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Humidity – The overlooked variable in the thermal biology of mosquito‐borne disease

Joel J. Brown, Mercedes Pascual, Michael C. Wimberly and 2 more

Ecology Letters · 2023 · CC BY

doi:10.22541/au.168053633.38060615/v1

Abstract

Vector‐borne diseases cause significant financial and human loss, with billions of dollars spent on control. Arthropod vectors experience a complex suite of environmental factors that affect fitness, population growth and species interactions across multiple spatial and temporal scales. Temperature and water availability are two of the most important abiotic variables influencing their distributions and abundances. While extensive research on temperature exists, the influence of humidity on vector and pathogen parameters affecting disease dynamics are less understood. Humidity is often underemphasized, and when considered, is often treated as independent of temperature even though desiccation likely contributes to declines in trait performance at warmer temperatures. This Perspectives explores how humidity shapes the thermal performance of mosquito‐borne pathogen transmission. We summarize what is known about its effects and propose a conceptual model for how temperature and humidity interact to shape the range of temperatures across which mosquitoes persist and achieve high transmission potential. We discuss how failing to account for these interactions hinders efforts to forecast transmission dynamics and respond to epidemics of mosquito‐borne infections. We outline future research areas that will ground the effects of humidity on the thermal biology of pathogen transmission in a theoretical and empirical framework to improve spatial and temporal prediction of vector‐borne pathogen transmission.

Full text

From PubMed Central, U.S. National Library of Medicine, as current on Oct 26, 2026. Paragraph numbers are ours, so an answer can point at one.

INTRODUCTION

1Vector-borne parasites are common, important biological enemies of humans, animals and plants, transmitted by one living organism to another. Despite the recent gains in reducing the overall global burden for parasites like malaria, vector-borne diseases still account for 17% of all infectious diseases and cause 700,000 deaths in humans annually. Livestock and crop systems are also plagued by vector-borne diseases, which place serious constraints on agricultural production globally, and vector-borne diseases can be devastating in wildlife populations, particularly when introduced to new areas. Collectively, tens of billions of dollars are spent every year on control, medical interventions and mitigating loss of productivity.

2The dependence of many pathogens on ectothermic arthropod vectors for transmission means that vector-borne diseases are highly sensitive to variation in the environment. Arthropod vectors experience a complex suite of environmental factors, both abiotic (e.g., temperature, rainfall, humidity, salinity) and biotic (e.g., biological enemies, inter- and intraspecific interactions and variation in habitat quality). These factors vary in their relative effects on organismal fitness, can synergize, and exert their effects at different spatial scales with important consequences for the abundance and distribution of arthropod vectors, vector population dynamics and pathogen transmission.

3In vector ecology, there has been a strong emphasis on studying the effects of temperature on mosquito-borne pathogen transmission (reviewed in ). In addition to temperature, water availability is another critical abiotic variable influencing ectotherm biology, and both play important roles determining the distribution and abundance of ectotherms and species richness. Body temperature has important effects on the rates of enzymatic processes as well as the structural integrity of cellular membranes and proteins, while all cellular processes rely on water as a solvent for biochemical reactions and for trafficking nutrients into, within, and out of cells. Temperature also affects the amount of desiccation stress an organism experiences due to the fundamental relationship between ambient temperature and the amount of water the surrounding air can hold. Other fields at the climate-health interface have explored the effects of wet heat vs dry heat on the energy budgets of endotherms in the context of human heat stress and climate change. We anticipate that variation in relative humidity is also an important force shaping the thermal performance of ectotherms, including mosquitoes. Whereas metabolic theory has been well developed and widely applied in ecology to understand temperature effects we currently lack a similar framework for understanding how humidity and temperature interact to influence mosquitoes and their pathogens.

4In this Perspectives, we explore the effects of humidity on the thermal performance of mosquito-borne pathogen transmission. We begin by summarizing what is currently known about how temperature and humidity affects mosquito fitness, population dynamics and pathogen transmission, whilst highlighting current knowledge gaps. We present a conceptual framework for understanding the interaction between temperature and humidity and how it shapes the range of temperatures across which mosquitoes persist and achieve high transmission potential. We then discuss how failing to account for these interactions across climate variables hinders efforts to forecast transmission dynamics and to respond to epidemics of mosquito-borne infections. We end by outlining future research areas that will ground the effects of humidity on thermal performance of pathogen transmission in a theoretical and empirical basis to improve spatial and temporal prediction of vector-borne pathogen transmission. Such a framework will inform multiple fields (thermal, disease and landscape ecology and epidemiology) and a diversity of vector-borne disease systems (human, wildlife, domestic animals and plants).

