No retraction, correction or concern found when last checked on Oct 16, 2026.

Endoplasmic reticulum stress signalling – from basic mechanisms to clinical applications

Aitor Almanza, Antonio Carlesso, Chetan Chintha and 22 more

The FEBS Journal · 2018 · Review

Abstract

The endoplasmic reticulum ( ER ) is a membranous intracellular organelle and the first compartment of the secretory pathway. As such, the ER contributes to the production and folding of approximately one‐third of cellular proteins, and is thus inextricably linked to the maintenance of cellular homeostasis and the fine balance between health and disease. Specific ER stress signalling pathways, collectively known as the unfolded protein response ( UPR ), are required for maintaining ER homeostasis. The UPR is triggered when ER protein folding capacity is overwhelmed by cellular demand and the UPR initially aims to restore ER homeostasis and normal cellular functions. However, if this fails, then the UPR triggers cell death. In this review, we provide a UPR signalling‐centric view of ER functions, from the ER 's discovery to the latest advancements in the understanding of ER and UPR biology. Our review provides a synthesis of intracellular ER signalling revolving around proteostasis and the UPR , its impact on other organelles and cellular behaviour, its multifaceted and dynamic response to stress and its role in physiology, before finally exploring the potential exploitation of this knowledge to tackle unresolved biological questions and address unmet biomedical needs. Thus, we provide an integrated and global view of existing literature on ER signalling pathways and their use for therapeutic purposes.

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References 377

1.
Porter KR, Claude A & Fullam EF (1945 ) A study of tissue culture cells by electron microscopy: methods and preliminary observations. J Exp Med 81, 233–246.
Not in our library10.1084/jem.81.3.233
2.
Palade GE & Porter KR (1954 ) Studies on the endoplasmic reticulum. I. Its identification in cells in situ. J Exp Med 100, 641–656.
Not in our library10.1084/jem.100.6.641
3.
Alberts B, Johnson A, Lewis J, Raff M, Roberts K & Walter P (2002 ) Molecular Biology of the Cell, 4th edn. Garland Science, New York, NY.
Not in our library
4.
Borgese N, Francolini M & Snapp E (2006 ) Endoplasmic reticulum architecture: structures in flux. Curr Opin Cell Biol 18, 358–364.
Not in our library10.1016/j.ceb.2006.06.008
5.
Shibata Y, Voeltz GK & Rapoport TA (2006 ) Rough sheets and smooth tubules. Cell 126, 435–439.
Not in our library10.1016/j.cell.2006.07.019
6.
Hayashi T, Rizzuto R, Hajnoczky G & Su TP (2009 ) MAM: more than just a housekeeper. Trends Cell Biol 19, 81–88.
Not in our library10.1016/j.tcb.2008.12.002
7.
Toulmay A & Prinz WA (2011 ) Lipid transfer and signaling at organelle contact sites: the tip of the iceberg. Curr Opin Cell Biol 23, 458–463.
Not in our library10.1016/j.ceb.2011.04.006
8.
Daste F, Galli T & Tareste D (2015 ) Structure and function of longin SNAREs. J Cell Sci 128, 4263–4272.
Not in our library10.1242/jcs.178574
9.
Rowland AA, Chitwood PJ, Phillips MJ & Voeltz GK (2014 ) ER contact sites define the position and timing of endosome fission. Cell 159, 1027–1041.
Not in our library10.1016/j.cell.2014.10.023
10.
Wilhelm LP, Tomasetto C & Alpy F (2016 ) Touché! STARD3 and STARD3NL tether the ER to endosomes. Biochem Soc Trans 44, 493–498.
Not in our library10.1042/bst20150269
11.
Wilhelm LP, Wendling C, Védie B, Kobayashi T, Chenard M, Tomasetto C, Drin G & Alpy F (2017 ) STARD3 mediates endoplasmic reticulum‐to‐endosome cholesterol transport at membrane contact sites. EMBO J 36, 1412–1433.
Not in our library10.15252/embj.201695917
12.
Henne WM, Zhu L, Balogi Z, Stefan C, Pleiss JA & Emr SD (2015 ) Mdm1/Snx13 is a novel ER–endolysosomal interorganelle tethering protein. J Cell Biol 210, 541–551.
Not in our library10.1083/jcb.201503088
13.
Hayashi‐Nishino M, Fujita N, Noda T, Yamaguchi A, Yoshimori T & Yamamoto A (2010 ) Electron tomography reveals the endoplasmic reticulum as a membrane source for autophagosome formation. Autophagy 6, 301–303.
Not in our library10.4161/auto.6.2.11134
14.
Uemura T, Yamamoto M, Kametaka A, Sou Y, Yabashi A, Yamada A, Annoh H, Kametaka S, Komatsu M & Waguri S (2014 ) A cluster of thin tubular structures mediates transformation of the endoplasmic reticulum to autophagic isolation membrane. Mol Cell Biol 34, 1695–1706.
Not in our library10.1128/mcb.01327-13
15.
Stefan CJ, Manford AG, Baird D, Yamada‐Hanff J, Mao Y & Emr SD (2011 ) Osh proteins regulate phosphoinositide metabolism at ER‐plasma membrane contact sites. Cell 144, 389–401.
Not in our library10.1016/j.cell.2010.12.034
16.
Braakman I & Bulleid NJ (2011 ) Protein folding and modification in the mammalian endoplasmic reticulum. Annu Rev Biochem 80, 71–99.
Not in our library10.1146/annurev-biochem-062209-093836
17.
Hebert DN & Molinari M (2007 ) In and out of the ER: protein folding, quality control, degradation, and related human diseases. Physiol Rev 87, 1377–1408.
Not in our library10.1152/physrev.00050.2006
18.
Wallis AK & Freedman RB (2013 ) Assisting oxidative protein folding: how do protein disulphide‐isomerases couple conformational and chemical processes in protein folding? Top Curr Chem 328, 1–34.
Not in our library10.1007/128_2011_171
19.
Aebi M, Bernasconi R, Clerc S & Molinari M (2010 ) N‐glycan structures: recognition and processing in the ER. Trends Biochem Sci 35, 74–82.
Not in our library10.1016/j.tibs.2009.10.001
20.
Meusser B, Hirsch C, Jarosch E & Sommer T (2005 ) ERAD: the long road to destruction. Nat Cell Biol 7, 766–772.
Not in our library10.1038/ncb0805-766
21.
Hebert DN, Bernasconi R & Molinari M (2010 ) ERAD substrates: which way out? Semin Cell Dev Biol 21, 526–532.
Not in our library10.1016/j.semcdb.2009.12.007
22.
Kobayashi T, Tanaka K, Inoue K & Kakizuka A (2002 ) Functional ATPase activity of p97/valosin‐containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells. J Biol Chem 277, 47358–47365.
Not in our library10.1074/jbc.m207783200
23.
Enns GM, Shashi V, Bainbridge M, Gambello MJ, Zahir FR, Bast T, Crimian R, Schoch K, Platt J, Cox R et al (2014 ) Mutations in NGLY1 cause an inherited disorder of the endoplasmic reticulum‐associated degradation (ERAD) pathway. Genet Med 16, 751–758.
Not in our library10.1038/gim.2014.22
24.
Kamhi‐Nesher S, Shenkman M, Tolchinsky S, Fromm SV, Ehrlich R & Lederkremer GZ (2001 ) A novel quality control compartment derived from the endoplasmic reticulum. Mol Biol Cell 12, 1711–1723.
Not in our library10.1091/mbc.12.6.1711
25.
Huyer G, Longsworth GL, Mason DL, Mallampalli MP, McCaffery JM, Wright RL & Michaelis S (2004 ) A striking quality control subcompartment in Saccharomyces cerevisiae: the endoplasmic reticulum‐associated compartment. Mol Biol Cell 15, 908–921.
Not in our library10.1091/mbc.e03-07-0546
26.
Brown MS & Goldstein JL (1999 ) A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc Natl Acad Sci USA 96, 11041–11048.
Not in our library10.1073/pnas.96.20.11041
27.
Membrane phospholipid synthesis and endoplasmic reticulum function · 2009
Not checked
28.
Yen C‐LE, Stone SJ, Koliwad S, Harris C & Farese RV (2008 ) Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. J Lipid Res 49, 2283–2301.
Not in our library10.1194/jlr.r800018-jlr200
29.
Jo Y & DeBose‐Boyd RA (2010 ) Control of cholesterol synthesis through regulated ER‐associated degradation of HMG CoA reductase. Crit Rev Biochem Mol Biol 45, 185–198.
Not in our library10.3109/10409238.2010.485605
30.
Patwardhan GA, Beverly LJ & Siskind LJ (2016 ) Sphingolipids and mitochondrial apoptosis. J Bioenerg Biomembr 48, 153–168.
Not in our library10.1007/s10863-015-9602-3
31.
Barlowe C, Orci L, Yeung T, Hosobuchi M, Hamamoto S, Salama N, Rexach MF, Ravazzola M, Amherdt M & Schekman R (1994 ) COPII: a membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum. Cell 77, 895–907.
Not in our library10.1016/0092-8674(94)90138-4
32.
Siddiqi S, Saleem U, Abumrad NA, Davidson NO, Storch J, Siddiqi SA & Mansbach CM (2010 ) A novel multiprotein complex is required to generate the prechylomicron transport vesicle from intestinal ER. J Lipid Res 51, 1918–1928.
Not in our library10.1194/jlr.m005611
33.
Clapham DE (2007 ) Calcium signaling. Cell 131, 1047–1058.
Not in our library10.1016/j.cell.2007.11.028
34.
Meldolesi J & Pozzan T (1998 ) The endoplasmic reticulum Ca2 + store: a view from the lumen. Trends Biochem Sci 23, 10–14.
Not in our library10.1016/s0968-0004(97)01143-2
35.
Hetz C (2012 ) The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol 13, 89–102.
Not in our library10.1038/nrm3270
36.
Hanahan D & Weinberg RA (2011 ) Hallmarks of cancer: the next generation. Cell 144, 646–674.
Not in our library10.1016/j.cell.2011.02.013
37.
Holderfield M, Deuker MM, McCormick F & McMahon M (2014 ) Targeting RAF kinases for cancer therapy: BRAF mutated melanoma and beyond. Nat Rev Cancer 14, 455–467.
Not in our library10.1038/nrc3760
38.
Piwocka K, Vejda S, Cotter TG, O'Sullivan GC & McKenna SL (2006 ) Bcr‐Abl reduces endoplasmic reticulum releasable calcium levels by a Bcl‐2‐independent mechanism and inhibits calcium‐dependent apoptotic signaling. Blood 107, 4003–4010.
Not in our library10.1182/blood-2005-04-1523
39.
Pluquet O, Pourtier A & Abbadie C (2015 ) The unfolded protein response and cellular senescence. A review in the theme: cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. Am J Physiol Cell Physiol 308, C415–C425.
Not in our library10.1152/ajpcell.00334.2014
40.
Chen H‐J, Anagnostou G, Chai A, Withers J, Morris A, Adhikaree J, Pennetta G & de Belleroche JS (2010 ) Characterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosis. J Biol Chem 285, 40266–40281.
Not in our library10.1074/jbc.m110.161398
41.
Nishimura AL, Mitne‐Neto M, Silva HCA, Richieri‐Costa A, Middleton S, Cascio D, Kok F, Oliveira JRM, Gillingwater T, Webb J et al (2004 ) A Mutation in the vesicle‐trafficking protein VAPB causes late‐onset spinal muscular atrophy and amyotrophic lateral sclerosis. Am J Hum Genet 75, 822–831.
Not in our library10.1086/425287
42.
Harding HP & Ron D (2002 ) Endoplasmic reticulum stress and the development of diabetes: a review. Diabetes 51, S455–S461.
Not in our library10.2337/diabetes.51.2007.s455
43.
Oyadomari S, Koizumi A, Takeda K, Gotoh T, Akira S, Araki E & Mori M (2002 ) Targeted disruption of the Chop gene delays endoplasmic reticulum stress‐mediated diabetes. J Clin Invest 109, 525–532.
Not in our library10.1172/jci14550
44.
Colombo C, Porzio O, Liu M, Massa O, Vasta M, Salardi S, Beccaria L, Monciotti C, Toni S, Pedersen O et al (2008 ) Seven mutations in the human insulin gene linked to permanent neonatal/infancy‐onset diabetes mellitus. J Clin Invest 118, 2148–2156.
Not in our library10.1172/jci33777
45.
Støy J, Edghill EL, Flanagan SE, Ye H, Paz VP, Pluzhnikov A, Below JE, Hayes MG, Cox NJ, Lipkind GM et al (2007 ) Insulin gene mutations as a cause of permanent neonatal diabetes. Proc Natl Acad Sci USA 104, 15040–15044.
Not in our library10.1073/pnas.0707291104
46.
Giampietri C, Petrungaro S, Conti S, Facchiano A, Filippini A & Ziparo E (2015 ) Cancer microenvironment and endoplasmic reticulum stress response. Mediators Inflamm 2015, 417281.
