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Machine Learning and Decision Support in Critical Care
Alistair E. W. Johnson, Mohammad M. Ghassemi, Shamim Nemati and 3 more
Proceedings of the IEEE · 2016 · CC BY
doi:10.1109/jproc.2015.2501978
Abstract
Clinical data management systems typically provide caregiver teams with useful information, derived from large, sometimes highly heterogeneous, data sources that are often changing dynamically. Over the last decade there has been a significant surge in interest in using these data sources, from simply re-using the standard clinical databases for event prediction or decision support, to including dynamic and patient-specific information into clinical monitoring and prediction problems. However, in most cases, commercial clinical databases have been designed to document clinical activity for reporting, liability and billing reasons, rather than for developing new algorithms. With increasing excitement surrounding "secondary use of medical records" and "Big Data" analytics, it is important to understand the limitations of current databases and what needs to change in order to enter an era of "precision medicine." This review article covers many of the issues involved in the collection and preprocessing of critical care data. The three challenges in critical care are considered: compartmentalization, corruption, and complexity. A range of applications addressing these issues are covered, including the modernization of static acuity scoring; on-line patient tracking; personalized prediction and risk assessment; artifact detection; state estimation; and incorporation of multimodal data sources such as genomic and free text data.
References 208
- 1.
Vincent JL. Critical care-where have we been and where are we going. Crit Care. 2013;17(Suppl 1):S2.
Not in our library10.1186/cc11500
- 2.
Pronovost P, Angus D, Dorman TR, Dremsizov KA, Young TT. Physician Staffing Patterns and Clinical Outcomes in Critically Ill Patient: a Systematic Review. JAMA. 2002;288(17):2151-2162.
Not in our library10.1001/jama.288.17.2151
- 3.
Kane R, Shamliyan T, Mueller C, Duval S, Wilt TJ. The association of registered nurse staffing levels and patient outcomes: Systematic review and meta-analysis. Medical Care. 2007;45(12):1195-1204.
Not in our library10.1097/mlr.0b013e3181468ca3
- 4.
- 5.
Halpern NA, Pastores SM. Critical care medicine in the United States 2000–2005: An analysis of bed numbers, occupancy rates, payer mix, and costs*. Critical care medicine. 2010;38(1):65-71.
Not in our library10.1097/ccm.0b013e3181b090d0
- 6.
Badawi O, Brennan T, Celi LA, Feng M, Ghassemi M, Ippolito A, Johnson A, Mark RG, Mayaud L, Moody G, et al. Making big data useful for health care: a summary of the inaugural MIT critical data conference. JMIR medical informatics. 2014;2(2).
Not in our library10.2196/medinform.3447
- 7.
Riley GF. Administrative and claims records as sources of health care cost data. Medical care. 2009;47(7_Supplement_1):S51-S55.
Not in our library10.1097/mlr.0b013e31819c95aa
- 8.
Johnson AEW, Kramer A, Clifford GD. Data preprocessing and mortality prediction: the Physionet/CinC 2012 challenge revisited. Computing in Cardiology Conference (CinC), 2014. 2014;41:157-160.
Not in our library
- 9.
The Health Insurance Portability and Accountability Act of 1996 (HIPAA). 1996.
Not in our library
- 10.
Caldicott F. Information: To share or not to share. information governance review. Information: To share or not to share. 2013.
Not in our library
- 11.
Ince DC, Hatton L, Graham-Cumming J. The case for open computer programs. Nature. 2012;482(7386):485-488.
Not in our library10.1038/nature10836
- 12.
Ness Roberta B, Joint Policy Committee, et al. Influence of the HIPAA privacy rule on health research. Jama. 2007;298(18):2164-2170.
Not in our library10.1001/jama.298.18.2164
- 13.
O'Keefe CM. Privacy and the use of health data-reducing disclosure risk. electronic Journal of Health Informatics. 2008;3(1):5.
Not in our library
- 14.
Standards for privacy of individually identifiable health information. final rule. Federal Register. 2002;67(157):53181.
Not in our library
- 15.
Doyle P, Lane J, Theeuwes J, Zayatz L. Confidentiality, Disclosure and Data Access: Theory and Practical Applications for Statistical Agencies. 2004.
Not in our library
- 16.
- 17.
Murphy SN, Weber G, Mendis M, Gainer V, Chueh HC, Churchill S, Kohane I. Serving the enterprise and beyond with informatics for integrating biology and the bedside (i2b2). Journal of the American Medical Informatics Association. 2010;17(2):124-130.
Not in our library10.1136/jamia.2009.000893
- 18.
Dwork C. Differential privacy. Encyclopedia of Cryptography and Security. 2011;338-340.
Not in our library
- 19.
Mohammed N, Jiang X, Chen R, Fung BC, Ohno-Machado L. Privacy-preserving heterogeneous health data sharing. Journal of the American Medical Informatics Association. 2013;20(3):462-469.
Not in our library10.1136/amiajnl-2012-001027
- 20.
Goldberger A, Amaral L, Glass L. PhysioBank, PhysioToolkit, and PhysioNet: Components of a new research resource for complex physiologic signals. Circulation. 2000;101(23):e215-e220.
Not in our library10.1161/01.cir.101.23.e215
- 21.
Saeed M, Lieu C, Raber G, Mark RG. MIMIC II: a massive temporal icu patient database to support research in intelligent patient monitoring. Comput Cardiol. 2002;29:641-4.
Not in our library
- 22.
Saeed M, Villarroel M, Reisner AT, Clifford G, Lehman LH, Moody G, Heldt T, Kyaw TH, Moody B, Mark RG. Multiparameter intelligent monitoring in intensive care (MIMIC II): a public-access intensive care unit database. Crit Care Med. 2011;39(5):952-960.
Not in our library10.1097/ccm.0b013e31820a92c6
- 23.
Registration listing. 2015.
Not in our library
- 24.
Lesh K, Weininger S, Goldman JM, Wilson B, Himes G. Medical device interoperability-assessing the environment. hcmdss-mdpnp. 2007;3-12.
Not in our library
- 25.
Charles D, King J, Patel V, Furukawa MF. Adoption of electronic health record systems among U.S. non-federal acute care hospitals: 2008-2012. ONC Data Brief. 2013;(9).
