Clinical Cancer Therapy by NK Cells via Antibody‐Dependent Cell‐Mediated Cytotoxicity

Abstract

Natural killer (NK) cells are powerful effector cells that can be directed to eliminate tumor cells through tumor‐targeted monoclonal antibodies (mAbs). Some tumor‐targeted mAbs have been successfully applied in the clinic and are included in the standard of care for certain malignancies. Strategies to augment the antitumor response by NK cells have led to an increased understanding of how to improve their effector responses. Next‐generation reagents, such as molecularly modified mAbs and mAb‐cytokine fusion proteins (immunocytokines, ICs) designed to augment NK‐mediated killing, are showing promise in preclinical and some clinical settings. Continued research into the antitumor effects induced by NK cells and tumor‐targeted mAbs suggests that additional intrinsic and extrinsic factors may influence the antitumor response. Therefore more research is needed that focuses on evaluating which NK cell and tumor criteria are best predictive of a clinical response and which combination immunotherapy regimens to pursue for distinct clinical settings.

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• Identification of an ADAM17 Cleavage Region in Human CD16 (FcγRIII) and the Engineering of a Non-Cleavable Version of the Receptor in NK Cells · 2015
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• NK cell-mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy · 2015
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• Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses · 2014
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• A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer · 2013
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• Natural Killer Cell Mediated Antibody-Dependent Cellular Cytotoxicity in Tumor Immunotherapy with Therapeutic Antibodies · 2013
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• The Critical Role of the Tumor Microenvironment in Shaping Natural Killer Cell-Mediated Anti-Tumor Immunity · 2013
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• Immune Microenvironment in Tumor Progression: Characteristics and Challenges for Therapy · 2012
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