Not in our library10.1155/2015/417281
47.
Jin ML, Park SY, Kim YH, Oh J‐I, Lee SJ & Park G (2014 ) The neuroprotective effects of cordycepin inhibit glutamate‐induced oxidative and ER stress‐associated apoptosis in hippocampal HT22 cells. Neurotoxicology 41, 102–111.
Not in our library10.1016/j.neuro.2014.01.005
48.
Stechmann B, Bai S‐K, Gobbo E, Lopez R, Merer G, Pinchard S, Panigai L, Tenza D, Raposo G, Beaumelle B et al (2010 ) Inhibition of retrograde transport protects mice from lethal ricin challenge. Cell 141, 231–242.
Not in our library10.1016/j.cell.2010.01.043
49.
Olden K, Pratt RM, Jaworski C & Yamada KM (1979 ) Evidence for role of glycoprotein carbohydrates in membrane transport: specific inhibition by tunicamycin. Proc Natl Acad Sci USA 76, 791–795.
Not in our library10.1073/pnas.76.2.791
50.
Schultz AM & Oroszlan S (1979 ) Tunicamycin inhibits glycosylation of precursor polyprotein encoded by env gene of Rauscher murine leukemia virus. Biochem Biophys Res Commun 86, 1206–1213.
Not in our library10.1016/0006-291x(79)90245-6
51.
Datema R & Schwarz RT (1979 ) Interference with glycosylation of glycoproteins. Inhibition of formation of lipid‐linked oligosaccharides in vivo. Biochem J 184, 113–123.
Not in our library10.1042/bj1840113
52.
Cleland WW (1964 ) Dithiothreitol, a new protective reagent for SH groups. Biochemistry 3, 480–482.
Not in our library10.1021/bi00892a002
53.
Liu ES, Ou JH & Lee AS (1992 ) Brefeldin A as a regulator of grp78 gene expression in mammalian cells. J Biol Chem 267, 7128–7133.
Not in our library
54.
Thastrup O, Cullen PJ, Drøbak BK, Hanley MR & Dawson AP (1990 ) Thapsigargin, a tumor promoter, discharges intracellular Ca2 + stores by specific inhibition of the endoplasmic reticulum Ca2(+)‐ATPase. Proc Natl Acad Sci USA 87, 2466–2470.
Not in our library10.1073/pnas.87.7.2466
55.
Pirot P, Naamane N, Libert F, Magnusson NE, Ørntoft TF, Cardozo AK & Eizirik DL (2007 ) Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs. Diabetologia 50, 1006–1014.
Not in our library10.1007/s00125-007-0609-0
56.
Malo A, Krüger B, Göke B & Kubisch CH (2013 ) 4‐phenylbutyric acid reduces endoplasmic reticulum stress, trypsin activation, and acinar cell apoptosis while increasing secretion in rat pancreatic acini. Pancreas 42, 92–101.
Not in our library10.1097/mpa.0b013e318259f6ca
57.
Lee YY, Hong SH, Lee YJ, Chung SS, Jung HS, Park SG & Park KS (2010 ) Tauroursodeoxycholate (TUDCA), chemical chaperone, enhances function of islets by reducing ER stress. Biochem Biophys Res Commun 397, 735–739.
Not in our library10.1016/j.bbrc.2010.06.022
58.
Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Görgün CZ & Hotamisligil GS (2006 ) Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313, 1137–1140.
Not in our library10.1126/science.1128294
59.
Lepock JR (2005 ) How do cells respond to their thermal environment? Int J Hyperthermia 21, 681–687.
Not in our library10.1080/02656730500307298
60.
Bettaieb A & Averill‐Bates DA (2005 ) Thermotolerance induced at a mild temperature of 40°C protects cells against heat shock‐induced apoptosis. J Cell Physiol 205, 47–57.
Not in our library10.1002/jcp.20386
61.
Liu Y, Sakamoto H, Adachi M, Zhao S, Ukai W, Hashimoto E, Hareyama M, Ishida T, Imai K & Shinomura Y (2012 ) Heat stress activates ER stress signals which suppress the heat shock response, an effect occurring preferentially in the cortex in rats. Mol Biol Rep 39, 3987–3993.
Not in our library10.1007/s11033-011-1179-2
62.
Liu X, Wang M, Chen H, Guo Y, Ma F, Shi F, Bi Y & Li Y (2013 ) Hypothermia protects the brain from transient global ischemia/reperfusion by attenuating endoplasmic reticulum response‐induced apoptosis through CHOP. PLoS ONE 8, e53431.
Not in our library10.1371/journal.pone.0053431
63.
Mollereau B (2015 ) Cooling‐induced ER stress is good for your brain. EBioMedicine 2, 482–483.
Not in our library10.1016/j.ebiom.2015.05.008
64.
Endoplasmic Reticulum Stress and Associated ROS · 2016
No notice
65.
An Involvement of Oxidative Stress in Endoplasmic Reticulum Stress and Its Associated Diseases · 2012
No notice
66.
Cadenas E & Davies KJ (2000 ) Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 29, 222–230.
Not in our library10.1016/s0891-5849(00)00317-8
67.
Knupp J, Arvan P & Chang A (2018 ) Increased mitochondrial respiration promotes survival from endoplasmic reticulum stress. Cell Death Differ.
Not in our library10.1038/s41418-018-0133-4
68.
Tu BP & Weissman JS (2004 ) Oxidative protein folding in eukaryotes: mechanisms and consequences. J Cell Biol 164, 341–346.
Not in our library10.1083/jcb.200311055
69.
Malhotra JD & Kaufman RJ (2007 ) Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double‐edged sword? Antioxid Redox Signal 9, 2277–2293.
Not in our library10.1089/ars.2007.1782
70.
Cao SS & Kaufman RJ (2014 ) Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. Antioxid Redox Signal 21, 396–413.
Not in our library10.1089/ars.2014.5851
71.
Montibeller L & de Belleroche J (2018 ) Amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) are characterised by differential activation of ER stress pathways: focus on UPR target genes. Cell Stress Chaperones.
Not in our library10.1007/s12192-018-0897-y
72.
Bertolotti A, Zhang Y, Hendershot LM, Harding HP & Ron D (2000 ) Dynamic interaction of BiP and ER stress transducers in the unfolded‐protein response. Nat Cell Biol 2, 326–332.
Not in our library10.1038/35014014
73.
Shen J, Chen X, Hendershot L & Prywes R (2002 ) ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev Cell 3, 99–111.
Not in our library10.1016/s1534-5807(02)00203-4
74.
Kopp MC, Nowak PR, Larburu N, Adams CJ & Ali MMU (2018 ) In vitro FRET analysis of IRE1 and BiP association and dissociation upon endoplasmic reticulum stress. Elife 7, e30257.
Not in our library10.7554/elife.30257
75.
A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response · 2017
No notice
76.
Sepulveda D, Rojas‐Rivera D, Rodríguez DA, Groenendyk J, Köhler A, Lebeaupin C, Ito S, Urra H, Carreras‐Sureda A, Hazari Y et al (2018 ) Interactome screening identifies the ER luminal chaperone Hsp47 as a regulator of the unfolded protein response transducer IRE1α. Mol Cell 69, 238–252.e7.
Not in our library10.1016/j.molcel.2017.12.028
77.
Ye J, Rawson RB, Komuro R, Chen X, Davé UP, Prywes R, Brown MS & Goldstein JL (2000 ) ER stress induces cleavage of membrane‐bound ATF6 by the same proteases that process SREBPs. Mol Cell 6, 1355–1364.
Not in our library10.1016/s1097-2765(00)00133-7
78.
Carrara M, Prischi F & Ali MMU (2013 ) UPR signal activation by luminal sensor domains. Int J Mol Sci 14, 6454–6466.
Not in our library10.3390/ijms14036454
79.
Tirasophon W, Welihinda AA & Kaufman RJ (1998 ) A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev 12, 1812–1824.
Not in our library10.1101/gad.12.12.1812
80.
Wang XZ, Harding HP, Zhang Y, Jolicoeur EM, Kuroda M & Ron D (1998 ) Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J 17, 5708–5717.
Not in our library10.1093/emboj/17.19.5708
81.
Iwawaki T, Hosoda A, Okuda T, Kamigori Y, Nomura‐Furuwatari C, Kimata Y, Tsuru A & Kohno K (2001 ) Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress. Nat Cell Biol 3, 158–165.
Not in our library10.1038/35055065
82.
Bertolotti A, Wang X, Novoa I, Jungreis R, Schlessinger K, Cho JH, West AB & Ron D (2001 ) Increased sensitivity to dextran sodium sulfate colitis in IRE1β‐deficient mice. J Clin Invest 107, 585–593.
Not in our library10.1172/jci11476
83.
Martino MB, Jones L, Brighton B, Ehre C, Abdulah L, Davis CW, Ron D, O'Neal WK & Ribeiro CMP (2013 ) The ER stress transducer IRE1β is required for airway epithelial mucin production. Mucosal Immunol 6, 639–654.
Not in our library10.1038/mi.2012.105
84.
Iwawaki T, Akai R, Yamanaka S & Kohno K (2009 ) Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci USA 106, 16657–16662.
Not in our library10.1073/pnas.0903775106
85.
Bouchecareilh M, Higa A, Fribourg S, Moenner M & Chevet E (2011 ) Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response. FASEB J 25, 3115–3129.
Not in our library10.1096/fj.11-182931
86.
Sanches M, Duffy NM, Talukdar M, Thevakumaran N, Chiovitti D, Canny MD, Lee K, Kurinov I, Uehling D, Al‐awar R et al (2014 ) Structure and mechanism of action of the hydroxy‐aryl‐aldehyde class of IRE1 endoribonuclease inhibitors. Nat Commun 5, 4202.
Not in our library10.1038/ncomms5202
87.
Phosphoregulation of Ire1 RNase splicing activity · 2014
Corrected
88.
Urano F, Wang X‐Z, Bertolotti A, Zhang Y, Chung P, Harding HP & Ron D (2000 ) Coupling of stress in the endoplasmic reticulum to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287, 664–666.
Not in our library10.1126/science.287.5453.664
89.
Bork P & Sander C (1993 ) A hybrid protein kinase‐RNase in an interferon‐induced pathway? FEBS Lett 334, 149–152.
Not in our library10.1016/0014-5793(93)81701-z
90.
Sidrauski C & Walter P (1997 ) The transmembrane kinase Ire1p is a site‐specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 90, 1031–1039.
Not in our library10.1016/s0092-8674(00)80369-4
91.
Yoshida H, Matsui T, Yamamoto A, Okada T & Mori K (2001 ) XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107, 881–891.
Not in our library10.1016/s0092-8674(01)00611-0
92.
Greer CL, Peebles CL, Gegenheimer P & Abelson J (1983 ) Mechanism of action of a yeast RNA ligase in tRNA splicing. Cell 32, 537–546.
Not in our library10.1016/0092-8674(83)90473-7
93.
Sidrauski C, Cox JS & Walter P (1996 ) tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. Cell 87, 405–413.
Not in our library10.1016/s0092-8674(00)81361-6
94.
Schwer B, Sawaya R, Ho CK & Shuman S (2004 ) Portability and fidelity of RNA‐repair systems. Proc Natl Acad Sci USA 101, 2788–2793.
Not in our library10.1073/pnas.0305859101
95.
Tanaka N, Meineke B & Shuman S (2011 ) RtcB, a novel RNA ligase, can catalyze tRNA splicing and HAC1 mRNA splicing in vivo. J Biol Chem 286, 30253–30257.
Not in our library10.1074/jbc.c111.274597
96.
Baltz AG, Munschauer M, Schwanhäusser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold‐Brown D, Drew K, Milek M et al (2012 ) The mRNA‐bound proteome and its global occupancy profile on protein‐coding transcripts. Mol Cell 46, 674–690.
Not in our library10.1016/j.molcel.2012.05.021
97.
Lu Y, Liang FX & Wang X (2014 ) A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB. Mol Cell 55, 758–770.
Not in our library10.1016/j.molcel.2014.06.032
98.
Liou HC, Boothby MR, Finn PW, Davidon R, Nabavi N, Zeleznik‐Le NJ, Ting JP & Glimcher LH (1990 ) A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter. Science 247, 1581–1584.
Not in our library10.1126/science.2321018
99.
Yoshimura T, Fujisawa J & Yoshida M (1990 ) Multiple cDNA clones encoding nuclear proteins that bind to the tax‐dependent enhancer of HTLV‐1: all contain a leucine zipper structure and basic amino acid domain. EMBO J 9, 2537–2542.
Not in our library10.1002/j.1460-2075.1990.tb07434.x
100.
Nojima H, Leem Sh, Araki H, Sakai A, Nakashima N, Kanaoka Y & Ono Y (1994 ) Hac1: a novel yeast bZIP protein binding to the CRE motif is a multicopy suppressor for cdcW mutant of Schizosaccharomyces pombe. Nucleic Acids Res 22, 5279–5288.
