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Imperfect wound healing sets the stage for chronic diseases

Paul Martin, Carlos Pardo-Pastor, R. Gisli Jenkins and 1 more

Science · 2024 · Review

Abstract

Although the age of the genome gave us much insight about how our organs fail with disease, it also suggested that diseases do not arise from mutations alone; rather, they develop as we age. In this Review, we examine how wound healing might act to ignite disease. Wound healing works well when we are younger, repairing damage from accidents, environmental assaults, and battles with pathogens. Yet, with age and accumulation of mutations and tissue damage, the repair process can devolve, leading to inflammation, fibrosis, and neoplastic signaling. We discuss healthy wound responses and how our bodies might misappropriate these pathways in disease. Although we focus predominantly on epithelial-based (lung and skin) diseases, similar pathways might operate in cardiac, muscle, and neuronal diseases.

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References 150

1.
Virchow R. Die Krankenaften Geschwulste. 1863;255.
Not in our library
2.
Haddow A. Advances in Cancer Research. 1973;16:181-234.
Not in our library10.1016/s0065-230x(08)60341-3
3.
Flier JS, Underhill LH, Dvorak HF. Tumors: Wounds That Do Not Heal. New England Journal of Medicine. 1986;315:1650-1659.
Not in our library10.1056/nejm198612253152606
4.
Martin D, Gutkind JS. Human tumor-associated viruses and new insights into the molecular mechanisms of cancer. Oncogene. 2008;27(Suppl 2):S31-42.
Not in our library10.1038/onc.2009.351
5.
Bister K. Discovery of oncogenes: The advent of molecular cancer research. Proc Natl Acad Sci U S A. 2015;112:15259-15260.
Not in our library10.1073/pnas.1521145112
6.
Jassim A, Rahrmann EP, Simons BD, Gilbertson RJ. Cancers make their own luck: theories of cancer origins. Nature Reviews Cancer. 2023;23:710-724.
Not in our library10.1038/s41568-023-00602-5
7.
Swanton C, et al. Embracing cancer complexity: Hallmarks of systemic disease. Cell. 2024;187:1589-1616.
Not in our library10.1016/j.cell.2024.02.009
8.
Rahal Z, Scheet P, Kadara H. Somatic Mutations in Normal Tissues: Calm before the Storm. Cancer Discovery. 2024;14:605-609.
Not in our library10.1158/2159-8290.cd-23-1508
9.
Weeden CE, Hill W, Lim EL, Grönroos E, Swanton C. Impact of risk factors on early cancer evolution. Cell. 2023;186:1541-1563.
Not in our library10.1016/j.cell.2023.03.013
10.
Lung adenocarcinoma promotion by air pollutants · 2023
No notice
11.
MacCarthy-Morrogh L, Martin P. The hallmarks of cancer are also the hallmarks of wound healing. Sci Signal. 2020;13:eaay8690.
Not in our library10.1126/scisignal.aay8690
12.
Peña OA, Martin P. Cellular and molecular mechanisms of skin wound healing. Nature Reviews Molecular Cell Biology. 2024;25:599-616.
Not in our library10.1038/s41580-024-00715-1
13.
Headland SE, Norling LV. The resolution of inflammation: Principles and challenges. Semin Immunol. 2015;27:149-160.
Not in our library10.1016/j.smim.2015.03.014
14.
Acute Inflammation in Tissue Healing · 2022
No notice
15.
Chen WY, Rogers AA. Recent insights into the causes of chronic leg ulceration in venous diseases and implications on other types of chronic wounds. Wound Repair Regen. 2007;15:434-449.
Not in our library10.1111/j.1524-475x.2007.00250.x
16.
Resolution of Inflammation: What Controls Its Onset? · 2016
No notice
17.
Defining stem cell dynamics and migration during wound healing in mouse skin epidermis · 2017
No notice
18.
Park S, et al. Tissue-scale coordination of cellular behaviour promotes epidermal wound repair in live mice. Nat Cell Biol. 2017;19:155-163.
Not in our library10.1038/ncb3472
19.
Turley J, et al. Deep learning reveals a damage signalling hierarchy that coordinates different cell behaviours driving wound re-epithelialisation. Development. 2024;151.
Not in our library10.1242/dev.202943
20.