Not in our library
- 26.
Black N, Payne M. Directory of clinical databases: improving and promoting their use. Quality and Safety in Health Care. 2003;12(5):348-352.
Not in our library10.1136/qhc.12.5.348
- 27.
Cooke CR, Iwashyna TJ. Using existing data to address important clinical questions in critical care. Critical care medicine. 2013;41(3):886.
Not in our library10.1097/ccm.0b013e31827bfc3c
- 28.
Iwashyna TJ, Ely EW, Smith DM, Langa KM. Long-term cognitive impairment and functional disability among survivors of severe sepsis. Jama. 2010;304(16):1787-1794.
Not in our library10.1001/jama.2010.1553
- 29.
Finney JM, Walker AS, Peto TE, Wyllie DH. An efficient record linkage scheme using graphical analysis for identifier error detection. BMC medical informatics and decision making. 2011;11(1):7.
Not in our library10.1186/1472-6947-11-7
- 30.
McShea M, Holl R, Badawi O, Riker RR, Silfen E. The eicu research institute-a collaboration between industry, health-care providers, and academia. Engineering in Medicine and Biology Magazine, IEEE. 2010;29(2):18-25.
Not in our library10.1109/memb.2009.935720
- 31.
Zimmerman JE, Kramer AA, McNair DS, Malila FM. Acute physiology and chronic health evaluation (apache) iv: Hospital mortality assessment for todays critically ill patients*. Critical care medicine. 2006;34(5):1297-1310.
Not in our library10.1097/01.ccm.0000215112.84523.f0
- 32.
Zimmerman JE, Kramer AA. Outcome prediction in critical care: the Acute Physiology and Chronic Health Evaluation models. Current Opinion in Critical Care. 2008;14:491-497.
Not in our library10.1097/mcc.0b013e32830864c0
- 33.
ICD 9 CM The International Classification of Diseases 9 Rev: Clinical Modification; Vol 1: Diseases: Tabular List; Vol 2: Diseases: Alphabetic Index; Vol 3: Procedures: Tabular List and Alphabetic Index. 1980.
Not in our library
- 34.
O'malley KJ, Cook KF, Price MD, Wildes KR, Hurdle JF, Ashton CM. Measuring diagnoses: Icd code accuracy. Health services research. 2005;40(5p2):1620-1639.
Not in our library10.1111/j.1475-6773.2005.00444.x
- 35.
Pestian JP, Brew C, Matykiewicz P, Hovermale D, Johnson N, Cohen KB, Duch W. A shared task involving multi-label classification of clinical free text. Proceedings of the Workshop on BioNLP 2007: Biological, Translational, and Clinical Language Processing. 2007;97-104.
Not in our library
- 36.
Bos L, Donnelly K. Snomed-CT: The advanced terminology and coding system for ehealth. Stud Health Technol Inform. 2006;121:279-290.
Not in our library
- 37.
Elkin PL, Brown SH, Husser CS, Bauer BA, Wahner-Roedler D, Rosenbloom ST, Speroff T. Evaluation of the content coverage of snomed CT: ability of snomed clinical terms to represent clinical problem lists. in Mayo Clinic Proceedings. 2006;81(6):741-748.
Not in our library10.4065/81.6.741
- 38.
McDonald CJ, Huff SM, Suico JG, Hill G, Leavelle D, Aller R, Forrey A, Mercer K, DeMoor G, Hook J, et al. Loinc, a universal standard for identifying laboratory observations: a 5-year update. Clinical chemistry. 2003;49(4):624-633.
Not in our library10.1373/49.4.624
- 39.
Whetzel P, Noy N, Shah N, Alexander P, Nyulas C, Tudorache T, Musen M. Bioportal: enhanced functionality via new web services from the national center for biomedical ontology to access and use ontologies in software applications. Nucleic Acids Res. 2011;39.
Not in our library10.1093/nar/gkr469
- 40.
D'Amore JD, Mandel JC, Kreda DA, Swain A, Koromia GA, Sundareswaran S, Alschuler L, Dolin RH, Mandl KD, Kohane IS, et al. Are meaningful use stage 2 certified ehrs ready for interoperability? findings from the smart c-CDa collaborative. Journal of the American Medical Informatics Association. 2014;21(6):1060-1068.
Not in our library10.1136/amiajnl-2014-002883
- 41.
Nouira K, Trabelsi A. Intelligent monitoring system for intensive care units. Journal of medical systems. 2012;36(4):2309-2318.
Not in our library10.1007/s10916-011-9698-x
- 42.
Imhoff M, Bauer M, Gather U, Löhlein D. Statistical pattern detection in univariate time series of intensive care on-line monitoring data. Intensive care medicine. 1998;24(12):1305-1314.
Not in our library10.1007/s001340050767
- 43.
West M, Harrison PJ, Migon HS. Dynamic generalized linear models and bayesian forecasting. Journal of the American Statistical Association. 1985;80(389):73-83.
Not in our library
- 44.
Becker C, Gather U. The largest nonidentifiable outlier: A comparison of multivariate simultaneous outlier identification rules. Computational Statistics & Data Analysis. 2001;36(1):119-127.
Not in our library
- 45.
Nizami S, Green JR, McGregor C. Implementation of artifact detection in critical care: a methodological review. Biomedical Engineering, IEEE Reviews in. 2013;6:127-142.
Not in our library10.1109/rbme.2013.2243724
- 46.
Tsien CL, Fackler JC. Poor prognosis for existing monitors in the intensive care unit. Critical care medicine. 1997;25(4):614-619.
Not in our library10.1097/00003246-199704000-00010
- 47.
Chambrin MC, Ravaux P, Calvelo-Aros D, Jaborska a, Chopin C, Boniface B. Multicentric study of monitoring alarms in the adult intensive care unit (ICU): a descriptive analysis. Intensive Care Medicine. 1999;25(12):1360-6.
Not in our library10.1007/s001340051082
- 48.
Li Q, Mark RG, Clifford GD. Robust heart rate estimation from multiple asynchronous noisy sources using signal quality indices and a Kalman filter. Physiological measurement. 2008;29(1):15-32.
Not in our library10.1088/0967-3334/29/1/002
- 49.
