Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks

Abstract

Inflammatory bowel disease (IBD) is a complex multifactorial disease of unknown etiology. Thus, dozens of different animal models of IBD have been developed in past decades. Animal models of IBD are valuable and indispensable tools that provide a wide range of options for investigating involvement of various factors into the pathogenesis of IBD and to evaluate different therapeutic options. However, the dextran sulphate sodium (DSS-) induced colitis model has some advantages when compared to other animal models of colitis. It is well appreciated and widely used model of inflammatory bowel disease because of its simplicity. It has many similarities to human IBD, which are mentioned in the paper. In spite of its simplicity and wide applicability, there are also traps that need to be taken into account when using DSS model. As demonstrated in the present paper, various factors may affect susceptibility to DSS-induced lesions and modify results.

Cited by papers we hold 17

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• Strain-Specific Anti-inflammatory Properties of Two Akkermansia muciniphila Strains on Chronic Colitis in Mice · 2019
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• REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis · 2018
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• The PSMP-CCR2 interactions trigger monocyte/macrophage-dependent colitis · 2017
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• Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-κB and STAT3 activation · 2017
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• Therapeutic Potential of Amino Acids in Inflammatory Bowel Disease · 2017
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• Anti-Inflammatory Properties of the Enaminone E121 in the Dextran Sulfate Sodium (DSS) Colitis Model. · 2016
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• The Dual Role of Neutrophils in Inflammatory Bowel Diseases · 2016
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• Bifidobacterium longum CCM 7952 Promotes Epithelial Barrier Function and Prevents Acute DSS-Induced Colitis in Strictly Strain-Specific Manner · 2015
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• Animal models to study acute and chronic intestinal inflammation in mammals · 2015
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• Upregulation of the Transient Receptor Potential Ankyrin 1 Ion Channel in the Inflamed Human and Mouse Colon and Its Protective Roles · 2014
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• Dextran sodium sulfate inhibits the activities of both polymerase and reverse transcriptase: lithium chloride purification, a rapid and efficient technique to purify RNA · 2013
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• Commensal Bacteria-Dependent Indole Production Enhances Epithelial Barrier Function in the Colon · 2013
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