Shaw T, Martin P. Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes. EMBO Rep. 2009;10:881-886.
Not in our library10.1038/embor.2009.102
21.
Weavers H, Wood W, Martin P. Injury Activates a Dynamic Cytoprotective Network to Confer Stress Resilience and Drive Repair. Curr Biol. 2019;29:3851-3862.
Not in our library10.1016/j.cub.2019.09.035
22.
Nunan R, et al. Ephrin-Bs Drive Junctional Downregulation and Actin Stress Fiber Disassembly to Enable Wound Re-epithelialization. Cell Rep. 2015;13:1380-1395.
Not in our library10.1016/j.celrep.2015.09.085
23.
Rohani MG, Parks WC. Matrix remodeling by MMPs during wound repair. Matrix Biol. 2015;44-46:113-121.
Not in our library10.1016/j.matbio.2015.03.002
24.
Living in Your Skin: Microbes, Molecules, and Mechanisms · 2021
No notice
25.
De Lorenzo G, Ferrari S, Cervone F, Okun E. Extracellular DAMPs in Plants and Mammals: Immunity, Tissue Damage and Repair. Trends Immunol. 2018;39:937-950.
Not in our library10.1016/j.it.2018.09.006
26.
Liu L, et al. Induction of neutrophil extracellular traps during tissue injury: Involvement of STING and Toll-like receptor 9 pathways. Cell Prolif. 2019;52:e12579.
Not in our library10.1111/cpr.12579
27.
Willenborg S, et al. Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. Cell Metab. 2021;33:2398-2414.
Not in our library10.1016/j.cmet.2021.10.004
28.
Shook BA, et al. Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair. Science. 2018;362.
Not in our library10.1126/science.aar2971
29.
Mori R, Shaw TJ, Martin P. Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring. J Exp Med. 2008;205:43-51.
Not in our library10.1084/jem.20071412
30.
Knipper JA, et al. Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair. Immunity. 2015;43:803-816.
Not in our library10.1016/j.immuni.2015.09.005
31.
Hinz B. The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship. Matrix Biol. 2015;47:54-65.
Not in our library10.1016/j.matbio.2015.05.006
32.
Ferguson MW, O’Kane S. Scar-free healing: from embryonic mechanisms to adult therapeutic intervention. Philos Trans R Soc Lond B Biol Sci. 2004;359:839-850.
Not in our library10.1098/rstb.2004.1475
33.
Occleston NL, Laverty HG, O’Kane S, Ferguson MW. Prevention and reduction of scarring in the skin by Transforming Growth Factor beta 3 (TGFbeta3): from laboratory discovery to clinical pharmaceutical. J Biomater Sci Polym Ed. 2008;19:1047-1063.
Not in our library10.1163/156856208784909345
34.
Jiang D, Rinkevich Y. Distinct fibroblasts in scars and regeneration. Curr Opin Genet Dev. 2021;70:7-14.
Not in our library10.1016/j.gde.2021.04.005
35.
Usansky I, et al. A developmental basis for the anatomical diversity of dermis in homeostasis and wound repair. J Pathol. 2021;253:315-325.
Not in our library10.1002/path.5589
36.
Szpaderska AM, Zuckerman JD, DiPietro LA. Differential injury responses in oral mucosal and cutaneous wounds. J Dent Res. 2003;82:621-626.
Not in our library10.1177/154405910308200810
37.
Cho H, et al. In the face and neck, keloid scar distribution is related to skin thickness and stiffness changes associated with movement. Wound Repair Regen. 2024;32:419-428.
Not in our library10.1111/wrr.13180
38.
Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression · 2018
No notice
39.
Lucas T, et al. Differential roles of macrophages in diverse phases of skin repair. J Immunol. 2010;184:3964-3977.
Not in our library10.4049/jimmunol.0903356
40.
Komi DEA, Khomtchouk K, Santa Maria PL. A Review of the Contribution of Mast Cells in Wound Healing: Involved Molecular and Cellular Mechanisms. Clin Rev Allergy Immunol. 2020;58:298-312.
Not in our library10.1007/s12016-019-08729-w
41.
Witherden DA, Havran WL. Cross-talk between intraepithelial γδ T cells and epithelial cells. J Leukoc Biol. 2013;94:69-76.
Not in our library10.1189/jlb.0213101
42.