THE EFFECTS OF TEMPERATURE ON MOSQUITO POPULATION DYNAMICS AND PATHOGEN TRANSMISSION

5Numerous studies have demonstrated that mosquito-borne pathogen transmission is both seasonally and geographically limited at various spatial scales by variation in ambient temperature (e.g., malaria, Zika, chikungunya and dengue). The effects of temperature on ectotherm performance, including mosquito vectors, are typically non-linear, with performance steadily increasing from zero at a minimum critical temperature (CTmin) up to an optimum temperature (Topt), followed by a steep decline towards the critical thermal maximum (CTmax) (Figure 1). The CTmin and CTmax represent the operational limits for trait performance because temperatures that exceed their range are not permissive for ectotherm development, survival or reproduction. These thermal limits in ectotherm performance are consistent with the metabolic theory of ecology, which posits that organismal physiological and enzymatic rates will increase predictably with temperature because of increased efficiency of biochemical reactions up to Topt. The steep decline in performance above the Topt is attributed to the declining efficiency of metabolic processes due to decreases in protein stability as temperatures increase, eventually resulting in organismal death at the Tmax. Collectively, this information gives us a Thermal Performance Curve (TPC), which can be used to infer ecological and evolutionary outcomes.

6Mosquitoes, like other ectotherms, are highly susceptible to changes in ambient temperature, which demonstrably affects their growth rate, reproduction, metabolic rate, lifespan (e.g.,;;; ), biting rate, immunity, and ability to acquire, carry and transmit pathogens in a non-linear, unimodal fashion. These temperature-trait relationships can vary in overall shape (e.g., symmetric or asymmetric non-linear relationships) due to differences in the temperatures that optimize and constrain various traits, which in combination will determine the predicted thermal minimum, maximum and optimum for mosquito fitness, intrinsic growth rates of mosquito populations, and pathogen transmission (Figure 1).

7Process-based models, which traditionally have relied upon temperature relationships grounded in metabolic theory, have enhanced our ability to predict the effects of environmental drivers on spatial and temporal dynamics of vector-borne disease. Several key biological insights have resulted from this general approach. First, temperate areas of the world that currently experience relatively cool temperatures are expected to increase in thermal suitability for many mosquito-borne diseases with future climate warming, and, in temperate regions, mosquito-borne pathogens can invade or spread during the summer in seasonally varying environments. Secondly, areas that are currently permissive (near the Topt) or warmer than the Topt for transmission are expected to experience a decline in thermal suitability with future warming. Third, because mosquito and pathogen species can have different qualitative and quantitative relationships with temperature (resulting in different CTmin, CTmax and Topt), shifts in thermal suitability with climate and land-use change could also alter the prevalence and magnitude of mosquito-borne diseases in a given area, such as sub-Saharan Africa. Fourth, small variations in ambient temperature at fine-spatial scales can contribute to high heterogeneity in predicted suitability for pathogen transmission across various environments, which can have important ramifications for predicting mosquito-borne pathogen transmission and targeting interventions. Finally, disease intervention efforts can also be directly or indirectly affected by variation in ambient temperature. Various insecticides, entomopathogenic fungi and Wolbachia transinfections are thermally sensitive, indicating that the efficacy and cost of these interventions could vary seasonally, across geographic regions and with future climate and land-use change.

THE EFFECTS OF HUMIDITY ON MOSQUITO FITNESS, POPULATION DYNAMICS AND PATHOGEN TRANSMISSION

8Spatial and temporal variation in atmospheric moisture has important implications for an organism’s ability to hydroregulate (Box 1). Hydroregulation is defined as the suite of physiological and behavioural responses organisms utilize to regulate water balance and tolerate dehydrating environmental conditions. The relationship between organismal fitness and optimal hydroregulation is complex, with significant costs to fitness (e.g., decreased survival and reproduction) occurring when organisms become dehydrated or overhydrated. Insects have a suite of adaptations to conserve water, like physiological changes in skin or cuticular permeability, differential regulation of urine and faeces production, and behavioural changes in activity. Insects also can mitigate water loss by regulating water intake via changes in water utilization, food sources and selection of specific habitats). Finally, insects can also produce water via metabolic processes. Maintaining water balance is a particular challenge for blood-feeding (haematophagic) vectors, like mosquitoes, where the act of taking a blood meal results in overhydration that requires specialized adaptations for the excretion of water, which, in turn, enhances susceptibility to desiccation overall.

