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Neuroprotective Function of DJ-1 in Parkinson’s Disease

Hiroyoshi Ariga, Kazuko Takahashi-Niki, Izumi Kato and 3 more

Oxidative Medicine and Cellular Longevity · 2013 · Review

doi:10.1155/2013/683920

Abstract

Parkinson’s disease (PD) is caused by dopaminergic neuronal death in the substantia nigra, resulting in a reduced level of dopamine in the striatum. Oxidative stress and mitochondrial dysfunction are thought to be major causes of neurodegeneration in PD. Although genetic and environmental factors are thought to affect the onset of PD, precise mechanisms at the molecular level have not been elucidated. The DJ-1 gene is a causative gene for familial PD ( park7 ) and also an oncogene. DJ-1 has various functions, including transcriptional regulation, antioxidative stress reaction, and chaperone, protease, and mitochondrial regulation, and its activity is regulated by its oxidative status, especially that of cysteine 106 (C106) of DJ-1. Excess oxidation of DJ-1, which renders DJ-1 inactive, has been observed in patients with sporadic PD and Alzheimer’s disease, suggesting that DJ-1 also participates in the onset and pathogenesis of sporadic PD as well as familial PD. DJ-1 is also a stress sensor and its expression is increased upon various stresses, including oxidative stress. In this review, we describe functions of DJ-1 against oxidative stress and possible roles of DJ-1 in the pathogenesis of PD.

Full text

From PubMed Central, U.S. National Library of Medicine, as current on Oct 18, 2026. Paragraph numbers are ours, so an answer can point at one.

1. Introduction

Parkinson's disease (PD) is a progressive neurodegenerative disease that occurs in approximately 1% of the population over the age of 65 years. There are two types of PD, familial and sporadic forms of PD. Although familial PD cases account for 10% of total cases of PD, investigations of the functions of familial PD gene products have provided great insights into the molecular mechanisms of the onset of PD, and familial PD gene products are thought to also play roles in the pathogenesis of sporadic PD (see recent reviews).

The DJ-1 gene has been identified by us as a novel oncogene that transforms mouse NIH3T3 cells in cooperation with activated ras in 1997. In 2003, Bonifati et al. found a large deletion and missense mutation in the DJ-1 gene in Italian and Dutch PD patients, leading to identification of the DJ-1 gene as a causative gene for familial PD park7 with recessive inheritance. Twenty-three pathogenic deletion and point mutations were found in patients with PD (see Parkinson's disease mutation database and references therein, http://www.molgen.ua.ac.be/PDmutDB/default.cfm?MT=0-&ML=0&Page=Home). Compared to parkin and Pink1, other causative genes of familial PD with recessive inheritance, the number of mutations in the DJ-1 gene is small; numbers of mutations of the three genes are the order of parkin > Pink1 > DJ-1. This might be due to the position of DJ-1 during the course of onset of PD; DJ-1 may be placed upstream of Pink1 and parkin.

In this review, we describe functions of DJ-1 against oxidative stress and discuss how loss of function of DJ-1 affects the pathogenesis of PD.

2. Structure, Expression, and Function of DJ-1

DJ-1 is comprised of 189 amino acids with seven β-strands and nine α-helices in total and is present as a dimer. Amino acid sequences of DJ-1 are conserved from prokaryotes to eukaryotes and they are now named DJ-1 superfamily. DJ-1 is structurally most similar to the monomer subunit of protease I, the intracellular cysteine protease from Pyrococcus horikoshii. DJ-1, however, contains an additional α-helix at the C-terminal region, which blocks the putative catalytic site of DJ-1.

DJ-1 is expressed in almost all cells and tissues, including the brain. DJ-1 is expressed in both neurons and glia cells. The expression level of DJ-1 is increased in cells, including reactive astrocytes, under an oxidative stress condition, and overexpression of DJ-1 is observed in reactive astrocytes in sporadic PD and other neurodegenerative diseases. Knockdown or knockout of DJ-1 expression in astrocytes impairs astrocyte-mediated neuroprotection against oxidative stress through deregulation of mitochondrial complex I and inflammatory responses.