Khalid KA, Nawi AFM, Zulkifli N, Barkat MA, Hadi H. Aging and Wound Healing of the Skin: A Review of Clinical and Pathophysiological Hallmarks. Life (Basel). 2022;12.
Not in our library10.3390/life12122142
43.
Wick KD, Ware LB, Matthay MA. Acute respiratory distress syndrome. BMJ. 2024;387:e076612.
Not in our library10.1136/bmj-2023-076612
44.
Residual Lung Abnormalities after COVID-19 Hospitalization: Interim Analysis of the UKILD Post–COVID-19 Study · 2023
No notice
45.
Liang J, et al. Reciprocal interactions between alveolar progenitor dysfunction and aging promote lung fibrosis. eLife. 2023;12:e85415.
Not in our library10.7554/elife.85415
46.
Bartleson JM, et al. SARS-CoV-2, COVID-19 and the aging immune system. Nature Aging. 2021;1:769-782.
Not in our library10.1038/s43587-021-00114-7
47.
Han S, Budinger GRS, Gottardi CJ. Alveolar epithelial regeneration in the aging lung. The Journal of Clinical Investigation. 2023;133.
Not in our library10.1172/jci170504
48.
Parimon T, et al. Senescence of alveolar epithelial progenitor cells: a critical driver of lung fibrosis. American Journal of Physiology-Cell Physiology. 2023;325:C483-C495.
Not in our library10.1152/ajpcell.00239.2023
49.
Margaritte-Jeannin P, et al. HLA-DQ relative risks for coeliac disease in European populations: a study of the European Genetics Cluster on Coeliac Disease. Tissue Antigens. 2004;63:562-567.
Not in our library10.1111/j.0001-2815.2004.00237.x
50.
Brodin P, et al. Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences. Cell. 2015;160:37-47.
Not in our library10.1016/j.cell.2014.12.020
51.
Furman D, et al. Chronic inflammation in the etiology of disease across the life span. Nature Medicine. 2019;25:1822-1832.
Not in our library10.1038/s41591-019-0675-0
52.
The potential impacts of micro-and-nano plastics on various organ systems in humans · 2024
No notice
53.
Ehlers S, Kaufmann SHE. Infection, inflammation, and chronic diseases: consequences of a modern lifestyle. Trends in Immunology. 2010;31:184-190.
Not in our library10.1016/j.it.2010.02.003
54.
Thompson RC, et al. Twenty years of microplastic pollution research—what have we learned? Science. 2024;386:eadl2746.
Not in our library10.1126/science.adl2746
55.
Constant DA, Nice TJ, Rauch I. Innate immune sensing by epithelial barriers. Curr Opin Immunol. 2021;73:1-8.
Not in our library10.1016/j.coi.2021.07.014
56.
Rosenblatt J, Raff MC, Cramer LP. An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism. Curr Biol. 2001;11:1847-1857.
Not in our library10.1016/s0960-9822(01)00587-5
57.
Liesman RM, et al. RSV-encoded NS2 promotes epithelial cell shedding and distal airway obstruction. The Journal of Clinical Investigation. 2014;124:2219-2233.
Not in our library10.1172/jci72948
58.
Moshiri J, Craven AR, Mixon SB, Amieva MR, Kirkegaard K. Mechanosensitive extrusion of Enterovirus A71-infected cells from colonic organoids. Nat Microbiol. 2023;8:629-639.
Not in our library10.1038/s41564-023-01339-5
59.
Eisenhoffer GT, et al. Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. Nature. 2012;484:546-549.
Not in our library10.1038/nature10999
60.
Kajita M, Fujita Y. EDAC: Epithelial defence against cancer-cell competition between normal and transformed epithelial cells in mammals. J Biochem. 2015;158:15-23.
Not in our library10.1093/jb/mvv050
61.
Gudipaty SA, et al. Mechanical stretch triggers rapid epithelial cell division through Piezo1. Nature. 2017;543:118-121.
Not in our library10.1038/nature21407
62.
Bagley DC, et al. Bronchoconstriction damages airway epithelia by crowding-induced excess cell extrusion. Science. 2024;384:66-73.
Not in our library10.1126/science.adk2758
63.
Christenson SA, Smith BM, Bafadhel M, Putcha N. Chronic obstructive pulmonary disease. The Lancet. 2022;399:2227-2242.