9Instead of measuring humidity directly (Box 1), many studies use related variables, like seasonal precipitation or land cover to predict mosquito population dynamics or pathogen transmission. Mosquito-borne diseases generally peak during, or following, periods of highest rainfall. Rainfall can matter as a standalone variable, since standing water is essential for mosquitoes’ ontogenetic development. However, the effect of precipitation on mosquito population dynamics and disease transmission can operate through other factors that covary with precipitation, such as increased humidity and shifts in temperature that impact mosquito development rates, adult survival and reproduction, parasite development rates and mosquito-human contact rates. The relationship between mosquitoes and precipitation is even more difficult to discern for mosquito species that develop in artificial, human watered containers, where complex interactions can occur between amount of rainfall and access to piped water. Similarly, measures of land cover such as the normalized difference vegetation index (NDVI) have been used to account for areas too dry for widespread mosquito habitat. Ultimately, the use of these proxy measures obscures our understanding of how relative humidity and other environmental variables affect transmission, which, in turn, constrains our ability to predict how mosquito-borne pathogens will respond to future climate and land-use change.

10Several studies have demonstrated statistical associations between humidity and mosquito abundance, as well as vector-borne disease incidence and prevalence. For example, the sizes of seasonal malaria epidemics in two cities in India exhibit a clear association with relative humidity (Figure 2), with a higher correlation than for temperature or rainfall. A semi-mechanistic epidemiological model that incorporates this effect of relative humidity on the transmission rate parameter accurately predicts the temporal dynamics of the disease, including the multiyear cycles in the size of seasonal epidemics. Such predictions can inform mosquito control efforts and targeting prophylaxes. However, the underlying biology of the relationships that exist between humidity and these response variables are often assumed and based on a limited number of empirical studies (summarized in Table 1). Experimental work has thus far shown generally positive effects of increased relative humidity on mosquito survival and desiccation tolerance, production and development of eggs and mosquito activity (up to 90% relative humidity). In contrast, biting rates exhibited increases when conditions are drier and the effect of humidity on vector competence is less clear (Table 1).

11Despite the existing body of research, we still do not have a sufficient knowledge base for incorporating the effects of humidity into the current temperature-trait modelling framework. Results from observations studies cannot necessarily be extrapolated to new locations or into the future. Further, the effects of humidity on mosquito and pathogen fitness described by experimental / causation studies are of limited resolution, typically exploring a limited number of humidity levels and encompassing only a handful of mosquito species. The need to better incorporate humidity effects is not unique to vector-borne diseases, but parallels trends seen in the larger body of ecological work on the effects of climate variability and climate change on heat health in ectotherms. In the following section, we outline how variation in relative humidity interacts with temperature to change the thermal performance of ectothermic vectors and, consequently, pathogen transmission.

CONSIDERING THE COMBINED EFFECTS OF TEMPERATURE AND HUMIDITY ON TRANSMISSION

12The optimal regulation of both body temperature and water balance is crucial for organismal performance and fitness. Due to the fundamental relationship that exists between temperature and the amount of moisture the air can hold (Figure 3), variations in both relative humidity and temperature will alter the degree of moisture stress ectothermic organisms, like mosquitoes, experience. For a given amount of atmospheric moisture, warmer temperatures result in higher saturation vapour pressures that reduce relative humidity and increase vapour pressure deficit (Figure 3). Depending on the ambient temperature, variation in relative humidity can exacerbate or buffer the negative effects of higher temperature on mosquito fitness and pathogen transmission. The current manner in which thermal performance of vector-borne pathogen transmission is conceptualized and empirically measured does not explicitly account for these effects. Even when relative humidity is held constant, increases in temperature will increase the vapour pressure deficit and the evaporative stress an adult mosquito experiences. Thus, it is currently unclear if the thermal maximum of a given trait, which is typically an upper lethal limit, is really being driven by temperature effects on metabolic function or rather is a function of dehydration and water stress on the organism. Understanding the physiological mechanisms underpinning mosquito responses to these abiotic constraints will be critical for predicting how transmission will shift with future anthropogenic change.