DJ-1 is a multifunctional protein that participates in transcriptional regulation, antioxidative stress reaction, and chaperone, protease, and mitochondrial regulation (Figure 1). DJ-1 is located in the cytoplasm, nucleus, and mitochondria in cells, and secreted DJ-1 has been observed in various cultured cells and tissues, including cancer cells and tissues and astrocytes. DJ-1 is translocated from the cytoplasm to nucleus upon exposure to growth factors, and oxidation of C106 described later is necessary for nuclear translocation of DJ-1. DJ-1 contains three cysteine residues, C46, C56, and C106. Of the three cysteine residues, C106 is highly susceptible to oxidative stress and is oxidized as SOH, SO2H, and then SO3H, and mutation of C106 results in loss of all of DJ-1's functions (Figure 2). DJ-1 at C106 with SO3H is thought to be an inactive form of DJ-1, and excessive oxidized DJ-1 has been observed in brains of patients with PD and Alzheimer's disease. DJ-1 thus possesses quenching activity against reactive oxygen species (ROS) by self-oxidation of its cysteine residues. Phylogenetic analyses showed that, of the DJ-1 superfamily from prokaryotic and eukaryotic representatives, C106 is highly conserved and important for their functions, including enzymatic activities such as thiamin biosynthetic enzymes, protease and isocyanide hydratase, chaperone, and stress response (, references therein). DJ-1 is also modified by sumoylation, S-nitrosylation, and phosphorylation (Figure 3). Sumoylation of DJ-1 occurs under an oxidative stress condition in concomitant with acidic shift of DJ-1. Sumoylation of DJ-1 at lysine 130 is necessary for its activity, and excess sumoylation is observed in an L166P pathogenic mutant of DJ-1. S-nitrosylation is observed at cysteines 46 and 53 of DJ-1 under a nitrosative stress condition and affects dimerization of DJ-1, which is necessary for DJ-1 to exert its function. DJ-1 is also phosphorylated in a p53-dependent manner, but phosphorylated amino acid(s) and the effect of phosphorylation on DJ-1 function are not known. From these points, it is thought that DJ-1 also participates in the pathogenesis of sporadic PD as well as familial PD.

3. Transcriptional Regulation of DJ-1 in Response to Oxidative Stress and Dopamine Synthesis

Although DJ-1 does not directly bind to DJ-1, it regulates the activity of DNA-binding transcription factors as a coactivator or corepressor through binding to DJ-1-binding transcription factors. Transcription factors whose activity is regulated by DJ-1 include the androgen receptor, polypyrimidine tract-binding protein-associated splicing factor (PSF), p53, nuclear factor erythroid-2-related factor 2 (Nrf2), and sterol regulatory element binding protein (SREBP). Considering oxidative stress response and dopamine synthesis, regulation of Nrf2, p53, and PSF by DJ-1 is important. Nrf2 is a master transcription factor for oxidative stress and detoxication responses. Without such stresses, Nrf2 is localized in the cytoplasm in a complex with Keap1, resulting in degradation by the ubiquitin-proteasome system. Upon oxidative stress, DJ-1 sequesters Keap1, leading to translocation of Nrf2 into the nucleus to activate various antioxidative stress genes, thereby decreasing the ROS level. p53 is a tumor suppressor and plays roles in induction of senescence and apoptosis in cells and in regulation of mitochondrial homeostasis against oxidative stress. DJ-1 directly binds to p53 and regulates p53 activity in various ways; p53 is activated by Topors-mediated sumoylation and inactivated by DJ-1 through inhibition of Topors activity, and DJ-1 binds to the DNA-binding region of p53 to inhibit p53 transcriptional activity when affinity of p53 or its mutants to DNA is low, leading to cell cycle progression. It has also been reported that DJ-1 inhibits the induction of apoptosis by p53-induced Bax expression. DJ-1 stimulates the expression of superoxide dismutase (SOD 3) and glutathione ligase genes by an unknown mechanism to reduce ROS level.