Not in our library10.1093/nar/22.24.5279
101.
Cox JS & Walter P (1996 ) A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell 87, 391–404.
Not in our library10.1016/s0092-8674(00)81360-4
102.
Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, Clark SG & Ron D (2002 ) IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP‐1 mRNA. Nature 415, 92–96.
Not in our library10.1038/415092a
103.
Chen CY, Malchus NS, Hehn B, Stelzer W, Avci D, Langosch D & Lemberg MK (2014 ) Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u. EMBO J 33, 2492–2506.
Not in our library10.15252/embj.201488208
104.
Yanagitani K, Imagawa Y, Iwawaki T, Hosoda A, Saito M, Kimata Y & Kohno K (2009 ) Cotranslational Targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA. Mol Cell 34, 191–200.
Not in our library10.1016/j.molcel.2009.02.033
105.
Yanagitani K, Kimata Y, Kadokura H & Kohno K (2011 ) Translational pausing ensures membrane targeting and cytoplasmic splicing of XBP1u mRNA. Science 331, 586–589.
Not in our library10.1126/science.1197142
106.
Kanda S, Yanagitani K, Yokota Y, Esaki Y & Kohno K (2016 ) Autonomous translational pausing is required for XBP1u mRNA recruitment to the ER via the SRP pathway. Proc Natl Acad Sci 113, E5886–E5895.
Not in our library10.1073/pnas.1604435113
107.
Chalmers F, Sweeney B, Cain K & Bulleid NJ (2017 ) Inhibition of IRE1α‐mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response. Wellcome Open Res 2, 36.
Not in our library10.12688/wellcomeopenres.11764.2
108.
He Y, Sun S, Sha H, Liu Z, Yang L, Xue Z, Chen H & Qi L (2010 ) Emerging roles for XBP1, a sUPeR transcription factor. Gene Expr 15, 13–25.
Not in our library10.3727/105221610x12819686555051
109.
Travers KJ, Patil CK, Wodicka L, Lockhart DJ, Weissman JS & Walter P (2000 ) Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER‐associated degradation. Cell 101, 249–258.
Not in our library10.1016/s0092-8674(00)80835-1
110.
Iwakoshi NN, Lee A‐H & Glimcher LH (2003 ) The X‐box binding protein‐1 transcription factor is required for plasma cell differentiation and the unfolded protein response. Immunol Rev 194, 29–38.
Not in our library10.1034/j.1600-065x.2003.00057.x
111.
Sriburi R, Jackowski S, Mori K & Brewer JW (2004 ) XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. J Cell Biol 167, 35–41.
Not in our library10.1083/jcb.200406136
112.
Korchak HM (2008 ) Regulation of hepatic lipogenesis. Tufts Folia Med 8, 134–143.
Not in our library
113.
So JS, Hur KY, Tarrio M, Ruda V, Frank‐Kamenetsky M, Fitzgerald K, Koteliansky V, Lichtman AH, Iwawaki T, Glimcher LH et al (2012 ) Silencing of lipid metabolism genes through IRE1α‐mediated mRNA decay lowers plasma lipids in mice. Cell Metab 16, 487–499.
Not in our library10.1016/j.cmet.2012.09.004
114.
Zhou Y, Lee J, Reno CM, Sun C, Park SW, Chung J, Lee J, Fisher SJ, White MF, Biddinger SB et al (2011 ) Regulation of glucose homeostasis through a XBP‐1–FoxO1 interaction. Nat Med 17, 356–365.
Not in our library10.1038/nm.2293
115.
Park SW, Herrema H, Salazar M, Cakir I, Cabi S, Basibuyuk Sahin F, Chiu YH, Cantley LC & Ozcan U (2014 ) BRD7 regulates XBP1s’ activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K. Cell Metab 20, 73–84.
Not in our library10.1016/j.cmet.2014.04.006
116.
Liu J, Ibi D, Taniguchi K, Lee J, Herrema H, Akosman B, Mucka P, Salazar Hernandez MA, Uyar MF, Park SW et al (2016 ) Inflammation improves glucose homeostasis through IKKβ‐XBP1s interaction. Cell 167, 1052–1066.e18.
Not in our library10.1016/j.cell.2016.10.015
117.
Lee J, Sun C, Zhou Y, Lee J, Gokalp D, Herrema H, Park SW, Davis RJ & Ozcan U (2011 ) p38 MAPK–mediated regulation of Xbp1s is crucial for glucose homeostasis. Nat Med 17, 1251–1260.
Not in our library10.1038/nm.2449
118.
Yingfeng D, Zhao WV, Caroline T, Ningguo G, William HL, Anwarul F, Joyce RJ, Guosheng L, Jin Y, Mark LA et al (2013 ) The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism. J Clin Invest 123, 455–468.
Not in our library10.1172/jci62819
119.
Özcan U, Cao Q, Yilmaz E, Lee A‐H, Iwakoshi NN, Özdelen E, Tuncman G, Görgün C, Glimcher Laurie H & Hotamisligil GS (2004 ) Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306, 457–461.
Not in our library10.1126/science.1103160
120.
Akiyama M, Liew CW, Lu S, Hu J, Martinez R, Hambro B, Kennedy RT & Kulkarni RN (2013 ) X‐box binding protein 1 is essential for insulin regulation of pancreatic a‐cell function. Diabetes 62, 2439–2449.
Not in our library10.2337/db12-1747
121.
Liu Y, Adachi M, Zhao S, Hareyama M, Koong AC, Luo D & Rando TA (2010 ) Preventing oxidative stress a new role for XBP1. Cell 16, 847–857.
Not in our library10.1038/cdd.2009.14
122.
Tao R, Chen H, Gao C, Xue P, Yang F, Han J‐DJ, Zhou B & Chen Y‐G (2011 ) Xbp1‐mediated histone H4 deacetylation contributes to DNA double‐strand break repair in yeast. Cell Res 21, 1619–1633.
Not in our library10.1038/cr.2011.58
123.
Wu J & Kaufman RJ (2006 ) From acute ER stress to physiological roles of the Unfolded Protein Response. Cell Death Differ 13, 374–384.
Not in our library10.1038/sj.cdd.4401840
124.
Blais A, Tsikitis M, Acosta‐Alvear D, Sharan R, Kluger Y & Dynlacht BD (2005 ) An initial blueprint for myogenic differentiation. Genes Dev 19, 553–569.
Not in our library10.1101/gad.1281105
125.
Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi‐Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F & Glimcher LH (2001 ) Plasma cell differentiation requires the transcription factor XBP‐1. Nature 412, 300–307.
Not in our library10.1038/35085509
126.
Lee A‐H, Chu GC, Iwakoshi NN & Glimcher LH (2005 ) XBP‐1 is required for biogenesis of cellular secretory machinery of exocrine glands. EMBO J 24, 4368–4380.
Not in our library10.1038/sj.emboj.7600903
127.
Huh WJ, Esen E, Geahlen JH, Bredemeyer AJ, Lee A, Shi G, Konieczny SF, Glimcher LH & Mills JC (2010 ) XBP1 controls maturation of gastric zymogenic cells by induction of MIST1 and expansion of the rough endoplasmic reticulum. Gastroenterology 139, 2038–2049.
Not in our library10.1053/j.gastro.2010.08.050
128.
Sha H, He Y, Chen H, Wang C, Zenno A, Shi H, Yang X & Zhang X (2009 ) The IRE1α‐XBP1 pathway of the unfolded protein response is required for adipogenesis. Cell Metab 9, 556–564.
Not in our library10.1016/j.cmet.2009.04.009
129.
Masaki T, Yoshida M & Noguchi S (1999 ) Targeted disruption of CRE‐Binding factor TREB5 gene leads to cellular necrosis in cardiac myocytes at the embryonic stage. Biochem Biophys Res Commun 261, 350–356.
Not in our library10.1006/bbrc.1999.0972
130.
Reimold AM, Etkin A, Clauss I, Perkins A, Friend DS, Zhang J, Horton HF, Scott A, Orkin SH, Byrne MC et al (2000 ) An essential role in liver development for transcription factor XBP‐1. Genes Dev 14, 152–157.
Not in our library
131.
Sone M, Zeng X, Larese J & Ryoo HD (2013 ) A modified UPR stress sensing system reveals a novel tissue distribution of IRE1/XBP1 activity during normal Drosophila development. Cell Stress Chaperones 18, 307–319.
Not in our library10.1007/s12192-012-0383-x
132.
Ono SJ, Liout H, Davidont R, Strominger JL & Glimchert LH (1991 ) Human X‐box‐binding protein 1 is required for the transcription of a subset of human class II major histocompatibility genes and forms a heterodimer with c‐fos. Proc Natl Acad Sci USA 88, 4309–4312.
Not in our library10.1073/pnas.88.10.4309
133.
Ding L, Yan J, Zhu J, Zhong H, Lu Q, Wang Z, Huang C & Ye Q (2003 ) Ligand‐independent activation of estrogen receptor α by XBP‐1. Nucleic Acids Res 31, 5266–5274.
Not in our library10.1093/nar/gkg731
134.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori‐Katayama M, Bertin N et al (2010 ) An atlas of combinatorial transcriptional regulation in mouse and man. Cell 140, 744–752.
Not in our library10.1016/j.cell.2010.01.044
135.
Reinke AW, Baek J, Ashenberg O & Keating AE (2013 ) Networks of bZIP protein‐protein interactions diversified over a billion years of evolution. Science 340, 730–734.
Not in our library10.1126/science.1233465
136.
Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt MB, Hatziapostolou M, Lim E, Tam WL, Ni M, Chen Y et al (2014 ) XBP1 promotes triple‐negative breast cancer by controlling the HIF1α pathway. Nature 508, 103–107.
Not in our library10.1038/nature13119
137.
Hollien J, Lin JH, Li H, Stevens N, Walter P & Weissman JS (2009 ) Regulated Ire1‐dependent decay of messenger RNAs in mammalian cells. J Cell Biol 186, 323–331.
Not in our library10.1083/jcb.200903014
138.
Maurel M, Chevet E, Tavernier J & Gerlo S (2014 ) Getting RIDD of RNA: IRE1 in cell fate regulation. Trends Biochem Sci 39, 245–254.
Not in our library10.1016/j.tibs.2014.02.008
139.
Dual IRE1 RNase functions dictate glioblastoma development · 2018
Corrected
140.
Tirasophon W, Lee K, Callaghan B, Welihinda A & Kaufman RJ (2000 ) The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response. Genes Dev 14, 2725–2736.
Not in our library10.1101/gad.839400
141.
Hollien J & Weissman JS (2006 ) Decay of endoplasmic reticulum‐localized mRNAs during the unfolded protein response. Science 313, 104–107.
Not in our library10.1126/science.1129631
142.
Han D, Lerner AG, Vande WL, Upton J‐P, Xu W, Hagen A, Backes BJ, Oakes SA & Papa FR (2009 ) IRE1α kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell 138, 562–575.
Not in our library10.1016/j.cell.2009.07.017
143.
The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis · 2012
No notice
144.
Mishiba K‐0049, Nagashima Y, Suzuki E, Hayashi N, Ogata Y, Shimada Y & Koizumi N (2013 ) Defects in IRE1 enhance cell death and fail to degrade mRNAs encoding secretory pathway proteins in the Arabidopsis unfolded protein response. Proc Natl Acad Sci 110, 5713–5718.
Not in our library10.1073/pnas.1219047110
145.
Hayashi S, Wakasa Y, Ozawa K & Takaiwa F (2016 ) Characterization of IRE1 ribonuclease‐mediated mRNA decay in plants using transient expression analyses in rice protoplasts. New Phytol 210, 1259–1268.
Not in our library10.1111/nph.13845
146.
Oikawa D, Tokuda M, Hosoda A & Iwawaki T (2010 ) Identification of a consensus element recognized and cleaved by IRE1α. Nucleic Acids Res 38, 6265–6273.
Not in our library10.1093/nar/gkq452
147.
Iqbal J, Dai K, Seimon T, Jungreis R, Oyadomari M, Kuriakose G, Ron D, Tabas I & Hussain MM (2008 ) IRE1β Inhibits chylomicron production by selectively degrading MTP mRNA. Cell Metab 7, 445–455.
Not in our library10.1016/j.cmet.2008.03.005
148.
Imagawa Y, Hosoda A, Sasaka S, Tsuru A & Kohno K (2008 ) RNase domains determine the functional difference between IRE1α and IRE1β. FEBS Lett 582, 656–660.
Not in our library10.1016/j.febslet.2008.01.038
149.
Shi Y, Vattem KM, Sood R, An J, Liang J, Stramm L & Wek RC (1998 ) Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha‐subunit kinase, PEK, involved in translational control. Mol Cell Biol 18, 7499–7509.
Not in our library10.1128/mcb.18.12.7499
150.
