The Neurobiology of Opioid Dependence: Implications for Treatment

Abstract

Opioid tolerance, dependence, and addiction are all manifestations of brain changes resulting from chronic opioid abuse. The opioid abuser's struggle for recovery is in great part a struggle to overcome the effects of these changes. Medications such as methadone, LAAM, buprenorphine, and naltrexone act on the same brain structures and processes as addictive opioids, but with protective or normalizing effects. Despite the effectiveness of medications, they must be used in conjunction with appropriate psychosocial treatments.

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Cited by papers we hold 3

• Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain · 2022
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• Opioid Analgesia and Opioid-Induced Adverse Effects: A Review · 2021
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• A comparative study of the effectiveness of group-based cognitive behavioral therapy and dialectical behavioral therapy in reducing depressive symptoms in Iranian women substance abusers · 2018
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