Middle Cerebral Artery Occlusion Model in Rodents: Methods and Potential Pitfalls

Abstract

A variety of animal models have been developed for modeling ischemic stroke. The middle cerebral artery occlusion (MCAO) model has been utilized extensively, especially in rodents. While the MCAO model provides stroke researchers with an excellent platform to investigate the disease, controversial or even paradoxical results are occasionally seen in the literature utilizing this model. Various factors exert important effects on the outcome in this stroke model, including the age and sex of the animal examined. This paper discusses emerging information on the effects of age and sex on ischemic outcomes after MCAO, with an emphasis on mouse models of stroke.

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• Mitochondrial ferritin attenuates cerebral ischaemia/reperfusion injury by inhibiting ferroptosis · 2021
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• Metabolome Changes in Cerebral Ischemia · 2020
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• Tau exacerbates excitotoxic brain damage in an animal model of stroke · 2017
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• Ischemic stroke induces gut permeability and enhances bacterial translocation leading to sepsis in aged mice · 2016
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