Clifford GD, Behar J, Li Q, Rezek I. Signal quality indices and data fusion for determining clinical acceptability of electrocardiograms. Physiol Meas. 2012;33(9):1419.
Not in our library10.1088/0967-3334/33/9/1419
- 50.
Pan J, Tompkins WJ. A real-time QRS detection algorithm. IEEE Trans Biomed Eng. 1985;32(3):230-236.
Not in our library10.1109/tbme.1985.325532
- 51.
Hamilton PS, Tompkins WJ. Quantitative investigation of QRS detection rules using the MIT/BIH arrhythmia database. Biomedical Engineering, IEEE Transactions on. 1986;(12):1157-1165.
Not in our library10.1109/tbme.1986.325695
- 52.
Zong W, Moody G, Jiang D. A robust open-source algorithm to detect onset and duration of QRS complexes. Computers in Cardiology. 2003;30:737-740.
Not in our library
- 53.
Behar J, Oster J, Li Q, Clifford GD. ECG signal quality during arrhythmia and its application to false alarm reduction. Transactions on Biomedical Engineering. 2013;60(6):1660-1666.
Not in our library10.1109/tbme.2013.2240452
- 54.
Cortes C, Vapnik V. Support-vector networks. Machine Learning. 1995;20(3):273-297.
Not in our library
- 55.
Li Q, Clifford GD. Signal quality and data fusion for false alarm reduction in the intensive care unit. Journal of electrocardiology. 2012;45(6):596-603.
Not in our library10.1016/j.jelectrocard.2012.07.015
- 56.
Tipping ME. Sparse bayesian learning and the relevance vector machine. The journal of machine learning research. 2001;1:211-244.
Not in our library
- 57.
Morgado E, Alonso-Atienza F, Santiago-Mozos R, Barquero-Pérez Ó, Silva I, Ramos J, Mark R. Quality estimation of the electrocardiogram using cross-correlation among leads. Biomedical engineering online. 2015;14(1):59.
Not in our library10.1186/s12938-015-0053-1
- 58.
Breiman L, Friedman J, Stone CJ, Olshen RA. Classification and regression trees. 1984.
Not in our library
- 59.
Quinlan JR. C4. 5: programs for machine learning. 2014.
Not in our library
- 60.
Cohen WW. Fast effective rule induction. Proceedings of the twelfth international conference on machine learning. 1995;115-123.
Not in our library
- 61.
Barachant A, Andreev A, Congedo M. The riemannian potato: an automatic and adaptive artifact detection method for online experiments using riemannian geometry. TOBI Workshop lV. 2013;19-20.
Not in our library
- 62.
Tsien CL, Kohane IS, McIntosh N. Building ICU artifact detection models with more data in less time. Proceedings of the AMIA Symposium American Medical Informatics Association. 2001;706.
Not in our library
- 63.
Imhoff M, Kuhls S, Gather U, Fried R. Smart alarms from medical devices in the or and icu. Best Practice & Research Clinical Anaesthesiology. 2009;23(1):39-50.
Not in our library10.1016/j.bpa.2008.07.008
- 64.
Cvach M. Monitor alarm fatigue: an integrative review. Biomedical Instrumentation & Technology. 2012;46(4):268-277.
Not in our library10.2345/0899-8205-46.4.268
- 65.
- 66.
Zong W, Moody G, Mark R. Reduction of false arterial blood pressure alarms using signal quality assessement and relationships between the electrocardiogram and arterial blood pressure. Medical and Biological Engineering and Computing. 2004;42(5):698-706.
Not in our library10.1007/bf02347553
- 67.
Clifford Gari D, Silva Ikaro, Moody Benjamin, Li Qiao, Kella Danesh, Shahin Abdullah, Kooistra Tristan, Perry Diane, Mark Roger G. Computing in Cardiology. 2015;42:273-276.
Not in our library10.1109/cic.2015.7408639
- 68.
Plesinger F, Klimes P, Halamek J, Jurak P. False alarms in intensive care unit monitors: Detection of life-threatening arrhythmias using elementary algebra, descriptive statistics and fuzzy logic. Computing in Cardiology Conference (CinC), 2015. 2015.
Not in our library
- 69.
Antink CH, Leonhardt S. Reducing false arrhythmia alarms using robust interval estimation and machine learning. Computing in Cardiology Conference (CinC), 2015. 2015.
Not in our library
- 70.
Fallet S, Yazdani S, Vesin JM. A multimodal approach to reduce false arrhythmia alarms in the intensive care unit. Computing in Cardiology Conference (CinC), 2015. 2015.
Not in our library
- 71.
Clifford GD, Long WJ, Moody GB, Szolovits P. Robust parameter extraction for decision support using multimodal intensive care data. Philosophical transactions Series A, Mathematical, physical, and engineering sciences. 2009;367(1887):411-429.
Not in our library10.1098/rsta.2008.0157
- 72.
Metnitz PGH, Moreno RP, Almeida E, Jordan B, Bauer P, Campos RA, Iapichino G, Edbrooke D, Capuzzo M, Le Gall JR. SAPS 3–From evaluation of the patient to evaluation of the intensive care unit. Part 1: Objectives, methods and cohort description. Intensive Care Medicine. 2005;31(10):1336-44.
Not in our library10.1007/s00134-005-2762-6
- 73.
Tukey JW. Exploratory data analysis. 1977.
Not in our library
- 74.
Barnett V, Lewis T. Outliers in statistical data. 1994;3.
Not in our library
- 75.
Fialho A, Celi L, Cismondi F, Vieira S, Reti S, Sousa J, Finkelstein S, et al. Disease-based modeling to predict fluid response in intensive care units. Methods Inf Med. 2013;52(6):494-502.
Not in our library10.3414/me12-01-0093
- 76.
Aleks N, Russell SJ, Madden MG, Morabito D, Staudenmayer K, Cohen M, Manley GT. Probabilistic detection of short events, with application to critical care monitoring. Advances in Neural Information Processing Systems. 2009;49-56.
Not in our library
- 77.
Quinn JA, Williams CK, McIntosh N. Factorial switching linear dynamical systems applied to physiological condition monitoring. Pattern Analysis and Machine Intelligence, IEEE Transactions on. 2009;31(9):1537-1551.