Dopamine is synthesized from tyrosine by two enzymes: tyrosine hydroxylase (TH) converts tyrosine to L-DOPA and L-DOPA carboxylase (DDC) converts L-DOPA to dopamine. Dopamine is then packed in synaptic vesicles by vesicular monoamine transporter 2 (VMAT2). Although TH level in PD patients is decreased, it is not changed in DJ-1-knockout mice. DJ-1 positively regulates human TH gene expression by sequestering transcriptional repressor PSF from the human TH gene promoter (Figure 4). This upregulation is only observed in the human TH gene due to lack of the PSF-recognition sequence in the mouse TH gene, and highly oxidized DJ-1 loses this activity. This finding indicates one of the reasons for no change in TH level in DJ-1-knockout mice. DJ-1 also regulates enzymatic activities of TH and DDC. When the sum of SH (reduced) and SOH forms of C106 is more than 50% of total forms of C106, DJ-1 upregulates TH and DDC activities, suggesting that the activity of DJ-1 toward TH and DDC is changed depending on the level of oxidative stress and that it is decreased with aging, which is one of the crucial factors for onset of PD (Figure 5). DJ-1 positively regulates expression of the VMAT2 gene and VMAT2 activity through transcriptional coactivator and protein-protein interaction, respectively. Since VMAT2 re-uptakes excess dopamine into synaptic vesicles to prevent neurons from oxidized dopamine-induced damage, upregulation of VMAT activity by DJ-1 contributes to this reaction. Pathogenic mutations of DJ-1, including both homozygous and heterozygous mutations, have reduced stimulating activity against TH, DDC, and VMAT2.

4. Chaperone and Protease Activity of DJ-1

Structures of DJ-1, Escherichia coli chaperone Hsp31 and an Archaea protease are conserved. DJ-1 inhibits the aggregation of α-synuclein under an oxidative condition by its chaperone activity. As stated in Section 2, the structure of DJ-1 is similar to that of cysteine protease from Pyrococcus horikoshii, but C-terminal α-helix 9 blocks a catalytic domain of protease. DJ-1 in dopaminergic cells undergoes C-terminal cleavage in response to mild oxidative stress, and a C-terminally cleaved form of DJ-1 with activated protease activity enhances cytoprotective action against oxidative stress-induced apoptosis. Although protease activity is still in debate, low protease activity of DJ-1 has been reported. Transthyretin, a causative protein in familial amyloidotic polyneuropathy (FAP), is degraded in cells transfected with full-sized DJ-1 and in vitro by recombinant DJ-1 lacking α-helix 9, and mutation of C106 in DJ-1 results in loss of its protease activity. Localizations of DJ-1 and amyloid plaque of transthyretin in FAP patients are mirror images, and faint staining of DJ-1 is observed in the outer halo of Lewy bodies in PD patients. These results suggest that α-helix 9 of DJ-1 is opened in cells under oxidative stress conditions in which oxidized protein(s) begins to aggregate and that DJ-1 degrades an aggregated protein(s) that causes neurodegenerative diseases. Identification of the recognition sequence of DJ-1 protease and of the protein(s) that opens α-helix 9 of DJ-1 in cells will lead to elucidation of the physiological role of DJ-1 protease.

5. DJ-1-Mediated Signaling Pathways against Oxidative Stress

There are several pathways against oxidative stress and these pathways prevent cell death, thereby leading to cell growth. The phosphoinositide 3-kinase (PI3 K)/Akt pathway is the major growth signaling pathway. When cells receive growth signals such as epidermal growth factor (EGF) stimulation, PI3 K triggers phosphorylation of Akt/protein kinase B (PKB), leading to activation of continuous phosphorylation cascades, resulting in stimulation of cell growth (see reviews and references therein). Phosphatase and Tensin homolog deleted from chromosome 10 (PTEN) is a lipid phosphatase that inhibits PI3 K and acts as a negative regulator of the PI3 K/Akt pathway. DJ-1 directly binds to PTEN to inhibit its enzymatic activity. After oxidative stress such as that caused by injection of a neurotoxin into mice or by addition of a neurotoxin to cultured cells, the Akt pathway is activated concomitantly with inactivation of PTEN in mouse brains and cultured cells, and the phosphorylation level of Akt is reduced in DJ-1-knockout mice, leading to neuronal cell death.

