Bone Marrow Microenvironment in Multiple Myeloma Progression

Abstract

Substantial advances have been made in understanding the biology of multiple myeloma (MM) through the study of the bone marrow (BM) microenvironment. Indeed, the BM niche appears to play an important role in differentiation, migration, proliferation, survival, and drug resistance of the malignant plasma cells. The BM niche is composed of a cellular compartment (stromal cells, osteoblasts, osteoclasts, endothelial cells, and immune cells) and a noncellular compartment including the extracellular matrix (ECM) and the liquid milieu (cytokines, growth factors, and chemokines). In this paper we discuss how the interaction between the malignant plasma cell and the BM microenvironment allowed myeloma progression through cell homing and the new concept of premetastatic niche.

Cited by papers we hold 6

• Identification of biomarkers for early diagnosis of multiple myeloma by weighted gene co-expression network analysis and their clinical relevance · 2022
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• Resistance to Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia—From Molecular Mechanisms to Clinical Relevance · 2021
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• A worm gel-based 3D model to elucidate the paracrine interaction between multiple myeloma and mesenchymal stem cells · 2020
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• Therapy resistance mediated by exosomes · 2019
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• Microenvironment drug resistance in multiple myeloma: emerging new players · 2016
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• Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms · 2013
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