Not in our library10.1109/tpami.2008.191
- 78.
Georgatzis K, Williams CK. Discriminative switching linear dynamical systems applied to physiological condition monitoring. arXiv preprint arXiv:1504.06494. 2015.
Not in our library10.1109/tpami.2008.191
- 79.
Hug CW, Clifford GD, Reisner AT. Clinician blood pressure documentation of stable intensive care patients: an intelligent archiving agent has a higher association with future hypotension. Critical care medicine. 2011;39(5):1006-1014.
Not in our library10.1097/ccm.0b013e31820eab8e
- 80.
Snow R, O'Connor B, Jurafsky D, Ng AY. Cheap and fast— but is it good?: evaluating non-expert annotations for natural language tasks. Proceedings of the conference on empirical methods in natural language processing. 2008;254-263.
Not in our library
- 81.
Zhu T, Johnson AEW, Behar J, Clifford GD. Crowd-sourced annotation of ECG signals using contextual information. Annals of Biomedical Engineering. 2014;42(4):871-884.
Not in our library10.1007/s10439-013-0964-6
- 82.
Kohler BU, Hennig C, Orglmeister R. The principles of software QRS detection. Engineering in Medicine and Biology Magazine, IEEE. 2002;21(1):42-57.
Not in our library10.1109/51.993193
- 83.
Jakob S, Korhonen I, Ruokonen E, Virtanen T, Kogan A, Takala J. Detection of artifacts in monitored trends in intensive care. Computer methods and programs in biomedicine. 2000;63(3):203-209.
Not in our library10.1016/s0169-2607(00)00110-3
- 84.
Yang P, Dumont GA, Ansermino JM. Sensor fusion using a hybrid median filter for artifact removal in intraoperative Heart Rate monitoring. Journal of clinical monitoring and computing. 2009;23(2):75-83.
Not in our library10.1007/s10877-009-9163-2
- 85.
Allen J, Murray A. Assessing ECG signal quality on a coronary care unit. Physiological measurement. 1996;17(4):249.
Not in our library10.1088/0967-3334/17/4/002
- 86.
Kaiser W, Findeis M. Novel signal processing methods for exercise ECG. Special issue on Electrocardiography in Ischemic Heart Disease, Proceedings of IJBEM. 2000;2.
Not in our library
- 87.
Chen L, McKenna T, Reisner A, Reifman J. Algorithms to qualify respiratory data collected during the transport of trauma patients. Physiological measurement. 2006;27(9):797.
Not in our library10.1088/0967-3334/27/9/004
- 88.
Johnson AEW, Behar J, Andreotti F, Clifford GD, Oster J. Multimodal heart beat detection using signal quality indices. Physiological measurement. 2015;36(8):1665.
Not in our library10.1088/0967-3334/36/8/1665
- 89.
Harvey AC. Forecasting, structural time series models and the Kalman filter. 1990.
Not in our library
- 90.
Sittig DF, Factor M. Physiologic trend detection and artifact rejection: a parallel implementation of a multi-state Kalman filtering algorithm. Computer Methods and Programs in Biomedicine. 1990;31(1):1-10.
Not in our library10.1016/0169-2607(90)90026-6
- 91.
Feldman JM, Ebrahim MH, Bar-Kana I. Robust Sensor Fusion improves Heart Rate estimation: clinical evaluation. Journal of clinical monitoring. 1997;13(6):379-384.
Not in our library10.1023/a:1007476707284
- 92.
Ebrahim MH, Feldman JM, Bar-Kana I. A Robust Sensor Fusion method for Heart Rate estimation. Journal of clinical monitoring. 1997;13(6):385-393.
Not in our library10.1023/a:1007438224122
- 93.
Tarassenko L, Townsend N, Clifford G, Mason L, Burton J, Price J. Medical signal processing using the software monitor. Intelligent Sensor Processing (Ref No 2001/050), A DERA/IEE Workshop on. 2001;3/1-3/4.
Not in our library
- 94.
Challa S, Koks D. Bayesian and dempster-shafer fusion. Sadhana. 2004;29(2):145-174.
Not in our library
- 95.
Wartzek T, Brueser C, Walter M, Leonhardt S. Robust Sensor Fusion of Unobtrusively Measured Heart Rate. IEEE Journal of Biomedical and Health Informatics. 2013;18:654-660.
Not in our library10.1109/jbhi.2013.2274211
- 96.
Oster J, Behar J, Johnson AEW, Sayadi O, Nemati S, Clifford GD. Semi-supervised ECG beat Classification and Novelty Detection based on Switching Kalman Filters. Biomedical Engineering, IEEE Transactions on. 2014.
Not in our library10.1109/tbme.2015.2402236
- 97.
Eddy DM. Variations in physician practice: the role of uncertainty. Health affairs. 1984;3(2):74-89.
Not in our library10.1377/hlthaff.3.2.74
- 98.
Little RJ, Rubin DB. Statistical analysis with missing data. 2014.
Not in our library
- 99.
Vesin A, Azoulay E, Ruckly S, Vignoud L, Rusinovà K, Benoit D, Soares M, Azeivedo-Maia P, Abroug F, Benbenishty J, et al. Reporting and handling missing values in clinical studies in intensive care units. Intensive care medicine. 2013;39(8):1396-1404.
Not in our library10.1007/s00134-013-2949-1
- 100.
Sterne JA, White IR, Carlin JB, Spratt M, Royston P, Kenward MG, Wood AM, Carpenter JR. Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. BMJ. 2009;338.
Not in our library10.1136/bmj.b2393
- 101.
Shah SJ, Katz DH, Selvaraj S, Burke MA, Yancy CW, Gheorghiade M, Bonow RO, Huang CC, Deo RC. Phenomapping for novel classification of heart failure with preserved ejection fraction. Circulation. 2014.
Not in our library10.1161/circulationaha.114.010637
- 102.
Waljee AK, Mukherjee A, Singal AG, Zhang Y, Warren J, Balis U, Marrero J, Zhu J, Higgins PD. Comparison of imputation methods for missing laboratory data in medicine. BMJ open. 2013;3(8):e002847.
Not in our library10.1136/bmjopen-2013-002847
- 103.
