Dual‐specificity MAP kinase phosphatases (MKPs)

Abstract

Dual‐specificity MAP kinase phosphatases (MKPs) provide a complex negative regulatory network that acts to shape the duration, magnitude and spatiotemporal profile of MAP kinase activities in response to both physiological and pathological stimuli. Individual MKPs may exhibit either exquisite specificity towards a single mitogen‐activated protein kinase (MAPK) isoform or be able to regulate multiple MAPK pathways in a single cell or tissue. They can act as negative feedback regulators of MAPK activity, but can also provide mechanisms of crosstalk between distinct MAPK pathways and between MAPK signalling and other intracellular signalling modules. In this review, we explore the current state of knowledge with respect to the regulation of MKP expression levels and activities, the mechanisms by which individual MKPs recognize and interact with different MAPK isoforms and their role in the spatiotemporal regulation of MAPK signalling.

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97. 97.

    Keyse SM. Dual-specificity MAP kinase phosphatases (MKPs) and cancer. Cancer Metastasis Rev. 2008;27:253-261.

    Not in our library10.1007/s10555-008-9123-1

98. 98.

    Brondello JM, Pouyssegur J, McKenzie FR. Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation. Science. 1999;286:2514-2517.

    Not in our library10.1126/science.286.5449.2514

99. 99.

    Lin YW, Chuang SM, Yang JL. ERK1/2 achieves sustained activation by stimulating MAPK phosphatase-1 degradation via the ubiquitin–proteasome pathway. J Biol Chem. 2003;278:21534-21541.

    Not in our library10.1074/jbc.m301854200

100. 100.

     Lin YW, Yang JL. Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling. J Biol Chem. 2006;281:915-926.

     Not in our library10.1074/jbc.m508720200

101. 101.

     Marchetti S, Gimond C, Chambard JC, Touboul T, Roux D, Pouyssegur J, Pages G. Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation. Mol Cell Biol. 2005;25:854-864.

     Not in our library10.1128/mcb.25.2.854-864.2005

102. 102.

     Bermudez O, Marchetti S, Pages G, Gimond C. Post-translational regulation of the ERK phosphatase DUSP6/MKP3 by the mTOR pathway. Oncogene. 2008;27:3685-3691.

     Not in our library10.1038/sj.onc.1211040

103. 103.

     Cejudo-Marin R, Tarrega C, Nunes-Xavier CE, Pulido R. Caspase-3 cleavage of DUSP6/MKP3 at the interdomain region generates active MKP3 fragments that regulate ERK1/2 subcellular localization and function. J Mol Biol. 2012;420:128-138.

     Not in our library10.1016/j.jmb.2012.04.004

104. 104.

     Tanoue T, Yamamoto T, Maeda R, Nishida E. A novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs. J Biol Chem. 2001;276:26629-26639.

     Not in our library10.1074/jbc.m101981200

105. 105.

     Masuda K, Shima H, Katagiri C, Kikuchi K. Activation of ERK induces phosphorylation of MAPK phosphatase-7, a JNK specific phosphatase, at Ser-446. J Biol Chem. 2003;278:32448-32456.

     Not in our library10.1074/jbc.m213254200

106. 106.

     Katagiri C, Masuda K, Urano T, Yamashita K, Araki Y, Kikuchi K, Shima H. Phosphorylation of Ser-446 determines stability of MKP-7. J Biol Chem. 2005;280:14716-14722.

     Not in our library10.1074/jbc.m500200200

107. 107.

     Masuda K, Katagiri C, Nomura M, Sato M, Kakumoto K, Akagi T, Kikuchi K, Tanuma N, Shima H. MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm. Biochem Biophys Res Commun. 2010;393:201-206.

     Not in our library10.1016/j.bbrc.2010.01.097

108. 108.

     Cao W, Bao C, Padalko E, Lowenstein CJ. Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling. J Exp Med. 2008;205:1491-1503.

     Not in our library10.1084/jem.20071728

109. 109.

     Kim KH, An DR, Song J, Yoon JY, Kim HS, Yoon HJ, Im HN, Kim J, Kim DJ, Lee SJ, et al. Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7. Proc Natl Acad Sci USA. 2012;109:7729-7734.