13We utilize a trait-based approach that leverages a widely used relative R0 model to present a framework that outlines the manner in which variation in relative humidity could influence the thermal performance of vector-borne pathogen transmission (Figures 4 and 5). Overall, we anticipate that variation in relative humidity could result in significant shifts in the qualitative shape of the temperature-trait relationship and cause these effects to vary with mosquito traits. Drawing from the literature on other ectotherms, insects and what little we do know for mosquitoes, we outline several hypotheses for how variation in relative humidity may affect the thermal performance of mosquito and pathogen traits (Table 2). We anticipate variation in relative humidity will be important throughout the mosquito life cycle, with the largest effects at temperatures that approach the upper thermal limit (Tmax) for a given trait, with little to no effect of variation in relative humidity on the predicted thermal minimum (Tmin) (Table 2). This hypothesis is based on the observation that for a given change in relative humidity, the corresponding change in vapour pressure deficit and evaporative stress will be greater at higher temperatures (Figures 3 and 4). How variation in relative humidity affects the predicted thermal optimum (Topt) of a given trait will be somewhat dependent on the specific trait as well as the magnitude of the effect at warmer temperatures.

14The nature and magnitude of the effects of relative humidity and temperature variation on mosquito and pathogen traits important for transmission could differ depending on mosquito life stage. One way in which relative humidity and temperature interact to affect developing mosquitoes is through the evaporation rate of larval habitat, which is also determined by the size and surface area of the larval habitat and rate of water replenishment. A second type of interaction could involve altering some intrinsic factor of the larval environment such as surface tension, microbial growth or solute concentration. Causal evidence from semi-field experiments shows negative effects of high relative humidity at temperatures near or above the predicted thermal optimum for Aedes albopictus on larval survival and the probability of adult emergence. One possibility is that both temperature and water vapour in the atmosphere will affect the surface tension of aquatic larval habitats. Warm temperatures and high humidity may cause larval habitats to have too little surface tension, while cool and dry larval environments may have too high surface tension, negatively affecting the ability of larval mosquitoes to breath, access nutrients and emerge from the pupal stage. In all likelihood, both types of effect could be important in the field. Thus, the effects of relative humidity on the rate of evaporation relative to larval development or shifts in intrinsic conditions of larval habitats could have substantial effects on the thermal performance curves for both mosquito development rate (MDR), the probability of egg to adult survival (pEA) and consequently the intrinsic growth rate of mosquito populations.

15Once adults emerge from the larval environment, variation in relative humidity could potentially increase or decrease the predicted upper thermal limit for adult traits that are critical for mosquito population dynamics and transmission (Figure 4, Table 2). For example, decreases in relative humidity at warm temperatures could decrease mosquito survival (by increasing the per capita daily mortality rate (μ)) via increasing desiccation stress. This, in turn, will decrease the temperatures at which mosquitoes can survive to become infected and to transmit vector-borne pathogens. Evidence from other insect systems would predict that decreases in relative humidity at warm temperatures could also decrease the per capita daily biting rate (a) and production of eggs (EFD) by altering mosquito activity and blood feeding due to shifts in behaviour (e.g., utilization of specific habitats, times of day or times of season;;;;; ) and physiological responses (e.g., decreased metabolic rate) to increase desiccation resistance or tolerance. However, the evidence that does exist for mosquitoes suggests decreases in relative humidity can actually increase biting rates on hosts (e.g., Culex pipiens, Ae. aegypti, An. quadramaculatus; ). It remains unclear if this pattern would persist in the field for mosquito species that utilize sugar sources for hydration and nutrition, because nectar-feeding mosquitoes can increase sugar feeding behaviour when environmental conditions are dry.

16Finally, we also anticipate that the development of mosquito-borne pathogens and parasites, and potentially mosquito susceptibility to infection, should be affected by variation in relative humidity under different ambient temperature conditions based on physiological acclimation responses. Aquaporin water channels allow organisms to rapidly move water (aquaporins) or water and glycerol (aquaglyceroporins) across cellular membranes to promote cellular function. Mosquitoes utilize aquaporins and aquaglyceroporins to minimize water loss in desiccating environments and to maintain glycerol concentrations to stabilize proteins when mosquitoes are exposed to high heat. The physiological responses of mosquitoes to optimally thermo- and hydroregulate under sub-optimal temperature and relative humidity environments could also have consequences for the energy available to developing pathogen.