Kim SH, Yang HJ, Kim SH, Lee GS. Physiocover: Recovering the missing values in physiological data of intensive care units. International Journal of Contents. 2014;10(2):47-58.
Not in our library
- 104.
Long Q, Johnson BA. Variable selection in the presence of missing data: resampling and imputation. Biostatistics. 2015;kxv003.
Not in our library10.1093/biostatistics/kxv003
- 105.
Moreno RP, Metnitz PGH, Almeida E, Jordan B, Bauer P, Campos RA, Iapichino G, Edbrooke D, Capuzzo M, Le Gall JR. SAPS 3–From evaluation of the patient to evaluation of the intensive care unit. Part 2: Development of a prognostic model for hospital mortality at ICU admission. Intensive Care Medicine. 2005;31(10):1345-55.
Not in our library10.1007/s00134-005-2763-5
- 106.
Schafer JL, Graham JW. Missing data: our view of the state of the art. Psychological methods. 2002;7(2):147.
Not in our library
- 107.
Dempster AP, Laird NM, Rubin DB. Maximum likelihood from incomplete data via the em algorithm. Journal of the royal statistical society Series B (methodological). 1977;39:1-38.
Not in our library
- 108.
Rubin DB. Multiple imputations in sample surveys-a phenomenological bayesian approach to nonresponse. Proceedings of the survey research methods section of the American Statistical Association. 1978;1:20-34.
Not in our library
- 109.
Rubin DB. Multiple imputation for nonresponse in surveys. 2004.
Not in our library
- 110.
Chevret S, Seaman S, Resche-Rigon M. Multiple imputation: a mature approach to dealing with missing data. Intensive care medicine. 2015;41(2):348-350.
Not in our library10.1007/s00134-014-3624-x
- 111.
Clifton L, Clifton DA, Pimentel M, Watkinson PJ, Tarassenko L, et al. Gaussian process regression in vital-sign early warning systems. Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE. 2012;6161-6164.
Not in our library10.1109/embc.2012.6347400
- 112.
Lasko TA. Nonstationary Gaussian Process Regression for Evaluating Clinical Laboratory Test Sampling Strategies. Proceedings of the AAAI Conference on Artificial Intelligence. 2015;2015:1777-1783.
Not in our library
- 113.
Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive care medicine. 2013;39(2):165-228.
Not in our library10.1007/s00134-012-2769-8
- 114.
Lindenauer PK, Lagu T, Shieh MS, Pekow PS, Rothberg MB. Association of diagnostic coding with trends in hospitalizations and mortality of patients with pneumonia, 2003-2009. Jama. 2012;307(13):1405-1413.
Not in our library10.1001/jama.2012.384
- 115.
Halpern Y, Choi Y, Horng S, Sontag D. Using anchors to estimate clinical state without labeled data. AMIA Annual Symposium Proceedings. 2014;2014:606.
Not in our library
- 116.
Elkan C, Noto K. Learning classifiers from only positive and unlabeled data. Proceedings of the 14th ACM SIGKDD international conference on Knowledge discovery and data mining. 2008;213-220.
Not in our library
- 117.
Gjø rup T, Kelbaek HS, Nielsen DL, Kreiner S, Godtfredsen J. Reproducibility of electrocardiographic interpretation in patients with suspected myocardial infarction. A controlled study of the effect of a training trial. Tech Rep. 1994;1.
Not in our library
- 118.
Bond R, Finlay D, Clifford GD, Drew B, Breen C, Guldenring D, Gallagher AG. Eye tracking technology and the 12-lead electrocardiogram: Where the experts look? 39th Annual Conference of the International Society for Computerized Electrocardiography. 2014.
Not in our library
- 119.
Salerno SM, Alguire PC, Waxman HS. Competency in interpretation of 12-lead electrocardiograms: a summary and appraisal of published evidence. Ann Intern Med. 2003;138(9):751-760.
Not in our library10.7326/0003-4819-138-9-200305060-00013
- 120.
Clifford G, Azuaje F, McSharry P. Advanced methods and tools for ECG data analysis. 2006.
Not in our library
- 121.
Dawid AP, Skene AM. Maximum likelihood estimation of observer error-rates using the EM algorithm. J R Stat Soc Ser C Appl Stat. 1979;28(1):20-28.
Not in our library
- 122.
Raykar V, Yu S, Zhao L, Jerebko A, Florin C, Valadez G, Bogoni L, Moy L. Supervised learning from multiple experts: Whom to trust when everyone lies a bit. Proceedings of the 26th Annual International Conference on Machine Learning. 2009;889-896.
Not in our library
- 123.
Raykar VC, Yu S, Zhao LH, Valadez GH, Florin C, Bogoni L, Moy L, Blei D. Learning from crowds. J Mach Learn Res. 2010;1297-1322.
Not in our library
- 124.
Zhu T, Behar J, Papastylianou T, Clifford GD. Crowdlabel: A Crowd-sourcing Platform for Electrophysiology. Comput Cardiol. 2014;41.
Not in our library
- 125.
Welinder P, Perona P. Online crowdsourcing: rating annotators and obtaining cost-effective labels. Computer Vision and Pattern Recognition Workshops (CVPRW), 2010 IEEE Computer Society Conference on. 2010;25-32.
Not in our library
- 126.
Welinder P, Branson S, Perona P, Belongie SJ. The multidimensional wisdom of crowds. Advances in neural information processing systems. 2010;2424-2432.
Not in our library
- 127.
Zhu T, Dunkley N, Behar J, Clifton DA, Clifford GD. Fusing continuous-valued medical labels using a Bayesian model. arXiv preprint arXiv:1503.06619. 2015.
Not in our library10.1007/s10439-015-1344-1
- 128.
Holzinger A, Röcker C, Ziefle M. From smart health to smart hospitals. Smart Health. 2015;1-20.
Not in our library
- 129.
Power GS, Harrison DA. Why try to predict icu outcomes? Current opinion in critical care. 2014;20(5):544-549.
Not in our library10.1097/mcc.0000000000000136
- 130.
Knaus WA, Zimmerman JE, Wagner DP, Draper EA, Lawrence DE. APACHE-acute physiology and chronic health evaluation: a physiologically based classification system. Critical Care Medicine. 1981;9:591-597.
