The ageing neuromuscular system and sarcopenia: a mitochondrial perspective

Abstract

Skeletal muscles undergo structural and functional decline with ageing, culminating in sarcopenia. The underlying neuromuscular mechanisms have been the subject of intense investigation, revealing mitochondrial abnormalities as potential culprits within both nerve and muscle cells. Implicated mechanisms involve impaired mitochondrial dynamics, reduced organelle biogenesis and quality control via mitophagy, accumulation of mitochondrial DNA (mtDNA) damage and respiratory chain defect, metabolic disturbance, pro‐apoptotic signalling, and oxidative stress. This article provides an overview of the cellular mechanisms whereby mitochondria may promote maladaptive changes within motor neurons, the neuromuscular junction (NMJ) and muscle fibres. Lifelong physical activity, which promotes mitochondrial health across tissues, is emerging as an effective countermeasure for sarcopenia. image

Cited by papers we hold 7

• Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia · 2024
  No notice
• Blood Flow Restriction Training for the Intervention of Sarcopenia: Current Stage and Future Perspective · 2022
  Not checked
• The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies · 2021
  No notice
• Role of Age-Related Mitochondrial Dysfunction in Sarcopenia · 2020
  No notice
• Diagnosis and Treatment of Mitochondrial Myopathies · 2018
  No notice
• Acute Sarcopenia Secondary to Hospitalisation - An Emerging Condition Affecting Older Adults · 2018
  No notice
• Oxidative damage to DNA in independent-living elderly persons and their correlations with sociodemographic, anthropometric, and functional parameters · 2017
  Not checked

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.