Immune pathways and defence mechanisms in honey bees Apis mellifera

Abstract

Social insects are able to mount both group‐level and individual defences against pathogens. Here we focus on individual defences, by presenting a genome‐wide analysis of immunity in a social insect, the honey bee Apis mellifera . We present honey bee models for each of four signalling pathways associated with immunity, identifying plausible orthologues for nearly all predicted pathway members. When compared to the sequenced Drosophila and Anopheles genomes, honey bees possess roughly one‐third as many genes in 17 gene families implicated in insect immunity. We suggest that an implied reduction in immune flexibility in bees reflects either the strength of social barriers to disease, or a tendency for bees to be attacked by a limited set of highly coevolved pathogens.

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References 79

1. 1.

   Agaisse H, Perrimon N. The roles of JAK/STAT signaling in Drosophila immune responses. Immunol Rev. 2004;198:72-82.

   Not in our library10.1111/j.0105-2896.2004.0133.x

2. 2.

   Agaisse H, Petersen U-M, Boutros M, Mathey-Prevot B, Perrimon N. Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. Dev Cell. 2003;5:441-450.

   Not in our library10.1016/s1534-5807(03)00244-2

3. 3.

   Albert S, Klaudiny J. The MRJP/YELLOW protein family of Apis mellifera: Identification of new members in the EST library. J Insect Physiol. 2004;50:51-59.

   Not in our library10.1016/j.jinsphys.2003.09.008

4. 4.

   Aronstein K, Saldivar E. Characterization of a honey bee Toll related receptor gene Am18w and its potential involvement in antimicrobial immune defense. Apidologie. 2005;36:3-14.

   Not in our library

5. 5.

   Baeg GH, Zhou R, Perrimon N. Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. Genes Dev. 2005;19:1861-1870.

   Not in our library10.1101/gad.1320705

6. 6.

   Beutler B. Innate immunity: an overview. Biochem Mol Immunol. 2004;40:845-859.

   Not in our library10.1016/j.molimm.2003.10.005

7. 7.

   Bilak H, Tauszig-Delamasure S, Imler JL. Toll and Toll-like receptors in Drosophila. Biochem Soc Trans. 2003;31:648-651.

   Not in our library10.1042/bst0310648

8. 8.

   Blandin S, Levashina EA. Thioester-containing proteins and insect immunity. Mol Immunol. 2004;40:903-908.

   Not in our library10.1016/j.molimm.2003.10.010

9. 9.

   Boomsma JJ, Schmid-Hempel P, Hughes WO.H, Fellowes MHG, Rolff J. Life histories and parasite pressure across the major groups of social insects. Insect Evolutionary Ecology. 2005;139-176.

   Not in our library

10. 10.

    Boutros M, Agaisse H, Perrimon N. Sequential activation of signaling pathways during innate immune responses in Drosophila. Dev Cell. 2002;3:711-722.

    Not in our library10.1016/s1534-5807(02)00325-8

11. 11.

    Brodsgaard CJ, Ritter W, Hansen H. Response of in vitro reared honey bee larvae to various doses of Paenibacillus larvae larvae spores. Apidologie. 1998;29:569-578.

    Not in our library

12. 12.

    Brown CR, Brown MB. Empirical measurement of parasite transmission between groups in a colonial bird. Ecology. 2004;85:1619-1626.

    Not in our library

13. 13.

    Burgett DM, Morse RA, Flottum K. Antibiotic systems in honey, nectar, and pollen. Honey Bee Pest, Predators, and Diseases. 1997;455-468.

    Not in our library

14. 14.

    Casteels-Josson K, Capaci T, Casteels P, Tempst P. Apidaecin multipeptide precursor structure: a putative mechanism for amplification of the insect antibacterial response. Embo J. 1993;12:1569-1578.

    Not in our library10.1002/j.1460-2075.1993.tb05801.x

15. 15.

    Casteels-Josson K, Zhang W, Capaci T, Casteels P, Tempst P. Acute transcriptional response of the honeybee peptide-antibiotics gene repertoire and required post-translational conversion of the precursor structures. J Biol Chem. 1994;269:28569-28575.

    Not in our library

16. 16.

    Chang CI, Chelliah Y, Borek D, Mengin-Lecreulx D, Deisenhofer J. Structure of tracheal cytotoxin in complex with a heterodimeric pattern-recognition receptor. Science. 2006;311:1761-1764.

    Not in our library10.1126/science.1123056

17. 17.

    Chen Y, Pettis JS, Evans JD, Feldlaufer MF, Kramer M. Transmission of Kashmir bee virus by the ectoparasitic mite Varroa destructor. Apidologie. 2004;35:441-448.

    Not in our library

18. 18.

    Chenna R, Sugawara H, Koike T, Lopez R, Gibson TJ, Higgins DG, Thompson JD. Multiple sequence alignment with the Clustal series of programs. Nucleic Acids Res. 2003;31:3497-3500.

    Not in our library10.1093/nar/gkg500

19. 19.

    Christe P, Oppliger A, Bancalà F, Castella G, Chapuisat M. Evidence for collective medication in ants. Ecol Lett. 2003;6:19-22.

    Not in our library

20. 20.