Harding HP, Zhang Y & Ron D (1999 ) Protein translation and folding are coupled by an endoplasmic‐reticulum‐resident kinase. Nature 397, 271–274.
Not in our library10.1038/16729
151.
Recent insights into PERK-dependent signaling from the stressed endoplasmic reticulum [version 1; referees: 3 approved] · 2017
Not checked
152.
Lloyd MA, Osborne JC, Safer B, Powell GM & Merrick WC (1980 ) Characteristics of eukaryotic initiation factor 2 and its subunits. J Biol Chem 255, 1189–1193.
Not in our library
153.
Ernst H, Duncan RF & Hershey JWB (1987 ) Cloning and sequencing of complementary DNAs encoding the alpha‐subunit of translational initiation factor‐Eif‐2 ‐ characterization of the protein and its messenger RNA. J Biol Chem 262, 1206–1212.
Not in our library
154.
Adams SL, Safer B & Anderson WFMW (1975 ) Eukaryotic initiation complex formation. Evidence for two distinct pathways. J Biol Chem 250, 9083–9089.
Not in our library
155.
Rowlands AG, Panniers R & Henshaw EC (1988 ) The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2. J Biol Chem 263, 5526–5533.
Not in our library
156.
Harding HP, Zhang Y, Bertolotti A, Zeng H & Ron D (2000 ) Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell 5, 897–904.
Not in our library10.1016/s1097-2765(00)80330-5
157.
Hai T, Liu F, Coukos WJ & Green MR (1989 ) Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA‐binding heterodimers. Genes Dev 3, 2083–2090.
Not in our library10.1101/gad.3.12b.2083
158.
Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M & Ron D (2000 ) Regulated translation initiation controls stress‐induced gene expression in mammalian cells. Mol Cell 6, 1099–1108.
Not in our library10.1016/s1097-2765(00)00108-8
159.
Vallejo M, Ron D, Miller CP & Habener JF (1993 ) C/ATF, a member of the activating transcription factor family of DNA‐binding proteins, dimerizes with CAAT/enhancer‐binding proteins and directs their binding to cAMP response elements. Proc Natl Acad Sci USA 90, 4679–4683.
Not in our library10.1073/pnas.90.10.4679
160.
Fawcett TW, Martindale JL, Guyton KZ, Hai T & Holbrook NJ (1999 ) Complexes containing activating transcription factor (ATF)/cAMP‐responsive‐element‐binding protein (CREB) interact with the CCAAT/enhancer‐binding protein (C/EBP)–ATF composite site to regulate Gadd153 expression during the stress response. Biochem J 339, 135–141.
Not in our library
161.
Han J, Back SH, Hur J, Lin Y, Gildersleeve R, Shan J, Yuan CL, Krokowski D, Wang S, Hatzoglou M et al (2013 ) ER‐stress‐induced transcriptional regulation increases protein synthesis leading to cell death. Nat Cell Biol 15, 481–490.
Not in our library10.1038/ncb2738
162.
Hiramatsu N, Messah C, Han J, LaVail MM, Kaufman RJ & Lin JH (2014 ) Translational and posttranslational regulation of XIAP by eIF2α and ATF4 promotes ER stress‐induced cell death during the unfolded protein response. Mol Biol Cell 25, 1411–1420.
Not in our library10.1091/mbc.e13-11-0664
163.
Chen YJ, Tan BCM, Cheng YY, Chen JS & Lee SC (2009 ) Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions. Nucleic Acids Res 38, 764–777.
Not in our library10.1093/nar/gkp1034
164.
Palam LR, Baird TD & Wek RC (2011 ) Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation. J Biol Chem 286, 10939–10949.
Not in our library10.1074/jbc.m110.216093
165.
Gene Expression Regulation by Upstream Open Reading Frames and Human Disease · 2013
No notice
166.
Fornace AJ, Alamo I & Hollander MC (1988 ) DNA damage‐inducible transcripts in mammalian cells. Proc Natl Acad Sci USA 85, 8800–8804.
Not in our library10.1073/pnas.85.23.8800
167.
Fornace AJ, Nebert DW, Hollander MC, Luethy JD, Papathanasiou M, Fargnoli J & Holbrook NJ (1989 ) Mammalian genes coordinately regulated by growth arrest signals and DNA‐damaging agents. Mol Cell Biol 9, 4196–4203.
Not in our library10.1128/mcb.9.10.4196-4203.1989
168.
Lee YY, Cevallos RC & Jan E (2009 ) An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2 phosphorylation. J Biol Chem 284, 6661–6673.
Not in our library10.1074/jbc.m806735200
169.
Ma Y & Hendershot LM (2003 ) Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress. J Biol Chem 278, 34864–34873.
Not in our library10.1074/jbc.m301107200
170.
Marciniak SJ, Yun CY, Oyadomari S, Novoa I, Zhang Y, Jungreis R, Nagata K, Harding HP & Ron D (2004 ) CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev 18, 3066–3077.
Not in our library10.1101/gad.1250704
171.
Connor JH, Weiser DC, Li S, John M, Li SHI & Hallenbeck JM (2001 ) Growth arrest and DNA damage‐inducible protein GADD34 assembles a novel signaling complex containing Protein Phosphatase 1 and inhibitor 1. Mol Cell Biol 21, 6841–6850.
Not in our library10.1128/mcb.21.20.6841-6850.2001
172.
Novoa I, Zeng H, Harding HP & Ron D (2001 ) Feedback inhibition of the unfolded protein response by GADD34‐mediated dephosphorylation of eIF2alpha. J Cell Biol 153, 1011–1022.
Not in our library10.1083/jcb.153.5.1011
173.
Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, Calfon M, Sadri N, Yun C, Popko B, Paules R et al (2003 ) An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell 11, 619–633.
Not in our library10.1016/s1097-2765(03)00105-9
174.
Quirós PM, Prado MA, Zamboni N, D'Amico D, Williams RW, Finley D, Gygi SP & Auwerx J (2017 ) Multi‐omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals. J Cell Biol 216, 2027–2045.
Not in our library10.1083/jcb.201702058
175.
Rajesh K, Krishnamoorthy J, Kazimierczak U, Tenkerian C, Papadakis AI, Wang S, Huang S & Koromilas AE (2015 ) Phosphorylation of the translation initiation factor eIF2α at serine 51 determines the cell fate decisions of Akt in response to oxidative stress. Cell Death Dis 6, e1591.
Not in our library10.1038/cddis.2014.554
176.
Lee IC, Ho XY, George SE, Goh CW, Sundaram JR, Pang KKL, Luo W, Yusoff P, Sze NSK & Shenolikar S (2017 ) Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function. Cell Death Differ 25, 255–267.
Not in our library10.1038/cdd.2017.152
177.
Chen D, Fan Z, Rauh M, Buchfelder M, Eyupoglu IY & Savaskan N (2017 ) ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT‐dependent manner. Oncogene 36, 5593–5608.
Not in our library10.1038/onc.2017.146
178.
Wu Z, Li M, Zheng W, Hu Q, Cheng Z & Guo F (2017 ) Silencing of both ATF4 and PERK inhibits cell cycle progression and promotes the apoptosis of differentiating chondrocytes. Int J Mol Med 40, 101–111.
Not in our library10.3892/ijmm.2017.2985
179.
Ishizawa J, Kojima K, Chachad D, Ruvolo P, Ruvolo V, Jacamo RO, Borthakur G, Mu H, Zeng Z, Tabe Y et al (2016 ) ATF4 induction through an atypical integrated stress response to ONC201 triggers p53‐independent apoptosis in hematological malignancies. Sci Signal 9, ra17.
Not in our library10.1126/scisignal.aac4380
180.
Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors · 2017
No notice
181.
Zhu C, Johansen FE & Prywes R (1997 ) Interaction of ATF6 and serum response factor. Mol Cell Biol 17, 4957–4966.
Not in our library10.1128/mcb.17.9.4957
182.
Yamamoto K, Sato T, Matsui T, Sato M, Okada T, Yoshida H, Harada A & Mori K (2007 ) Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1. Dev Cell 13, 365–376.
Not in our library10.1016/j.devcel.2007.07.018
183.
Asada R, Kanemoto S, Kondo S, Saito A & Imaizumi K (2011 ) The signalling from endoplasmic reticulum‐resident bZIP transcription factors involved in diverse cellular physiology. J Biochem 149, 507–518.
Not in our library10.1093/jb/mvr041
184.
McMahon M, Samali A & Chevet E (2017 ) Regulation of the unfolded protein response by noncoding RNA. Am J Physiol Cell Physiol 313, C243–C254.
Not in our library10.1152/ajpcell.00293.2016
185.
Oslowski CM & Urano F (2011 ) Measuring ER stress and the unfolded protein response using mammalian tissue culture system. Methods Enzymol 490, 71–92.
Not in our library10.1016/b978-0-12-385114-7.00004-0
186.
Yoshida H, Matsui T, Hosokawa N, Kaufman RJ, Nagata K & Mori K (2003 ) A time‐dependent phase shift in the mammalian unfolded protein response. Dev Cell 4, 265–271.
Not in our library10.1016/s1534-5807(03)00022-4
187.
Sano R & Reed JC (2013 ) ER stress‐induced cell death mechanisms. Biochim Biophys Acta 1833, 3460–3470.
Not in our library10.1016/j.bbamcr.2013.06.028
188.
Bartoszewska S, Kochan K, Madanecki P, Piotrowski A, Ochocka R, Collawn JF & Bartoszewski R (2013 ) Regulation of the unfolded protein response by microRNAs. Cell Mol Biol Lett 18, 555–578.
Not in our library10.2478/s11658-013-0106-z
189.
Wortel IMN, van der Meer LT, Kilberg MS & van Leeuwen FN (2017 ) Surviving stress: modulation of ATF4‐mediated stress responses in normal and malignant cells. Trends Endocrinol Metab 28, 794–806.
Not in our library10.1016/j.tem.2017.07.003
190.
Gorman AM, Healy SJ, Jager R & Samali A (2012 ) Stress management at the ER: regulators of ER stress‐induced apoptosis. Pharmacol Ther 134, 306–316.
Not in our library10.1016/j.pharmthera.2012.02.003
191.
Ron D & Walter P (2007 ) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8, 519–529.
Not in our library10.1038/nrm2199
192.
Hoyer‐Hansen M & Jaattela M (2007 ) Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium. Cell Death Differ 14, 1576–1582.
Not in our library10.1038/sj.cdd.4402200
193.
Cheng X, Liu H, Jiang CC, Fang L, Chen C, Zhang XD & Jiang ZW (2014 ) Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin‐1 in breast cancer cells. Int J Mol Med 34, 772–781.
Not in our library10.3892/ijmm.2014.1822
194.
Giorgi C, Missiroli S, Patergnani S, Duszynski J, Wieckowski MR & Pinton P (2015 ) Mitochondria‐associated membranes: composition, molecular mechanisms, and physiopathological implications. Antioxid Redox Signal 22, 995–1019.
Not in our library10.1089/ars.2014.6223
195.
Santel A & Fuller MT (2001 ) Control of mitochondrial morphology by a human mitofusin. J Cell Sci 114, 867–874.
Not in our library10.1242/jcs.114.5.867
196.
Muñoz JP, Ivanova S, Sánchez‐Wandelmer J, Martínez‐Cristóbal P, Noguera E, Sancho A, Díaz‐Ramos A, Hernández‐Alvarez MI, Sebastián D, Mauvezin C et al (2014 ) Erratum: Mfn2 modulates the UPR and mitochondrial function via repression of PERK (EMBO Journal 32 (2348‐2361) ). EMBO J 33, 171.
Not in our library10.1038/emboj.2013.168
197.
Verfaillie T, Rubio N, Garg AD, Bultynck G, Rizzuto R, Decuypere JP, Piette J, Linehan C, Gupta S, Samali A et al (2012 ) PERK is required at the ER‐mitochondrial contact sites to convey apoptosis after ROS‐based ER stress. Cell Death Differ 19, 1880–1891.
Not in our library10.1038/cdd.2012.74
198.
Sigma-1 Receptor Chaperone at the ER-Mitochondrion Interface Mediates the Mitochondrion-ER-Nucleus Signaling for Cellular Survival · 2013
No notice
199.
Lisbona F, Rojas‐Rivera D, Thielen P, Zamorano S, Todd D, Martinon F, Glavic A, Kress C, Lin JH, Walter P et al (2009 ) BAX inhibitor‐1 is a negative regulator of the ER stress sensor IRE1alpha. Mol Cell 33, 679–691.
Not in our library10.1016/j.molcel.2009.02.017
200.
Vannuvel K, Renard P, Raes M & Arnould T (2013 ) Functional and morphological impact of ER stress on mitochondria. J Cell Physiol 228, 1802–1818.
Not in our library10.1002/jcp.24360
201.
Bravo R, Vicencio JM, Parra V, Troncoso R, Munoz JP, Bui M, Quiroga C, Rodriguez AE, Verdejo HE, Ferreira J et al (2011 ) Increased ER‐mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress. J Cell Sci 124, 2511.
