Evolutionary Divergence in DNA Damage Responses among Fungi
Jacob L. Steenwyk
mBio · 2021
doi:10.1128/mbio.03348-20 (opens in a new tab)
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Abstract
Cell cycle checkpoints and DNA repair pathways contribute to maintaining genome integrity and are thought to be evolutionarily ancient and broadly conserved. For example, in the yeast Saccharomyces cerevisiae and humans, DNA damage induces activation of a checkpoint effector kinase, Rad53p (human homolog Chk2), to promote cell cycle arrest and transcription of DNA repair genes.
Abstract licence: CC BY
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