Probiotic Interference of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 with the Opportunistic Fungal Pathogen Candida albicans

Abstract

Candida albicans is the most important Candida species causing vulvovaginal candidiasis (VVC). VVC has significant medical and economical impact on women’s health and wellbeing. While current antifungal treatment is reasonably effective, supportive and preventive measures such as application of probiotics are required to reduce the incidence of VVC. We investigated the potential of the probiotics Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 towards control of C. albicans . In vitro experiments demonstrated that lactic acid at low pH plays a major role in suppressing fungal growth. Viability staining following cocultures with lactobacilli revealed that C. albicans cells lost metabolic activity and eventually were killed. Transcriptome analyses showed increased expression of stress-related genes and lower expression of genes involved in fluconazole resistance, which might explain the increased eradication of Candida in a previous clinical study on conjoint probiotic therapy. Our results provide insights on the impact of probiotics on C. albicans survival.

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Cited by papers we hold 6

• The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives · 2020
  No notice
• Effects of a Novel Probiotic Combination on Pathogenic Bacterial-Fungal Polymicrobial Biofilms · 2019
  Not checked
• Fungal-Bacterial Interactions in Health and Disease · 2019
  No notice
• Development of the Human Mycobiome over the First Month of Life and across Body Sites · 2018
  No notice
• Isolation of Vaginal Lactobacilli and Characterization of Anti-Candida Activity · 2015
  No notice
• Study and use of the probiotic Lactobacillus reuteri in pigs: a review · 2015
  No notice

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