E‐Cadherin/ β ‐Catenin Complex and the Epithelial Barrier

Abstract

E‐Cadherin/ β ‐catenin complex plays an important role in maintaining epithelial integrity and disrupting this complex affect not only the adhesive repertoire of a cell, but also the Wnt‐signaling pathway. Aberrant expression of the complex is associated with a wide variety of human malignancies and disorders of fibrosis resulting from epithelial‐mesenchymal transition. These associations provide insights into the complexity that is likely responsible for the fibrosis/tumor suppressive action of E‐cadherin/ β ‐catenin.

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• Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex · 2020
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• The Oral Microbiome and Cancer · 2020
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• The Epithelial-to-Mesenchymal Transition as a Possible Therapeutic Target in Fibrotic Disorders · 2020
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• The Regulatory Role of MicroRNAs in Breast Cancer · 2019
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