Epidermal stem cells are retained in vivo throughout skin aging

Abstract

Summary In healthy individuals, skin integrity is maintained by epidermal stem cells which self‐renew and generate daughter cells that undergo terminal differentiation. It is currently unknown whether epidermal stem cells influence or are affected by skin aging. We therefore compared young and aged skin stem cell abundance, organization, and proliferation. We discovered that despite age‐associated differences in epidermal proliferation, dermal thickness, follicle patterning, and immune cell abundance, epidermal stem cells were maintained at normal levels throughout life. These findings, coupled with observed dermal gene expression changes, suggest that epidermal stem cells themselves are intrinsically aging resistant and that local environmental or systemic factors modulate skin aging.

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Cited by papers we hold 4

• Focus on the Contribution of Oxidative Stress in Skin Aging · 2022
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• Type XVII collagen coordinates proliferation in the interfollicular epidermis · 2017
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• Ultraviolet Radiation‐Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging · 2016
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• Aging and Replicative Senescence Have Related Effects on Human Stem and Progenitor Cells · 2009
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