Not in our library10.1016/s0140-6736(22)00470-6
64.
Perotin J-M, et al. Delay of airway epithelial wound repair in COPD is associated with airflow obstruction severity. Respiratory Research. 2014;15:151.
Not in our library10.1186/s12931-014-0151-9
65.
Walters EH, Shukla SD, Mahmood MQ, Ward C. Fully integrating pathophysiological insights in COPD: an updated working disease model to broaden therapeutic vision. European Respiratory Review. 2021;30:200364.
Not in our library10.1183/16000617.0364-2020
66.
Bouin M, et al. Rectal distention testing in patients with irritable bowel syndrome: sensitivity, specificity, and predictive values of pain sensory thresholds. Gastroenterology. 2002;122:1771-1777.
Not in our library10.1053/gast.2002.33601
67.
Coates MD, et al. Abdominal Pain in Inflammatory Bowel Disease: An Evidence-Based, Multidisciplinary Review. Crohns Colitis 360. 2023;5:otad055.
Not in our library10.1093/crocol/otad055
68.
Ravimohan S, Kornfeld H, Weissman D, Bisson GP. Tuberculosis and lung damage: from epidemiology to pathophysiology. Eur Respir Rev. 2018;27.
Not in our library10.1183/16000617.0077-2017
69.
Mathai SK, Newton CA, Schwartz DA, Garcia CK. Pulmonary fibrosis in the era of stratified medicine. Thorax. 2016;71:1154.
Not in our library10.1136/thoraxjnl-2016-209172
70.
Leavy OC, et al. The Use of Genetic Information to Define Idiopathic Pulmonary Fibrosis in UK Biobank. Chest. 2023;163:362-365.
Not in our library10.1016/j.chest.2022.07.027
71.
Peters A. Ambient air pollution and Alzheimer’s disease: the role of the composition of fine particles. Proceedings of the National Academy of Sciences. 2023;120:e2220028120.
Not in our library10.1073/pnas.2220028120
72.
Fadista J, et al. Shared genetic etiology between idiopathic pulmonary fibrosis and COVID-19 severity. EBioMedicine. 2021;65:103277.
Not in our library10.1016/j.ebiom.2021.103277
73.
Verma A, et al. A MUC5B Gene Polymorphism, rs35705950-T, Confers Protective Effects Against COVID-19 Hospitalization but Not Severe Disease or Mortality. Am J Respir Crit Care Med. 2022;206:1220-1229.
Not in our library10.1164/rccm.202109-2166oc
74.
Costain G, et al. Hereditary Mucin Deficiency Caused by Biallelic Loss of Function of MUC5B. Am J Respir Crit Care Med. 2022;205:761-768.
Not in our library10.1164/rccm.202106-1456oc
75.
Oldham JM, et al. PCSK6 and Survival in Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine. 2023;207:1515-1524.
Not in our library10.1164/rccm.202205-0845oc
76.
Zhou H, et al. UBQLN1 deficiency mediates telomere shortening and IPF through interacting with RPA1. PLOS Genetics. 2023;19:e1010856.
Not in our library10.1371/journal.pgen.1010856
77.
Fainberg HP, et al. Cluster analysis of blood biomarkers to identify molecular patterns in pulmonary fibrosis: assessment of a multicentre, prospective, observational cohort with independent validation. The Lancet Respiratory Medicine. 2024;12:681-692.
Not in our library10.1016/s2213-2600(24)00147-4
78.
Khanna D, et al. Systemic Sclerosis-Associated Interstitial Lung Disease: How to Incorporate Two Food and Drug Administration-Approved Therapies in Clinical Practice. Arthritis Rheumatol. 2022;74:13-27.
Not in our library10.1002/art.41933
79.
Bialik JF, et al. Profibrotic epithelial phenotype: a central role for MRTF and TAZ. Scientific reports. 2019;9:4323.
Not in our library10.1038/s41598-019-40764-7
80.
Ma HY, et al. Inhibition of MRTF activation as a clinically achievable anti-fibrotic mechanism for pirfenidone. Eur Respir J. 2023;61.
Not in our library10.1183/13993003.00604-2022
81.
Kulkarni AB, et al. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A. 1993;90:770-774.
