Supraspinal fatigue after normoxic and hypoxic exercise in humans

Abstract

Key points Processes leading to fatigue occur within the exercising muscle (peripheral fatigue) and the nervous system (central fatigue). We asked whether central processes of fatigue would be increased after strenuous exercise in environments where oxygen availability is reduced (hypoxia) compared to the same absolute exercise intensity at sea‐level. Our main finding was that the contribution of central processes to fatigue was increased after exercise in hypoxia (equivalent to ∼3800 m above sea‐level). The greater amount of central fatigue in hypoxia was due to suboptimal neural output from the brain and was associated with reductions in oxygen availability. The findings provide a plausible mechanism for why exercise performance is impaired at high altitude, and might help our understanding of exercise limitation in patients with reduced oxygen delivery to the brain.

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Cited by papers we hold 2

• Fatigue and Human Performance: An Updated Framework · 2022
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• Bilateral knee extensor fatigue modulates force and responsiveness of the corticospinal pathway in thenon-fatigued, dominant elbow flexors · 2016
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