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DeepIGeoS: A Deep Interactive Geodesic Framework for Medical Image Segmentation

Guotai Wang, Maria A. Zuluaga, Wenqi Li and 8 more

IEEE Transactions on Pattern Analysis and Machine Intelligence · 2019 · CC BY

doi:10.1109/tpami.2018.2840695

Abstract

Accurate medical image segmentation is essential for diagnosis, surgical planning and many other applications. Convolutional Neural Networks (CNNs) have become the state-of-the-art automatic segmentation methods. However, fully automatic results may still need to be refined to become accurate and robust enough for clinical use. We propose a deep learning-based interactive segmentation method to improve the results obtained by an automatic CNN and to reduce user interactions during refinement for higher accuracy. We use one CNN to obtain an initial automatic segmentation, on which user interactions are added to indicate mis-segmentations. Another CNN takes as input the user interactions with the initial segmentation and gives a refined result. We propose to combine user interactions with CNNs through geodesic distance transforms, and propose a resolution-preserving network that gives a better dense prediction. In addition, we integrate user interactions as hard constraints into a back-propagatable Conditional Random Field. We validated the proposed framework in the context of 2D placenta segmentation from fetal MRI and 3D brain tumor segmentation from FLAIR images. Experimental results show our method achieves a large improvement from automatic CNNs, and obtains comparable and even higher accuracy with fewer user interventions and less time compared with traditional interactive methods.

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References 65

  1. 1.

    Withey D. and Koles Z., “Medical image segmentation: Methods and software,” in Proc. Joint Meeting 6th Int. Symp. Noninvasive Functional Source Imaging Brain Heart Int. Conf. Functional Biomedical Imaging, 2007, pp. 140–143.

    Not in our library

  2. 2.
  3. 3.

    Zhao F. and Xie X., “An overview of interactive medical image segmentation,” Ann. BMVA, vol. 2013, no. 7, pp. 1–22, 2013.

    Not in our library

  4. 4.

    Hamamci A., Kucuk N., Karaman K., Engin K., and Unal G., “Tumor-Cut: Segmentation of brain tumors on contrast enhanced MR images for radiosurgery applications,” IEEE Trans. Medical Imaging, vol. 31, no. 3, pp. 790–804, Mar. 2012.

    Not in our library10.1109/tmi.2011.2181857

  5. 5.

    Yushkevich P. A., Piven J., Hazlett H. C., Smith R. G., Ho S., Gee J. C., and Gerig G., “User-guided 3D active contour segmentation of anatomical structures: Significantly improved efficiency and reliability,” NeuroImage, vol. 31, no. 3, pp. 1116–1128, 2006.

    Not in our library10.1016/j.neuroimage.2006.01.015

  6. 6.

    Wang G., Zuluaga M. A., Pratt R., Aertsen M., Doel T., Klusmann M., David A. L., Deprest J., Vercauteren T., and Ourselin S., “Slic-Seg: A minimally interactive segmentation of the placenta from sparse and motion-corrupted fetal MRI in multiple views,” Med. Image Anal., vol. 34, pp. 137–147, 2016.

    Not in our library10.1016/j.media.2016.04.009

  7. 7.

    Grady L., “Random walks for image segmentation,” IEEE Trans. Pattern Anal. Mach. Intell., vol. 28, no. 11, pp. 1768–1783, Nov. 2006.

    Not in our library10.1109/tpami.2006.233

  8. 8.

    Boykov Y. Y. and Jolly M. P., “Interactive graph cuts for optimal boundary & region segmentation of objects in N-D images,” in Proc. 8th IEEE Int. Conf. Comput. Vis., 2001, pp. 105–112.

    Not in our library

  9. 9.

    Rother C., Kolmogorov V., and Blake A., “GrabCut: Interactive foreground extraction using iterated graph cuts,” ACM Trans. Graph., vol. 23, no. 3, pp. 309–314, 2004.

    Not in our library

  10. 10.

    Litjens G., Kooi T., Bejnordi B. E., Setio A. A. A., Ciompi F., Ghafoorian M., van der Laak J. A., Ginneken B. V., and Sánchez C. I., “A survey on deep learning in medical image analysis,” Med. Image Anal., vol. 42, pp. 60–88, 2017.