Apoptosis signal-regulating kinase 1 (ASK1) is mitogen-activated protein kinase-kinase-kinase 5 (MAP3 K5). It activates c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases in response to various stresses such as oxidative stress, endoplasmic reticulum stress and calcium influx. TNF-α, LPS, and ischemia also trigger the generation of ROS, resulting in activation of ASK1 (see reviews, references therein). ASK1 has been found to be involved in cancer, diabetes, and cardiovascular diseases and neurodegenerative diseases. These phenomena are similar to those observed in DJ-1-mediated diseases. The generation of ROS is also crucial for TNF-α-induced signaling pathway that leads to apoptosis, and treatment of cells with antioxidants such as N-acetyl-l-cysteine (NAC) inhibits apoptosis induction. Daxx, a death domain-associated protein, associates with ASK1 in the cytoplasm to induce apoptosis after cells are treated with TNF-α. DJ-1 binds to both Daxx and ASK1 to sequester Daxx into the nucleus, preventing Daxx from association with ASK1, thereby inhibiting oxidative stress-induced apoptosis in H2O2-treated cultured cells and MPTP-administered-PD model mice. Pathogenic mutants of DJ-1 do not have this activity.

The ERK pathway is the main cell-progression pathway starting from Ras, followed by Raf, Mek, and ERK. DJ-1 protects against dopamine toxicity through the Erk kinase pathway in which DJ-1 and Erk are mutually activated upon administration of dopamine into mice or cultured cells. It has been reported that an accelerated loss of substantia nigra cell bodies containing dopamine neurons was observed in aging mice lacking DJ-1 and the glial cell line-derived neurotrophic factor receptor Ret and that DJ-1 interacts with ERK signaling. Furthermore, DJ-1 protects dopaminergic neurons against rotenone-induced apoptosis by enhancing ERK-dependent mitophagy. Thus, DJ-1 prevents cells from oxidative stress-induced death by regulating various signaling pathways.

6. Role of DJ-1 in Mitochondrial Homeostasis

Mitochondrial dysfunction, including reduced mitochondrial complex I activity and mitochondrial membrane potential, is observed in PD patients and in DJ-1-knockout mice and flies. Fragmented mitochondria are observed in DJ-1-knockout mice and cells. Although a portion of DJ-1 is present in mitochondria under normal conditions and DJ-1 binds to subunits of mitochondrial complex I to regulate its activity, the translocation of DJ-1 into mitochondria is stimulated by oxidative stress, and oxidation of C106 with SO2H and N-terminal 12 amino acids is necessary for mitochondrial translocation of DJ-1. Pathogenic DJ-1 mutants such as L166P and M26I DJ-1 are localized in mitochondria as monomers. DJ-1 ectopically targeted to mitochondria by the addition of an N-terminal mitochondrial targeting sequence has been shown to be more protective against oxidative stress-induced cell death. Considering these findings, it is thought that localization of DJ-1 as a dimer in mitochondria is required for DJ-1 to play a role in antioxidative stress reaction and that DJ-1 localized in mitochondria as a monomer, such as M26I and L166P DJ-1, is, in contrast, harmful to cells.

DJ-1 has no mitochondria-targeting sequence and binds to several chaperones, including Hsp70, CHIP, and mitochondrial Hsp70/mortalin/Grp75, suggesting that translocation of DJ-1 into mitochondria relies on or depends on other proteins, including mortalin. Mortalin plays a central role in mitochondrial homeostasis through its capacity to direct the import of nuclear-encoded proteins carrying an internal mitochondrial targeting sequence into mitochondria, and mutations of the mortalin gene were found in patients with Parkinson's disease.

The role of DJ-1 in autophagy is still in debate, and almost all of the reports focused on mitochondria-specific autophagy, mitophagy. When mitochondrial membrane potential is decreased, DJ-1 is translocated into mitochondria to induce mitophagy, which is clearance of damaged mitochondria. DJ-1 seems to act in parallel to the Pink1/Parkin-mediated mitophagy pathway. Although mitochondrial functions of DJ-1 have been extensively studied, the precise mechanism of mitophagy induction by DJ-1 is still poorly understood.

7. Conclusion and Perspective

DJ-1 has multiple functions and plays a protective role against oxidative stress-induced cell death by using all of its functions. DJ-1 is also a stress sensor and its expression is increased upon various stresses, including oxidative stress. Loss of function and reduced function of DJ-1 trigger the onset of oxidative stress-related diseases, including Parkinson's disease, stroke, familial amyloidotic polyneuropathy, chronic obstructive pulmonary disease (COPD), and type II diabetes. The oxidative status of C106 of DJ-1 determines all of the functions of DJ-1. Excess oxidation of C106 renders DJ-1 inactive, and highly oxidized DJ-1 has been observed in patients with Parkinson's disease and Alzheimer's disease. These results suggest that block of excessive oxidation of DJ-1 is a therapeutic target for the oxidative stress-related diseases stated earlier. Indeed, DJ-1-binding compounds that bind to the C106 region of DJ-1 showed neuroprotective activity against neurodegeneration in Parkinson's disease and stroke animal models through inhibition of excessive oxidation of C106 of DJ-1.

