Different Adipose Depots: Their Role in the Development of Metabolic Syndrome and Mitochondrial Response to Hypolipidemic Agents

Abstract

Adipose tissue metabolism is closely linked to insulin resistance, and differential fat distributions are associated with disorders like hypertension, diabetes, and cardiovascular disease. Adipose tissues vary in their impact on metabolic risk due to diverse gene expression profiles, leading to differences in lipolysis and in the production and release of adipokines and cytokines, thereby affecting the function of other tissues. In this paper, the roles of the various adipose tissues in obesity are summarized, with particular focus on mitochondrial function. In addition, we discuss how a functionally mitochondrial-targeted compound, the modified fatty acid tetradecylthioacetic acid (TTA), can influence mitochondrial function and decrease the size of specific fat depots.

Cited by papers we hold 5

• Nutritional assessment among adult patients with suspected or confirmed active tuberculosis disease in rural India. · 2020
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• Maturation of White Adipose Tissue Function in C57BL/6j Mice From Weaning to Young Adulthood · 2019
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• Regulation of visceral and epicardial adipose tissue for preventing cardiovascular injuries associated to obesity and diabetes · 2017
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• Relationships between Rodent White Adipose Fat Pads and Human White Adipose Fat Depots · 2016
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• Intrinsic features in microRNA transcriptomes link porcine visceral rather than subcutaneous adipose tissues to metabolic risk. · 2013
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