Not in our library10.1073/pnas.90.2.770
82.
Massagué J. TGFbeta in Cancer. Cell. 2008;134:215-230.
Not in our library10.1016/j.cell.2008.07.001
83.
John AE, et al. Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33-mediated macrophage polarization and emphysema. Sci Signal. 2016;9:ra104.
Not in our library10.1126/scisignal.aad5568
84.
Froese AR, et al. Stretch-induced Activation of Transforming Growth Factor-β1 in Pulmonary Fibrosis. Am J Respir Crit Care Med. 2016;194:84-96.
Not in our library10.1164/rccm.201508-1638oc
85.
Tatler AL, et al. Integrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthma. J Immunol. 2011;187:6094-6107.
Not in our library10.4049/jimmunol.1003507
86.
Kim KK, et al. Epithelial cell α3β1 integrin links β-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. The Journal of Clinical Investigation. 2009;119:213-224.
Not in our library10.1172/jci36940
87.
Goodwin AT, et al. Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation. Development. 2023;150.
Not in our library10.1242/dev.201046
88.
Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study · 2017
No notice
89.
Cairns JT, et al. Loss of ELK1 has differential effects on age-dependent organ fibrosis. Int J Biochem Cell Biol. 2020;120:105668.
Not in our library10.1016/j.biocel.2019.105668
90.
Nagy R, Sweet K, Eng C. Highly penetrant hereditary cancer syndromes. Oncogene. 2004;23:6445-6470.
Not in our library10.1038/sj.onc.1207714
91.
Morgillo F, Della Corte CM, Fasano M, Ciardiello F. Mechanisms of resistance to EGFR-targeted drugs: lung cancer. ESMO Open. 2016;1:e000060.
Not in our library10.1136/esmoopen-2016-000060
92.
A Compendium of Mutational Signatures of Environmental Agents · 2019
No notice
93.
Riva L, et al. The mutational signature profile of known and suspected human carcinogens in mice. Nature Genetics. 2020;52:1189-1197.
Not in our library10.1038/s41588-020-0692-4
94.
Martincorena I, et al. Somatic mutant clones colonize the human esophagus with age. Science. 2018;362:911-917.
Not in our library10.1126/science.aau3879
95.
Pollock PM, et al. High frequency of BRAF mutations in nevi. Nature Genetics. 2003;33:19-20.
Not in our library10.1038/ng1054
96.
Rahal Z, Sinjab A, Wistuba II, Kadara H. Game of clones: Battles in the field of carcinogenesis. Pharmacology & Therapeutics. 2022;237:108251.
Not in our library10.1016/j.pharmthera.2022.108251
97.
Yizhak K, et al. RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues. Science. 2019;364:eaaw0726.
Not in our library10.1126/science.aaw0726
98.
Yokoyama A, et al. Age-related remodelling of oesophageal epithelia by mutated cancer drivers. Nature. 2019;565:312-317.
Not in our library10.1038/s41586-018-0811-x
99.
Barker N, et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature. 2009;457:608-611.
Not in our library10.1038/nature07602
100.
Zhu M, et al. Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease. Cell. 2019;177:608-621.
Not in our library10.1016/j.cell.2019.03.026
101.
Casasent AK, et al. Learning to distinguish progressive and non-progressive ductal carcinoma in situ. Nature Reviews Cancer. 2022;22:663-678.
Not in our library10.1038/s41568-022-00512-y
102.
Lips EH, et al. Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer. Nature Genetics. 2022;54:850-860.
Not in our library10.1038/s41588-022-01082-3
103.
Transient loss of Polycomb components induces an epigenetic cancer fate · 2024
No notice
104.
Chang VC, et al. Glyphosate exposure and urinary oxidative stress biomarkers in the Agricultural Health Study. JNCI: Journal of the National Cancer Institute. 2023;115:394-404.
Not in our library10.1093/jnci/djac242
105.
Li S, Keenan JI, Shaw IC, Frizelle FA. Could Microplastics Be a Driver for Early Onset Colorectal Cancer? Cancers (Basel). 2023;15.
Not in our library10.3390/cancers15133323
106.
Cordenonsi M, et al. The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells. Cell. 2011;147:759-772.
Not in our library10.1016/j.cell.2011.09.048
107.
