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6-Fluoro-4-oxochroman-2-carboxylic acid

Pei Chen, Shan Qian, Zhe-Qin Shi and 1 more

Acta Crystallographica Section E · 2010

doi:10.1107/s1600536809054555 (opens in a new tab)

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Abstract

The title compound, C10H7FO4, is an intermediate in the synthesis of the drug Fidarestat, (2S,4S)-2-aminoformyl-6-fluoro-spiro[chroman-4,4′-imidazolidine]-2′,5′-dione. The dihydropyranone ring adopts an envelope conformation with the asymmetric C atom in the flap position. In the crystal, the molecules are linked into zigzag chains along [100] by O—H...O hydrogen bonds and C—H...π interactions involving the benzene ring.

Abstract licence: CC BY

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