Not in our library10.1097/00003246-198108000-00008
- 131.
Knaus WA, Zimmerman JE, Wagner DP, Draper EA. APACHE II: a severity of disease classification system. Critical Care Medicine. 1985;13:818-829.
Not in our library
- 132.
Knaus WA, Wagner DP, Draper EA, Zimmerman JE, Bergner M, Bastos PG, Sirio CA, Murphy DJ, Lotring T, Damiano A. The APACHE III prognostic system. risk prediction of hospital mortality for critically ill hospitalized adults. Chest. 1991;100(6):1619-1636.
Not in our library10.1378/chest.100.6.1619
- 133.
LeGall JR, Loirat P, Alperovitch A, Glaser P, Granthil C, Mathieu D, Mercier P, Thomas R, Villers D. A simplified acute physiology score for ICU patients. Critical Care Medicine. 1984;12(11):975-977.
Not in our library10.1097/00003246-198411000-00012
- 134.
LeGall JR, Lemeshow S, Saulnier F. A new simplified acute physiology score (SAPS-II) based on a european north-american multicenter study. JAMA. 1993;270(24):2957-2963.
Not in our library10.1001/jama.270.24.2957
- 135.
Lemeshow S, Teres D, Pastides H. A method for predicting survival and mortality of ICU patients using objectively derived weights. Critical Care Medicine. 1985;13:519-525.
Not in our library10.1097/00003246-198507000-00001
- 136.
Lemeshow S, Teres D, Klar J. Mortality probability model (MPM II) based on an international cohort of intensive care unit patients. JAMA. 1993;270:2478-2486.
Not in our library
- 137.
Higgins TL, Teres D, Copes WS, Nathanson BH, Stark M, Kramer AA. Assessing contemporary intensive care unit outcome: an updated Mortality Probability Admission Model (MPM0-III). Critical Care Medicine. 2007;35(3):827-35.
Not in our library10.1097/01.ccm.0000257337.63529.9f
- 138.
Johnson AEW, Kramer AA, Clifford GD. A new severity of illness scale using a subset of acute physiology and chronic health evaluation data elements shows comparable predictive accuracy. Critical care medicine. 2013;41(7):1711-1718.
Not in our library10.1097/ccm.0b013e31828a24fe
- 139.
Dybowski R, Weller P, Chang R, Gant V. Prediction of outcome in critically ill patients using artificial neural network synthesised by genetic algorithm. Lancet. 1996;347(9009):1146-50.
Not in our library10.1016/s0140-6736(96)90609-1
- 140.
Clermont G, Angus D, DiRusso S, Griffin M, Linde-Zwirble W. Predicting hospital mortality for patients in the intensive care unit: A comparison of artificial neural networks with logistic regression models. Critical Care Medicine. 2001;29(2):291-296.
Not in our library10.1097/00003246-200102000-00012
- 141.
Wong LS, Young JD. A comparison of ICU mortality prediction using the APACHE II scoring system and artificial neural networks. Anaesthesia. 1999;54(11):1048-54.
Not in our library10.1046/j.1365-2044.1999.01104.x
- 142.
Silva I, Moody GB, Scott DJ, Celi LA, Mark RG. Predicting In-Hospital Mortality of ICU Patients: The PhysioNet/Computing in Cardiology Challenge 2012. Computing in Cardiology. 2012;39:245-248.
Not in our library
- 143.
Johnson AEW, Dunkley N, Mayaud L, Tsanas A, Kramer AA, Clifford GD. Patient Specific Predictions in the Intensive Care Unit Using a Bayesian Ensemble. Computing in Cardiology. 2012;39:249-252.
Not in our library
- 144.
Citi L, Barbieri R. Physionet 2012 challenge: predicting mortality of ICu patients using a cascaded SVM-glm paradigm. Comput Cardiol. 2012;39:257-60.
Not in our library
- 145.
Pirracchio R, Petersen ML, Carone M, Rigon MR, Chevret S, van der Laan MJ. Mortality prediction in intensive care units with the super icu learner algorithm (sicula): a population-based study. The Lancet Respiratory Medicine. 2015;3(1):42-52.
Not in our library10.1016/s2213-2600(14)70239-5
- 146.
Mayer CC, Bachler M, Hörtenhuber M, Stocker C, Holzinger A, Wassertheurer S. Selection of entropy-measure parameters for knowledge discovery in heart rate variability data. BMC bioinformatics. 2014;15(Suppl 6):S2.
Not in our library10.1186/1471-2105-15-s6-s2
- 147.
Saria S, et al. Integration of early physiological responses predicts later illness severity in preterm infants. Science translational medicine. 2010;2(48):48-65.
Not in our library10.1126/scitranslmed.3001304
- 148.
Ghassemi MM, Richter SE, Eche IM, Chen TW, Danziger J, Celi LA. A data-driven approach to optimized medication dosing: a focus on heparin. Intensive care medicine. 2014;40(9):1332-1339.
Not in our library10.1007/s00134-014-3406-5
- 149.
Ghassemi MM, Westover MB, Badawi RG, Mark Omar, Nemati S. Personalized medication dosing via sequential regression: A focus on heparin. American Journal of Respiratory and Critical Care. 2015.
Not in our library
- 150.
Nemati S, Adams R. Identifying outcome-discriminative dynamics in multivariate physiological cohort time series. Advanced State Space Methods for Neural and Clinical Data. 2015;283.
Not in our library
- 151.
Nachimuthu SK, Wong A, Haug PJ. Modeling glucose homeostasis and insulin dosing in an intensive care unit using dynamic bayesian networks. AMIA Annual Symposium Proceedings. 2010;2010:532.
Not in our library
- 152.
Smith A, West M, Gordon K, Knapp M, Trimble I. Monitoring kidney transplant patients. The Statistician. 1983;32:46-54.
Not in our library
- 153.
Gather U, Imhoff M, Fried R. Graphical models for multivariate time series from intensive care monitoring. Statistics in medicine. 2002;21(18):2685-2701.
Not in our library10.1002/sim.1209
- 154.
Williams C, Quinn J, Mcintosh N. Factorial switching kalman filters for condition monitoring in neonatal intensive care. Advances in Neural Information Processing Systems. 2005;1513-1520.