Not in our library10.1242/jcs.080762
202.
Cullinan SB & Diehl JA (2004 ) PERK‐dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress. J Biol Chem 279, 20108–20117.
Not in our library10.1074/jbc.m314219200
203.
Wang C, Li H, Meng Q, Du Y, Xiao F, Zhang Q, Yu J, Li K, Chen S, Huang Z et al (2014 ) ATF4 deficiency protects hepatocytes from oxidative stress via inhibiting CYP2E1 expression. J Cell Mol Med 18, 80–90.
Not in our library10.1111/jcmm.12166
204.
Li G, Mongillo M, Chin KT, Harding H, Ron D, Marks AR & Tabas I (2009 ) Role of ERO1‐α‐mediated stimulation of inositol 1,4,5‐triphosphate receptor activity in endoplasmic reticulum stress‐induced apoptosis. J Cell Biol 186, 783–792.
Not in our library10.1083/jcb.200904060
205.
Eletto D, Chevet E, Argon Y & Appenzeller‐Herzog C (2014 ) Redox controls UPR to control redox. J Cell Sci 127, 3649–3658.
Not in our library10.1242/jcs.153643
206.
Appenzeller‐Herzog C & Hall MN (2012 ) Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling. Trends Cell Biol 22, 274–282.
Not in our library10.1016/j.tcb.2012.02.006
207.
Patricia F, Julien B, Justine L, Patrick M, Joëlle F, Cécile V, Thomas W, Serge M, Colette R, Jean‐Yves S et al (2017 ) mTOR inhibitors activate PERK signaling and favor viability of gastrointestinal neuroendocrine cell lines. Oncotarget 8, 20974–20987.
Not in our library10.18632/oncotarget.15469
208.
Tenkerian C, Krishnamoorthy J, Mounir Z, Kazimierczak U, Khoutorsky A, Staschke KA, Kristof AS, Wang S, Hatzoglou M & Koromilas AE (2015 ) mTORC2 balances AKT activation and eIF2α serine 51 phosphorylation to promote survival under stress. Mol Cancer Res 13, 1377–1388.
Not in our library10.1158/1541-7786.mcr-15-0184-t
209.
Feng B, Yao PM, Li Y, Devlin CM, Zhang D, Harding HP, Sweeney M, Rong JX, Kuriakose G, Fisher EA et al (2003 ) The endoplasmic reticulum is the site of cholesterol‐induced cytotoxicity in macrophages. Nat Cell Biol 5, 781–792.
Not in our library10.1038/ncb1035
210.
Fu S, Yang L, Li P, Hofmann O, Dicker L, Hide W, Lin X, Watkins SM, Ivanov AR & Hotamisligil GS (2011 ) Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature 473, 528–531.
Not in our library10.1038/nature09968
211.
Kaplowitz N, Than TA, Ph D, Shinohara M & Ji C (2007 ) Endoplasmic reticulum stress and liver injury. Semin Liver Dis 27, 367–377.
Not in our library10.1055/s-2007-991513
212.
Oyadomari S, Harding HP, Zhang Y, Oyadomari M & Ron D (2008 ) De‐phosphorylation of translation initiation factor 2α (eIF2α) enhances glucose tolerance and attenuates hepato‐steatosis in mice. Cell Metab 7, 520–532.
Not in our library10.1016/j.cmet.2008.04.011
213.
Li H, Meng Q, Xiao F, Chen S, Du Y, Yu J, Wang C & Guo F (2011 ) ATF4 deficiency protects mice from high‐carbohydrate‐diet‐induced liver steatosis. Biochem J 438, 283–289.
Not in our library10.1042/bj20110263
214.
Xiao G, Zhang T, Yu S, Lee S, Calabuig‐Navarro V, Yamauchi J, Ringquist S & Dong HH (2013 ) ATF4 protein deficiency protects against high fructose‐induced hypertriglyceridemia in mice. J Biol Chem 288, 25350–25361.
Not in our library10.1074/jbc.m113.470526
215.
Wang S, Chen Z, Lam V, Han J, Hassler J, Finck BN, Davidson NO & Kaufman RJ (2012 ) IRE1α‐XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis. Cell Metab 16, 473–486.
Not in our library10.1016/j.cmet.2012.09.003
216.
Lee AH, Scapa EF, Cohen DE & Glimcher LH (2008 ) Regulation of hepatic lipogenesis by the transcription factor XBP1. Science (80‐) 320, 1492–1496.
Not in our library10.1126/science.1158042
217.
Yi H, Gu C, Li M, Zhang Z, Li Q, Feng J, Zhou J & Du J (2017 ) PERK/eIF2α contributes to changes of insulin signaling in HepG2 cell induced by intermittent hypoxia. Life Sci 181, 17–22.
Not in our library10.1016/j.lfs.2017.04.022
218.
Hosogai N, Fukuhara A, Oshima K, Miyata Y, Tanaka S, Segawa K, Furukawa S, Tochino Y, Komuro R, Matsuda M et al (2007 ) Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 56, 901–911.
Not in our library10.2337/db06-0911
219.
Kim B, Kim MS & Hyun CK (2017 ) Syringin attenuates insulin resistance via adiponectin‐mediated suppression of low‐grade chronic inflammation and ER stress in high‐fat diet‐fed mice. Biochem Biophys Res Commun 488, 40–45.
Not in our library10.1016/j.bbrc.2017.05.003
220.
Lipson KL, Fonseca SG, Ishigaki S, Nguyen LX, Foss E, Bortell R, Rossini AA & Urano F (2006 ) Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum‐resident protein kinase IRE1. Cell Metab 4, 245–254.
Not in our library10.1016/j.cmet.2006.07.007
221.
Lee A‐H, Heidtman K, Hotamisligil GS & Glimcher LH (2011 ) Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion. Proc Natl Acad Sci 108, 8885–8890.
Not in our library10.1073/pnas.1105564108
222.
Seo H‐Y, Kim YD, Lee K‐M, Min A‐K, Kim M‐K, Kim H‐S, Won K‐C, Park J‐Y, Lee K‐U, Choi H‐S et al (2008 ) Endoplasmic reticulum stress‐induced activation of activating transcription factor 6 decreases insulin gene expression via up‐regulation of orphan nuclear receptor small heterodimer partner. Endocrinology 149, 3832–3841.
Not in our library10.1210/en.2008-0015
223.
Shao M, Shan B, Liu Y, Deng Y, Yan C, Wu Y, Mao T, Qiu Y, Zhou Y, Jiang S et al (2014 ) Hepatic IRE1α regulates fasting‐induced metabolic adaptive programs through the XBP1s–PPARα axis signalling. Nat Commun 5, 3528.
Not in our library10.1038/ncomms4528
224.
Kim H, Tu HC, Ren D, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ & Cheng EH (2009 ) Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis. Mol Cell 36, 487–499.
Not in our library10.1016/j.molcel.2009.09.030
225.
Gomez‐Bougie P, Halliez M, Moreau P, Pellat‐Deceunynck C & Amiot M (2016 ) Repression of Mcl‐1 and disruption of the Mcl‐1/Bak interaction in myeloma cells couple ER stress to mitochondrial apoptosis. Cancer Lett 383, 204–211.
Not in our library10.1016/j.canlet.2016.09.030
226.
Li J, Lee B & Lee AS (2006 ) Endoplasmic reticulum stress‐induced apoptosis: multiple pathways and activation of p53‐up‐regulated modulator of apoptosis (PUMA) and NOXA by p53. J Biol Chem 281, 7260–7270.
Not in our library10.1074/jbc.m509868200
227.
Ogata M, Hino S, Saito A, Morikawa K, Kondo S, Kanemoto S, Murakami T, Taniguchi M, Tanii I, Yoshinaga K et al (2006 ) Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 26, 9220–9231.
Not in our library10.1128/mcb.01453-06
228.
Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, Baehrecke EH & Lenardo MJ (2004 ) Regulation of an ATG7‐beclin 1 program of autophagic cell death by caspase‐8. Science (80‐.) 304, 1500–1502.
Not in our library10.1126/science.1096645
229.
Kim I, Shu CW, Xu W, Shiau CW, Grant D, Vasile S, Cosford ND & Reed JC (2009 ) Chemical biology investigation of cell death pathways activated by endoplasmic reticulum stress reveals cytoprotective modulators of ASK1. J Biol Chem 284, 1593–1603.
Not in our library10.1074/jbc.m807308200
230.
Deng X, Xiao L, Lang W, Gao F, Ruvolo P & May WS (2001 ) Novel Role for JNK as a Stress‐activated Bcl2 Kinase. J Biol Chem 276, 23681–23688.
Not in our library10.1074/jbc.m100279200
231.
Puthalakath H, O'Reilly LA, Gunn P, Lee L, Kelly PN, Huntington ND, Hughes PD, Michalak EM, McKimm‐Breschkin J, Motoyama N et al (2007 ) ER stress triggers apoptosis by activating BH3‐only protein Bim. Cell 129, 1337–1349.
Not in our library10.1016/j.cell.2007.04.027
232.
Yamaguchi H & Wang H‐G (2004 ) CHOP is involved in endoplasmic reticulum stress‐induced apoptosis by enhancing DR5 expression in human carcinoma cells. J Biol Chem 279, 45495–45502.
Not in our library10.1074/jbc.m406933200
233.
Maytin EV, Ubeda M, Lin JC & Habener JF (2001 ) Stress‐Inducible Transcription Factor CHOP/gadd153 Induces Apoptosis in Mammalian Cells via p38 Kinase‐Dependent and ‐Independent Mechanisms. Exp Cell Res 267, 193–204.
Not in our library10.1006/excr.2001.5248
234.
Wei S‐G, Yu Y, Weiss RM & Felder RB (2016 ) Endoplasmic reticulum stress increases brain MAPK signaling, inflammation and renin‐angiotensin system activity and sympathetic nerve activity in heart failure. Am J Physiol Heart Circ Physiol 311, H871–H880.
Not in our library10.1152/ajpheart.00362.2016
235.
Nolan K, Walter F, Tuffy LP, Poeschel S, Gallagher R, Haunsberger S, Bray I, Stallings RL, Concannon CG & Prehn JH (2016 ) Endoplasmic reticulum stress‐mediated upregulation of miR‐29a enhances sensitivity to neuronal apoptosis. Eur J Neurosci 43, 640–652.
Not in our library10.1111/ejn.13160
236.
Wu Y, Li X, Jia J, Zhang Y, Li J, Zhu Z, Wang H, Tang J & Hu J (2018 ) Transmembrane E3 ligase RNF183 mediates ER stress‐induced apoptosis by degrading Bcl‐xL. Proc Natl Acad Sci USA 115, E2762–E2771.
Not in our library10.1073/pnas.1716439115
237.
Galluzzi L, Buqué A, Kepp O, Zitvogel L & Kroemer G (2016 ) Immunogenic cell death in cancer and infectious disease. Nat Rev Immunol 17, 97.
Not in our library10.1038/nri.2016.107
238.
Garg AD & Agostinis P (2017 ) Cell death and immunity in cancer: from danger signals to mimicry of pathogen defense responses. Immunol Rev 280, 126–148.
Not in our library10.1111/imr.12574
239.
Fan H, Tang HB, Kang J, Shan L, Song H, Zhu K, Wang J, Ju G & Wang YZ (2015 ) Involvement of endoplasmic reticulum stress in the necroptosis of microglia/macrophages after spinal cord injury. Neuroscience 311, 362–373.
Not in our library10.1016/j.neuroscience.2015.10.049
240.
Linkermann A & Green DR (2014 ) Necroptosis. N Engl J Med 370, 455–465.
Not in our library10.1056/nejmra1310050
241.
Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells · 2015
No notice
242.
Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD & Levine B (2005 ) Bcl‐2 antiapoptotic proteins inhibit Beclin 1‐dependent autophagy. Cell 122, 927–939.
Not in our library10.1016/j.cell.2005.07.002
243.
Gandin V, Pellei M, Tisato F, Porchia M, Santini C & Marzano C (2012 ) A novel copper complex induces paraptosis in colon cancer cells via the activation of ER stress signalling. J Cell Mol Med 16, 142–151.
Not in our library10.1111/j.1582-4934.2011.01292.x
244.
Fan J, Long H, Li Y, Liu Y, Zhou W, Li Q, Yin G, Zhang N & Cai W (2013 ) Edaravone protects against glutamate‐induced PERK/EIF2α/ATF4 integrated stress response and activation of caspase‐12. Brain Res 1519, 1–8.
Not in our library10.1016/j.brainres.2013.04.037
245.
Akamatsu K, Shibata M‐A, Ito Y, Sohma Y, Azuma H & Otsuki Y (2009 ) Riluzole induces apoptotic cell death in human prostate cancer cells via endoplasmic reticulum stress. Anticancer Res 29, 2195–2204.
Not in our library
246.
Cao J, Dai DL, Yao L, Yu HH, Ning B, Zhang Q, Chen J, Cheng WH, Shen W & Yang ZX (2012 ) Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway. Mol Cell Biochem 364, 115–129.
