Rheumatoid Factors: Clinical Applications

Abstract

Rheumatoid factors are antibodies directed against the Fc region of immunoglobulin G. First detected in patients with rheumatoid arthritis 70 years ago, they can also be found in patients with other autoimmune and nonautoimmune conditions, as well as in healthy subjects. Rheumatoid factors form part of the workup for the differential diagnosis of arthropathies. In clinical practice, it is recommended to measure anti-cyclic citrullinated peptide antibodies and rheumatoid factors together because anti-cyclic citrullinated peptide antibodies alone are only moderately sensitive, and the combination of the two markers improves diagnostic accuracy, especially in the case of early rheumatoid arthritis. Furthermore, different rheumatoid factor isotypes alone or in combination can be helpful when managing rheumatoid arthritis patients, from the time of diagnosis until deciding on the choice of therapeutic strategy.

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• Recent Advances in Understanding the Pathogenesis of Rheumatoid Arthritis: New Treatment Strategies · 2021
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• Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis · 2020
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• Autoantibodies and B Cells: The ABC of rheumatoid arthritis pathophysiology · 2019
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• C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production and glomerulonephropathy in mice · 2016
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