Synthesis and Antifungal Activity of 2-Ketophenyl-3-substituted aryl-1-thiazolidin-4-ones

A new series of 2‐ketophenyl‐3‐substituted aryl‐1‐ thiazolidin‐4‐ones were synthesized by cyclocondensation of ketoazomethines and thioglycolic acid. Ketoazomethines were synthesized by condensation of phenyl glyoxal (prepared by partial oxidation of acetophenone) and various para ‐substituted anilines. Their structures were elucidated by elemental analysis, IR and H 1 NMR; they were screened for their antifungal activity against hazardous fungi namely Fusarium Oxysporum, Pythium, Sclerotium and Alternaria brassicola .

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