Not in our library10.1007/s11010-011-1211-9
247.
Du S, Zhou J, Jia Y & Huang K (2010 ) SelK is a novel ER stress‐regulated protein and protects HepG2 cells from ER stress agent‐induced apoptosis. Arch Biochem Biophys 502, 137–143.
Not in our library10.1016/j.abb.2010.08.001
248.
Li S, Zhao F, Cheng S, Wang X & Hao Y (2013 ) Uric acid‐induced endoplasmic reticulum stress triggers phenotypic change in rat glomerular mesangial cells. Nephrology 18, 682–689.
Not in our library10.1111/nep.12127
249.
Apostolou A, Shen Y, Liang Y, Luo J & Fang S (2008 ) Armet, a UPR‐upregulated protein, inhibits cell proliferation and ER stress‐induced cell death. Exp Cell Res 314, 2454–2467.
Not in our library10.1016/j.yexcr.2008.05.001
250.
Morishima N, Nakanishi K, Takenouchi H, Shibata T & Yasuhiko Y (2002 ) An endoplasmic reticulum stress‐specific caspase cascade in apoptosis. Cytochrome c‐independent activation of caspase‐9 by caspase‐12. J Biol Chem 277, 34287–34294.
Not in our library10.1074/jbc.m204973200
251.
Saito A, Ochiai K, Kondo S, Tsumagari K, Murakami T, Cavener DR & Imaizumi K (2011 ) Endoplasmic reticulum stress response mediated by the PERK‐eIF2(alpha)‐ATF4 pathway is involved in osteoblast differentiation induced by BMP2. J Biol Chem 286, 4809–4818.
Not in our library10.1074/jbc.m110.152900
252.
Chang YJ, Chen WY, Huang CY, Liu HH & Wei PL (2015 ) Glucose‐regulated protein 78 (GRP78) regulates colon cancer metastasis through EMT biomarkers and the NRF‐2/HO‐1 pathway. Tumor Biol 36, 1859–1869.
Not in our library10.1007/s13277-014-2788-x
253.
Tanjore H, Cheng D‐S, Degryse AL, Zoz DF, Abdolrasulnia R, Lawson WE & Blackwell TS (2011 ) Alveolar epithelial cells undergo epithelial‐to‐mesenchymal transition in response to endoplasmic reticulum stress. J Biol Chem 286, 30972–30980.
Not in our library10.1074/jbc.m110.181164
254.
Mo XT, Zhou WC, Cui WH, Li DL, Li LC, Xu L, Zhao P & Gao J (2015 ) Inositol‐requiring protein 1 ‐ X‐box‐binding protein 1 pathway promotes epithelial‐mesenchymal transition via mediating snail expression in pulmonary fibrosis. Int J Biochem Cell Biol 65, 230–238.
Not in our library10.1016/j.biocel.2015.06.006
255.
Effect of hypoxia on the expression of genes encoding insulin-like growth factors and some related proteins in U87 glioma cells without IRE1 function · 2016
Not checked
256.
Li H, Chen X, Gao Y, Wu J, Zeng F & Song F (2015 ) XBP1 induces snail expression to promote epithelial‐ to‐mesenchymal transition and invasion of breast cancer cells. Cell Signal 27, 82–89.
Not in our library10.1016/j.cellsig.2014.09.018
257.
Jin C, Jin Z, Chen N‐Z, Lu M, Liu C‐B, Hu W‐L & Zheng C‐G (2016 ) Activation of IRE1α‐XBP1 pathway induces cell proliferation and invasion in colorectal carcinoma. Biochem Biophys Res Commun 470, 75–81.
Not in our library10.1016/j.bbrc.2015.12.119
258.
Feng YX, Sokol ES, Del Vecchio CA, Sanduja S, Claessen JHL, Proia TA, Jin DX, Reinhardt F, Ploegh HL, Wang Q et al (2014 ) Epithelial‐to‐mesenchymal transition activates PERK‐eIF2α and sensitizes cells to endoplasmic reticulum stress. Cancer Discov 4, 702–715.
Not in our library10.1158/2159-8290.cd-13-0945
259.
Moon SY, Kim HS, Nho KW, Jang YJ & Lee SK (2014 ) Endoplasmic reticulum stress induces epithelial‐mesenchymal transition through autophagy via activation of c‐Src kinase. Nephron Exp Nephrol 126, 127–140.
Not in our library10.1159/000362457
260.
Greenwood M, Bordieri L, Greenwood MP, Rosso Melo M, Colombari DS, Colombari E, Paton JFR & Murphy D (2014 ) Transcription factor CREB3L1 regulates vasopressin gene expression in the rat hypothalamus. J Neurosci 34, 3810–3820.
Not in our library10.1523/jneurosci.4343-13.2014
261.
Azuma Y, Hagiwara D, Lu W, Morishita Y, Suga H, Goto M, Banno R, Sugimura Y, Oyadomari S, Mori K et al (2014 ) Activating transcription factor 6α is required for the vasopressin neuron system to maintain water balance under dehydration in male mice. Endocrinology 155, 4905–4914.
Not in our library10.1210/en.2014-1522
262.
Marwarha G, Claycombe K, Schommer J, Collins D & Ghribi O (2016 ) Palmitate‐induced endoplasmic reticulum stress and subsequent C/EBPα homologous protein activation attenuates leptin and Insulin‐like growth factor 1 expression in the brain. Cell Signal 28, 1789–1805.
Not in our library10.1016/j.cellsig.2016.08.012
263.
Marwarha G, Dasari B & Ghribi O (2012 ) Endoplasmic reticulum stress‐induced CHOP activation mediates the down‐regulation of leptin in human neuroblastoma SH‐SY5Y cells treated with the oysterol 27‐hydroxycholesterol. Cell Signal 24, 484–492.
Not in our library10.1016/j.cellsig.2011.09.029
264.
Martínez‐Sánchez N, Seoane‐Collazo P, Contreras C, Varela L, Villarroya J, Rial‐Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez‐Martínez R et al (2017 ) Hypothalamic AMPK‐ER Stress‐JNK1 axis mediates the central actions of thyroid hormones on energy balance. Cell Metab 26, 212–229.e12.
Not in our library10.1016/j.cmet.2017.06.014
265.
Zughaier SM, Stauffer BB & McCarty NA (2014 ) Inflammation and ER stress downregulate BDH2 expression and dysregulate intracellular iron in macrophages. J Immunol Res 2014, 140728.
Not in our library10.1155/2014/140728
266.
Mori K (2009 ) Signalling pathways in the unfolded protein response: development from yeast to mammals. J Biochem 146, 743–750.
Not in our library10.1093/jb/mvp166
267.
Michalak M & Gye MC (2015 ) Endoplasmic reticulum stress in periimplantation embryos. Clin Exp Reprod Med 42, 1–7.
Not in our library10.5653/cerm.2015.42.1.1
268.
Li J, Chen Z, Gao LY, Colorni A, Ucko M, Fang S & Du SJ (2015 ) A transgenic zebrafish model for monitoring xbp1 splicing and endoplasmic reticulum stress in vivo. Mech Dev 137, 33–44.
Not in our library10.1016/j.mod.2015.04.001
269.
Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish · 2017
Not checked
270.
Richardson CE, Kinkel S & Kim DH (2011 ) Physiological IRE‐1‐XBP‐1 and PEK‐1 signaling in Caenorhabditis elegans larval development and immunity. PLoS Genet 7, 1–10.
Not in our library10.1371/journal.pgen.1002391
271.
Shi W, Xu G, Wang C, Sperber SM, Chen Y, Zhou Q, Deng Y & Zhao H (2015 ) Heat shock 70‐kDa protein 5 (Hspa5) is essential for pronephros formation by mediating retinoic acid signaling. J Biol Chem 290, 577–589.
Not in our library10.1074/jbc.m114.591628
272.
Luo S, Mao C, Lee B & Lee AS (2006 ) GRP78/BiP Is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development. Mol Cell Biol 26, 5688–5697.
Not in our library10.1128/mcb.00779-06
273.
Zhang X, Szabo E, Michalak M & Opas M (2007 ) Endoplasmic reticulum stress during the embryonic development of the central nervous system in the mouse. Int J Dev Neurosci 25, 455–463.
Not in our library10.1016/j.ijdevneu.2007.08.007
274.
Kratochvílová K, Moráň L, Paďourová S, Stejskal S, Tesařová L, Šimara P, Hampl A, Koutná I & Vaňhara P (2016 ) The role of the endoplasmic reticulum stress in stemness, pluripotency and development. Eur J Cell Biol 95, 115–123.
Not in our library10.1016/j.ejcb.2016.02.002
275.
Hao L, Vassena R, Wu G, Han Z, Cheng Y, Latham KE & Sapienza C (2009 ) The unfolded protein response contributes to preimplantation mouse embryo death in the DDK syndrome. Biol Reprod 80, 944–953.
Not in our library10.1095/biolreprod.108.072546
276.
Yang Y, Cheung HH, Tu J, Miu KK & Chan WY (2016 ) New insights into the unfolded protein response in stem cells. Oncotarget 7, 54010–54027.
Not in our library10.18632/oncotarget.9833
277.
Latham KE (2015 ) Endoplasmic reticulum stress signaling in mammalian oocytes and embryos: life in balance. Int Rev Cell Mol Biol 316, 227–265.
Not in our library10.1016/bs.ircmb.2015.01.005
278.
Gao Y, Sartori DJ, Li C, Yu Q‐C, Kushner JA, Simon MC & Diehl JA (2012 ) PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis. Mol Cell Biol 32, 5129–5139.
Not in our library10.1128/mcb.01009-12
279.
Bettigole SE, Lis R, Adoro S, Lee AH, Spencer LA & Weller PFGL (2015 ) The transcription factor XBP1 is selectively required for eosinophil differentiation. Nat Immunol 16, 829–837.
Not in our library10.1038/ni.3225
280.
Leung A, Gregory NS, Allen L‐AH & Sluka KA (2017 ) Regular physical activity prevents chronic pain by altering muscle macrophage phenotype and increasing IL‐10 in mice. Pain 157, 70–79.
Not in our library10.1097/j.pain.0000000000000312
281.
Todd DJ, McHeyzer‐Williams LJ, Kowal C, Lee AH, Volpe BT, Diamond B, McHeyzer‐Williams MG & Glimcher LH (2009 ) XBP1 governs late events in plasma cell differentiation and is not required for antigen‐specific memory B cell development. J Exp Med 206, 2151–2159.
Not in our library10.1084/jem.20090738
282.
van Galen P, Kreso A, Mbong N, Kent DG, Fitzmaurice T, Chambers JE, Xie S, Laurenti E, Hermans K, Eppert K et al (2014 ) The unfolded protein response governs integrity of the haematopoietic stem‐cell pool during stress. Nature 510, 268–272.
Not in our library10.1038/nature13228
283.
Matsuzaki S, Hiratsuka T, Taniguchi M, Shingaki K, Kubo T, Kiya K, Fujiwara T, Kanazawa S, Kanematsu R, Maeda T et al (2015 ) Physiological ER stress mediates the differentiation of fibroblasts. PLoS ONE 10, 1–11.
Not in our library10.1371/journal.pone.0123578
284.
Arensdorf AM, Diedrichs D & Rutkowski DT (2013 ) Regulation of the transcriptome by ER stress: non‐canonical mechanisms and physiological consequences. Front Genet 4, 1–16.
Not in our library10.3389/fgene.2013.00256
285.
Murakami T, Saito A, Hino S, Kondo S, Kanemoto S, Chihara K, Sekiya H, Tsumagari K, Ochiai K, Yoshinaga K et al (2009 ) Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation. Nat Cell Biol 11, 1205–1211.
Not in our library10.1038/ncb1963
286.
Hamamura K & Yokota H (2007 ) Stress to endoplasmic reticulum of mouse osteoblasts induces apoptosis and transcriptional activation for bone remodeling. FEBS Lett 581, 1769–1774.
Not in our library10.1016/j.febslet.2007.03.063
287.
Cui M, Kanemoto S, Cui X, Kaneko M, Asada R, Matsuhisa K, Tanimoto K, Yoshimoto Y, Shukunami C & Imaizumi K (2015 ) OASIS modulates hypoxia pathway activity to regulate bone angiogenesis. Sci Rep 5, 16455.
Not in our library10.1038/srep16455
288.
Kondo S, Murakami T, Tatsumi K, Ogata M, Kanemoto S, Otori K, Iseki K, Wanaka A & Imaizumi K (2005 ) OASIS, a CREB/ATF‐family member, modulates UPR signalling in astrocytes. Nat Cell Biol 7, 186–194.
Not in our library10.1038/ncb1213
289.
Asada R, Saito A, Kawasaki N, Kanemoto S, Iwamoto H, Oki M, Miyagi H, Izumi S & Imaizumi K (2012 ) The endoplasmic reticulum stress transducer OASIS is involved in the terminal differentiation of goblet cells in the large intestine. J Biol Chem 287, 8144–8153.