     Not in our library10.1073/pnas.1120251109

110. 110.

     Dickinson RJ, Delavaine L, Cejudo-Marin R, Stewart G, Staples CJ, Didmon MP, Trinidad AG, Alonso A, Pulido R, Keyse SM. Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates crosstalk between protein kinase A and MAP kinase signaling pathways. J Biol Chem. 2011;286:38018-38026.

     Not in our library10.1074/jbc.m111.255844

111. 111.

     Jeffrey KL, Camps M, Rommel C, Mackay CR. Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses. Nat Rev Drug Discov. 2007;6:391-403.

     Not in our library10.1038/nrd2289

112. 112.

     Christie GR, Williams DJ, Macisaac F, Dickinson RJ, Rosewell I, Keyse SM. The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic development. Mol Cell Biol. 2005;25:8323-8333.

     Not in our library10.1128/mcb.25.18.8323-8333.2005

113. 113.

     Emanuelli B, Eberle D, Suzuki R, Kahn CR. Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance. Proc Natl Acad Sci USA. 2008;105:3545-3550.

     Not in our library10.1073/pnas.0712275105

114. 114.

     Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet. 2010;42:579-589.

     Not in our library10.1038/ng.609

115. 115.

     Xu H, Dembski M, Yang Q, Yang D, Moriarty A, Tayber O, Chen H, Kapeller R, Tartaglia LA. Dual specificity mitogen-activated protein (MAP) kinase phosphatase-4 plays a potential role in insulin resistance. J Biol Chem. 2003;278:30187-30192.

     Not in our library10.1074/jbc.m302010200

116. 116.

     Dry JR, Pavey S, Pratilas CA, Harbron C, Runswick S, Hodgson D, Chresta C, McCormack R, Byrne N, Cockerill M, et al. Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244). Cancer Res. 2010;70:2264-2273.

     Not in our library10.1158/0008-5472.can-09-1577

117. 117.

     Pratilas CA, Solit DB. Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response. Clin Cancer Res. 2010;16:3329-3334.

     Not in our library10.1158/1078-0432.ccr-09-3064

118. 118.

     Pratilas CA, Hanrahan AJ, Halilovic E, Persaud Y, Soh J, Chitale D, Shigematsu H, Yamamoto H, Sawai A, Janakiraman M, et al. Genetic predictors of MEK dependence in non-small cell lung cancer. Cancer Res. 2008;68:9375-9383.

     Not in our library10.1158/0008-5472.can-08-2223

119. 119.

     Sanchez-Perez I, Martinez-Gomariz M, Williams D, Keyse SM, Perona R. CL100/MKP-1 modulates JNK activation and apoptosis in response to cisplatin. Oncogene. 2000;19:5142-5152.

     Not in our library10.1038/sj.onc.1203887

120. 120.

     Small GW, Shi YY, Higgins LS, Orlowski RZ. Mitogen-activated protein kinase phosphatase-1 is a mediator of breast cancer chemoresistance. Cancer Res. 2007;67:4459-4466.

     Not in our library10.1158/0008-5472.can-06-2644

121. 121.

     Wang J, Zhou JY, Wu GS. ERK-dependent MKP-1-mediated cisplatin resistance in human ovarian cancer cells. Cancer Res. 2007;67:11933-11941.

     Not in our library10.1158/0008-5472.can-07-5185

122. 122.

     Wang Z, Xu J, Zhou JY, Liu Y, Wu GS. Mitogen-activated protein kinase phosphatase-1 is required for cisplatin resistance. Cancer Res. 2006;66:8870-8877.

     Not in our library10.1158/0008-5472.can-06-1280

123. 123.

     Balko JM, Cook RS, Vaught DB, Kuba MG, Miller TW, Bhola NE, Sanders ME, Granja-Ingram NM, Smith JJ, Meszoely IM, et al. Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance. Nat Med. 2012;18:1052-1059.

     Not in our library10.1038/nm.2795

124. 124.

     Wan PT, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, Good VM, Jones CM, Marshall CJ, Springer CJ, Barford D, et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell. 2004;116:855-867.

     Not in our library10.1016/s0092-8674(04)00215-6

125. 125.

