Optogenetic inhibition of cocaine seeking in rats

Abstract

Inhibitory optogenetics was used to examine the roles of the prelimbic cortex ( PL ), the nucleus accumbens core ( NAcore ) and the PL projections to the NAcore in the reinstatement of cocaine seeking. Rats were microinjected into the PL or NAcore with an adeno‐associated virus containing halorhodopsin or archaerhodopsin. After 12 days of cocaine self‐administration, followed by extinction training, animals underwent reinstatement testing along with the presence/absence of optically induced inhibition via laser light. Bilateral optical inhibition of the PL , NAcore or the PL fibers in the NAcore inhibited the reinstatement of cocaine seeking.

Shown for reading. Its publisher allows quoting it, not republishing it.

References 7

1. 1.

   Chow BY, Han X, Dobry AS, Qian X, Chuong AS, Li M, Henninger MA, Belfort GM, Lin Y, Monahan PE, Boyden ES. High-performance genetically targetable optical neural silencing by light-driven proton pumps. Nature. 2010;463:98-102.

   Not in our library10.1038/nature08652

2. 2.

   Deisseroth K. 2012.

   Not in our library

3. 3.

   Gradinaru V, Zhang F, Ramakrishnan C, Mattis J, Prakash R, Diester I, Goshen I, Thompson KR, Deisseroth K. Molecular and cellular approaches for diversifying and extending optogenetics. Cell. 2010;141:154-165.

   Not in our library10.1016/j.cell.2010.02.037

4. 4.

   Kalivas PW, Volkow N, Seamans J. Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission. Neuron. 2005;45:647-650.

   Not in our library10.1016/j.neuron.2005.02.005

5. 5.

   Moran MM, McFarland K, Melendez RI, Kalivas PW, Seamans JK. Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking. J Neurosci. 2005;25:6389-6393.

   Not in our library10.1523/jneurosci.1007-05.2005

6. 6.

   Moussawi K, Pacchioni A, Moran M, Olive MF, Gass JT, Lavin A, Kalivas PW. N-Acetylcysteine reverses cocaine-induced metaplasticity. Nat Neurosci. 2009;12:182-189.

   Not in our library10.1038/nn.2250

7. 7.

   Stuber GD, Sparta DR, Stamatakis AM, van Leeuwen WA, Hardjoprajitno JE, Cho S, Tye KM, Kempadoo KA, Zhang F, Deisseroth K, Bonci A. Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking. Nature. 2011;475:377-380.

   Not in our library10.1038/nature10194

Cited by papers we hold 3

• One Is Not Enough: Understanding and Modeling Polysubstance Use · 2020
  No notice
• Magnetothermal genetic deep brain stimulation of motor behaviors in awake, freely moving mice · 2017
  No notice
• Optogenetic dissection of medial prefrontal cortex circuitry · 2014
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.