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Agent-Based Modeling in Public Health: Current Applications and Future Directions
Melissa Tracy, Magdalena Cerdá, Katherine M. Keyes
Annual Review of Public Health · 2018 · Review · CC BY
doi:10.1146/annurev-publhealth-040617-014317 (opens in a new tab)
Abstract
Agent-based modeling is a computational approach in which agents with a specified set of characteristics interact with each other and with their environment according to predefined rules. We review key areas in public health where agent-based modeling has been adopted, including both communicable and noncommunicable disease, health behaviors, and social epidemiology. We also describe the main strengths and limitations of this approach for questions with public health relevance. Finally, we describe both methodologic and substantive future directions that we believe will enhance the value of agent-based modeling for public health. In particular, advances in model validation, comparisons with other causal modeling procedures, and the expansion of the models to consider comorbidity and joint influences more systematically will improve the utility of this approach to inform public health research, practice, and policy.
References 110
- 1.
Auchincloss AH, Diez Roux AV. A new tool for epidemiology: the usefulness of dynamic-agent models in understanding place effects on health. Am J Epidemiol. 2008;168(1):1-8.
Not in our library10.1093/aje/kwn118 (opens in a new tab)
- 2.
Auchincloss AH, Garcia LMT. Brief introductory guide to agent-based modeling and an illustration from urban health research. Cad Saude Publica. 2015;31(Suppl 1):65-78.
Not in our library10.1590/0102-311x00051615 (opens in a new tab)
- 3.
Auchincloss AH, Riolo RL, Brown DG, Cook J, Diez Roux AV. An agent-based model of income inequalities in diet in the context of residential segregation. Am J Prev Med. 2011;40(3):303-11.
Not in our library10.1016/j.amepre.2010.10.033 (opens in a new tab)
- 4.
Axelrod R, Conte R, Hegselmann R, Terna P. Advancing the art of simulation in the social sciences. Simulating Social Phenomena. 1997;21-40.
Not in our library
- 5.
Badland H, White M, Macaulay G, Eagleson S, Mavoa S, et al. Using simple agent-based modeling to inform and enhance neighborhood walkability. Int J Health Geogr. 2013;12:58.
Not in our library10.1186/1476-072x-12-58 (opens in a new tab)
- 6.
Blok DJ, de Vlas SJ, Bakker R, van Lenthe FJ. Reducing income inequalities in food consumption: explorations with an agent-based model. Am J Prev Med. 2015;49(4):605-13.
Not in our library10.1016/j.amepre.2015.03.042 (opens in a new tab)
- 7.
Bonabeau E. Agent-based modeling: methods and techniques for simulating human systems. PNAS. 2002;99(Suppl 3):7280-87.
Not in our library10.1073/pnas.082080899 (opens in a new tab)
- 8.
Bruch EE, Mare RD. Neighborhood choice and neighborhood change. Am J Sociol. 2006;112(3):667-709.
Not in our library
- 9.
Butts JA, Roman CG, Bostwick L, Porter JR. Cure violence: a public health model to reduce gun violence. Annu Rev Public Health. 2015;36:39-53.
Not in our library10.1146/annurev-publhealth-031914-122509 (opens in a new tab)
- 10.
Cerdá M, Tracy M, Ahern J, Galea S. Addressing population health and health inequalities: the role of fundamental causes. Am J Public Health. 2014;104(Suppl 4):S609-19.
Not in our library10.2105/ajph.2014.302055 (opens in a new tab)
- 11.
Cerdá M, Tracy M, Keyes KM. Reducing urban violence: a contrast of public health and criminal justice approaches. Epidemiology. 2018;29(1):142-50.
Not in our library10.1097/ede.0000000000000756 (opens in a new tab)
- 12.
Cerdá M, Tracy M, Keyes KM, Galea S. To treat or to prevent? Reducing the population burden of violence-related post-traumatic stress disorder. Epidemiology. 2015;26(5):681-89.
Not in our library10.1097/ede.0000000000000350 (opens in a new tab)
- 13.
Chao D, Hashimoto H, Kondo N. Dynamic impact of social stratification and social influence on smoking prevalence by gender: an agent-based model. Soc Sci Med. 2015;147:280-87.
Not in our library10.1016/j.socscimed.2015.08.041 (opens in a new tab)
- 14.
Cherng ST, Tam J, Christine PJ, Meza R. Modeling the effects of e-cigarettes on smoking behavior: implications for future adult smoking prevalence. Epidemiology. 2016;27(6):819-26.
Not in our library10.1097/ede.0000000000000497 (opens in a new tab)
- 15.
Chowell G, Sattenspiel L, Bansal S, Viboud C. Mathematical models to characterize early epidemic growth: a review. Phys Life Rev. 2016;18:66-97.
Not in our library10.1016/j.plrev.2016.07.005 (opens in a new tab)
- 16.
Christakis NA, Fowler JH. The spread of obesity in a large social network over 32 years. N Engl J Med. 2007;357(4):370-79.
Not in our library10.1056/nejmsa066082 (opens in a new tab)
- 17.
Codella J, Safdar N, Heffernan R, Alagoz O. An agent-based simulation model for Clostridium difficile infection control. Med Decis Mak. 2015;35(2):211-29.