IMPLICATIONS FOR UNDERSTANDING PATHOGEN TRANSMISSION AND CONTROL IN A CHANGING WORLD

17Understanding the respective effects of variation in temperature and humidity, as well as any interaction between variables, will be critical for addressing how the regional and global distributions of mosquito vectors, and the seasonality and intensity of vector-borne pathogen transmission, will shift in response to future climate and land-use change. Based on the importance of maintaining optimal temperature and water balance in other organisms, we also argue that variation in temperature, humidity and water availability are important selective determinants driving local adaptation of mosquitoes to various environments as well as their capacity to respond to future environmental change. Finally, variation in temperature and humidity will also likely affect the efficacy, coverage and cost of disease control programs.

Human-mediated environmental change

18Human-mediated climate change is resulting in widespread and uneven changes in global temperature, humidity and precipitation patterns and more frequent extreme weather events. In addition to climate warming, regional changes in humidity and precipitation will result in increased drought in some areas, while others become wetter. If mosquitoes and their transmission cycles are more sensitive to humidity at higher temperatures, then future increases in wet vs. dry heat may have very different implications for mosquito populations and pathogen risk. Regional variation in temperature and relative humidity could have important implications for both the seasonal timing and peak of vector-borne disease as well as pathogen persistence or emergence. For example, it has been suggested that future temperatures in tropical Africa will exceed the thermal optimum for malaria and result in reduced transmission. However, these tropical regions are characterized by humid heat, and malaria may persist if the maximum temperature for transmission increases at high humidity. Similarly, the potential for arboviruses to expand into warming temperate climates may be greater in regions with increasing humid heat vs. dry heat, which has not been considered in current mechanistic model projections of disease risk with various climate change scenarios [e.g.,].

19Land-use change is another key human driver affecting mosquito-borne disease transmission. For example, urban landscapes are one of the most rapidly growing land cover types across the globe, with the proportion of people living in urban environment projected to increase from 55% to 68% between now and 2050. High environmental heterogeneity in urban areas creates substantial variation in the local microclimates mosquitoes experience, through differences in temperature, moisture and wind speed. These differences are mediated by the extent of impervious surfaces, the distribution of vegetation and the three-dimensional structure created by buildings and trees. Together, these changes result in urban heat and dry islands with higher land surface and near-surface air temperatures and lower relative humidity compared to more vegetated landscapes. This fine-scale variation in mosquito microclimate can have significant implications for multiple mosquito species (e.g., Aedes aegypti, Ae. albopictus, Anopheles stephensi) that drive urban outbreaks of diseases (e.g., dengue, chikungunya, Zika and malaria).

20Small-scale variation in temperature and relative humidity could also have important implications for the spatial distribution of risk in urban environments (Figure 5). Recent studies that combine field experimentation with direct monitoring of urban microclimates and mosquito abundance demonstrate that fine-scale variation (e.g., individual neighbourhoods or city blocks) in both temperature and relative humidity can have important implications for mosquito life history, population dynamics and disease transmission within urban environments. Thus, neighbourhoods with a high proportion of impervious surfaces that experience mean temperatures near or exceeding the thermal optimum for transmission could experience even higher decreases in vectorial capacity than what models would predict from temperature alone, if drier conditions increase desiccation stress and reduce mosquito survival.

21To generalize the effects of changing temperature and humidity across diverse locations and into the future, it will be necessary to develop a conceptual framework that incorporates the psychometrics of temperature and atmospheric moisture with mosquito biology and the natural and built environments in which transmission occurs. Incorporating the effects of humidity into hierarchical models and assessment of mosquito population dynamics and disease transmission will increase the precision of mapping environmental suitability, both globally and regionally with human-mediated environmental change, as well as across heterogeneous human-modified landscapes.

Local adaptation and capacity to adapt in the future

22There is growing interest in the factors driving adaptation of mosquitoes to local environmental conditions for providing insights into the long-term responses of mosquito species to future warming. Mosquito species are composed of an array of locally adapted populations across their respective ranges. Substantial genetic variation exists in mosquito species and at fine-spatial scales, with significant consequences for transmission potential. This genetic variation can interact with local environmental conditions to impact the capacity of mosquito vectors to transmit human pathogens (e.g., dengue; and chikungunya; ). Yet, we still do not have a clear understanding of what environmental factors are driving this differentiation.