Not in our library
- 155.
van der Heijden M, Velikova M, Lucas PJ. Learning bayesian networks for clinical time series analysis. Journal of biomedical informatics. 2014;48:94-105.
Not in our library10.1016/j.jbi.2013.12.007
- 156.
Xing Z, Pei J, Keogh E. A brief survey on sequence classification. ACM SIGKDD. 2010;12(1):40-48.
Not in our library
- 157.
Liao TW. Clustering of time series dataa survey. Pattern recognition. 2005;38(11):1857-1874.
Not in our library
- 158.
Rennie JD, Jaakkola T. Using term informativeness for named entity detection. Proceedings of the 28th annual international ACM SIGIR conference on Research and development in information retrieval. 2005;353-360.
Not in our library
- 159.
Lehman L, Kyaw T, Clifford G, Mark R. A temporal search engine for a massive multi-parameter clinical information database. Computers in Cardiology, 2007. 2007;637-640.
Not in our library
- 160.
Lehman L, Saeed M, Moody G, Mark R. Similarity-based searching in multi-parameter time series databases. in Computers in Cardiology, 2008. 2008;653-656.
Not in our library10.1109/cic.2008.4749126
- 161.
Sow DM, Sun J, Biem A, Hu J, Blount M, Ebadollahi S. Real-time analysis for short-term prognosis in intensive care. IBM Journal of Research and Development. 2012;56(5):3-1.
Not in our library
- 162.
Nemati S, Ghassemi MM. A fast and memory-efficient algorithm for learning and retrieval of phenotypic dynamics in multivariate cohort time series. Big Data (Big Data), 2014 IEEE International Conference on. 2014;41-44.
Not in our library
- 163.
Avent RK, Charlton JD. A critical review of trend-detection methodologies for biomedical monitoring systems. Crit Rev Biomed Eng. 1990;17(6):621-59.
Not in our library
- 164.
Saeed M, Mark R. A novel method for the efficient retrieval of similar multiparameter physiologic time series using wavelet-based symbolic representations. AMIA Annu Symp Proc. 2006;679-83.
Not in our library
- 165.
Hauskrecht M, Batal I, Valko M, Visweswaran S, Cooper GF, Clermont G. Outlier detection for patient monitoring and alerting. Journal of Biomedical Informatics. 2013;46(1):47-55.
Not in our library10.1016/j.jbi.2012.08.004
- 166.
Saria S, et al. Learning individual and population level traits from clinical temporal data. NIPS, Predictive Models in Personalized Medicine workshop. 2010.
Not in our library
- 167.
Schulam P, Wigley F, Saria S. Clustering longitudinal clinical marker trajectories from electronic health data: Applications to phenotyping and endotype discovery. 2015.
Not in our library
- 168.
Ross J, Dy J. Nonparametric mixture of gaussian processes with constraints. Proceedings of the 30th International Conference on Machine Learning (ICML-13). 2013;1346-1354.
Not in our library
- 169.
Lehman LH, Adams R, Mayaud L, Moody G, Malhotra A, Mark R, Nemati S. A physiological time series dynamics-based approach topatient monitoring and outcome prediction. Biomedical and Health Informatics, IEEE Journal of. 2014;PP(99):1-1.
Not in our library10.1109/jbhi.2014.2330827
- 170.
Marlin BM, Kale DC, Khemani RG, Wetzel RC. Unsupervised pattern discovery in electronic health care data using probabilistic clustering models. Proceedings of the 2nd ACM SIGHIT International Health Informatics Symposium. 2012;389-398.
Not in our library
- 171.
Nemati S, Adams R. Supervised learning in dynamic bayesian networks. Tech Rep. 2014.
Not in our library
- 172.
Bengio Y, Courville A, Vincent P. Representation learning: A review and new perspectives. Pattern Analysis and Machine Intelligence, IEEE Transactions on. 2013;35(8):1798-1828.
Not in our library10.1109/tpami.2013.50
- 173.
Rumelhart DE, Hinton GE, Williams RJ. Learning representations by back-propagating errors. Cognitive modeling. 1988;323:533-536.
Not in our library10.1038/323533a0
- 174.
Phadia E. Prior Processes and their Applications: Nonparametric Bayesian Estimation. 2013.
Not in our library
- 175.
Shi J, Choi T. Gaussian Process Regression Analysis for Functional Data. 2011.
Not in our library
- 176.
Clifton L, Clifton DA, Pimentel MA, Watkinson PJ, Tarassenko L. Gaussian processes for personalized e-health monitoring with wearable sensors. Biomedical Engineering, IEEE Transactions on. 2013;60(1):193-197.
Not in our library10.1109/tbme.2012.2208459
- 177.
Orphanidou C, Bonnici T, Charlton P, Clifton D, Vallance D, Tarassenko L. Signal quality indices for the electrocardiogram and photoplethysmogram: Derivation and applications to wireless monitoring. IEEE Journal of Biomedical and Health Informatics. 2015;19(3):832-838.
Not in our library10.1109/jbhi.2014.2338351
- 178.
Clifton DA, Clifton L, Hugueny S, Wong D, Tarassenko L. An extreme function theory for novelty detection. Selected Topics in Signal Processing, IEEE Journal of. 2013;7(1):28-37.
Not in our library
- 179.
Clifton L, Clifton D, Pimentel M. Gaussian Processes for Personalised e-Health Monitoring with Wearable Sensors. Biomedical Engineering IEEE Transactions on. 2011;(c):1-4.
Not in our library10.1109/tbme.2012.2208459
- 180.
Clifton D, Hugueny S, Tarassenko L, et al. Pinning the tail on the distribution: a multivariate extension to the generalised pareto distribution. Machine learning for signal processing (MLSP), 2011 IEEE International Workshop on. 2011;1-6.
Not in our library
- 181.
Clifton L, Clifton DA, Zhang Y, Watkinson P, Tarassenko L, Yin H. Probabilistic novelty detection with support vector machines. IEEE Transactions on Reliability. 2014;63.
Not in our library
- 182.
Clifton D, Wong D, Clifton L, Pullinger R, Tarassenko L. A large-scale clinical validation of an integrated monitoring system in the emergency department. IEEE Transactions on Information Technology in Biomedicine. 2013;17(4):835-877.
