Skip to content
naulon

No retraction, correction or concern found when last checked on Nov 4, 2026.

Cutaneous responses to environmental stressors

Giuseppe Valacchi, Claudia Sticozzi, Alessandra Pecorelli and 3 more

Annals of the New York Academy of Sciences · 2012 · Review

doi:10.1111/j.1749-6632.2012.06724.x

Abstract

Living organisms are continuously exposed to environmental pollutants. Because of its critical location, the skin is a major interface between the body and the environment and provides a biological barrier against an array of chemical and physical environmental pollutants. The skin can be defined as our first defense against the environment because of its constant exposure to oxidants, including ultraviolet (UV) radiation and other environmental pollutants such as diesel fuel exhaust, cigarette smoke (CS), halogenated hydrocarbons, heavy metals, and ozone (O 3 ). The exposure to environmental pro‐oxidant agents leads to the formation of reactive oxygen species (ROS) and the generation of bioactive molecules that can damage skin cells. This short review provides an overview of the effects and mechanisms of action of CS, O 3 , and UV on cutanous tissues.

Shown for reading. Its publisher allows quoting it, not republishing it.

References 63

  1. 1.

    Monteiro-Riviere NA. Toxicology of the Skin. 2010.

    Not in our library

  2. 2.

    Baroni A, et al. Structure and function of the epidermis related to barrier properties. Clin. Dermatol. 2012;30:257-262.

    Not in our library10.1016/j.clindermatol.2011.08.007

  3. 3.

    Bickers DR, Athar M. Oxidative stress in the pathogenesis of skin disease. J. Invest. Dermatol. 2006;126:2565-2575.

    Not in our library10.1038/sj.jid.5700340

  4. 4.

    Svobodova A, Walterova D, Vostalova J. Ultraviolet light induced alteration to the skin. Biomed. Pap. Med. Fac. Univ. Palacky. Olomouc. Czech. Repub. 2006;150:25-38.

    Not in our library10.5507/bp.2006.003

  5. 5.

    Valacchi G, Fortino V, Bocci V. The dual action of ozone on the skin. Br. J. Dermatol. 2005;153:1096-1100.

    Not in our library10.1111/j.1365-2133.2005.06939.x

  6. 6.

    Niki E, et al. Membrane damage from lipid oxidation induced by free radicals and cigarette smoke. Ann. N.Y. Acad. Sci. 1993;686:29-37.

    Not in our library10.1111/j.1749-6632.1993.tb39150.x

  7. 7.

    Pillai S, Oresajo C, Hayward J. Ultraviolet radiation and skin aging: roles of reactive oxygen species, inflammation and protease activation, and strategies for prevention of inflammation-induced matrix degradation—a review. Int. J. Cosmet. Sci. 2005;27:17-34.

    Not in our library10.1111/j.1467-2494.2004.00241.x

  8. 8.

    Dhar A, Young MR, Colburn NH. The role of AP-1, NF-kappaB and ROS/NOS in skin carcinogenesis: the JB6 model is predictive. Mol. Cell Biochem. 2002;234–235:185-193.

    Not in our library

  9. 9.

    Kim AL, et al. Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice. J. Invest. Dermatol. 2005;124:1318-1325.

    Not in our library10.1111/j.0022-202x.2005.23747.x

  10. 10.

    Wlaschek M, et al. Solar UV irradiation and dermal photoaging. J. Photochem. Photobiol. B. 2001;63:41-51.

    Not in our library10.1016/s1011-1344(01)00201-9

  11. 11.

    Dehkharghani S, et al. The economic burden of skin disease in the United States. J. Am. Acad. Dermatol. 2003;48:592-599.

    Not in our library10.1067/mjd.2003.178

  12. 12.

    Thorpe KE, Florence CS, Joski P. Which medical conditions account for the rise in health care spending? Health Aff. 2004.

    Not in our library10.1377/hlthaff.w4.437

  13. 13.

    Pattison DI, Davies MJ. Actions of ultraviolet light on cellular structures. EXS. 2006;96:131-157.

    Not in our library10.1007/3-7643-7378-4_6

  14. 14.

    Huang XX, Bernerd F, Halliday GM. Ultraviolet A within sunlight induces mutations in the epidermal basal layer of engineered human skin. Am. J. Pathol. 2009;174:1534-1543.

    Not in our library10.2353/ajpath.2009.080318

  15. 15.

    Rass K, Reichrath J. UV damage and DNA repair in malignant melanoma and nonmelanoma skin cancer. Adv. Exp. Med. Biol. 2008;624:162-178.

    Not in our library10.1007/978-0-387-77574-6_13

  16. 16.

    Halliday GM, Byrne SN, Damian DL. Ultraviolet A radiation: its role in immunosuppression and carcinogenesis. Semin. Cutan. Med. Surg. 2011;30:214-221.

    Not in our library10.1016/j.sder.2011.08.002

  17. 17.

    Assefa Z, et al. Ultraviolet radiation-induced apoptosis in keratinocytes: on the role of cytosolic factors. Biochim. Biophys. Acta. 2005;1755:90-106.

    Not in our library10.1016/j.bbcan.2005.04.001

  18. 18.

    Rehemtulla A, et al. Ultraviolet radiation-induced apoptosis is mediated by activation of CD-95 (Fas/APO-1). J. Biol. Chem. 1997;272:25783-25786.

    Not in our library10.1074/jbc.272.41.25783

  19. 19.

    Kulms D, Schwarz T. Independent contribution of three different pathways to ultraviolet-B-induced apoptosis. Biochem. Pharmacol. 2002;64:837-841.

