Retrospective Analysis of Cushing’s Disease with or without Hyperprolactinemia

Objective . We compared the characteristics of patients with Cushing’s disease alone with those of patients with Cushing’s disease and hyperprolactinemia. Methods . Eighty-four patients were enrolled between 2002 and 2011, in a hospital in China. Clinical, endocrinological, and histopathological data, MRI scans, and surgical outcomes were reviewed throughout the follow-up period. Results . Patients with Cushing’s disease and hyperprolactinemia had a younger age at diagnosis (30.28 ± 14.23 versus 36.08 ± 10.91 years; P = 0.037 ) and a larger adenoma maximal diameter (2.44 ± 1.32 versus 1.44 ± 1.05 cm; P < 0.001 ) than patients with Cushing’s disease alone. Menstrual disorders ( P = 0.027 ) and visual field defects ( P = 0.021 ) were more common and progressive obesity ( P = 0.009 ) and hypertension ( P < 0.001 ) were less common in patients with Cushing’s disease and hyperprolactinemia. The rate of normalization of hormonal levels was lower (41.7% versus 91.7%; P < 0.001 ) and the recurrence rate was higher (36.1% versus 8.3%; P < 0.001 ) in patients with Cushing’s disease and hyperprolactinemia. Conclusions . Careful long-term follow-up is needed of patients with Cushing’s disease and hyperprolactinemia.

Abstract licence: CC BY

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