Panciera T, et al. Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties. Nature materials. 2020;19:797-806.
Not in our library10.1038/s41563-020-0615-x
108.
Pardo-Pastor C, et al. Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses. Proceedings of the National Academy of Sciences. 2018;115:1925-1930.
Not in our library10.1073/pnas.1718177115
109.
Zanconato F, et al. Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth. Nature Cell Biology. 2015;17:1218-1227.
Not in our library10.1038/ncb3216
110.
Ge Y, et al. Stem Cell Lineage Infidelity Drives Wound Repair and Cancer. Cell. 2017;169:636-650.
Not in our library10.1016/j.cell.2017.03.042
111.
Piccolo S, Panciera T, Contessotto P, Cordenonsi M. YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches. Nat Cancer. 2023;4:9-26.
Not in our library10.1038/s43018-022-00473-z
112.
Grzelak EM, et al. Pharmacological YAP activation promotes regenerative repair of cutaneous wounds. Proceedings of the National Academy of Sciences. 2023;120:e2305085120.
Not in our library10.1073/pnas.2305085120
113.
Thompson BJ. YAP/TAZ: Drivers of Tumor Growth, Metastasis, and Resistance to Therapy. BioEssays. 2020;1900162.
Not in our library10.1002/bies.201900162
114.
Hung W-C, et al. Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways. Cell Reports. 2016;15:1430-1441.
Not in our library10.1016/j.celrep.2016.04.035
115.
Pardo-Pastor C, Rosenblatt J. Piezo1 activates non-canonical EGFR endocytosis and signaling. Sci Adv. 2023;9.
Not in our library10.1126/sciadv.adi1328
116.
Rethink of EGFR in Cancer With Its Kinase Independent Function on Board · 2019
No notice
117.
Gallini S, et al. Injury prevents Ras mutant cell expansion in mosaic skin. Nature. 2023;619:167-175.
Not in our library10.1038/s41586-023-06198-y
118.
Alonso-Curbelo D, et al. A gene–environment-induced epigenetic program initiates tumorigenesis. Nature. 2021;590:642-648.
Not in our library10.1038/s41586-020-03147-x
119.
Del Poggetto E, et al. Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis. Science. 2021;373:eabj0486.
Not in our library10.1126/science.abj0486
120.
Park JH, et al. Polypropylene microplastics promote metastatic features in human breast cancer. Scientific reports. 2023;13:6252.
Not in our library10.1038/s41598-023-33393-8
121.
Bogden AE, Moreau JP, Eden PA. Proliferative response of human and animal tumours to surgical wounding of normal tissues: onset, duration and inhibition. Br J Cancer. 1997;75:1021-1027.
Not in our library10.1038/bjc.1997.175
122.
Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis · 2023
No notice
123.
Naik S, et al. Inflammatory memory sensitizes skin epithelial stem cells to tissue damage. Nature. 2017;550:475-480.
Not in our library10.1038/nature24271
124.
The wound inflammatory response exacerbates growth of pre‐neoplastic cells and progression to cancer · 2015
No notice
125.
Bonamonte D, et al. Squamous Cell Carcinoma in Patients with Inherited Epidermolysis Bullosa: Review of Current Literature. Cells. 2022;11.
Not in our library10.3390/cells11081365
126.
van Neerven SM, Vermeulen L. Cell competition in development, homeostasis and cancer. Nature Reviews Molecular Cell Biology. 2023;24:221-236.
Not in our library10.1038/s41580-022-00538-y
127.
Morata G. Cell competition: A historical perspective. Dev Biol. 2021;476:33-40.
Not in our library10.1016/j.ydbio.2021.02.012
128.
Tanimura N, Fujita Y. Epithelial defense against cancer (EDAC). Seminars in Cancer Biology. 2020;63:44-48.
Not in our library10.1016/j.semcancer.2019.05.011
129.
Kohashi K, et al. Sequential oncogenic mutations influence cell competition. Current Biology. 2021;31:3984-3995.
Not in our library10.1016/j.cub.2021.06.064
130.
Pothapragada SP, Gupta P, Mukherjee S, Das T. Matrix mechanics regulates epithelial defence against cancer by tuning dynamic localization of filamin. Nature Communications. 2022;13:218.
Not in our library10.1038/s41467-021-27896-z
131.