    Not in our library10.1016/j.media.2017.07.005

  11. 11.

    Long J., Shelhamer E., and Darrell T., “Fully convolutional networks for semantic segmentation,” in Proc. IEEE Conf. Comput. Vis. Pattern Recognit., 2015, pp. 3431–3440.

    Not in our library10.1109/tpami.2016.2572683

  12. 12.

    Ronneberger O., Fischer P., and Brox T., “U-Net: Convolutional networks for biomedical image segmentation,” in Proc. Medical Image Comput. Comput.-Assisted Intervention, 2015, pp. 234–241.

    Not in our library

  13. 13.

    Milletari F., Navab N., and Ahmadi S.-A., “V-Net: Fully convolutional neural networks for volumetric medical image segmentation,” in Proc. 4th Int. Conf. 3D Vis., 2016, pp. 565–571.

    Not in our library

  14. 14.

    Li W., Wang G., Fidon L., Ourselin S., Cardoso M. J., and Vercauteren T., “On the compactness, efficiency, and representation of 3D convolutional networks: brain parcellation as a pretext task,” in Proc. Inf. Process. Medical Imaging, 2017, pp. 348–360.

    Not in our library

  15. 15.

    Kamnitsas K., Ledig C., Newcombe V. F. J., Simpson J. P., Kane A. D., Menon D. K., Rueckert D., and Glocker B., “Efficient multi-scale 3D CNN with fully connected CRF for accurate brain lesion segmentation,” Med. Image Anal., vol. 36, pp. 61–78, 2017.

    Not in our library10.1016/j.media.2016.10.004

  16. 16.

    Krizhevsky A., Sutskever I., and Hinton G. E., “ImageNet classification with deep convolutional neural networks,” in Proc. 25th Int. Conf. Neural Inf. Process. Syst., 2012, pp. 1097–1105.

    Not in our library

  17. 17.

    Simonyan K. and Zisserman A., “Very deep convolutional networks for large-scale image recognition,” arXiv preprint arXiv:1409.1556.

    Not in our library

  18. 18.

    He K., Zhang X., Ren S., and Sun J., “Deep residual learning for image recognition,” in Proc. IEEE Conf. Comput. Vis. Pattern Recognit., 2016, pp. 770–778.

    Not in our library

  19. 19.

    Havaei M., Davy A., Warde-Farley D., Biard A., Courville A., Bengio Y., Pal C., Jodoin P.-M., and Larochelle H., “Brain tumor segmentation with deep neural networks,” Med. Image Anal., vol. 35, pp. 18–31, 2016.

    Not in our library10.1016/j.media.2016.05.004

  20. 20.

    Girshick R., Donahue J., Darrell T., and Malik J., “Rich feature hierarchies for accurate object detection and semantic segmentation,” in Proc. IEEE Conf. Comput. Vis. Pattern Recognit., 2014, pp. 580–587.

    Not in our library

  21. 21.

    Abdulkadir A., Lienkamp S. S., Brox T., and Ronneberger O., “3D U-Net: Learning dense volumetric segmentation from sparse annotation,” in Proc. Medical Image Comput. Comput.-Assisted Intervention, 2016, pp. 424–432.

    Not in our library

  22. 22.

    Chen L.-C., Papandreou G., Kokkinos I., Murphy K., and Yuille A. L., “Semantic image segmentation with deep convolutional nets and fully connected CRFs,” arXiv preprint arXiv:1412.7062.

    Not in our library10.1109/tpami.2017.2699184

  23. 23.

    Yu F. and Koltun V., “Multi-scale context aggregation by dilated convolutions,” arXiv preprint arXiv:1511.07122.

    Not in our library

  24. 24.

    Ondruska P., Dequaire J., Wang D. Z., and Posner I., “End-to-end tracking and semantic segmentation using recurrent neural networks,” arXiv preprint arXiv:1604.05091.

    Not in our library

  25. 25.

    Dai J., He K., Li Y., Ren S., and Sun J., “Instance-sensitive fully convolutional networks,” in Proc. 14th Eur. Conf. Comput. Vis., 2016, pp. 534–549.

    Not in our library

  26. 26.