Not in our library10.1074/jbc.m111.332593
290.
Saito A (2014 ) Physiological functions of endoplasmic reticulum stress transducer OASIS in central nervous system. Anat Sci Int 89, 11–20.
Not in our library10.1007/s12565-013-0214-x
291.
van der Harg JM, van Heest JC, Bangel FN, Patiwael S, van Weering JRT & Scheper W (2017 ) The UPR reduces glucose metabolism via IRE1 signaling. Biochim Biophys Acta 1864, 655–665.
Not in our library10.1016/j.bbamcr.2017.01.009
292.
Topisirovic I & Sonenberg N (2011 ) mRNA translation and energy metabolism in cancer: the role of the MAPK and mTORC1 Pathways. Cold Spring Harb Symp Quant Biol 76, 355–367.
Not in our library10.1101/sqb.2011.76.010785
293.
Lowe CE, Dennis RJ, Obi U, O'Rahilly S & Rochford JJ (2012 ) Investigating the involvement of the ATF6α pathway of the unfolded protein response in adipogenesis. Int J Obes (Lond) 36, 1248–1251.
Not in our library10.1038/ijo.2011.233
294.
The Role of IRE1α in the Degradation of Insulin mRNA in Pancreatic β-Cells · 2008
No notice
295.
Zhang N, Yang X, Yuan F, Zhang L, Wang Y, Wang L, Mao Z, Luo J, Zhang H, Zhu WG et al (2018 ) Increased amino acid uptake supports autophagy‐deficient cell survival upon glutamine deprivation. Cell Rep 10, 3006–3020.
Not in our library10.1016/j.celrep.2018.05.006
296.
Rubio‐Patiño C, Bossowski JP, De Donatis GM, Mondragón L, Villa E, Aira LE, Chiche J, Mhaidly R, Lebeaupin C, Marchetti S et al (2018 ) Low‐protein diet induces IRE1α‐dependent anticancer immunosurveillance. Cell Metab 27, 828–842.
Not in our library10.1016/j.cmet.2018.02.009
297.
Xue Z, He Y, Ye K, Gu Z, Mao Y & Qi L (2011 ) A conserved structural determinant located at the interdomain region of mammalian inositol‐requiring enzyme 1α. J Biol Chem 286, 30859–30866.
Not in our library10.1074/jbc.m111.273714
298.
Waller DD, Jansen G, Golizeh M, Martel‐Lorion C, Dejgaard K, Shiao TC, Mancuso J, Tsantrizos YS, Roy R, Sebag M et al (2016 ) A covalent cysteine‐targeting kinase inhibitor of Ire1 permits allosteric control of endoribonuclease activity. ChemBioChem 17, 843–851.
Not in our library10.1002/cbic.201500485
299.
Wiseman RL, Zhang Y, Lee KPK, Harding HP, Haynes CM, Price J, Sicheri F & Ron D (2010 ) Flavonol activation defines an unanticipated ligand‐binding site in the kinase‐RNase domain of IRE1. Mol Cell 38, 291–304.
Not in our library10.1016/j.molcel.2010.04.001
300.
Rong J, Pass I, Diaz PW, Ngo TA, Sauer M, Magnuson G, Zeng F‐Y, Hassig CA, Jackson MR, Cosford NDP et al (2015 ) Cell‐based high‐throughput luciferase reporter gene assays for identifying and profiling chemical modulators of endoplasmic reticulum signaling protein, IRE1. J Biomol Screen 20, 1232–1245.
Not in our library10.1177/1087057115600414
301.
Feldman HC, Tong M, Wang L, Meza‐Acevedo R, Gobillot TA, Lebedev I, Gliedt MJ, Hari SB, Mitra AK, Backes BJ et al (2016 ) Structural and functional analysis of the allosteric inhibition of IRE1α with ATP‐competitive ligands. ACS Chem Biol 11, 2195–2205.27227314
Not in our library
302.
Harrington PE, Biswas K, Malwitz D, Tasker AS, Mohr C, Andrews KL, Dellamaggiore K, Kendall R, Beckmann H, Jaeckel P et al (2015 ) Unfolded protein response in cancer: IRE1α inhibition by selective kinase ligands does not impair tumor cell viability. ACS Med Chem Lett 6, 68–72.
Not in our library10.1021/ml500315b
303.
Wang L, Perera BGK, Hari SB, Bhhatarai B, Backes BJ, Seeliger MA, Schürer SC, Oakes SA, Papa FR & Maly DJ (2012 ) Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nat Chem Biol 8, 982–989.
Not in our library10.1038/nchembio.1094
304.
Jha BK, Polyakova I, Kessler P, Dong B, Dickerman B, Sen GC & Silverman RH (2011 ) Inhibition of RNase L and RNA‐dependent protein kinase (PKR) by sunitinib impairs antiviral innate immunity. J Biol Chem 286, 26319–26326.
Not in our library10.1074/jbc.m111.253443
305.
Volkmann K, Lucas JL, Vuga D, Wang X, Brumm D, Stiles C, Kriebel D, Der‐Sarkissian A, Krishnan K, Schweitzer C et al (2011 ) Potent and selective inhibitors of the inositol‐requiring enzyme 1 endoribonuclease. J Biol Chem 286, 12743–12755.
Not in our library10.1074/jbc.m110.199737
306.
Cross BC, Bond PJ, Sadowski PG, Jha BK, Zak J, Goodman JM, Silverman RH, Neubert TA, Baxendale IR, Ron D et al (2012 ) The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1‐binding small molecule. Proc Natl Acad Sci USA 109, E869–E878.
Not in our library10.1073/pnas.1115623109
307.
Mimura N, Fulciniti M, Gorgun G, Tai Y‐T, Cirstea D, Santo L, Hu Y, Fabre C, Minami J, Ohguchi H et al (2012 ) Blockade of XBP1 splicing by inhibition of IRE1 is a promising therapeutic option in multiple myeloma. Blood 119, 5772–5781.
Not in our library10.1182/blood-2011-07-366633
308.
Papandreou I, Denko NC, Olson M, Van Melckebeke H, Lust S, Tam A, Solow‐Cordero DE, Bouley DM, Offner F, Niwa M et al (2011 ) Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood 117, 1311–1314.
Not in our library10.1182/blood-2010-08-303099
309.
Ri M, Tashiro E, Oikawa D, Shinjo S, Tokuda M, Yokouchi Y, Narita T, Masaki A, Ito A, Ding J et al (2012 ) Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress‐induced XBP1 mRNA splicing. Blood Cancer J 2, e79.
Not in our library10.1038/bcj.2012.26
310.
Tomasio SM, Harding HP, Ron D, Cross BCS & Bond PJ (2013 ) Selective inhibition of the unfolded protein response: targeting catalytic sites for Schiff base modification. Mol BioSyst 9, 2408–2416.
Not in our library10.1039/c3mb70234k
311.
Jiang D, Lynch C, Medeiros BC, Liedtke M, Bam R, Tam AB, Yang Z, Alagappan M, Abidi P, Le Q‐T et al (2016 ) Identification of Doxorubicin as an Inhibitor of the IRE1α‐XBP1 Axis of the Unfolded Protein Response. Sci Rep 6, 33353.
Not in our library10.1038/srep33353
312.
Park BK, Boobis A, Clarke S, Goldring CEP, Jones D, Kenna JG, Lambert C, Laverty HG, Naisbitt DJ, Nelson S et al (2011 ) Managing the challenge of chemically reactive metabolites in drug development. Nat Rev Drug Discov 10, 292–306.
Not in our library10.1038/nrd3408
313.
Wilson AJ (2009 ) Inhibition of protein–protein interactions using designed molecules. Chem Soc Rev 38, 3289.
Not in our library10.1039/b807197g
314.
Atkins C, Liu Q, Minthorn E, Zhang S‐Y, Figueroa DJ, Moss K, Stanley TB, Sanders B, Goetz A, Gaul N et al (2013 ) Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res 73, 1993–2002.
Not in our library10.1158/0008-5472.can-12-3109
315.
Axten JM, Medina JR, Feng Y, Shu A, Romeril SP, Grant SW, Li WH, Heerding DA, Minthorn E, Mencken T et al (2012 ) Discovery of 7‐methyl‐5‐(1‐{[3‐(trifluoromethyl)phenyl]acetyl}‐2,3‐dihydro‐1H‐indol‐5‐yl)‐7H‐pyrrolo[2,3‐d]pyrimidin‐4‐amine (GSK2606414), a potent and selective first‐in‐class inhibitor of protein kinase R (PKR)‐like endoplasmic reticulum kinase (PERK). J Med Chem 55, 7193–7207.
Not in our library10.1021/jm300713s
316.
Moreno JA, Halliday M, Molloy C, Radford H, Verity N, Axten JM, Ortori CA, Willis AE, Fischer PM, Barrett DA et al (2013 ) Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion‐infected mice. Sci Transl Med 138, 206ra138.
Not in our library10.1126/scitranslmed.3006767
317.
Harding HP, Zeng H, Zhang Y, Jungries R, Chung P, Plesken H, Sabatini DD & Ron D (2001 ) Diabetes mellitus and exocrine pancreatic dysfunction in perk‐/‐ mice reveals a role for translational control in secretory cell survival. Mol Cell 7, 1153–1163.
Not in our library10.1016/s1097-2765(01)00264-7
318.
Rojas‐Rivera D, Delvaeye T, Roelandt R, Nerinckx W, Augustyns K, Vandenabeele P & Bertrand MJ (2017 ) When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157. Cell Death Differ 24, 1100–1110.
Not in our library10.1038/cdd.2017.58
319.
Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response · 2015
No notice
320.
Sekine Y, Zyryanova A, Crespillo‐Casado A, Fischer PM, Harding HP & Ron D (2015 ) Stress responses. Mutations in a translation initiation factor identify the target of a memory‐enhancing compound. Science 348, 1027–1030.
Not in our library10.1126/science.aaa6986
321.
Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity · 2015
No notice
322.
The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly · 2015
No notice
323.
Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch · 2016
No notice
324.
Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress · 2016
No notice
325.
Bu L, Yu H, Fan L, Li X, Wang F, Liu J, Zhong F, Zhang C, Wei W, Wang H et al (2017 ) Melatonin, a novel selective ATF‐6 inhibitor, induces human hepatoma cell apoptosis through COX‐2 downregulation. World J Gastroenterol 23, 986–998.
Not in our library10.3748/wjg.v23.i6.986
326.
Xu S, Butkevich AN, Yamada R, Zhou Y, Debnath B, Duncan R, Zandi E, Petasis NA & Neamati N (2012 ) Discovery of an orally active small‐molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc Natl Acad Sci 109, 16348–16353.
Not in our library10.1073/pnas.1205226109
327.
Banerjee R, Pace NJ, Brown DR & Weerapana E (2013 ) 1,3,5‐Triazine as a modular scaffold for covalent inhibitors with streamlined target identification. J Am Chem Soc 135, 2497–2500.
Not in our library10.1021/ja400427e
328.
Chevet E, Hetz C & Samali A (2015 ) Endoplasmic reticulum stress‐activated cell reprogramming in oncogenesis. Cancer Discov 5, 586–597.
Not in our library10.1158/2159-8290.cd-14-1490
329.
Okada T, Haze K, Nadanaka S, Yoshida H, Seidah NG, Hirano Y, Sato R, Negishi M & Mori K (2003 ) A serine protease inhibitor prevents endoplasmic reticulum stress‐induced cleavage but not transport of the membrane‐bound transcription factor ATF6. J Biol Chem 278, 31024–31032.
Not in our library10.1074/jbc.m300923200
330.
Doultsinos D, Avril T, Lhomond S, Dejeans N, Guédat P & Chevet E (2017 ) Control of the unfolded protein response in health and disease. SLAS Discov 22, 787–800.
Not in our library10.1177/2472555217701685
331.
Delpino A & Castelli M (2002 ) The 78 kDa glucose‐regulated protein (GRP78/BIP) is expressed on the cell membrane, is released into cell culture medium and is also present in human peripheral circulation. Biosci Rep 22, 407–420.
Not in our library10.1023/a:1020966008615
332.
Chessler SD & Byers PH (1993 ) BiP binds type I procollagen pro alpha chains with mutations in the carboxyl‐terminal propeptide synthesized by cells from patients with osteogenesis imperfecta. J Biol Chem 268, 18226–18233.
Not in our library
333.
Booth L, Roberts JL, Cash DR, Tavallai S, Jean S, Fidanza A, Cruz‐Luna T, Siembiba P, Cycon KA, Cornelissen CN et al (2015 ) GRP78/BiP/HSPA5/DNA K is a universal therapeutic target for human disease. J Cell Physiol 230, 1661–1676.
Not in our library10.1002/jcp.24919
334.