Colom B, et al. Mutant clones in normal epithelium outcompete and eliminate emerging tumours. Nature. 2021;598:510-514.
Not in our library10.1038/s41586-021-03965-7
132.
Sanaki Y, Nagata R, Kizawa D, Léopold P, Igaki T. Hyperinsulinemia Drives Epithelial Tumorigenesis by Abrogating Cell Competition. Developmental Cell. 2020;53:379-389.
Not in our library10.1016/j.devcel.2020.04.008
133.
Sasaki A, et al. Obesity Suppresses Cell-Competition-Mediated Apical Elimination of RasV12-Transformed Cells from Epithelial Tissues. Cell Reports. 2018;23:974-982.
Not in our library10.1016/j.celrep.2018.03.104
134.
Mechanical cell competition kills cells via induction of lethal p53 levels · 2016
No notice
135.
Kozyrska K, et al. p53 directs leader cell behavior, migration, and clearance during epithelial repair. Science. 2022;375:eabl8876.
Not in our library10.1126/science.abl8876
136.
Dwivedi VK, et al. Replication stress promotes cell elimination by extrusion. Nature. 2021.
Not in our library10.1038/s41586-021-03526-y
137.
Slattum GM, Rosenblatt J. Tumour cell invasion: an emerging role for basal epithelial cell extrusion. Nature Reviews Cancer. 2014;14:495-501.
Not in our library10.1038/nrc3767
138.
Fadul J, Rosenblatt J. The forces and fates of extruding cells. Curr Opin Cell Biol. 2018;54:66-71.
Not in our library10.1016/j.ceb.2018.04.007
139.
KRas-transformed epithelia cells invade and partially dedifferentiate by basal cell extrusion · 2021
Not checked
140.
Zulueta-Coarasa T, Fadul J, Ahmed M, Rosenblatt J. Physical confinement promotes mesenchymal trans-differentiation of invading transformed cells in vivo. iScience. 2022;25:105330.
Not in our library10.1016/j.isci.2022.105330
141.
Lewis JM, et al. Langerhans Cells Facilitate UVB-Induced Epidermal Carcinogenesis. J Invest Dermatol. 2015;135:2824-2833.
Not in our library10.1038/jid.2015.207
142.
Zhang M, Chen H, Qian H, Wang C. Characterization of the skin keloid microenvironment. Cell Commun Signal. 2023;21:207.
Not in our library10.1186/s12964-023-01214-0
143.
Massen GM, et al. Using Routinely Collected Electronic Healthcare Record Data to Investigate Fibrotic Multimorbidity in England. Clin Epidemiol. 2024;16:433-443.
Not in our library10.2147/clep.s463499
144.
Younossi Z, et al. Nonalcoholic Steatohepatitis Is the Fastest Growing Cause of Hepatocellular Carcinoma in Liver Transplant Candidates. Clin Gastroenterol Hepatol. 2019;17:748-755.
Not in our library10.1016/j.cgh.2018.05.057
145.
Hubbard R, Venn A, Lewis S, Britton J. Lung cancer and cryptogenic fibrosing alveolitis. A population-based cohort study. Am J Respir Crit Care Med. 2000;161:5-8.
Not in our library10.1164/ajrccm.161.1.9906062
146.
Systemic Inflammation Predicts All-Cause Mortality: A Glasgow Inflammation Outcome Study · 2015
No notice
147.
Brown E, MacDonald A, Allen S, Allen D. The potential for a plastic recycling facility to release microplastic pollution and possible filtration remediation effectiveness. Journal of Hazardous Materials Advances. 2023;10:100309.
Not in our library
148.
Murray RL, O’Dowd E. Smoking cessation and lung cancer: never too late to quit. The Lancet Public Health. 2023;8:e664-e665.
Not in our library10.1016/s2468-2667(23)00158-5
149.
Ren X-M, Kuo Y, Blumberg B. Agrochemicals and obesity. Molecular and Cellular Endocrinology. 2020;515:110926.
Not in our library10.1016/j.mce.2020.110926
150.
The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019 · 2022
No notice

Cited by papers we hold 1

Systemic immune-inflammatory biomarkers combined with the CRP-albumin-lymphocyte index predict surgical site infection following posterior lumbar spinal fusion: a retrospective study using machine learning · 2025
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