Health related quality of life in a nationally representative sample of haematological patients

Abstract

Objectives: Knowledge of health related quality of life of haematological patients is limited. This study aimed at investigating the prevalence and predictors of symptoms and problems in a representative sample of haematological patients in Denmark. Methods: A random sample of patients with leukaemia, multiple myeloma and advanced lymphoma ( n = 732) received the European Organisation for Research and Treatment of Cancer quality‐of‐life questionnaire (EORTC QLQ‐C30). Mean scores were calculated. In addition, scores were dichotomised using two thresholds: patients reporting at least ‘a little’ of each EORTC QLQ‐C30 symptom/problem were classified as having a ‘symptom/problem’, and patients reporting at least ‘quite a bit’ were classified as having a ‘severe symptom/problem’. Multiple logistic regression was used to identify predictors. Results: In total, 470 (64%) patients participated. The most frequent symptoms/problems were fatigue (55%; severe 20%), reduced role function (49%; severe 23%), insomnia (46%; severe 15%), and pain (37%; severe 15%). Older patients and patients in active antineoplastic treatment had more symptoms and problems. There was only little evidence of social inequalities. Conclusion: This is probably the first nationally representative study of symptoms and problems in haematological patients. These patients have symptoms/problems that deserve attention. Health related quality of life is an important issue in haematological malignancies.

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References 36

1. 1.

   Clemmensen I, Nedergaard KH, Storm HH. [Cancer in Denmark] [in Danish]. 2006.

   Not in our library

2. 2.

   Fagerstrom L. The patient’s perceived caring needs as a message of suffering. J Adv Nurs. 1998;28:978-87.

   Not in our library10.1046/j.1365-2648.1998.00822.x

3. 3.

   Foot G, Sanson-Fisher R. Measuring the unmet needs of people living with cancer. Can Forum. 1995;19:131-5.

   Not in our library

4. 4.

   Zittoun R. Quality of life in hematological malignancies with brief reference to bone marrow transplantation. Leuk Res. 1993;17:727-31.

   Not in our library10.1016/0145-2126(93)90105-t

5. 5.

   Lim JW, Zebrack B. Social networks and quality of life for long-term survivors of leukemia and lymphoma. Support Care Cancer. 2006;14:185-92.

   Not in our library10.1007/s00520-005-0856-x

6. 6.

   Molica S. Quality of life in chronic lymphocytic leukemia: a neglected issue. Leuk Lymphoma. 2005;46:1709-14.

   Not in our library10.1080/10428190500244183

7. 7.

   Montgomery C, Pocock M, Titley K, Lloyd K. Individual quality of life in patients with leukaemia and lymphoma. Psychooncology. 2002;11:239-43.

   Not in our library10.1002/pon.557

8. 8.

   Efficace F, Novik A, Vignetti M, Mandelli F, Cleeland CS. Health-related quality of life and symptom assessment in clinical research of patients with hematologic malignancies: where are we now and where do we go from here? Haematologica. 2007;92:1596-8.

   Not in our library10.3324/haematol.11710

9. 9.

   Efficace F, Kemmler G, Vignetti M, Mandelli F, Molica S, Holzner B. Health-related quality of life assessment and reported outcomes in leukaemia randomised controlled trials – a systematic review to evaluate the added value in supporting clinical decision making. Eur J Cancer. 2008;44:1497-506.

   Not in our library10.1016/j.ejca.2008.03.017

10. 10.

    Stephens JM, Gramegna P, Laskin B, Botteman MF, Pashos CL. Chronic lymphocytic leukemia: economic burden and quality of life: literature review. Am J Ther. 2005;12:460-6.

    Not in our library10.1097/01.mjt.0000104489.93653.0f

11. 11.

    Levin TT, Li Y, Riskind J, Rai K. Depression, anxiety and quality of life in a chronic lymphocytic leukemia cohort. Gen Hosp Psychiatry. 2007;29:251-6.

    Not in our library10.1016/j.genhosppsych.2007.01.014

12. 12.

    Holzner B, Kemmler G, Kopp M, Nguyen-Van-Tam D, Sperner-Unterweger B, Greil R. Quality of life of patients with chronic lymphocytic leukemia: results of a longitudinal investigation over 1 yr. Eur J Haematol. 2004;72:381-9.

    Not in our library10.1111/j.1600-0609.2004.00233.x

13. 13.

    Schumacher A, Kessler T, Buchner T, Wewers D, van de LJ. Quality of life in adult patients with acute myeloid leukemia receiving intensive and prolonged chemotherapy – a longitudinal study. Leukemia. 1998;12:586-92.

    Not in our library10.1038/sj.leu.2400977

14. 14.

    Wisloff F, Eika S, Hippe E, Hjorth M, Holmberg E, Kaasa S, Palva I, Westin J. Measurement of health-related quality of life in multiple myeloma. Nordic Myeloma Study Group. Br J Haematol. 1996;92:604-13.

    Not in our library10.1046/j.1365-2141.1996.352889.x

15. 15.

    American joint committee on cancer. AJCC – Cancer Staging Manual. 2002.

    Not in our library

16. 16.

    Aaronson NK, Ahmedzai S, Bergman B, et al. The European-organization-for-research-and-treatment-of-cancer qlq-c30 - a quality-of-life instrument for use in international clinical-trials in oncology. J Natl Cancer Inst. 1993;85:365-76.

    Not in our library10.1093/jnci/85.5.365

17. 17.

    Fayers P, Aaronson NK, Bjordal K, Groenvold M, Curran D, Bottomley A. The EORTC QLQ-C30 Scoring Manual. 2001.