Zhu H, Chen X, Chen B, Chen B, Song W, Sun D & Zhao Y (2014 ) Activating transcription factor 4 promotes esophageal squamous cell carcinoma invasion and metastasis in mice and is associated with poor prognosis in human patients. PLoS ONE 9, 1–11.
Not in our library10.1371/journal.pone.0103882
335.
Yang J, Cheng D, Zhou S, Zhu B, Hu T & Yang Q (2015 ) Overexpression of X‐Box binding protein 1 (XBP1) correlates to poor prognosis and up‐regulation of PI3K/mTOR in human osteosarcoma. Int J Mol Sci 16, 28635–28646.
Not in our library10.3390/ijms161226123
336.
Bujisic B, De Gassart A, Tallant R, Demaria O, Zaffalon L, Chelbi S, Gilliet M, Bertoni F & Martinon F (2017 ) Impairment of both IRE1 expression and XBP1 activation is a hallmark of GCB DLBCL and contributes to tumor growth. Blood 129, 2420–2428.
Not in our library10.1182/blood-2016-09-741348
337.
Kaser A, Lee A‐H, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EES, Higgins DE, Schreiber S, Glimcher LH et al (2008 ) XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134, 743–756.
Not in our library10.1016/j.cell.2008.07.021
338.
Atkin JD, Farg MA, Walker AK, McLean C, Tomas D & Horne MK (2008 ) Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis. Neurobiol Dis 30, 400–407.
Not in our library10.1016/j.nbd.2008.02.009
339.
Amyotrophic Lateral Sclerosis Multiprotein Biomarkers in Peripheral Blood Mononuclear Cells · 2011
No notice
340.
Kim Y, Lee H, Manson SR, Lindahl M, Evans B, Miner JH, Urano F & Chen YM (2016 ) Mesencephalic astrocyte‐derived neurotrophic factor as a urine biomarker for endoplasmic reticulum stress‐related kidney diseases. J Am Soc Nephrol 27, 2974–2982.
Not in our library10.1681/asn.2014100986
341.
Mami I, Bouvier N, El Karoui K, Gallazzini M, Rabant M, Laurent‐Puig P, Li S, Tharaux PL, Beaune P, Thervet E et al (2016 ) Angiogenin mediates cell‐autonomous translational control under endoplasmic reticulum stress and attenuates kidney injury. J Am Soc Nephrol 27, 863–876.
Not in our library10.1681/asn.2015020196
342.
Dadey DYA, Kapoor V, Hoye K, Khudanyan A, Collins A, Thotala D & Hallahan DE (2016 ) Antibody targeting GRP78 enhances the efficacy of radiation therapy in human glioblastoma and non‐small‐cell lung cancer cell lines and tumor models. Clin Cancer Res 23, 2556–2564.
Not in our library10.1158/1078-0432.ccr-16-1935
343.
Lin YG, Shen J, Yoo E, Liu R, Yen HY, Mehta A, Rajaei A, Yang W, Mhawech‐Fauceglia P, DeMayo FJ et al (2015 ) Targeting the glucose‐regulated protein‐78 abrogates Pten‐null driven AKT activation and endometrioid tumorigenesis. Oncogene 34, 5418–5426.
Not in our library10.1038/onc.2015.4
344.
Chen YG, Ashok BT, Liu X, Garikapaty VPS, Mittelman A & Tiwari RK (2003 ) Induction of heat shock protein gp96 by immune cytokines. Cell Stress Chaperones 8, 242–248.
Not in our library10.1379/1466-1268(2003)008<0242:iohspg>2.0.co;2
345.
Zhang K, Peng Z, Huang X, Qiao Z, Wang X, Wang N, Xi H, Cui J, Gao Y, Huang X et al (2017 ) Phase II trial of adjuvant immunotherapy with autologous tumor‐derived Gp96 vaccination in patients with gastric cancer. J Cancer 8, 1826–1832.
Not in our library10.7150/jca.18946
346.
Tian S, Liu Z, Donahue C, Falo LD Jr & You Z (2012 ) Genetic targeting of the active transcription factor XBP1s to dendritic cells potentiates vaccine‐induced prophylactic and therapeutic antitumor immunity. Mol Ther 20, 432–442.
Not in our library10.1038/mt.2011.183
347.
Miller M, Rosenthal P, Beppu A, James L, Hoffman HM, Tam AB, Taylor A, Mcgeough MD, Pena CA, Niwa M et al (2014 ) ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma. J Immunol 192, 3475–3487.
Not in our library10.4049/jimmunol.1303047
348.
Endoplasmic reticulum chaperones and their roles in the immunogenicity of cancer vaccines · 2015
Not checked
349.
Graner MW, Zeng Y, Feng H & Katsanis E (2003 ) Tumor‐derived chaperone‐rich cell lysates are effective therapeutic vaccines against a variety of cancers. Cancer Immunol Immunother 52, 226–234.
Not in our library10.1007/s00262-002-0359-2
350.
Rapp UK & Kaufmann SH (2004 ) DNA vaccination with gp96‐peptide fusion proteins induces protection against an intracellular bacterial pathogen. Int Immunol 16, 597–605.
Not in our library10.1093/intimm/dxh064
351.
Qian J, Hong S, Wang S, Zhang L, Sun L, Wang M, Yang J & Kwak LW (2009 ) Myeloma cell line – derived, pooled heat shock proteins as a universal vaccine for immunotherapy of multiple myeloma. Blood 114, 3880–3890.
Not in our library10.1182/blood-2009-06-227355
352.
Argon Y & Simen BB (1999 ) GRP94, an ER chaperone with protein and peptide binding properties. Semin Cell Dev Biol 10, 495–505.
Not in our library10.1006/scdb.1999.0320
353.
Liu D, Liu X, Zhou T, Yao W, Zhao J, Zheng Z, Jiang W, Wang F, Aikhionbare FO, Hill DL et al (2015 ) IRE1‐RACK1 axis orchestrates ER stress preconditioning‐elicited cytoprotection from ischemia/reperfusion injury in liver. J Mol Cell Biol 8, 144–156.
Not in our library10.1093/jmcb/mjv066
354.
Bailly‐Maitre B, Fondevila C, Kaldas F, Droin N, Luciano F, Ricci J‐E, Croxton R, Krajewska M, Zapata JM, Kupiec‐Weglinski JW et al (2006 ) Cytoprotective gene bi‐1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia‐reperfusion injury. Proc Natl Acad Sci USA 103, 2809–2814.
Not in our library10.1073/pnas.0506854103
355.
Bi X, Zhang G, Wang X, Nguyen C, May HI, Li X, Al‐Hashimi AA, Austin RC, Gillette TG, Fu G et al (2018 ) Endoplasmic reticulum chaperone GRP78 protects heart from ischemia/reperfusion injury through Akt activation. Circ Res 122, 1545–1554.
Not in our library10.1161/circresaha.117.312641
356.
Martindale JJ, Fernandez R, Thuerauf D, Whittaker R, Gude N, Sussman MA & Glembotski CC (2006 ) Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen‐regulated form of ATF6. Circ Res 98, 1186–1193.
Not in our library10.1161/01.res.0000220643.65941.8d
357.
Peralta C & Brenner C (2011 ) Endoplasmic reticulum stress inhibition enhances liver tolerance to ischemia/reperfusion. Curr Med Chem 18, 2016–2024.
Not in our library10.2174/092986711795590039
358.
Folch‐Puy E, Panisello A, Oliva J, Lopez A, Benítez CC, Adam R & Roselló‐Catafau J (2016 ) Relevance of endoplasmic reticulum stress cell signaling in liver cold ischemia reperfusion injury. Int J Mol Sci 17, 1–12.
Not in our library10.3390/ijms17060807
359.
Kwon SK, Ahn M, Song HJ, Kang SK, Jung SB, Harsha N, Jee S, Moon JY, Suh KS, Do LS et al (2015 ) Nafamostat mesilate attenuates transient focal ischemia/reperfusion‐induced brain injury via the inhibition of endoplasmic reticulum stress. Brain Res 1627, 12–20.
Not in our library10.1016/j.brainres.2015.09.013
360.
Zhang H, Yue Y, Sun T, Wu X & Xiong S (2017 ) Transmissible endoplasmic reticulum stress from myocardiocytes to macrophages is pivotal for the pathogenesis of CVB3‐induced viral myocarditis. Sci Rep 7, 42162.
Not in our library10.1038/srep42162
361.
Rodvold JJ, Chiu KT, Hiramatsu N, Nussbacher JK, Galimberti V, Mahadevan NR, Willert K, Lin JH & Zanetti M (2017 ) Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells. Sci Signal 10, eaah7177
Not in our library10.1126/scisignal.aah7177
362.
Brownlie RJ, Myers LK, Wooley PH, Corrigall VM, Bodman‐Smith MD, Panayi GS & Thompson SJ (2006 ) Treatment of murine collagen‐induced arthritis by the stress protein BiP Via interleukin‐4 – producing regulatory t cells a novel function for an ancient protein. Arthritis Rheumatol 54, 854–863.
Not in our library10.1002/art.21654
363.
Kirkham B, Chaabo K, Hall C, Garrood T, Mant T, Allen E, Vincent A, Vasconcelos JC, Prevost AT, Panayi GS et al (2016 ) Safety and patient response as indicated by biomarker changes to binding immunoglobulin protein in the phase I/IIA RAGULA clinical trial in rheumatoid arthritis. Rheumatology (United Kingdom) 55, 1993–2000.
Not in our library10.1093/rheumatology/kew287
364.
Axten JM, Romeril SP, Shu A, Ralph J, Medina JR, Feng Y, Li WHH, Grant SW, Heerding DA, Minthorn E et al (2013 ) Discovery of GSK2656157: an optimized perk inhibitor selected for preclinical development. ACS Med Chem Lett 4, 964–968.
Not in our library10.1021/ml400228e
365.
Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D et al (2005 ) A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science 307, 935–939.
Not in our library10.1126/science.1101902
366.
Saxena S, Cabuy E & Caroni P (2009 ) A role for motoneuron subtype‐selective ER stress in disease manifestations of FALS mice. Nat Neurosci 12, 627–636.
Not in our library10.1038/nn.2297
367.
Colla E, Coune P, Liu Y, Pletnikova O, Troncoso JC, Iwatsubo T, Schneider BL & Lee MK (2012 ) Endoplasmic reticulum stress is important for the manifestations of α‐synucleinopathy in vivo. J Neurosci 32, 3306–3320.
Not in our library10.1523/jneurosci.5367-11.2012
368.
Guanabenz, which enhances the unfolded protein response, ameliorates mutant SOD1-induced amyotrophic lateral sclerosis · 2014
Not checked
369.
Das I, Krzyzosiak A, Schneider K, Wrabetz L, D'Antonio M, Barry N & Sigurdardottir ABA (2015 ) Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science 348, 239–242.
Not in our library10.1126/science.aaa4484
370.
Lee A‐H, Iwakoshi NN & Glimcher LH (2003 ) XBP‐1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol 23, 7448–7459.
Not in our library10.1128/mcb.23.21.7448-7459.2003
371.
Ghosh R, Wang L, Wang ES, Perera BGK, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H et al (2014 ) Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress. Cell 158, 534–548.
Not in our library10.1016/j.cell.2014.07.002
372.
Kawamura T, Tashiro E, Shindo K & Imoto M (2008 ) SAR study of a novel triene‐ansamycin group compound, quinotrierixin, and related compounds, as inhibitors of ER stress‐induced XBP1 activation II. Structure elucidation. J Antibiot (Tokyo) 61, 312–317.
Not in our library10.1038/ja.2008.44
373.
Chen D, Landis‐Piwowar KR, Chen MS & Dou QP (2007 ) Inhibition of proteasome activity by the dietary flavonoid apigenin is associated with growth inhibition in cultured breast cancer cells and xenografts. Breast Cancer Res 9, R80.
Not in our library10.1186/bcr1797
374.
Zhu M, Rajamani S, Kaylor J, Han S, Zhou F & Fink AL (2004 ) The flavonoid baicalein inhibits fibrillation of alpha‐synuclein and disaggregates existing fibrils. J Biol Chem 279, 26846–26857.
Not in our library10.1074/jbc.m403129200
375.
Kim D‐S, Ha K‐C, Kwon D‐Y, Kim M‐S, Kim H‐R, Chae S‐W & Chae H‐J (2008 ) Kaempferol protects ischemia/reperfusion‐induced cardiac damage through the regulation of endoplasmic reticulum stress. Immunopharmacol Immunotoxicol 30, 257–270.
Not in our library10.1080/08923970701812530
376.
Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation · 2016
No notice
377.
Higa A, Taouji S, Lhomond S, Jensen D, Fernandez‐Zapico ME, Simpson JC, Pasquet JM, Schekman R & Chevet E (2014 ) Endoplasmic reticulum stress‐activated transcription factor atf6α requires the disulfide isomerase PDIA5 to modulate chemoresistance. Mol Cell Biol 34, 1839–1849.
Not in our library10.1128/mcb.01484-13

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