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    Wang X, Petrie TG, Liu Y, Liu J, Fujioka H, Zhu X. Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction. Journal of Neurochemistry. 2012;121(5):830-839.

    Not in our library10.1111/j.1471-4159.2012.07734.x

  52. 52.

    Heo JY, Park JH, Kim SJ, et al. DJ-1 null dopaminergic neuronal cells exhibit defects in mitochondrial function and structure: involvement of mitochondrial complex I assembly. PLoS One. 2012;7(3, article e32629).

    Not in our library10.1371/journal.pone.0032629

  53. 53.

    Wagenfeld A, Gromoll J, Cooper TG. Molecular cloning and expression of rat contraception associated protein 1 (CAP1), a protein putatively involved in fertilization. Biochemical and Biophysical Research Communications. 1998;251(2):545-549.

    Not in our library10.1006/bbrc.1998.9512

  54. 54.

    Welch JE, Barbee RR, Roberts NL, Suarez JD, Klinefelter GR. Breakthrough in andrology: Sp22: a novel fertility protein from a highly conserved gene family. Journal of Andrology. 1998;19(4):385-393.

    Not in our library

  55. 55.

    Le Naour F, Misek DE, Krause MC, et al. Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer. Clinical Cancer Research. 2001;7(11):3328-3335.

    Not in our library

  56. 56.

    Allard L, Burkhard PR, Lescuyer P, et al. PARK7 and nucleoside diphosphate kinase A as plasma markers for the early diagnosis of stroke. Clinical Chemistry. 2005;51(11):2043-2051.

    Not in our library10.1373/clinchem.2005.053942

  57. 57.

    Waragai M, Wei J, Fujita M, et al. Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson’s disease. Biochemical and Biophysical Research Communications. 2006;345(3):967-972.

    Not in our library10.1016/j.bbrc.2006.05.011

  58. 58.

    Waragai M, Nakai M, Wei J, et al. Plasma levels of DJ-1 as a possible marker for progression of sporadic Parkinson’s disease. Neuroscience Letters. 2007;425(1):18-22.

    Not in our library10.1016/j.neulet.2007.08.010

  59. 59.

    Maita C, Tsuji S, Yabe I, et al. Secretion of DJ-1 into the serum of patients with Parkinson’s disease. Neuroscience Letters. 2008;431(1):86-89.

    Not in our library10.1016/j.neulet.2007.11.027

  60. 60.

    Tsuboi Y, Munemoto H, Ishikawa S, Matsumoto KI, Iguchi-Ariga SMM, Ariga H. DJ-1, a causative gene product of a familial form of Parkinson’s disease, is secreted through microdomains. The FEBS Letters. 2008;582(17):2643-2649.

    Not in our library10.1016/j.febslet.2008.06.043

  61. 61.

    Kim SJ, Park YJ, Hwang IY, Youdim MB, Park KS, Oh YJ. Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death. Free Radical Biology & Medicine. 2012;53(4):936-950.

    Not in our library10.1016/j.freeradbiomed.2012.05.035

  62. 62.

    Choi J, Sullards MC, Olzmann JA, et al. Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. The Journal of Biological Chemistry. 2006;281(16):10816-10824.

    Not in our library10.1074/jbc.m509079200

  63. 63.

    Mitsumoto A, Nakagawa Y. DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin. Free Radical Research. 2001;35(6):885-893.

    Not in our library10.1080/10715760100301381

  64. 64.

    Lucas JI, Marín I. A new evolutionary paradigm for the Parkinson disease gene DJ-1. Molecular Biology and Evolution. 2007;24(2):551-561.

    Not in our library10.1093/molbev/msl186

  65. 65.

    Shinbo Y, Niki T, Taira T, et al. Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities. Cell Death and Differentiation. 2006;13(1):96-108.

    Not in our library10.1038/sj.cdd.4401704

  66. 66.

    Ito G, Ariga H, Nakagawa Y, Iwatsubo T. Roles of distinct cysteine residues in S-nitrosylation and dimerization of DJ-1. Biochemical and Biophysical Research Communications. 2006;339(2):667-672.