    Not in our library10.1016/s0006-2952(02)01146-2

  20. 20.

    Dube MF, Green CR. Methods of collection of smoke for analytical purposes. Recent. Adv. Tobacco Sci. 1982;8:42-102.

    Not in our library

  21. 21.

    Church DF, Pryor WA. Free-radical chemistry of cigarette smoke and its toxicological implications. Environ. Health Perspect. 1985;64:111-126.

    Not in our library10.1289/ehp.8564111

  22. 22.

    Cueto R, Pryor WA. Cigarette smoke chemistry: conversion of nitric oxide to nitrogen dioxide and reactions of nitrogen oxides with other smoke components as studied by Fourier transform infrared spectroscopy. Vib. Spectrosc. 1994;7:97-111.

    Not in our library

  23. 23.

    Pryor WA, Prier DG, Church DF. Electron-spin resonance study of mainstream and sidestream cigarette smoke: nature of the free radicals in gas-phase smoke and in cigarette tar. Environ. Health Perspect. 1983;47:345-355.

    Not in our library10.1289/ehp.8347345

  24. 24.

    Pryor WA, Dooley MM, Church DF. Inactivation of human alpha-1-proteinase inhibitor by gas-phase cigarette smoke. Biochem. Biophys. Res. Commun. 1984;122:676-681.

    Not in our library10.1016/s0006-291x(84)80086-8

  25. 25.

    Dietrich M, et al. Vitamin C supplementation decreases oxidative stress biomarker F2-isoprostanes in plasma of nonsmokers exposed to environmental tobacco smoke. Nutr. Cancer. 2003;45:176-184.

    Not in our library10.1207/s15327914nc4502_06

  26. 26.

    Chow CK. Cigarette smoking and oxidative damage in the lung. Ann. N.Y. Acad. Sci. 1993;686:289-298.

    Not in our library10.1111/j.1749-6632.1993.tb39189.x

  27. 27.

    Solly S. Clinical lectures on paralysis. Lancet. 1856;2:641-643.

    Not in our library

  28. 28.

    Model D. Smoker's face: an underrated clinical sign? Br. Med. J. 1985;291:1760-1762.

    Not in our library10.1136/bmj.291.6511.1760

  29. 29.

    Just M, et al. Effect of smoking on skin elastic fibres: morphometric and immunohistochemical analysis. Br. J. Dermatol. 2007;156:85-91.

    Not in our library10.1111/j.1365-2133.2006.07575.x

  30. 30.

    Yin L, Morita A, Tsuji T. Alterations of extracellular matrix induced by tobacco smoke extract. Arch. Dermatol. Res. 2000;292:188-194.

    Not in our library10.1007/s004030050476

  31. 31.

    Kavli G, et al. Psoriasis: familial predisposition and environmental factors. Br. Med. J. 1985;291:999-1000.

    Not in our library10.1136/bmj.291.6501.999

  32. 32.

    Naldi L, Peli L, Parazzini F. Association of early-stage psoriasis with smoking and male alcohol consumption: evidence from an Italian case-control study. Arch. Dermatol. 1999;135:1479-1484.

    Not in our library10.1001/archderm.135.12.1479

  33. 33.

    Gupta MA, Gupta AK, Watteel GN. Cigarette smoking in men may be a risk factor for increased severity of psoriasis of the extremities. Br. J. Dermatol. 1996;135:859-860.

    Not in our library10.1111/j.1365-2133.1996.tb03909.x

  34. 34.

    Isik B, Ceylan A, Isik R. Oxidative stress in smokers and non-smokers. Inhal. Toxicol. 2007;19:767-769.

    Not in our library10.1080/08958370701401418

  35. 35.

    Nestle FO, Kaplan DH, Barker J. Psoriasis. N. Engl. J. Med. 2009;361:496-509.

    Not in our library10.1056/nejmra0804595

  36. 36.

    Nofal A, et al. Vascular endothelial growth factor in psoriasis: an indicator of disease severity and control. J. Eur. Acad. Dermatol. Venereol. 2009;23:803-806.

    Not in our library10.1111/j.1468-3083.2009.03181.x

  37. 37.

    Odenbro A, et al. The risk for cutaneous malignant melanoma, melanoma in situ and intraocular malignant melanoma in relation to tobacco use and body mass index. Br. J. Dermatol. 2007;156:99-105.

    Not in our library10.1111/j.1365-2133.2006.07537.x

  38. 38.

    Grant WB. A meta-analysis of second cancers after a diagnosis of nonmelanoma skin cancer: additional evidence that solar ultraviolet-B irradiance reduces the risk of internal cancers. J. Steroid. Biochem. Mol. Biol. 2007;103:668-674.

    Not in our library10.1016/j.jsbmb.2006.12.030

  39. 39.

    El-Hakim IE, Uthman MA. Squamous cell carcinoma and keratoacanthoma of the lower lip associated with “Goza” and “Shisha” smoking. Int. J. Dermatol. 1999;38:108-110.

    Not in our library10.1046/j.1365-4362.1999.00448.x

  40. 40.

    Grodstein F, Speizer FE, Hunter DJ. A prospective study of incident squamous cell carcinoma of the skin in the nurses’ health study. J. Natl. Cancer Inst. 1995;87:1061-1066.

    Not in our library10.1093/jnci/87.14.1061

All 63 references

Cited by papers we hold 1

Reads

Read by people on this page

None yet.

Checked or read by AI through naulon

None yet.

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.

Are you an author?

Is this your paper?

Claim it to add your note and be paid when agents cite it. Free.