     Pratilas CA, Taylor BS, Ye Q, Viale A, Sander C, Solit DB, Rosen N. (V600E)BRAF is associated with disabled feedback inhibition of RAF–MEK signaling and elevated transcriptional output of the pathway. Proc Natl Acad Sci USA. 2009;106:4519-4524.

     Not in our library10.1073/pnas.0900780106

126. 126.

     Friday BB, Yu C, Dy GK, Smith PD, Wang L, Thibodeau SN, Adjei AA. BRAF V600E disrupts AZD6244-induced abrogation of negative feedback pathways between extracellular signal-regulated kinase and Raf proteins. Cancer Res. 2008;68:6145-6153.

     Not in our library10.1158/0008-5472.can-08-1430

127. 127.

     Ritt DA, Monson DM, Specht SI, Morrison DK. Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling. Mol Cell Biol. 2010;30:806-819.

     Not in our library10.1128/mcb.00569-09

128. 128.

     Little AS, Balmanno K, Sale MJ, Newman S, Dry JR, Hampson M, Edwards PA, Smith PD, Cook SJ. Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells. Sci Signal. 2011;4:ra17.

     Not in our library10.1126/scisignal.2001752

129. 129.

     Kuilman T, Michaloglou C, Mooi WJ, Peeper DS. The essence of senescence. Genes Dev. 2010;24:2463-2479.

     Not in our library10.1101/gad.1971610

130. 130.

     Michaloglou C, Vredeveld LC, Mooi WJ, Peeper DS. BRAF(E600) in benign and malignant human tumours. Oncogene. 2008;27:877-895.

     Not in our library10.1038/sj.onc.1210704

131. 131.

     Woods D, Parry D, Cherwinski H, Bosch E, Lees E, McMahon M. Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol Cell Biol. 1997;17:5598-5611.

     Not in our library10.1128/mcb.17.9.5598

132. 132.

     Zhu J, Woods D, McMahon M, Bishop JM. Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev. 1998;12:2997-3007.

     Not in our library10.1101/gad.12.19.2997

133. 133.

     Sarma U, Ghosh I. Different designs of kinase-phosphatase interactions and phosphatase sequestration shapes the robustness and signal flow in the MAPK cascade. BMC Syst Biol. 2012;6:82.

     Not in our library10.1186/1752-0509-6-82

134. 134.

     Akella R, Moon TM, Goldsmith EJ. Unique MAP Kinase binding sites. Biochim Biophys Acta. 2008;1784:48-55.

     Not in our library10.1016/j.bbapap.2007.09.016

Cited by papers we hold 19

• FOXO transcription factor family in cancer and metastasis · 2020
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• Functions of p38 MAP Kinases in the Central Nervous System · 2020
  No notice
• Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition · 2019
  Not checked
• Targeting Oncogenic BRAF: Past, Present, and Future · 2019
  No notice
• Regulation of Dual-Specificity Phosphatase (DUSP) Ubiquitination and Protein Stability · 2019
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• Dual-Specificity Phosphatases in Immunity and Infection: An Update · 2019
  No notice
• Roles of Mitogen-Activated Protein Kinases in Osteoclast Biology · 2018
  No notice
• ETS-targeted therapy: can it substitute for MEK inhibitors? · 2017
  Not checked
• Control of cell death and mitochondrial fission by ERK 1/2 MAP kinase signalling · 2017
  No notice
• Linc-RoR promotes MAPK/ERK signaling and confers estrogen-independent growth of breast cancer · 2017
  No notice
• The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation · 2016
  No notice
• Let-7a gene knockdown protects against cerebral ischemia/reperfusion injury · 2016
  Not checked
• Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming · 2016
  No notice
• Inhibition of ROS and upregulation of inflammatory cytokines by FoxO3a promotes survival against Salmonella typhimurium · 2016
  Not checked
• The regulation of oncogenic Ras/ERK signalling by dual-specificity mitogen activated protein kinase phosphatases (MKPs) · 2016
  No notice
• Negative feedback regulation of the ERK1/2 MAPK pathway · 2016
  No notice
• Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats. · 2014
  Not checked
• The Concise Guide to PHARMACOLOGY 2013/14: Enzymes · 2013
  No notice
• Crosstalk and Signaling Switches in Mitogen-Activated Protein Kinase Cascades · 2012
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