No retraction, correction or concern found when last checked on Oct 18, 2026.
Extensive migration of young neurons into the infant human frontal lobe
Mercedes F. Paredes, David James, Sara Gil-Perotin and 10 more
Science · 2016
Abstract
Building the human brain As the brain develops, neurons migrate from zones of proliferation to their final locations, where they begin to build circuits. Paredes et al. have discovered that shortly after birth, a group of neurons that proliferates near the ventricles migrates in chains alongside circulatory vessels into the frontal lobes (see the Perspective by McKenzie and Fishell). Young neurons that migrate postnatally into the anterior cingulate cortex then develop features of inhibitory interneurons. The number of migratory cells decreases over the first 7 months of life, and by 2 years of age, migratory cells are not evident. Any damage during migration, such as hypoxia, may affect the child's subsequent physical and behavioral development. Science , this issue p. 81 ; see also p. 38
Shown for reading. Its publisher allows quoting it, not republishing it.
References 43
- 1.
Gandhi SP, Yanagawa Y, Stryker MP. Delayed plasticity of inhibitory neurons in developing visual cortex. Proc Natl Acad Sci USA. 2008;105:16797-16802.
Not in our library10.1073/pnas.0806159105
- 2.
Toyoizumi T, et al. A theory of the transition to critical period plasticity: Inhibition selectively suppresses spontaneous activity. Neuron. 2013;80:51-63.
Not in our library10.1016/j.neuron.2013.07.022
- 3.
Marín O, Rubenstein JL. A long, remarkable journey: Tangential migration in the telencephalon. Nat Rev Neurosci. 2001;2:780-790.
Not in our library10.1038/35097509
- 4.
Nery S, Fishell G, Corbin JG. The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations. Nat Neurosci. 2002;5:1279-1287.
Not in our library10.1038/nn971
- 5.
Ma T, et al. Subcortical origins of human and monkey neocortical interneurons. Nat Neurosci. 2013;16:1588-1597.
Not in our library10.1038/nn.3536
- 6.
Hansen DV, et al. Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences. Nat Neurosci. 2013;16:1576-1587.
Not in our library10.1038/nn.3541
- 7.
Lavdas AA, Grigoriou M, Pachnis V, Parnavelas JG. The medial ganglionic eminence gives rise to a population of early neurons in the developing cerebral cortex. J Neurosci. 1999;19:7881-7888.
Not in our library10.1523/jneurosci.19-18-07881.1999
- 8.
Korr H, Schmitz C. Facts and fictions regarding post-natal neurogenesis in the developing human cerebral cortex. J Theor Biol. 1999;200:291-297.
Not in our library10.1006/jtbi.1999.0992
- 9.
Sidman RL, Rakic P. Neuronal migration, with special reference to developing human brain: A review. Brain Res. 1973;62:1-35.
Not in our library10.1016/0006-89937390617-3
- 10.
García-Verdugo JM, et al. The proliferative ventricular zone in adult vertebrates: A comparative study using reptiles, birds, and mammals. Brain Res Bull. 2002;57:765-775.
Not in our library10.1016/s0361-92300100769-9
- 11.
Paredes MF, Sorrells SF, Garcia-Verdugo JM, Alvarez-Buylla A. Brain size and limits to adult neurogenesis. J Comp Neurol. 2016;524:646-664.
Not in our library10.1002/cne.23896
- 12.
Lois C, García-Verdugo JM, Alvarez-Buylla A. Chain migration of neuronal precursors. Science. 1996;271:978-981.
Not in our library10.1126/science.271.5251.978
- 13.
Betarbet R, Zigova T, Bakay RA, Luskin MB. Dopaminergic and GABAergic interneurons of the olfactory bulb are derived from the neonatal subventricular zone. Int J Dev Neurosci. 1996;14:921-930.
Not in our library10.1016/s0736-57489600066-4
- 14.
Lledo PM, Saghatelyan A, Lemasson M. Inhibitory interneurons in the olfactory bulb: From development to function. Neuroscientist. 2004;10:292-303.
Not in our library10.1177/1073858404263460
- 15.
Suzuki SO, Goldman JE. Multiple cell populations in the early postnatal subventricular zone take distinct migratory pathways: A dynamic study of glial and neuronal progenitor migration. J Neurosci. 2003;23:4240-4250.
Not in our library10.1523/jneurosci.23-10-04240.2003
- 16.
Inta D, et al. Neurogenesis and widespread forebrain migration of distinct GABAergic neurons from the postnatal subventricular zone. Proc Natl Acad Sci USA. 2008;105:20994-20999.
Not in our library10.1073/pnas.0807059105
- 17.
Le Magueresse C, et al. “Small axonless neurons”: Postnatally generated neocortical interneurons with delayed functional maturation. J Neurosci. 2011;31:16731-16747.
Not in our library10.1523/jneurosci.4273-11.2011
- 18.
De Marchis S, Fasolo A, Puche AC. Subventricular zone-derived neuronal progenitors migrate into the subcortical forebrain of postnatal mice. J Comp Neurol. 2004;476:290-300.
Not in our library10.1002/cne.20217
- 19.
Wang C, et al. Identification and characterization of neuroblasts in the subventricular zone and rostral migratory stream of the adult human brain. Cell Res. 2011;21:1534-1550.
Not in our library10.1038/cr.2011.83
- 20.
Sanai N, et al. Corridors of migrating neurons in the human brain and their decline during infancy. Nature. 2011;478:382-386.
Not in our library10.1038/nature10487
- 21.