23The work that has been done in this area to date has largely focused on the effects of temperature variation in driving local adaptation of current mosquito populations. However, research from the broader field of ectotherms [e.g., reviewed in, vertebrates;, insects] suggests that selection on thermal response curves are constrained by other metabolic stressors, like desiccation stress, as temperatures warm. For example, a study on 94 Drosophila species from diverse climates found substantial variation in the upper thermal limits among species. Further, the species specific CTmax correlated positively with increasing temperature in dry environments, with species from hot and dry environments exhibiting higher heat tolerance. However, this relationship completely disappeared for species inhabiting wet environments suggesting temperature as a selective force is less important when humidity is high. A similar study in ectothermic vertebrates (400 lizards), found the thermal optimum to be more strongly related to ambient precipitation than to average temperature. Environmental mean temperature was only found to be predictive of the lower thermal limit (CTmin).

24Both common garden and experimental evolution studies, two standard approaches to measure local adaptation and evolutionary potential of a particular species, could be incorrectly attributing observed phenotypic responses to temperature selection when they could be responding to a combination of energetic effects and moisture stress. This impacts our ability to accurately characterize thermal response curves of mosquitoes, as well as their capacity to adapt to future environmental change. From our conceptual framework outlined above (Figure 5), we would predict that the current approach to studying local adaptation, steeped in metabolic theory of ecology, will be most predictive of mosquito population responses to future warming in regions of the world that currently exist below the species specific thermal optima (Topt). However, for mosquito populations that inhabit environments above their thermal optima, humidity will be an important determinant of their capacity to respond to future environmental change. For example, mosquito populations in warm and wet, humid environments may have less capacity to adapt to future climate change in a warming and drying environment than what would be predicted from evolutionary models that consider the effects of temperature alone. Conversely, mosquito populations that currently live in warm and dry environments may have a greater capacity to adapt to warming conditions if they exhibit higher heat tolerance than their counterparts inhabiting wetter areas of the geographic distribution.

Controlling mosquito populations and disease transmission

25There have been several mechanistic modelling efforts to understand how regional and seasonal environmental variation will impact the relative reproductive number of a pathogen, the intensity of human transmission and the efficacy of key disease interventions (e.g., Zika;, schistosomiasis; ). These studies have, again, focused largely on the effects of ambient temperature. However, seasonal and regional variation in humidity and precipitation could extend or shorten the transmission season and magnify or depress the intensity of epidemics as predicted from models incorporating the effects of temperature alone. For example, this is likely to be the case in seasonally dry environments where mosquito-borne disease transmission tends to be highest during or just after the rainy season and lowest during the hottest / driest parts of the season due to seasonal shifts in mosquito habitat, as well as the effects of temperature and humidity on mosquito and pathogen traits relevant for transmission.

26How variation in humidity affects the efficacy of current and novel mosquito control interventions also needs to be considered. Many novel mosquito control technologies involve the mass release of males that have been sterilized or genetically engineered to pass on traits that confer either severe fitness costs (i.e., population suppression approaches;;; ) or enhanced resistance to human pathogens (i.e., population replacement approaches). For example, the wMel strain of the symbiont Wolbachia can prevent dengue, chikungunya and Zika transmission in Ae. aegypti. Experimental work has determined that wMel infections are temperature sensitive, with high temperatures causing reductions in Wolbachia density and temperature variation affects the host-pathogen interaction and the outcome of infection in Wolbachia-infected mosquitoes. Based on the relationship between temperature and water balance laid out in this paper, further experiments should examine whether Wolbachia infections are limited by temperature alone or by cellular water availability, and examine what role mosquito desiccation stress plays in limiting Wolbachia abundance within mosquitoes at varying temperature.

27Furthermore, thermal performance differs between insecticide resistant vectors and their susceptible counterparts, with important implications for assessing fitness costs associated with insecticide resistance. Thus, insecticide resistant mosquitoes may have to optimize temperature and water needs across environmental constraints differently and, therefore, be affected by changes in humidity, with potentially important consequences for population dynamics, mosquito-pathogen interactions and transmission. Identifying these environmental constraints on efficacy and coverage will be critical for the successful implementation of current and future control programs.

CONCLUSIONS AND FUTURE DIRECTIONS

28Sufficiently understanding the performance of insect vectors within the natural environmental mosaics where they occur will require substantially more data on the spatial and temporal complexities in microclimate, behavioural responses to temperature and humidity change, plasticity in thermal tolerance traits and the eco-physiological mechanisms of vector water balance, coupled with broader understanding of the general relationships between water and temperature described in this paper. We have collated these goals into a general framework incorporating humidity into research questions and temperature-dependent mechanistic models (Figure 5 & Box 2). We intend for the evidence and theory presented here to be signposts for future research, leading to a collective broadening in our understanding of insect vectors and how their responses to climate variables will affect parasite transmission.

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