Diverse Humoral Immune Responses in Younger and Older Adult COVID-19 Patients

As numerous viral variants continue to emerge in the coronavirus disease 2019 (COVID-19) pandemic, determining antibody reactivity to SARS-CoV-2 epitopes becomes essential in discerning changes in the immune response to infection over time. This study enabled us to identify specific areas of antigenicity within the SARS-CoV-2 proteome, allowing us to detect correlations of epitopes with clinical metadata and immunological signals to gain holistic insight into SARS-CoV-2 infection.

Abstract licence: CC BY

1. 11.

   Distinct conformational states of SARS-CoV-2 spike protein · 2020

2. 14.

   Factors associated with COVID-19-related death using OpenSAFELY · 2020

3. 16.

   In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges · 2020

4. 18.

   Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity · 2020

5. 19.

   Analysis of the SARS-CoV-2 spike protein glycan shield reveals implications for immune recognition · 2020

6. 20.

   A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity · 2020

7. 21.

   Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity · 2020

8. 22.

   Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate · 2020

9. 23.

   Robust neutralizing antibodies to SARS-CoV-2 infection persist for months · 2020

10. 24.

    Preexisting and de novo humoral immunity to SARS-CoV-2 in humans · 2020

18 more references, whose wording the paper’s licence keeps private.

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.