Not in our library10.1109/jbhi.2012.2234130
- 183.
Duerichen R, Pimentel M, Clifton L, Schweikard A, Clifton DA, et al. Multitask gaussian processes for multivariate physiological time-series analysis. Biomedical Engineering, IEEE Transactions on. 2015;62(1):314-322.
Not in our library10.1109/tbme.2014.2351376
- 184.
Pimentel MA, Clifton DA, Tarassenko L. Gaussian process clustering for the functional characterisation of vital-sign trajectories. Machine Learning for Signal Processing (MLSP), 2013 IEEE International Workshop on. 2013;1-6.
Not in our library
- 185.
Behar J, Johnson AE, Oster J, Clifford G. An echo state neural network for foetal ECG extraction optimised by random search. NIPS. 2013.
Not in our library
- 186.
Ghassemi M, Lehman LH, Snoek J, Nemati S. Global optimization approaches for parameter tuning in biomedical signal processing: A focus of multi-scale entropy. Tech Rep. 2014.
Not in our library
- 187.
Snoek J, Larochelle H, Adams RP. Practical Bayesian optimization of machine learning algorithms. Advances in Neural Information Processing Systems. 2012;2951-2959.
Not in our library
- 188.
Fan J, Mei K, Peng J, Zheng N, Gao L. Hierarchical classification of large-scale patient records for automatic treatment stratification. 2015.
Not in our library10.1109/jbhi.2015.2414876
- 189.
Kale DC, Gong D, Che Z, Liu Y, Medioni G, Wetzel R, Ross P. An examination of multivariate time series hashing with applications to health care. Data Mining (ICDM), 2014 IEEE International Conference on. 2014;260-269.
Not in our library
- 190.
- 191.
Wiens J, Guttag J, Horvitz E. Patient risk stratification for hospital-associated c. diff as a time-series classification task (accepted for publication). Neural Information Processing Systems Foundation (NIPS). 2012.
Not in our library
- 192.
Liu TF, Shafer RW. Web resources for HIV type 1 genotypic-resistance test interpretation. Clinical Infectious Diseases. 2006;42(11):1608-1618.
Not in our library10.1086/503914
- 193.
Beerenwinkel N, Däumer M, Oette M, Korn K, Hoffmann D, Kaiser R, Lengauer T, Selbig J, Walter H. Geno2pheno: Estimating phenotypic drug resistance from HIV-1 genotypes. Nucleic Acids Research. 2003;31(13):3850-3855.
Not in our library10.1093/nar/gkg575
- 194.
Prosperi MC, Altmann A, Rosen-Zvi M, Aharoni E, Borgulya G, Bazso F, Sönnerborg A, Schülter E, Struck D, Ulivi G, et al. Investigation of expert rule bases, logistic regression, and non-linear machine learning techniques for predicting response to antiretroviral treatment. Antivir Ther. 2009;14(3):433-42.
Not in our library
- 195.
- 196.
Rishishwar L, Petit RA, Kraft CS, Jordan IK. Genome sequence-based discriminator for vancomycin-intermediate staphylococcus aureus. Journal of bacteriology. 2014;196(5):940-948.
Not in our library10.1128/jb.01410-13
- 197.
Drouin A, Giguere S, Sagatovich V, Deraspe M, Laviolette F, Marchand M, Corbeil J. Learning interpretable models of phenotypes from whole genome sequences with the set covering machine. Neural Information Processing Systems (NIPS), Computational Biology workshop. 2014.
Not in our library
- 198.
Niehaus KE, Walker TM, Crook DW, Peto TE, Clifton DA, et al. Machine learning for the prediction of antibacterial susceptibility in mycobacterium tuberculosis. Biomedical and Health Informatics (BHI), 2014 IEEE-EMBS International Conference on. 2014;618-621.
Not in our library
- 199.
Lehman Lw, Saeed M, Long W, Lee J, Mark R. Risk stratification of icu patients using topic models inferred from unstructured progress notes. AMIA Annual Symposium Proceedings. 2012;2012:505.
Not in our library
- 200.
Ghassemi M, Pimentel MA, Naumann T, Brennan T, Clifton DA, Szolovits P, Feng M. A multivariate timeseries modeling approach to severity of illness assessment and forecasting in ICu with sparse, heterogeneous clinical data. 2015.
Not in our library
- 201.
Ghassemi M, Mark R, Nemati S. A visualization of evolving clinical sentiment using vector representations of clinical notes. Tech Rep. 2015.
Not in our library10.1109/cic.2015.7410989
- 202.
Collins SA, Cato K, Albers D, Scott K, Stetson PD, Bakken S, Vawdrey DK. Relationship between nursing documentation and patients mortality. American Journal of Critical Care. 2013;22(4):306-313.
Not in our library10.4037/ajcc2013426
- 203.
Mandl KD, Kohane IS. Escaping the EHR trap - the future of health IT. New England Journal of Medicine. 2012;366(24):2240-2242.
Not in our library10.1056/nejmp1203102
- 204.
Celi LA, Mark RG, Stone DJ, Montgomery RA. “big data” in the intensive care unit closing the data loop. American journal of respiratory and critical care medicine. 2013;187(11):1157-1160.
Not in our library10.1164/rccm.201212-2311ed
- 205.
Holzinger A, Jurisica I. Knowledge discovery and data mining in biomedical informatics: The future is in integrative, interactive machine learning solutions. Interactive Knowledge Discovery and Data Mining in Biomedical Informatics. 2014;1-18.
Not in our library
- 206.
Deng J, Dong W, Socher R, Li LJ, Li K, Fei-Fei L. Imagenet: A large-scale hierarchical image database. Computer Vision and Pattern Recognition 2009 CVPR 2009 IEEE Conference on. 2009;248-255.
Not in our library
- 207.
Moody GB, Mark RG. The impact of the mit-bih arrhythmia database. Engineering in Medicine and Biology Magazine, IEEE. 2001;20(3):45-50.
Not in our library10.1109/51.932724
- 208.
Black N. High-quality clinical databases: breaking down barriers. The Lancet. 1999;353(9160):1205-1206.
Not in our library10.1016/s0140-6736(99)00108-7
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