    Not in our library

18. 18.

    SAS Institute Inc. SAS/STAT 9.1 User’s Guide. 2004.

    Not in our library

19. 19.

    Stromgren AS, Goldschmidt D, Groenvold M, Petersen MA, Jensen PT, Pedersen L, Hoermann L, Helleberg C, Sjogren P. Self-assessment in cancer patients referred to palliative care: a study of feasibility and symptom epidemiology. Cancer. 2002;94:512-20.

    Not in our library10.1002/cncr.10222

20. 20.

    Norum J, Wist EA. Quality of life in survivors of Hodgkin’s disease. Qual Life Res. 1996;5:367-74.

    Not in our library10.1007/bf00433921

21. 21.

    Hjermstad MJ, Fayers PM, Bjordal K, Kaasa S. Health-related quality of life in the general Norwegian population assessed by the European Organization for Research and Treatment of Cancer Core Quality-of-Life Questionnaire: the QLQ=C30 (+3). J Clin Oncol. 1998;16:1188-96.

    Not in our library10.1200/jco.1998.16.3.1188

22. 22.

    Schwarz R, Hinz A. Reference data for the quality of life questionnaire EORTC QLQ-C30 in the general German population. Eur J Cancer. 2001;37:1345-51.

    Not in our library10.1016/s0959-8049(00)00447-0

23. 23.

    Yun YH, Kim SH, Lee KM, Park SM, Kim YM. Age, sex, and comorbidities were considered in comparing reference data for health-related quality of life in the general and cancer populations. J Clin Epidemiol. 2007;60:1164-75.

    Not in our library10.1016/j.jclinepi.2006.12.014

24. 24.
    Baseline characteristics influencing quality of life in women undergoing gynecologic oncology surgery · 2007

    Not checked
25. 25.

    Parker PA, Baile WF, de Moor C, Cohen L. Psychosocial and demographic predictors of quality of life in a large sample of cancer patients. Psychooncology. 2003;12:183-93.

    Not in our library10.1002/pon.635

26. 26.

    King MT, Kenny P, Shiell A, Hall J, Boyages J. Quality of life three months and one year after first treatment for early stage breast cancer: influence of treatment and patient characteristics. Qual Life Res. 2000;9:789-800.

    Not in our library10.1023/a:1008936830764

27. 27.

    Lundh HC, Seiger A, Furst CJ. Quality of life in terminal care – with special reference to age, gender and marital status. Support Care Cancer. 2006;14:320-8.

    Not in our library10.1007/s00520-005-0886-4

28. 28.

    Walsh D, Donnelly S, Rybicki L. The symptoms of advanced cancer: relationship to age, gender, and performance status in 1,000 patients. Support Care Cancer. 2000;8:175-9.

    Not in our library10.1007/s005200050281

29. 29.

    Shanafelt TD, Bowen D, Venkat C, Slager SL, Zent CS, Kay NE, Reinalda M, Sloan JA, Call TG. Quality of life in chronic lymphocytic leukemia: an international survey of 1482 patients. Br J Haematol. 2007;139:255-64.

    Not in our library10.1111/j.1365-2141.2007.06791.x

30. 30.
    Quality of life in advanced cancer patients: the impact of sociodemographic and medical characteristics · 2001

    No notice
31. 31.

    Kornblith AB, Herndon JE, Zuckerman E, et al. Comparison of psychosocial adaptation of advanced stage Hodgkin’s disease and acute leukemia survivors. Cancer and Leukemia Group B. Ann Oncol. 1998;9:297-306.

    Not in our library10.1023/a:1008297130258

32. 32.

    Greenberg DB, Kornblith AB, Herndon JE, Zuckerman E, Schiffer CA, Weiss RB, Mayer RJ, Wolchok SM, Holland JC. Quality of life for adult leukemia survivors treated on clinical trials of Cancer and Leukemia Group B during the period 1971–1988: predictors for later psychologic distress. Cancer. 1997;80:1936-44.

    Not in our library10.1002/(sici)1097-0142(19971115)80:10<1936::aid-cncr10>3.0.co;2-z

33. 33.

    van den Beuken-van Everdingen MH, de Rijke JM, Kessels AG, Schouten HC, van Kleef M, Patijn J. High prevalence of pain in patients with cancer in a large population-based study in The Netherlands. Pain. 2007;132:312-20.

    Not in our library10.1016/j.pain.2007.08.022

34. 34.

    Andrykowski MA, Bishop MM, Hahn EA, Cella DF, Beaumont JL, Brady MJ, Horowitz MM, Sobocinski KA, Rizzo JD, Wingard JR. Long-term health-related quality of life, growth, and spiritual well-being after hematopoietic stem-cell transplantation. J Clin Oncol. 2005;23:599-608.

    Not in our library10.1200/jco.2005.03.189

35. 35.

    Barg FK, Cronholm PF, Straton JB, Keddem S, Knott K, Grater J, Houts P, Palmer SC. Unmet psychosocial needs of Pennsylvanians with cancer: 1986–2005. Cancer. 2007;110:631-9.

    Not in our library10.1002/cncr.22820

36. 36.

    Anderson H, Ward C, Eardley A, Gomm SA, Connolly M, Coppinger T, Corgie D, Williams JL, Makin WP. The concerns of patients under palliative care and a heart failure clinic are not being met. Palliat Med. 2001;15:279-86.

    Not in our library10.1191/026921601678320269

Cited by papers we hold 1

• The impact of disease-related symptoms and palliative care concerns on health-related quality of life in multiple myeloma: a multi-centre study · 2016
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