement for bone regeneration. Acta Biomaterialia. 2012;8(6):2297-2306.

    Not in our library10.1016/j.actbio.2012.02.021

53. 53.

    Zhou H., Xu H. H. K. The fast release of stem cells from alginate-fibrin microbeads in injectable scaffolds for bone tissue engineering. Biomaterials. 2011;32(30):7503-7513.

    Not in our library10.1016/j.biomaterials.2011.06.045

54. 54.

    Liu J., Xu H. H. K., Zhou H., Weir M. D., Chen Q., Trotman C. A. Human umbilical cord stem cell encapsulation in novel macroporous and injectable fibrin for muscle tissue engineering. Acta Biomaterialia. 2013;9(1):4688-4697.

    Not in our library10.1016/j.actbio.2012.08.009

55. 55.

    Kneser U., Voogd A., Ohnolz J., et al. Fibrin gel-immobilized primary osteoblasts in calcium phosphate bone cement: in vivo evaluation with regard to application as injectable biological bone substitute. Cells Tissues Organs. 2005;179(4):158-169.

    Not in our library10.1159/000085951

56. 56.

    Lee B. P., Dalsin J. L., Messersmith P. B., Smith A. M., Callow J. A. Biomimetic adhesive polymers based on mussel adhesive proteins. Biological Adhesives. 2006;257-278.

    Not in our library

57. 57.

    Hokugo A., Takamoto T., Tabata Y. Preparation of hybrid scaffold from fibrin and biodegradable polymer fiber. Biomaterials. 2006;27(1):61-67.

    Not in our library10.1016/j.biomaterials.2005.05.030

58. 58.

    Munirah S., Kim S. H., Ruszymah B. H. I., Khang G. The use of fibrin and poly (lactic-co-glycolic acid) hybrid scaffold for articular cartilage tissue engineering: an in vivo analysis. European Cells and Materials. 2008;15:41-52.

    Not in our library10.22203/ecm.v015a04

59. 59.

    Wang W., Li B., Yang J., et al. The restoration of full-thickness cartilage defects with BMSCs and TGF-beta 1 loaded PLGA/fibrin gel constructs. Biomaterials. 2010;31(34):8964-8973.

    Not in our library10.1016/j.biomaterials.2010.08.018

60. 60.

    Schek R. M., Michalek A. J., Iatridis J. C. Genipin-crosslinked fibrin hydrogels as a potential adhesive to augment intervertebral disc annulus repair. European Cells and Materials. 2011;21:373-383.

    Not in our library10.22203/ecm.v021a28

61. 61.

    Brunette M., Holmes H., Lancina M. G., et al. Inducible nitric oxide releasing poly-(ethylene glycol)-fibrinogen adhesive hydrogels for tissue regeneration. MRS Proceedings. 2013;1569:39-44.

    Not in our library10.1557/opl.2013.797

62. 62.

    Van Wagner M., Rhadigan J., Lancina M., et al. S-nitroso-N-acetylpenicillamine (SNAP) derivatization of peptide primary amines to create inducible nitric oxide donor biomaterials. ACS Applied Materials & Interfaces. 2013;5(17):8430-8439.

    Not in our library10.1021/am4017945

Cited by papers we hold 3

• Chlorite oxidized oxyamylose differentially influences the microstructure of fibrin and self assembling peptide hydrogels as well as dental pulp stem cell behavior · 2021
  Not checked
• Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity · 2021
  No notice
• Extracellular matrix molecules and their potential contribution to the function of transplanted pancreatic islets · 2018
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.