    Lea C., Vidal R., Reiter A., and Hager G. D., “Temporal convolutional networks for action segmentation and detection,” in Proc. Eur. Conf. Comput. Vis., 2016, pp. 47–54.

    Not in our library

  27. 27.

    Lin G., Shen C., Reid I., and van dan Hengel A., “Efficient piecewise training of deep structured models for semantic segmentation,” in Proc. IEEE Conf. Comput. Vis. Pattern Recognit., 2016, pp. 3194–3203.

    Not in our library

  28. 28.

    Pinheiro P. and Collobert R., “Recurrent convolutional neural networks for scene labeling,” in Proc. 31st Int. Conf. Int. Conf. Mach. Learn., 2014, pp. 82–90.

    Not in our library

  29. 29.

    Hariharan B., Arbeláez P., Girshick R., and Malik J., “Hypercolumns for object segmentation and fine-grained localization,” in Proc. IEEE Conf. Comput. Vis. Pattern Recognit., 2015, pp. 447–456.

    Not in our library10.1109/tpami.2016.2578328

  30. 30.

    Armstrong C. J., Price B. L., and Barrett W. A., “Interactive segmentation of image volumes with live surface,” Comput. Graph., vol. 31, no. 2, pp. 212–229, 2007.

    Not in our library

  31. 31.

    Cates J. E., Lefohn A. E., and Whitaker R. T., “GIST: An interactive, GPU-based level set segmentation tool for 3D medical images,” Med. Image Anal., vol. 8, no. 3, pp. 217–231, 2004.

    Not in our library10.1016/j.media.2004.06.022

  32. 32.

    Rajchl M., Lee M., Oktay O., Kamnitsas K., Passerat-Palmbach J., Bai W., Rutherford M., Hajnal J., Kainz B., and Rueckert D., “DeepCut: Object segmentation from bounding box annotations using convolutional neural networks,” IEEE Trans. Medical Imaging, vol. 36, no. 2, pp. 674–683, Feb. 2017.

    Not in our library10.1109/tmi.2016.2621185

  33. 33.

    Haider S. A., Shafiee M. J., Chung A., Khalvati F., Oikonomou A., Wong A., and Haider M. A., “Single-click, semi-automatic lung nodule contouring using hierarchical conditional random fields,” in Proc. IEEE 12th Int. Symp. Biomed. Imaging, 2015, pp. 1139–1142.

    Not in our library

  34. 34.

    Xu C. and Prince J. L., “Snakes, shapes, and gradient vector flow,” IEEE Trans. Image Process., vol. 7, no. 3, pp. 359–369, Mar. 1998.

    Not in our library10.1109/83.661186

  35. 35.

    Bai X. and Sapiro G., “A geodesic framework for fast interactive image and video segmentation and matting,” in Proc. IEEE 11th Int. Conf. Comput. Vis., 2007, pp. 1–8.

    Not in our library

  36. 36.

    Criminisi A., Sharp T., and Blake A., “GeoS: Geodesic image segmentation,” in Proc. Eur. Conf. Comput. Vis., 2008, pp. 99–112.

    Not in our library

  37. 37.

    Barinova O., Shapovalov R., Sudakov S., and Velizhev A., “Online random forest for interactive image segmentation,” in Proc. Int. Workshop Exp. Economics Mach. Learn., 2012, pp. 1–8.

    Not in our library

  38. 38.

    Luengo I., Darrow M. C., Spink M. C., Sun Y., Dai W., He C. Y., Chiu W., Pridmore T., Ashton A. W., Duke E. M., Basham M., and French A. P., “SuRVoS: Super-region volume segmentation workbench,” J. Structural Biol., vol. 198, no. 1, pp. 43–53, 2017.

    Not in our library10.1016/j.jsb.2017.02.007

  39. 39.

    Lin D., Dai J., Jia J., He K., and Sun J., “ScribbleSup: Scribble-supervised convolutional networks for semantic segmentation,” in Proc. IEEE Conf. Comput. Vis. Pattern Recognit., 2016, pp. 3159–3167.

    Not in our library

  40. 40.

    Xu N., Price B., Cohen S., Yang J., and Huang T., “Deep interactive object selection,” in Proc. IEEE Conf. Comput. Vis. Pattern Recognit., 2016, pp. 373–381.

    Not in our library

All 65 references

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