Inositol 1,4,5‐trisphosphate receptors and their protein partners as signalling hubs

Abstract

Inositol 1,4,5‐trisphosphate receptors (IP 3 Rs) are expressed in nearly all animal cells, where they mediate the release of Ca 2+ from intracellular stores. The complex spatial and temporal organization of the ensuing intracellular Ca 2+ signals allows selective regulation of diverse physiological responses. Interactions of IP 3 Rs with other proteins contribute to the specificity and speed of Ca 2+ signalling pathways, and to their capacity to integrate information from other signalling pathways. In this review, we provide a comprehensive survey of the proteins proposed to interact with IP 3 Rs and the functional effects that these interactions produce. Interacting proteins can determine the activity of IP 3 Rs, facilitate their regulation by multiple signalling pathways and direct the Ca 2+ that they release to specific targets. We suggest that IP 3 Rs function as signalling hubs through which diverse inputs are processed and then emerge as cytosolic Ca 2+ signals. image

Cited by papers we hold 2

• IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer · 2019
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• Communication between mitochondria and other organelles: a brand-new perspective on mitochondria in cancer · 2019
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