Reactive Oxygen Species in Health and Disease

Abstract

During the past decades, it became obvious that reactive oxygen species (ROS) exert a multitude of biological effects covering a wide spectrum that ranges from physiological regulatory functions to damaging alterations participating in the pathogenesis of increasing number of diseases. This review summarizes the key roles played by the ROS in both health and disease. ROS are metabolic products arising from various cells; two cellular organelles are intimately involved in their production and metabolism, namely, the endoplasmic reticulum and the mitochondria. Updates on research that tremendously aided in confirming the fundamental roles of both organelles in redox regulation will be discussed as well. Although not comprehensive, this review will provide brief perspective on some of the current research conducted in this area for better understanding of the ROS actions in various conditions of health and disease.

Cited by papers we hold 17

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• Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy · 2023
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• Possible Side Effects of Polyphenols and Their Interactions with Medicines · 2023
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• Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease · 2022
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• Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives · 2022
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• AMPK, Mitochondrial Function, and Cardiovascular Disease · 2020
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• Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment · 2020
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• Blood Flow Restriction Exercise: Considerations of Methodology, Application, and Safety · 2019
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• ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells · 2019
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• Portulaca oleracea L. (Purslane) extracts display antioxidant and hypoglycaemic effects · 2018
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• Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events · 2018
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• A systematic review of p53 regulation of oxidative stress in skeletal muscle · 2018
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• Roles of Heat Shock Proteins in Apoptosis, Oxidative Stress, Human Inflammatory Diseases, and Cancer · 2017
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• Redox Mechanism of Reactive Oxygen Species in Exercise · 2016
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• ROS and ROS‐Mediated Cellular Signaling · 2016
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• Targeting the Redox Balance in Inflammatory Skin Conditions · 2013
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