    Not in our library10.1016/j.bbrc.2005.11.058

  67. 67.

    Rahman-Roblick R, Hellman U, Becker S, et al. Proteomic identification of p53-dependent protein phosphorylation. Oncogene. 2008;27(35):4854-4859.

    Not in our library10.1038/onc.2008.124

  68. 68.

    Yamaguchi S, Yamane T, Takahashi-Niki K, et al. Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis. PLoS One. 2012;7(5, article e38144).

    Not in our library10.1371/journal.pone.0038144

  69. 69.

    Fan J, Ren H, Jia N, et al. DJ-1 decreases Bax expression through repressing p53 transcriptional activity. The Journal of Biological Chemistry. 2008;283(7):4022-4030.

    Not in our library10.1074/jbc.m707176200

  70. 70.

    Kato I, Maita H, Takahashi-Niki K, et al. Oxidized DJ-1 inhibits p53 by sequestering p53 from promoters in a DNA-binding affinity-dependent manner. Molecular and Cellular Biology. 2013;33(2):340-359.

    Not in our library10.1128/mcb.01350-12

  71. 71.

    Nishinaga H, Takahashi-Niki K, Taira T, Andreadis A, Iguchi-Ariga SMM, Ariga H. Expression profiles of genes in DJ-1-knockdown and L166P DJ-1 mutant cells. Neuroscience Letters. 2005;390(1):54-59.

    Not in our library10.1016/j.neulet.2005.07.053

  72. 72.

    Zhou W, Freed CR. DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T α-synuclein toxicity. The Journal of Biological Chemistry. 2005;280(52):43150-43158.

    Not in our library10.1074/jbc.m507124200

  73. 73.

    Goldberg MS, Pisani A, Haburcak M, et al. Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial parkinsonism-linked gene DJ-1. Neuron. 2005;45(4):489-496.

    Not in our library10.1016/j.neuron.2005.01.041

  74. 74.

    Kim RH, Smith PD, Aleyasin H, et al. Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6- tetrahydropyrindine (MPTP) and oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 2005;102(14):5215-5220.

    Not in our library10.1073/pnas.0501282102

  75. 75.

    Chen L, Cagniard B, Mathews T, et al. Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice. The Journal of Biological Chemistry. 2005;280(22):21418-21426.

    Not in our library10.1074/jbc.m413955200

  76. 76.

    Ishikawa S, Taira T, Niki T, et al. Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1. The Journal of Biological Chemistry. 2009;284(42):28832-28844.

    Not in our library10.1074/jbc.m109.019950

  77. 77.

    Ishikawa S, Tanaka Y, Takahashi-Niki K, Niki T, Ariga H, Iguchi-Ariga SMM. Stimulation of vesicular monoamine transporter 2 activity by DJ-1 in SH-SY5Y cells. Biochemical and Biophysical Research Communications. 2012;421(4):813-818.

    Not in our library10.1016/j.bbrc.2012.04.095

  78. 78.

    Yotsumoto F, Sanui A, Fukami T, et al. Efficacy of ligand-based targeting for the EGF system in cancer. Anticancer Research. 2009;29(11):4879-4885.

    Not in our library

  79. 79.

    Takeuchi K, Ito F. EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors. FEBS Journal. 2010;277(2):316-326.

    Not in our library10.1111/j.1742-4658.2009.07450.x

  80. 80.

    Kim RH, Peters M, Jang Y, et al. DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell. 2005;7(3):263-273.

    Not in our library10.1016/j.ccr.2005.02.010

  81. 81.

    Kim YC, Kitaura H, Taira T, Iguchi-Ariga SMM, Ariga H. Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN. International Journal of Oncology. 2009;35(6):1331-1341.

    Not in our library

  82. 82.

    Tang B, Xiong H, Sun P, et al. Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson’s disease. Human Molecular Genetics. 2006;15(11):1816-1825.

    Not in our library10.1093/hmg/ddl104

  83. 83.
    The roles of ASK family proteins in stress responses and diseases · 2009
    No notice
  84. 84.

    Shiizaki S, Naguro I, Ichijo H. Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling. Advances in Biological Regulation. 2013;53(1):135-144.

    Not in our library10.1016/j.jbior.2012.09.006

  85. 85.