Not in our library10.1177/0272989x14545788 (opens in a new tab)
- 18.
Assessing the Use of Agent-Based Models for Tobacco Regulation. 2015.
Not in our library
- 19.
Cooley P, Lee BY, Brown S, Cajka J, Chasteen B, et al. Protecting health care workers: a pandemic simulation based on Allegheny County. Influenza Other Respir Viruses. 2010;4(2):61-72.
Not in our library10.1111/j.1750-2659.2009.00122.x (opens in a new tab)
- 20.
Cooley P, Solano E. Agent-based model (ABM) validation considerations. 2011;126-31.
Not in our library
- 21.
Crooks AT. Constructing and implementing an agent-based model of residential segregation through vector GIS. Int J Geogr Inf Sci. 2010;24(5):661-75.
Not in our library
- 22.
Day TE, Ravi N, Xian H, Brugh A. An agent-based modeling template for a cohort of veterans with diabetic retinopathy. PLOS ONE. 2013;8(6):e66812.
Not in our library10.1371/journal.pone.0066812 (opens in a new tab)
- 23.
Day TE, Ravi N, Xian H, Brugh A. Sensitivity of diabetic retinopathy associated vision loss to screening interval in an agent-based/discrete event simulation model. Comput Biol Med. 2014;47:7-12.
Not in our library10.1016/j.compbiomed.2014.01.007 (opens in a new tab)
- 24.
Diez Roux AV. Complex systems thinking and current impasses in health disparities research. Am J Public Health. 2011;101(9):1627-34.
Not in our library10.2105/ajph.2011.300149 (opens in a new tab)
- 25.
Diez Roux AV. Health in cities: Is a systems approach needed? Cad Saude Publica. 2015;31(Suppl 1):9-13.
Not in our library10.1590/0102-311xde01s115 (opens in a new tab)
- 26.
Diez Roux AV. Invited commentary: the virtual epidemiologist—promise and peril. Am J Epidemiol. 2015;181(2):100-2.
Not in our library10.1093/aje/kwu270 (opens in a new tab)
- 27.
El-Sayed AM, Scarborough P, Seemann L, Galea S. Social network analysis and agent-based modeling in social epidemiology. Epidemiol Perspect Innov. 2012;9(1):1.
Not in our library10.1186/1742-5573-9-1 (opens in a new tab)
- 28.
Enanoria WTA, Liu F, Zipprich J, Harriman K, Ackley S, et al. The effect of contact investigations and public health interventions in the control and prevention of measles transmission: a simulation study. PLOS ONE. 2016;11(12):e0167160.
Not in our library10.1371/journal.pone.0167160 (opens in a new tab)
- 29.
Epstein JM. Agent-based computational models and generative social science. Complexity. 1999;4(5):41-60.
Not in our library
- 30.
Epstein JM. Modeling civil violence: an agent-based computational approach. PNAS. 2002;99(Suppl 3):7243-50.
Not in our library10.1073/pnas.092080199 (opens in a new tab)
- 31.
Epstein JM. Modelling to contain pandemics. Nature. 2009;460(7256):687.
Not in our library10.1038/460687a (opens in a new tab)
- 32.
Epstein JM, Axtell RL. Growing Artificial Societies: Social Science from the Bottom Up. 1996.
Not in our library
- 33.
Epstein JM, Cummings DAT, Chakravarty S, Singha RM, Burke DS. Toward a Containment Strategy for Smallpox Bioterror: An Individual-Based Computational Approach. 2004.
Not in our library
- 34.
Epstein JM, Pankajakshan R, Hammond RA. Combining computational fluid dynamics and agent-based modeling: a new approach to evacuation planning. PLOS ONE. 2011;6(5):e20139.
Not in our library10.1371/journal.pone.0020139 (opens in a new tab)
- 35.
Escudero DJ, Lurie MN, Mayer KH, Weinreb C, King M, et al. Acute HIV infection transmission among people who inject drugs in a mature epidemic setting. AIDS. 2016;30(16):2537-44.
Not in our library10.1097/qad.0000000000001218 (opens in a new tab)
- 36.
Fagiolo G, Moneta A, Windrum P. A critical guide to empirical validation of agent-based models in economics: methodologies, procedures, and open problems. Comput Econ. 2007;30(3):195-226.
Not in our library
- 37.
Ferencik R, Minyard K. Systems thinking in injury prevention: an innovative model for informing state and local policies. West J Emerg Med. 2011;12(3):273-74.
Not in our library
- 38.
Ferguson NM, Cummings DAT, Cauchemez S, Fraser C, Riley S, et al. Strategies for containing an emerging influenza pandemic in Southeast Asia. Nature. 2005;437(7056):209-14.
Not in our library10.1038/nature04017 (opens in a new tab)
- 39.
Fink DS, Keyes KM, Cerdá M. Social determinants of population health: a systems sciences approach. Curr Epidemiol Rep. 2016;3(1):98-105.
Not in our library10.1007/s40471-016-0066-8 (opens in a new tab)
- 40.
Fonoberova M, Fonoberov VA, Mezić I. Global sensitivity/uncertainty analysis for agent-based models. Reliab Eng Syst Saf. 2013;118:8-17.
Not in our library
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