Gleeson JG, Lin PT, Flanagan LA, Walsh CA. Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons. Neuron. 1999;23:257-271.
Not in our library10.1016/s0896-62730080778-3
- 22.
Ono K, Tomasiewicz H, Magnuson T, Rutishauser U. N-CAM mutation inhibits tangential neuronal migration and is phenocopied by enzymatic removal of polysialic acid. Neuron. 1994;13:595-609.
Not in our library10.1016/0896-62739490028-0
- 23.
Martini FJ, et al. Biased selection of leading process branches mediates chemotaxis during tangential neuronal migration. Development. 2009;136:41-50.
Not in our library10.1242/dev.025502
- 24.
Wichterle H, Garcia-Verdugo JM, Herrera DG, Alvarez-Buylla A. Young neurons from medial ganglionic eminence disperse in adult and embryonic brain. Nat Neurosci. 1999;2:461-466.
Not in our library10.1038/8131
- 25.
Wichterle H, Turnbull DH, Nery S, Fishell G, Alvarez-Buylla A. In utero fate mapping reveals distinct migratory pathways and fates of neurons born in the mammalian basal forebrain. Development. 2001;128:3759-3771.
Not in our library10.1242/dev.128.19.3759
- 26.
Nadarajah B, Brunstrom JE, Grutzendler J, Wong RO, Pearlman AL. Two modes of radial migration in early development of the cerebral cortex. Nat Neurosci. 2001;4:143-150.
Not in our library10.1038/83967
- 27.
Anderson SA, Marín O, Horn C, Jennings K, Rubenstein JL. Distinct cortical migrations from the medial and lateral ganglionic eminences. Development. 2001;128:353-363.
Not in our library10.1242/dev.128.3.353
- 28.
Soriano E, et al. Late appearance of parvalbuminimmunoreactive neurons in the rodent cerebral cortex does not follow an ‘inside-out’ sequence. Neurosci Lett. 1992;142:147-150.
Not in our library10.1016/0304-39409290360-j
- 29.
Letinic K, Kostovic I. Postnatal development of calciumbinding proteins calbindin and parvalbumin in human visual cortex. Cereb Cortex. 1998;8:660-669.
Not in our library10.1093/cercor/8.7.660
- 30.
Riccio O, et al. New pool of cortical interneuron precursors in the early postnatal dorsal white matter. Cereb Cortex. 2012;22:86-98.
Not in our library10.1093/cercor/bhr086
- 31.
Merkle FT, Mirzadeh Z, Alvarez-Buylla A. Mosaic organization of neural stem cells in the adult brain. Science. 2007;317:381-384.
Not in our library10.1126/science.1144914
- 32.
Sakamoto M, et al. Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning. J Neurosci. 2014;34:5788-5799.
Not in our library10.1523/jneurosci.0674-14.2014
- 33.
Cecchi GA, Petreanu LT, Alvarez-Buylla A, Magnasco MO. Unsupervised learning and adaptation in a model of adult neurogenesis. J Comput Neurosci. 2001;11:175-182.
Not in our library10.1023/a:1012849801892
- 34.
Barnea A, Nottebohm F. Seasonal recruitment of hippocampal neurons in adult free-ranging black-capped chickadees. Proc Natl Acad Sci USA. 1994;91:11217-11221.
Not in our library10.1073/pnas.91.23.11217
- 35.
Petreanu L, Alvarez-Buylla A. Maturation and death of adult-born olfactory bulb granule neurons: Role of olfaction. J Neurosci. 2002;22:6106-6113.
Not in our library10.1523/jneurosci.22-14-06106.2002
- 36.
Gould E, Beylin A, Tanapat P, Reeves A, Shors TJ. Learning enhances adult neurogenesis in the hippocampal formation. Nat Neurosci. 1999;2:260-265.
Not in our library10.1038/6365
- 37.
Southwell DG, Froemke RC, Alvarez-Buylla A, Stryker MP, Gandhi SP. Cortical plasticity induced by inhibitory neuron transplantation. Science. 2010;327:1145-1148.
Not in our library10.1126/science.1183962
- 38.
Hensch TK. Critical period plasticity in local cortical circuits. Nat Rev Neurosci. 2005;6:877-888.
Not in our library10.1038/nrn1787
- 39.
Lazarus MS, Huang ZJ. Distinct maturation profiles of perisomatic and dendritic targeting GABAergic interneurons in the mouse primary visual cortex during the critical period of ocular dominance plasticity. J Neurophysiol. 2011;106:775-787.
Not in our library10.1152/jn.00729.2010
- 40.
Robinson S, Li Q, Dechant A, Cohen ML. Neonatal loss of gamma-aminobutyric acid pathway expression after human perinatal brain injury. J Neurosurg. 2006;104(suppl.):396-408.
Not in our library10.3171/ped.2006.104.6.396
Cited by papers we hold 6
- The development and evolution of inhibitory neurons in primate cerebrum · 2022No notice
- Development of prefrontal cortex · 2021No notice
- Calcium Channels in Adult Brain Neural Stem Cells and in Glioblastoma Stem Cells · 2020Not checked
- Neural substrates of early executive function development · 2019No notice
- New insights into the development of the human cerebral cortex · 2019No notice
- Effect of Neuroinflammation on Synaptic Organization and Function in the Developing Brain: Implications for Neurodevelopmental and Neurodegenerative Disorders · 2017No notice
Reads
Read by people on this page
None yet.
Checked or read by AI through naulon
None yet.
A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.
Are you an author?
Is this your paper?
Claim it to add your note and be paid when agents cite it. Free.