Muscle-Specific PPARβ/δ Agonism May Provide Synergistic Benefits with Life Style Modifications

Peroxisome proliferator-activated receptor β / δ (PPAR β / δ ) has emerged as a powerful metabolic regulator in diverse tissues including fat, skeletal muscle, and the heart. It is now established that activation of PPAR β / δ promotes fatty acid oxidation in several tissues, such as skeletal muscle and adipose tissue. In muscle, PPAR β / δ appears to act as a central regulator of fatty acid catabolism. PPAR β / δ contents are increased in muscle during physiological situations such as physical exercise or long-term fasting, characterized by increased fatty acid oxidation. Targeted expression of an activated form of PPAR β / δ in skeletal muscle induces a switch to form increased numbers of type I muscle fibers resembling the fiber type transition by endurance training. Activation of PPAR β / δ also enhances mitochondrial capacity and fat oxidation in the skeletal muscle that resembles the effect of regular exercise. Therefore, it is hypothesized that muscle-specific PPAR β / δ agonists could be a key strategy to support the poor cardiorespiratory fitness associated with metabolic disorders.

Abstract licence: CC BY

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