    Iriyama T, Takeda K, Nakamura H, et al. ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. The EMBO Journal. 2009;28(7):843-853.

    Not in our library10.1038/emboj.2009.32

  86. 86.

    Benhar M, Engelberg D, Levitzki A. ROS, stress-activated kinases and stress signaling in cancer. The EMBO Reports. 2002;3(5):420-425.

    Not in our library10.1093/embo-reports/kvf094

  87. 87.

    Thandavarayan RA, Watanabe K, Ma M, et al. 14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy. Biochemical Pharmacology. 2008;75(9):1797-1806.

    Not in our library10.1016/j.bcp.2008.02.003

  88. 88.

    Yamamoto E, Dong YF, Kataoka K, et al. Olmesartan prevents cardiovascular injury and hepatic steatosis in obesity and diabetes, accompanied by apoptosis signal regulating Kinase-1 inhibition. Hypertension. 2008;52(3):573-580.

    Not in our library10.1161/hypertensionaha.108.112292

  89. 89.

    Izumiya Y, Kim S, Izumi Y, et al. Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II-induced cardiac hypertrophy and remodelling. Circulation Research. 2003;93(9):874-883.

    Not in our library10.1161/01.res.0000100665.67510.f5

  90. 90.

    Yamaguchi O, Higuchi Y, Hirotani S, et al. Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling. Proceedings of the National Academy of Sciences of the United States of America. 2003;100(26):15883-15888.

    Not in our library10.1073/pnas.2136717100

  91. 91.

    Nishitoh H, Matsuzawa A, Tobiume K, et al. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes & Development. 2002;16(11):1345-1355.

    Not in our library10.1101/gad.992302

  92. 92.

    Nishitoh H, Kadowaki H, Nagai A, et al. ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1. Genes & Development. 2008;22(11):1451-1464.

    Not in our library10.1101/gad.1640108

  93. 93.

    Kadowaki H, Nishitoh H, Urano F, et al. Amyloid β induces neuronal cell death through ROS-mediated ASK1 activation. Cell Death and Differentiation. 2005;12(1):19-24.

    Not in our library10.1038/sj.cdd.4401528

  94. 94.

    Abou-Sleiman PM, Healy DG, Quinn N, Lees AJ, Wood NW. The role of pathogenic DJ-1 mutations in Parkinson’s disease. Annals of Neurology. 2003;54(3):283-286.

    Not in our library10.1002/ana.10675

  95. 95.

    Hering R, Strauss KM, Tao X, et al. Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7). Human Mutation. 2004;24(4):321-329.

    Not in our library10.1002/humu.20089

  96. 96.

    Aleyasin H, Rousseaux MWC, Phillips M, et al. The Parkinson’s disease gene DJ-1 is also a key regulator of stroke-induced damage. Proceedings of the National Academy of Sciences of the United States of America. 2007;104(47):18748-18753.

    Not in our library10.1073/pnas.0709379104

  97. 97.

    Yanagisawa D, Kitamura Y, Inden M, et al. DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats. Journal of Cerebral Blood Flow and Metabolism. 2008;28(3):563-578.

    Not in our library10.1038/sj.jcbfm.9600553

  98. 98.

    Malhotra D, Thimmulappa R, Navas-Acien A, et al. Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. American Journal of Respiratory and Critical Care Medicine. 2008;178(6):592-604.

    Not in our library10.1164/rccm.200803-380oc

  99. 99.

    Jain D, Jain R, Eberhard D, et al. Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes. Journal of Molecular Cell Biology. 2012;4(4):221-230.

    Not in our library10.1093/jmcb/mjs025

  100. 100.

    Junn E, Taniguchi H, Jeong BS, Zhao X, Ichijo H, Mouradian MM. Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. Proceedings of the National Academy of Sciences of the United States of America. 2005;102(27):9691-9696.

    Not in our library10.1073/pnas.0409635102

  101. 101.

    Karunakaran S, Diwakar L, Saeed U, et al. Activation of apoptosis signal regulating kinase 1 (ASK1) and translocation of death-associated protein, Daxx, in substantia nigra pars compacta in a mouse model of Parkinson’s disease: protection by α-lipoic acid. The FASEB Journal. 2007;21(9):2226-2236.

    Not in our library10.1096/fj.06-7580com

  102. 102.