    Christophides GK, Zdobnov E, Barillas-Mury C, Birney E, Blandin S, Blass C, Brey PT, Collins FH, Danielli A, Dimopoulos G, Hetru C, Hoa NT, Hoffmann JA, Kanzok SM, Letunic I, Levashina EA, Loukeris TG, Lycett G, Meister S, Michel K, Moita LF, Müller H-M, Osta MA, Paskewitz SM, Reichhart J-M, Rzhetsky A, Troxler L, Vernick KD, Vlachou D, Volz J, Von Mering C, Xu J, Zheng L, Bork P, Kafatos FC. Immunity-related genes and gene families in Anopheles gambiae. Science. 2002;298:159-165.

    Not in our library10.1126/science.1077136

21. 21.

    Christophides GK, Vlachou D, Kafatos FC. Comparative and functional genomics of the innate immune system in the malaria vector Anopheles gambiae. Immunol Rev. 2004;198:127-148.

    Not in our library10.1111/j.0105-2896.2004.0127.x

22. 22.

    Dostert C, Jouanguy E, Irving P, Troxler L, Galiana-Arnoux D, Hetru C, Hoffmann JA, Imler JL. The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of Drosophila. Nature Immunol. 2005;6:946-953.

    Not in our library10.1038/ni1237

23. 23.

    Ekengren S, Hultmark D. A family of Turandot-related genes in the humoral stress response of Drosophila. Biochem Biophys Res Comms. 2001;284:998-1003.

    Not in our library10.1006/bbrc.2001.5067

24. 24.

    Ekengren S, Tryselius Y, Dushay MS, Liu G, Steiner H, Hultmark D. A humoral stress response in Drosophila. Curr Biol. 2001;11:1479-1479.

    Not in our library10.1016/s0960-9822(01)00452-3

25. 25.

    Evans JD. Transcriptional immune responses by honey bee larvae during invasion by the bacterial pathogen, Paenibacillus larvae. J Invertebr Pathol. 2004;85:105-111.

    Not in our library10.1016/j.jip.2004.02.004

26. 26.

    Evans JD. BeePath: An ordered quantitative-PCR array for exploring honey bee immunity and disease. J Invertebr Pathol. 2006.

    Not in our library10.1016/j.jip.2006.04.004

27. 27.

    Evans JD, Armstrong TN. Antagonistic interactions between honey bee bacterial symbionts and implications for disease. BMC Ecol. 2006;6:4-4.

    Not in our library10.1186/1472-6785-6-4

28. 28.

    Evans JD, Pettis JS. Colony-level effects of immune responsiveness in honey bees, Apis mellifera. Evolution. 2005;59:2270-2274.

    Not in our library10.1111/j.0014-3820.2005.tb00935.x

29. 29.

    Evans JD, Wheeler DE. Expression profiles during honeybee caste determination. Genome Biol. 2000;2.

    Not in our library10.1186/gb-2000-2-1-research0001

30. 30.

    Gilliam M. Identification and roles of non-pathogenic microflora associated with honey bees. FEMS Microbiol Lett. 1997;155:1-10.

    Not in our library

31. 31.

    Graveley BR, Kaur A, Rowen L, Gunning D, Lawrence Zipursky S, Clemens JC. The organization and evolution of the Dipteran and Hymenopteran Down syndrome cell adhesion molecule (Dscam) genes. RNA. 2004;10:1499-1506.

    Not in our library10.1261/rna.7105504

32. 32.

    Gregory PG, Evans JD, Rinderer T, De Guzman L. Conditional immune-gene suppression of honeybees parasitized by Varroa mites. J Insect Sci. 2005;5:1-5.

    Not in our library10.1093/jis/5.1.7

33. 33.

    Hoffmann JA. The immune response of Drosophila. Nature. 2003;426:33-38.

    Not in our library10.1038/nature02021

34. 34.

    Insights into social insects from the genome of the honeybee Apis mellifera. Nature. 2006.

    Not in our library10.1038/nature05260

35. 35.

    Hultmark D. Drosophila immunity: Paths and patterns. Curr Opin Immunol. 2003;15:12-19.

    Not in our library10.1016/s0952-7915(02)00005-5

36. 36.

    Irving P, Ubeda JM, Doucet D, Troxler L, Lagueux M, Zachary D, Hoffmann JA, Hetru C, Meister M. New insights into Drosophila larval haemocyte functions through genome-wide analysis. Cell Microbiol. 2005;7:335-350.

    Not in our library10.1111/j.1462-5822.2004.00462.x

37. 37.

    Jiang H, Kanost MR. The clip-domain family of serine proteinases in arthropods. Insect Biochem Mol Biol. 2000;30:95-105.

    Not in our library10.1016/s0965-1748(99)00113-7

38. 38.

    Jiang H, Wang Y, Guo X, Zou Z, Gu Y, Kanost MR, Scholz F, Trenczek TE. Molecular identification of a bevy of serine proteinases in Manduca sexta hemolymph. Insect Biochem Mol Biol. 2005;35:931-943.

    Not in our library10.1016/j.ibmb.2005.03.009

39. 39.

    Kambris Z, Hoffmann JA, Imler J-L, Capovilla M. Tissue and stage-specific expression of the Tolls in Drosophila embryos. Gene Expr Patterns. 2002;2:311-317.

    Not in our library10.1016/s1567-133x(02)00020-0

40. 40.

    Kanbar G, Engels W. Ultrastructure and bacterial infection of wounds in honey bee (Apis mellifera) pupae punctured by Varroa mites. Parasitol Res. 2003;90:349-354.

    Not in our library10.1007/s00436-003-0827-4

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