    Waak J, Weber SS, Görner K, et al. Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1. The Journal of Biological Chemistry. 2009;284(21):14245-14257.

    Not in our library10.1074/jbc.m806902200

  103. 103.

    Lev N, Ickowicz D, Barhum Y, Lev S, Melamed E, Offen D. DJ-1 protects against dopamine toxicity. Journal of Neural Transmission. 2009;116(2):151-160.

    Not in our library10.1007/s00702-008-0134-4

  104. 104.

    Aron L, Klein P, Pham TT, Kramer ER, Wurst W, Klein R. Pro-survival role for Parkinson’s associated gene DJ-1 revealed in trophically impaired dopaminergic neurons. PLoS Biology. 2010;8(4, article e1000349).

    Not in our library10.1371/journal.pbio.1000349

  105. 105.

    Gao H, Yang W, Qi Z, et al. DJ-1 protects dopaminergic neurons against rotenone-induced apoptosis by enhancing ERK-dependent mitophagy. Journal of Molecular Biology. 2012;423(2):232-248.

    Not in our library10.1016/j.jmb.2012.06.034

  106. 106.

    Mizuno Y, Ohta S, Tanaka M, et al. Deficiencies in complex I subunits of the respiratory chain in Parkinson’s disease. Biochemical and Biophysical Research Communications. 1989;163(3):1450-1455.

    Not in our library10.1016/0006-291x(89)91141-8

  107. 107.

    Parker WD, Boyson SJ, Parks JK. Abnormalities of the electron transport chain in idiopathic Parkinson’s disease. Annals of Neurology. 1989;26(6):719-723.

    Not in our library10.1002/ana.410260606

  108. 108.

    Schapira AHV, Cooper JM, Dexter D, Clark JB, Jenner P, Marsden CD. Mitochondrial complex I deficiency in Parkinson’s disease. Journal of Neurochemistry. 1990;54(3):823-827.

    Not in our library10.1111/j.1471-4159.1990.tb02325.x

  109. 109.

    Orth M, Schapira AHV. Mitochondrial involvement in Parkinson’s disease. Neurochemistry International. 2002;40(6):533-541.

    Not in our library10.1016/s0197-0186(01)00124-3

  110. 110.

    Mizuno Y, Yoshino H, Ikebe SI, et al. Mitochondrial dysfunction in Parkinson’s disease. Annals of Neurology. 1998;44(3):S99-S109.

    Not in our library10.1002/ana.410440715

  111. 111.

    Giaime E, Yamaguchi H, Gautier CA, Kitada T, Shen J. Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening. PLoS One. 2012;7(7, aricle e40501).

    Not in our library10.1371/journal.pone.0040501

  112. 112.

    Zhang L, Shimoji M, Thomas B, et al. Mitochondrial localization of the Parkinson’s disease related protein DJ-1: implications for pathogenesis. Human Molecular Genetics. 2005;14(14):2063-2073.

    Not in our library10.1093/hmg/ddi211

  113. 113.
    Monomer DJ-1 and its N-terminal sequence are necessary for mitochondrial localization of DJ-1 mutants. · 2013
    Not checked
  114. 114.

    de Mena L, Coto E, Sánchez-Ferrero E, et al. Mutational screening of the mortalin gene (HSPA9) in Parkinson’s disease. Journal of Neural Transmission. 2009;116(10):1289-1293.

    Not in our library10.1007/s00702-009-0273-2

  115. 115.

    Miyazaki S, Yanagida T, Nunome K, et al. DJ-1-binding compounds prevent oxidative stress-induced cell death and movement defect in Parkinson’s disease model rats. Journal of Neurochemistry. 2008;105(6):2418-2434.

    Not in our library10.1111/j.1471-4159.2008.05327.x

  116. 116.

    Kitamura Y, Watanabe S, Taguchi M, et al. Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson’s disease and stroke model rats. Molecular Neurodegeneration. 2011;6(1, article 48).

    Not in our library10.1186/1750-1326-6-48

  117. 117.

    Inden M, Kitamura Y, Takahashi K, et al. Protection against dopaminergic neurodegeneration in Parkinson's disease-model animals by a modulator of the oxidized form of DJ-1, a wild-type of familial Parkinson's disease-linked PARK7. Journal of Pharmacological Sciences. 2011;117(3):189-203.

    Not in our library10.1254/jphs.11151fp

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